All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Yang Wang, Tatiana Veremeyko, Andus Hon-Kit Wong, Rachid El Fatimy, Zhiyun Wei, Wei Cai, Anna M Krichevsk. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiology of aging. vol 51. 2017-09-28. PMID:28089352. microrna-132 is markedly downregulated in alzheimer's disease (ad) and related tauopathies, and its levels are closely associated with tau pathology in ad. 2017-09-28 2023-08-13 human
Yari Carlomagno, Dah-Eun Chloe Chung, Mei Yue, Monica Castanedes-Casey, Benjamin J Madden, Judy Dunmore, Jimei Tong, Michael DeTure, Dennis W Dickson, Leonard Petrucelli, Casey Coo. An acetylation-phosphorylation switch that regulates tau aggregation propensity and function. The Journal of biological chemistry. vol 292. issue 37. 2017-09-27. PMID:28760828. the aberrant accumulation of tau protein is a pathological hallmark of a class of neurodegenerative diseases known as tauopathies, including alzheimer's disease and related dementias. 2017-09-27 2023-08-13 Not clear
Jason G Kilian, Heng-Wei Hsu, Kenneth Mata, Fred W Wolf, Masashi Kitazaw. Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila. Neuroscience. vol 348. 2017-09-26. PMID:28215745. abnormal buildup of the microtubule associated protein tau is a major pathological hallmark of alzheimer's disease (ad) and various tauopathies. 2017-09-26 2023-08-13 mouse
Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago F Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buee, David Blu. Tau deletion promotes brain insulin resistance. The Journal of experimental medicine. vol 214. issue 8. 2017-09-26. PMID:28652303. the present data have far-reaching clinical implications and raise the hypothesis that pathophysiological tau loss-of-function favors brain insulin resistance, which is instrumental for cognitive and metabolic impairments in alzheimer's disease patients. 2017-09-26 2023-08-13 mouse
Luca C Gobbi, Henner Knust, Matthias Körner, Michael Honer, Christian Czech, Sara Belli, Dieter Muri, Martin R Edelmann, Thomas Hartung, Isabella Erbsmehl, Sandra Grall-Ulsemer, Andreas Koblet, Marianne Rueher, Sandra Steiner, Hayden T Ravert, William B Mathews, Daniel P Holt, Hiroto Kuwabara, Heather Valentine, Robert F Dannals, Dean F Wong, Edilio Borron. Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography. Journal of medicinal chemistry. vol 60. issue 17. 2017-09-26. PMID:28654263. identification of three novel radiotracers for imaging aggregated tau in alzheimer's disease with positron emission tomography. 2017-09-26 2023-08-13 human
Luca C Gobbi, Henner Knust, Matthias Körner, Michael Honer, Christian Czech, Sara Belli, Dieter Muri, Martin R Edelmann, Thomas Hartung, Isabella Erbsmehl, Sandra Grall-Ulsemer, Andreas Koblet, Marianne Rueher, Sandra Steiner, Hayden T Ravert, William B Mathews, Daniel P Holt, Hiroto Kuwabara, Heather Valentine, Robert F Dannals, Dean F Wong, Edilio Borron. Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography. Journal of medicinal chemistry. vol 60. issue 17. 2017-09-26. PMID:28654263. aggregates of tau and beta amyloid (aβ) plaques constitute the histopathological hallmarks of alzheimer's disease and are prominent targets for novel therapeutics as well as for biomarkers for diagnostic in vivo imaging. 2017-09-26 2023-08-13 human
Alberto Cornejo, Felipe Aguilar Sandoval, Leonardo Caballero, Luis Machuca, Patricio Muñoz, Julio Caballero, George Perry, Alejandro Ardiles, Carlos Areche, Francisco Mel. Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 32. issue 1. 2017-09-26. PMID:28701064. rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to alzheimer's disease. 2017-09-26 2023-08-13 Not clear
David J Irwin, Alberto Lleó, Sharon X Xie, Corey T McMillan, David A Wolk, Edward B Lee, Viviana M Van Deerlin, Leslie M Shaw, John Q Trojanowski, Murray Grossma. Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Annals of neurology. vol 82. issue 2. 2017-09-26. PMID:28719018. to test the hypotheses that (1) antemortem cerebrospinal fluid (csf) tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration (ftld) and (2) tauopathy patients have higher phosphorylated-tau levels compared to transactivation response element dna-binding protein 43 (tdp-43) proteinopathy patients while accounting for alzheimer's disease (ad) copathology. 2017-09-26 2023-08-13 Not clear
Evgenia Salta, Annerieke Sierksma, Elke Vanden Eynden, Bart De Stroope. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO molecular medicine. vol 8. issue 9. 2017-09-25. PMID:27485122. mir-132 loss de-represses itpkb and aggravates amyloid and tau pathology in alzheimer's brain. 2017-09-25 2023-08-13 mouse
Jared R Brosch, Martin R Farlow, Shannon L Risacher, Liana G Apostolov. Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 1. 2017-09-25. PMID:27873182. tau imaging in alzheimer's disease diagnosis and clinical trials. 2017-09-25 2023-08-13 Not clear
Jared R Brosch, Martin R Farlow, Shannon L Risacher, Liana G Apostolov. Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 1. 2017-09-25. PMID:27873182. in vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. 2017-09-25 2023-08-13 Not clear
Gwënaël Pottiez, Li Yang, Tessandra Stewart, Ning Song, Patrick Aro, Douglas R Galasko, Joseph F Quinn, Elaine R Peskind, Min Shi, Jing Zhan. Mass-Spectrometry-Based Method To Quantify in Parallel Tau and Amyloid β 1-42 in CSF for the Diagnosis of Alzheimer's Disease. Journal of proteome research. vol 16. issue 3. 2017-09-25. PMID:28112948. mass-spectrometry-based method to quantify in parallel tau and amyloid β 1-42 in csf for the diagnosis of alzheimer's disease. 2017-09-25 2023-08-13 Not clear
Zhi-Hao Wang, Pai Liu, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Shan Ping Yu, Jian-Zhi Wang, Keqiang Y. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Molecular cell. vol 67. issue 5. 2017-09-25. PMID:28826672. delta-secretase, a lysosomal asparagine endopeptidase (aep), simultaneously cleaves both app and tau, controlling the onset of pathogenesis of alzheimer's disease (ad). 2017-09-25 2023-08-13 mouse
Jennifer L Furman, Jaime Vaquer-Alicea, Charles L White, Nigel J Cairns, Peter T Nelson, Marc I Diamon. Widespread tau seeding activity at early Braak stages. Acta neuropathologica. vol 133. issue 1. 2017-09-22. PMID:27878366. transcellular propagation of tau aggregates may underlie the progression of pathology in alzheimer's disease (ad) and other tauopathies. 2017-09-22 2023-08-13 mouse
S Ozcelik, F Sprenger, Z Skachokova, G Fraser, D Abramowski, F Clavaguera, A Probst, S Frank, M Müller, M Staufenbiel, M Goedert, M Tolnay, D T Winkle. Co-expression of truncated and full-length tau induces severe neurotoxicity. Molecular psychiatry. vol 21. issue 12. 2017-09-21. PMID:26830137. abundant tau inclusions are a defining hallmark of several human neurodegenerative diseases, including alzheimer's disease. 2017-09-21 2023-08-13 mouse
Ben Sundra Ashok, Thekkuttuparambil Ananthanarayanan Ajith, Senthilkumar Sivanesa. Hypoxia-inducible factors as neuroprotective agent in Alzheimer's disease. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:28004401. beta amyloid (aβ)-42 peptide and phosphorylated tau protein have been demonstrated as the pathological hallmarks of alzheimer's disease (ad). 2017-09-21 2023-08-13 Not clear
Chiara Fania, Beatrice Arosio, Daniele Capitanio, Enrica Torretta, Cristina Gussago, Evelyn Ferri, Daniela Mari, Cecilia Gelf. Protein signature in cerebrospinal fluid and serum of Alzheimer's disease patients: The case of apolipoprotein A-1 proteoforms. PloS one. vol 12. issue 6. 2017-09-21. PMID:28628634. in the diagnosis of alzheimer's disease (ad) total tau (t-tau), tau phosphorylated at threonine 181 (p-tau181), and the 42 amino acid isoform of alpha β-amyloid (aβ) are well established surrogate csf markers. 2017-09-21 2023-08-13 Not clear
Young Doo Kim, Eun Il Jeong, Jihoon Nah, Seung-Min Yoo, Won Jae Lee, Youbin Kim, Seowon Moon, Se-Hoon Hong, Yong-Keun Jun. Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy. Journal of neurochemistry. vol 142. issue 5. 2017-09-21. PMID:28632947. in neurodegenerative diseases like alzheimer's disease (ad), tau is hyperphosphorylated and forms aggregates and neurofibrillary tangles in affected neurons. 2017-09-21 2023-08-13 mouse
David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Plat. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica. vol 132. issue 6. 2017-09-20. PMID:27770234. soluble pre-fibrillar tau and β-amyloid species emerge in early human alzheimer's disease and track disease progression and cognitive decline. 2017-09-20 2023-08-13 human
David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Plat. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica. vol 132. issue 6. 2017-09-20. PMID:27770234. post-mortem investigations of human alzheimer's disease (ad) have largely failed to provide unequivocal evidence in support of the original amyloid cascade hypothesis, which postulated deposition of β-amyloid (aβ) aggregates to be the cause of a demented state as well as inductive to tau neurofibrillary tangles (nfts). 2017-09-20 2023-08-13 human