| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Igor Shirolapov, Alexander Zakharov, Daria Smirnova, Elena Khivintseva, Mariya Sergeev. Aging Brain, Dementia and Impaired Glymphatic Pathway: Causal Relationships. Psychiatria Danubina. vol 35. issue Suppl 2. 2023-10-06. PMID:37800234. |
the hypotheses of β-amyloid and tau protein largely explain the main pathological features of alzheimer's disease, however, there remains a need for further research on biomarkers with high validity and predictive applicability in people without cognitive impairment and clinical symptoms and in the early stages of the disease. |
2023-10-06 |
2023-10-07 |
Not clear |
| Juan D Sánchez, Andrés R Alcántara, Juan F González, José María Sánchez-Monter. Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease. Expert opinion on drug discovery. 2023-10-06. PMID:37800875. |
alzheimer's disease is a multifactorial neurodegenerative disorder characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. |
2023-10-06 |
2023-10-07 |
Not clear |
| Romany Abskharon, Hope Pan, Michael R Sawaya, Paul M Seidler, Eileen J Olivares, Yu Chen, Kevin A Murray, Jeffrey Zhang, Carter Lantz, Megan Bentzel, David R Boyer, Duilio Cascio, Binh A Nguyen, Ke Hou, Xinyi Cheng, Els Pardon, Christopher K Williams, Alissa L Nana, Harry V Vinters, Salvatore Spina, Lea T Grinberg, William W Seeley, Jan Steyaert, Charles G Glabe, Rachel R Ogorzalek Loo, Joseph A Loo, David S Eisenber. Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 41. 2023-10-06. PMID:37801475. |
structure-based design of nanobodies that inhibit seeding of alzheimer's patient-extracted tau fibrils. |
2023-10-06 |
2023-10-15 |
mouse |
| Joshua T Emmerson, Janice C Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C Martinez-Trujillo, A Claudio Cuell. Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy. Neurobiology of disease. 2023-10-06. PMID:37802153. |
in tauopathies such as alzheimer's disease (ad) and frontotemporal dementia (ftd), the microtubule associated protein tau undergoes conformational and posttranslational modifications in a gradual, staged pathological process. |
2023-10-06 |
2023-10-15 |
human |
| Xi Chen, Tyler N Toueg, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional tau deposition reflects different pathways of subsequent neurodegeneration and memory decline in cognitively normal older adults. Annals of neurology. 2023-10-04. PMID:37789559. |
tau pathology is recognized as a primary contributor to neurodegeneration and clinical symptoms in alzheimer's disease (ad). |
2023-10-04 |
2023-10-07 |
Not clear |
| Peter Kunach, Jaime Vaquer-Alicea, Matthew S Smith, Robert Hopewell, Jim Monistrol, Luc Moquin, Joseph Therriault, Cecile Tissot, Nesrine Rahmouni, Gassan Massarweh, Jean-Paul Soucy, Marie-Christine Guiot, Brian K Shoichet, Pedro Rosa-Neto, Marc I Diamond, Sarah H Shahmoradia. Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240. bioRxiv : the preprint server for biology. 2023-10-04. PMID:37790438. |
cryo-em structure of alzheimer's disease tau filaments with pet ligand mk-6240. |
2023-10-04 |
2023-10-07 |
Not clear |
| Michael O Isei, Peter A Girardi, Joel Rodwell-Bullock, Keith Nehrke, Gail V W Johnso. Site-specific phosphorylation of tau impacts mitochondrial function and response to stressors. Journal of neurochemistry. 2023-10-03. PMID:37787052. |
phosphorylation of tau at sites associated with alzheimer's disease (ad) likely plays a role in the disease progression. |
2023-10-03 |
2023-10-07 |
mouse |
| Xiaoxiao Wu, Lili Zhu, Gang Wang, Qingwen Zhang, Zhenyu Qia. Dose-dependent binding behavior of anthraquinone derivative purpurin interacting with tau-derived peptide protofibril. Physical chemistry chemical physics : PCCP. 2023-10-02. PMID:37781899. |
alzheimer's disease is hallmarked by microtubule-associated protein tau tangles and amyloid-β plaques. |
2023-10-02 |
2023-10-07 |
Not clear |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharm. Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin. International review of neurobiology. vol 171. 2023-10-02. PMID:37783554. |
thus, efforts are needed to slow down or neutralize accumulation of amyloid beta peptide (aβp) and associated alzheimer's disease brain pathology including phosphorylated tau (p-tau) within the brain fluid environment. |
2023-10-02 |
2023-10-07 |
Not clear |
| E Scott Sills, Howard I Chu, Jing-Wen Wang, Samuel H Wood, Seang Lin Ta. Intrathecal autologous thrombin-activated condensed platelet cytokines in chronic neurodegenerative disease: A hypothesis for anti-inflammatory and regenerative response. Neuro endocrinology letters. vol 44. issue 6. 2023-09-30. PMID:37776559. |
cognitive decline and disordered neuronal signaling subsequently become cardinal features of alzheimer's disease (ad), typically progressing with amyloid-ß and tau protein accumulation. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jiahao Feng, Yifei She, Chongjia Li, Lei She. Metal ion mediated aggregation of Alzheimer's disease peptides and proteins in solutions and at surfaces. Advances in colloid and interface science. vol 320. 2023-09-30. PMID:37776735. |
although the pathogenesis of alzheimer's disease (ad) is still unclear, abnormally high concentrations of metal ions, like copper, iron and zinc, were found in senile plaques of ad brain, which inspires extensive studies on the fundamental molecular interactions of metal ions with the pathogenic hallmarks, amyloid-β (aβ) peptides and tau proteins, respectively forming senile plaques and neurofibrillary tangles (nfts) in ad brains. |
2023-09-30 |
2023-10-07 |
Not clear |
| Ngoc-Han Thi Nguyen, Ji Hun Kim, Su-Min Lee, Byung-Kwan Cho, Yang-Hoon Kim, Jiho Mi. Inhibition of Tau Phosphorylation and Aβ Accumulation by S. cerevisiae-derived Vacuoles in LPS-Induced SH-SY5Y Cells. Journal of biotechnology. 2023-09-30. PMID:37777088. |
neurodegenerative diseases, such as alzheimer's disease (ad), are characterized by the accumulation of intracellular tau and amyloid beta (aβ) proteins, which lead to neuroinflammation and neuronal apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Sandra O Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A F von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Tha. TDP-43 pathology is associated with increased tau burdens and seeding. Molecular neurodegeneration. vol 18. issue 1. 2023-09-30. PMID:37777806. |
most alzheimer's disease (ad) cases also exhibit limbic predominant age-related tdp-43 encephalopathy neuropathological changes (late-nc), besides amyloid-β plaques and neurofibrillary tangles (nfts) containing hyperphosphorylated tau (p-tau). |
2023-09-30 |
2023-10-07 |
Not clear |
| Honglu Yu, Min Xiong, Congcong Liu, Danhao Xia, Lanxia Meng, Zhentao Zhan. The γ-Adducin 1-357 fragment promotes tau pathology. Frontiers in aging neuroscience. vol 15. 2023-09-29. PMID:37771520. |
tau phosphorylation is a pathological hallmark of alzheimer's disease (ad). |
2023-09-29 |
2023-10-07 |
Not clear |
| Kenneth S Kosi. Tau and the hard problem faceoff. Cytoskeleton (Hoboken, N.J.). 2023-09-29. PMID:37772747. |
tau has attracted the attention of fundamental cell biologists for its control over microtubules and alzheimer biologists for its tendency to form pathological inclusions. |
2023-09-29 |
2023-10-07 |
Not clear |
| Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccam. Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins. Biology. vol 12. issue 9. 2023-09-28. PMID:37759663. |
noradrenaline (na) depletion occurs in alzheimer's disease (ad); however, its relationship with the pathological expression of tau and transactive response dna-binding protein 43 (tdp-43), two major hallmarks of ad, remains elusive. |
2023-09-28 |
2023-10-07 |
rat |
| Jacob Raber, Keaton Stagaman, Kristin D Kasschau, Conor Davenport, Leilani Lopes, Dennis Nguyen, Eileen Ruth Torres, Thomas J Sharpton, Glen Kisb. Behavioral and Cognitive Performance Following Exposure to Second-Hand Smoke (SHS) from Tobacco Products Associated with Oxidative-Stress-Induced DNA Damage and Repair and Disruption of the Gut Microbiome. Genes. vol 14. issue 9. 2023-09-28. PMID:37761842. |
we tested the hypothesis that shs inhalation drives changes in the gut microbiome, impacting behavioral and cognitive performance as well as neuropathology in two-month-old wild-type (wt) mice and mice expressing wild-type human tau, a genetic model pertinent to alzheimer's disease mice, following chronic shs exposure (10 months to ~30 mg/m |
2023-09-28 |
2023-10-07 |
mouse |
| Giavanna Paterno, Jose Torrellas, Brach M Bell, Kimberly-Marie M Gorion, Stephan S Quintin, Gabriela P Hery, Stefan Prokop, Benoit I Giasso. Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761979. |
these tau inclusions are pathological hallmarks of alzheimer's disease (ad), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp). |
2023-09-28 |
2023-10-07 |
Not clear |
| Ryszard Plut. The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762096. |
postischemic brain neurodegeneration, such as alzheimer's disease, is characterized by the accumulation of amyloid and tau protein. |
2023-09-28 |
2023-10-07 |
Not clear |
| Sangseong Kim, Jaekyong Jeon, Dulguun Ganbat, Taewoon Kim, Kyusoon Shin, Sungho Hong, Jongwook Hon. Alteration of Neural Network and Hippocampal Slice Activation through Exosomes Derived from 5XFAD Nasal Lavage Fluid. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762366. |
exosomes, key mediators of intercellular transmission of pathogenic proteins, such as amyloid-beta and tau, significantly influence the progression and exacerbation of alzheimer's disease (ad) pathology. |
2023-09-28 |
2023-10-07 |
mouse |