| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca C Gobbi, Henner Knust, Matthias Körner, Michael Honer, Christian Czech, Sara Belli, Dieter Muri, Martin R Edelmann, Thomas Hartung, Isabella Erbsmehl, Sandra Grall-Ulsemer, Andreas Koblet, Marianne Rueher, Sandra Steiner, Hayden T Ravert, William B Mathews, Daniel P Holt, Hiroto Kuwabara, Heather Valentine, Robert F Dannals, Dean F Wong, Edilio Borron. Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography. Journal of medicinal chemistry. vol 60. issue 17. 2017-09-26. PMID:28654263. |
aggregates of tau and beta amyloid (aβ) plaques constitute the histopathological hallmarks of alzheimer's disease and are prominent targets for novel therapeutics as well as for biomarkers for diagnostic in vivo imaging. |
2017-09-26 |
2023-08-13 |
human |
| Alberto Cornejo, Felipe Aguilar Sandoval, Leonardo Caballero, Luis Machuca, Patricio Muñoz, Julio Caballero, George Perry, Alejandro Ardiles, Carlos Areche, Francisco Mel. Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 32. issue 1. 2017-09-26. PMID:28701064. |
rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to alzheimer's disease. |
2017-09-26 |
2023-08-13 |
Not clear |
| David J Irwin, Alberto Lleó, Sharon X Xie, Corey T McMillan, David A Wolk, Edward B Lee, Viviana M Van Deerlin, Leslie M Shaw, John Q Trojanowski, Murray Grossma. Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Annals of neurology. vol 82. issue 2. 2017-09-26. PMID:28719018. |
to test the hypotheses that (1) antemortem cerebrospinal fluid (csf) tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration (ftld) and (2) tauopathy patients have higher phosphorylated-tau levels compared to transactivation response element dna-binding protein 43 (tdp-43) proteinopathy patients while accounting for alzheimer's disease (ad) copathology. |
2017-09-26 |
2023-08-13 |
Not clear |
| Evgenia Salta, Annerieke Sierksma, Elke Vanden Eynden, Bart De Stroope. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO molecular medicine. vol 8. issue 9. 2017-09-25. PMID:27485122. |
mir-132 loss de-represses itpkb and aggravates amyloid and tau pathology in alzheimer's brain. |
2017-09-25 |
2023-08-13 |
mouse |
| Jared R Brosch, Martin R Farlow, Shannon L Risacher, Liana G Apostolov. Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 1. 2017-09-25. PMID:27873182. |
tau imaging in alzheimer's disease diagnosis and clinical trials. |
2017-09-25 |
2023-08-13 |
Not clear |
| Jared R Brosch, Martin R Farlow, Shannon L Risacher, Liana G Apostolov. Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 1. 2017-09-25. PMID:27873182. |
in vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. |
2017-09-25 |
2023-08-13 |
Not clear |
| Gwënaël Pottiez, Li Yang, Tessandra Stewart, Ning Song, Patrick Aro, Douglas R Galasko, Joseph F Quinn, Elaine R Peskind, Min Shi, Jing Zhan. Mass-Spectrometry-Based Method To Quantify in Parallel Tau and Amyloid β 1-42 in CSF for the Diagnosis of Alzheimer's Disease. Journal of proteome research. vol 16. issue 3. 2017-09-25. PMID:28112948. |
mass-spectrometry-based method to quantify in parallel tau and amyloid β 1-42 in csf for the diagnosis of alzheimer's disease. |
2017-09-25 |
2023-08-13 |
Not clear |
| Zhi-Hao Wang, Pai Liu, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Shan Ping Yu, Jian-Zhi Wang, Keqiang Y. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Molecular cell. vol 67. issue 5. 2017-09-25. PMID:28826672. |
delta-secretase, a lysosomal asparagine endopeptidase (aep), simultaneously cleaves both app and tau, controlling the onset of pathogenesis of alzheimer's disease (ad). |
2017-09-25 |
2023-08-13 |
mouse |
| Jennifer L Furman, Jaime Vaquer-Alicea, Charles L White, Nigel J Cairns, Peter T Nelson, Marc I Diamon. Widespread tau seeding activity at early Braak stages. Acta neuropathologica. vol 133. issue 1. 2017-09-22. PMID:27878366. |
transcellular propagation of tau aggregates may underlie the progression of pathology in alzheimer's disease (ad) and other tauopathies. |
2017-09-22 |
2023-08-13 |
mouse |
| S Ozcelik, F Sprenger, Z Skachokova, G Fraser, D Abramowski, F Clavaguera, A Probst, S Frank, M Müller, M Staufenbiel, M Goedert, M Tolnay, D T Winkle. Co-expression of truncated and full-length tau induces severe neurotoxicity. Molecular psychiatry. vol 21. issue 12. 2017-09-21. PMID:26830137. |
abundant tau inclusions are a defining hallmark of several human neurodegenerative diseases, including alzheimer's disease. |
2017-09-21 |
2023-08-13 |
mouse |
| Ben Sundra Ashok, Thekkuttuparambil Ananthanarayanan Ajith, Senthilkumar Sivanesa. Hypoxia-inducible factors as neuroprotective agent in Alzheimer's disease. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:28004401. |
beta amyloid (aβ)-42 peptide and phosphorylated tau protein have been demonstrated as the pathological hallmarks of alzheimer's disease (ad). |
2017-09-21 |
2023-08-13 |
Not clear |
| Chiara Fania, Beatrice Arosio, Daniele Capitanio, Enrica Torretta, Cristina Gussago, Evelyn Ferri, Daniela Mari, Cecilia Gelf. Protein signature in cerebrospinal fluid and serum of Alzheimer's disease patients: The case of apolipoprotein A-1 proteoforms. PloS one. vol 12. issue 6. 2017-09-21. PMID:28628634. |
in the diagnosis of alzheimer's disease (ad) total tau (t-tau), tau phosphorylated at threonine 181 (p-tau181), and the 42 amino acid isoform of alpha β-amyloid (aβ) are well established surrogate csf markers. |
2017-09-21 |
2023-08-13 |
Not clear |
| Young Doo Kim, Eun Il Jeong, Jihoon Nah, Seung-Min Yoo, Won Jae Lee, Youbin Kim, Seowon Moon, Se-Hoon Hong, Yong-Keun Jun. Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy. Journal of neurochemistry. vol 142. issue 5. 2017-09-21. PMID:28632947. |
in neurodegenerative diseases like alzheimer's disease (ad), tau is hyperphosphorylated and forms aggregates and neurofibrillary tangles in affected neurons. |
2017-09-21 |
2023-08-13 |
mouse |
| David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Plat. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica. vol 132. issue 6. 2017-09-20. PMID:27770234. |
soluble pre-fibrillar tau and β-amyloid species emerge in early human alzheimer's disease and track disease progression and cognitive decline. |
2017-09-20 |
2023-08-13 |
human |
| David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Plat. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica. vol 132. issue 6. 2017-09-20. PMID:27770234. |
post-mortem investigations of human alzheimer's disease (ad) have largely failed to provide unequivocal evidence in support of the original amyloid cascade hypothesis, which postulated deposition of β-amyloid (aβ) aggregates to be the cause of a demented state as well as inductive to tau neurofibrillary tangles (nfts). |
2017-09-20 |
2023-08-13 |
human |
| Hongbo Xie, Haixia Wen, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Kehui Ke, Ming Hu, Xiujie Che. Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28179579. |
glycogen synthase kinase-3 beta and cyclin-dependent kinase 5 have been identified as being involved in the pathological hyperphosphorylation of tau proteins, which leads to the formation of neurofibrillary tangles and causes alzheimer's disease. |
2017-09-20 |
2023-08-13 |
Not clear |
| Chelsea T Tiernan, Stephen D Ginsberg, Angela L Guillozet-Bongaarts, Sarah M Ward, Bin He, Nicholas M Kanaan, Elliott J Mufson, Lester I Binder, Scott E Count. Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143424. |
conformational phosphorylation and cleavage events drive the tau protein from a soluble, monomeric state to a relatively insoluble, polymeric state that precipitates the formation of neurofibrillary tangles (nfts) in projection neurons in alzheimer's disease (ad), including the magnocellular perikarya located in the nucleus basalis of meynert (nbm) complex of the basal forebrain. |
2017-09-19 |
2023-08-13 |
human |
| Timothy A Couttas, Nupur Kain, Alexandra K Suchowerska, Lake-Ee Quek, Nigel Turner, Thomas Fath, Brett Garner, Anthony S Do. Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 43. 2017-09-19. PMID:27255818. |
loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of alzheimer's disease. |
2017-09-19 |
2023-08-13 |
Not clear |
| Yongli Xie, Yibin Tan, Youbiao Zheng, Xiubo Du, Qiong Li. Ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer's disease mice. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 22. issue 6. 2017-09-18. PMID:28502066. |
ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic alzheimer's disease mice. |
2017-09-18 |
2023-08-13 |
mouse |
| Kristina V Tugaeva, Philipp O Tsvetkov, Nikolai N Sluchank. Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction. PloS one. vol 12. issue 6. 2017-09-14. PMID:28575131. |
here, we focused on the 14-3-3 interaction with human tau protein associated with the development of several neurodegenerative disorders, including alzheimer's and parkinson's diseases. |
2017-09-14 |
2023-08-13 |
human |