| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahsan Habib, Darrell Sawmiller, Jun Ta. Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease. Journal of neuroscience research. vol 95. issue 4. 2017-11-16. PMID:27531392. |
in addition, sappα influences amyloid-β (aβ) production by direct modulation of app β-secretase proteolysis as well as aβ-related or unrelated tau pathology, hallmark pathologies of alzheimer's disease (ad). |
2017-11-16 |
2023-08-13 |
Not clear |
| Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjel. CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of aging. vol 49. 2017-11-16. PMID:27794264. |
we tested whether csf nfl levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established csf alzheimer's disease (ad) biomarkers, β-amyloid 1-42, and phosphorylated tau (p-tau). |
2017-11-16 |
2023-08-13 |
human |
| Hanna Cho, Jae Yong Choi, Seung Ha Lee, Jae Hoon Lee, Young-Chul Choi, Young Hoon Ryu, Myoung Sik Lee, Chul Hyoung Lyo. Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease. Neurobiology of aging. vol 53. 2017-11-16. PMID:28254589. |
excessive tau accumulation in the parieto-occipital cortex characterizes early-onset alzheimer's disease. |
2017-11-16 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Anders Lönneborg, Marina Boccardi, Kaj Blennow, Oskar Hansso. Clinical validity of cerebrospinal fluid Aβ42, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework. Neurobiology of aging. vol 52. 2017-11-16. PMID:28317649. |
clinical validity of cerebrospinal fluid aβ42, tau, and phospho-tau as biomarkers for alzheimer's disease in the context of a structured 5-phase development framework. |
2017-11-16 |
2023-08-13 |
Not clear |
| Sarah N Fontaine, Alexandria Ingram, Ryan A Cloyd, Shelby E Meier, Emily Miller, Danielle Lyons, Grant K Nation, Elizabeth Mechas, Blaine Weiss, Chiara Lanzillotta, Fabio Di Domenico, Frederick Schmitt, David K Powell, Moriel Vandsburger, Jose F Abisambr. Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach. Neurobiology of aging. vol 56. 2017-11-16. PMID:28500878. |
considering that tau tangle burden correlates well with cognitive impairment in alzheimer's patients, we performed our memri approach in a time course of aging mice and an accelerated mouse model of tauopathy. |
2017-11-16 |
2023-08-13 |
mouse |
| Moran Frenkel-Pinter, Shiri Stempler, Sharon Tal-Mazaki, Yelena Losev, Avnika Singh-Anand, Daniela Escobar-Álvarez, Jonathan Lezmy, Ehud Gazit, Eytan Ruppin, Daniel Sega. Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila. Neurobiology of aging. vol 56. 2017-11-16. PMID:28552182. |
the pathological hallmarks of alzheimer's disease (ad) are pathogenic oligomers and fibrils of misfolded amyloidogenic proteins (e.g., β-amyloid and hyper-phosphorylated tau in ad), which cause progressive loss of neurons in the brain and nervous system. |
2017-11-16 |
2023-08-13 |
human |
| C Iofrida, S Daniele, D Pietrobono, J Fusi, F Galetta, M L Trincavelli, U Bonuccelli, F Franzoni, C Martin. Influence of physical exercise on β-amyloid, α-synuclein and tau accumulation: an in vitro model of oxidative stress in human red blood cells. Archives italiennes de biologie. vol 155. issue 1-2. 2017-11-16. PMID:28715596. |
a common pathological feature of neurodegenerative disorders (nds), such as alzheimer's (ad) and parkinson's (pd) diseases, is the abnormal accumulation and misfolding of specific proteins, primarily α-synuclein (α-syn), β-amyloid1-42 (aβ) and tau, in brain and in peripheral tissues too. |
2017-11-16 |
2023-08-13 |
human |
| Heiko Braak, Kelly Del Tredic. Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases. Cold Spring Harbor perspectives in biology. vol 8. issue 11. 2017-11-13. PMID:27580631. |
potential pathways of abnormal tau and α-synuclein dissemination in sporadic alzheimer's and parkinson's diseases. |
2017-11-13 |
2023-08-13 |
human |
| Rosemary J Jackson, Nikita Rudinskiy, Abigail G Herrmann, Shaun Croft, JeeSoo Monica Kim, Veselina Petrova, Juan Jose Ramos-Rodriguez, Rose Pitstick, Susanne Wegmann, Monica Garcia-Alloza, George A Carlson, Bradley T Hyman, Tara L Spires-Jone. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European journal of neuroscience. vol 44. issue 12. 2017-11-13. PMID:27748574. |
human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of alzheimer's disease. |
2017-11-13 |
2023-08-13 |
mouse |
| Rosemary J Jackson, Nikita Rudinskiy, Abigail G Herrmann, Shaun Croft, JeeSoo Monica Kim, Veselina Petrova, Juan Jose Ramos-Rodriguez, Rose Pitstick, Susanne Wegmann, Monica Garcia-Alloza, George A Carlson, Bradley T Hyman, Tara L Spires-Jone. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European journal of neuroscience. vol 44. issue 12. 2017-11-13. PMID:27748574. |
alzheimer's disease is characterized by the presence of aggregates of amyloid beta (aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. |
2017-11-13 |
2023-08-13 |
mouse |
| Peter Dongmin Sohn, Tara E Tracy, Hye-In Son, Yungui Zhou, Renata E P Leite, Bruce L Miller, William W Seeley, Lea T Grinberg, Li Ga. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Molecular neurodegeneration. vol 11. issue 1. 2017-11-09. PMID:27356871. |
loss of polarized distribution of the axonal protein tau is an early sign of alzheimer's disease (ad) and other neurodegenerative disorders. |
2017-11-09 |
2023-08-13 |
Not clear |
| Chuanzhou Li, Jürgen Göt. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. The EMBO journal. vol 36. issue 21. 2017-11-09. PMID:28864542. |
somatodendritic accumulation of tau in alzheimer's disease is promoted by fyn-mediated local protein translation. |
2017-11-09 |
2023-08-13 |
Not clear |
| Chuanzhou Li, Jürgen Göt. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. The EMBO journal. vol 36. issue 21. 2017-11-09. PMID:28864542. |
in alzheimer's disease (ad), the axonally enriched protein tau forms hyperphosphorylated aggregates in the somatodendritic domain. |
2017-11-09 |
2023-08-13 |
Not clear |
| Z A Cordner, K L K Tamashir. Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice. Translational psychiatry. vol 6. issue 7. 2017-11-07. PMID:27404286. |
stressful life events, activation of the hypothalamic-pituitary-adrenal (hpa) axis and glucocorticoids are now thought to have a role in the development of several neurodegenerative and psychiatric disorders including alzheimer's disease (ad) through mechanisms that may include exacerbation of cognitive impairment, neuronal loss, and beta-amyloid (aβ) and tau neuropathology. |
2017-11-07 |
2023-08-13 |
mouse |
| b' Jin Chu, Domenico Pratic\\xc3\\xb. The 5-Lipoxygenase as modulator of Alzheimer\'s \\xce\\xb3-secretase and therapeutic target. Brain research bulletin. vol 126. issue Pt 2. 2017-11-06. PMID:27005438.' |
alzheimer's disease (ad) is an age-related, neurodegenerative disorder characterized by cognitive impairment with memory loss, extracellular amyloid beta (aβ) peptides aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (nft) accumulation. |
2017-11-06 |
2023-08-13 |
Not clear |
| Ting-Ting Chu, Na Gao, Qian-Qian Li, Pu-Guang Chen, Xi-Fei Yang, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei L. Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation. Cell chemical biology. vol 23. issue 4. 2017-11-06. PMID:27105281. |
tau, an important pathological protein of alzheimer's disease (ad), can mediate the toxicity of amyloid β (aβ). |
2017-11-06 |
2023-08-13 |
mouse |
| Thomas Arendt, Jens T Stieler, Max Holze. Tau and tauopathies. Brain research bulletin. vol 126. issue Pt 3. 2017-11-06. PMID:27615390. |
the second part deals with the pathophysiology of tau and description of tauopathies which comprise more than 20 disorders including alzheimer's disease, progressive supranuclear palsy, cortico basal degeneration, pick's disease and others. |
2017-11-06 |
2023-08-13 |
Not clear |
| Tae-In Kam, Hyejin Park, Youngdae Gwon, Sungmin Song, Seo-Hyun Kim, Seo Won Moon, Dong-Gyu Jo, Yong-Keun Jun. FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. eLife. vol 5. 2017-11-06. PMID:27834631. |
fcγriib-ship2 axis links aβ to tau pathology by disrupting phosphoinositide metabolism in alzheimer's disease model. |
2017-11-06 |
2023-08-13 |
Not clear |
| Jesse S Kerr, Bryan A Adriaanse, Nigel H Greig, Mark P Mattson, M Zameel Cader, Vilhelm A Bohr, Evandro F Fan. Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms. Trends in neurosciences. vol 40. issue 3. 2017-11-03. PMID:28190529. |
neurons affected in alzheimer's disease (ad) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (aβ) and tau pathologies. |
2017-11-03 |
2023-08-13 |
Not clear |
| Bartosz Nizynski, Wojciech Dzwolak, Krzysztof Nieznansk. Amyloidogenesis of Tau protein. Protein science : a publication of the Protein Society. vol 26. issue 11. 2017-11-03. PMID:28833749. |
the role of microtubule-associated protein tau in neurodegeneration has been extensively investigated since the discovery of tau amyloid aggregates in the brains of patients with alzheimer's disease (ad). |
2017-11-03 |
2023-08-13 |
Not clear |