| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W J Fesse. Concordance of Several Subcellular Interactions Initiates Alzheimer's Dementia: Their Reversal Requires Combination Treatment. American journal of Alzheimer's disease and other dementias. vol 32. issue 3. 2017-07-19. PMID:28423937. |
the pathogenesis of alzheimer's disease involves multiple pathways that, at the macrolevel, include decreased proliferation plus increased loss affecting neurons, astrocytes, and capillaries and, at the subcellular level, involve several elements: amyloid/amyloid precursor protein, presenilins, the unfolded protein response, the ubiquitin/proteasome system, the wnt/catenin system, the notch signaling system, mitochondria, mitophagy, calcium, and tau. |
2017-07-19 |
2023-08-13 |
Not clear |
| Jorge Sepulcre, Michel J Grothe, Mert Sabuncu, Jasmeer Chhatwal, Aaron P Schultz, Bernard Hanseeuw, Georges El Fakhri, Reisa Sperling, Keith A Johnso. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA neurology. vol 74. issue 7. 2017-07-19. PMID:28558094. |
abnormal accumulation of tau and amyloid-β (aβ) proteins in the human brain are 2 pathologic hallmarks of alzheimer disease (ad). |
2017-07-19 |
2023-08-13 |
human |
| Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinge. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. The Lancet. Neurology. vol 16. issue 7. 2017-07-19. PMID:28653647. |
since tau pathology is also central to alzheimer's disease and chronic traumatic encephalopathy, a successful tau therapeutic for psp might inform treatment of other neurodegenerative diseases. |
2017-07-19 |
2023-08-13 |
Not clear |
| Jorge Sepulcre, Aaron P Schultz, Mert Sabuncu, Teresa Gomez-Isla, Jasmeer Chhatwal, Alex Becker, Reisa Sperling, Keith A Johnso. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 28. 2017-07-18. PMID:27413148. |
we provide a comparative in vivo examination of the brain network-based distribution of two hallmarks of alzheimer's disease (ad) pathology in cognitively normal individuals: (1) tau, detected with a novel positron emission tomography (pet) tracer known as (18)f-av-1451; and (2) amyloid-β, quantified with (11)c-pib pet. |
2017-07-18 |
2023-08-13 |
human |
| Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duf. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. PloS one. vol 11. issue 7. 2017-07-18. PMID:27466814. |
3d volume imaging using idisco+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of alzheimer's disease (ad). |
2017-07-18 |
2023-08-13 |
mouse |
| Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Obioha Ukoumunne, Emma C Ladds, Steven Marti. CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). The Cochrane database of systematic reviews. vol 3. 2017-07-18. PMID:28328043. |
csf tau and the csf tau/abeta ratio for the diagnosis of alzheimer's disease dementia and other dementias in people with mild cognitive impairment (mci). |
2017-07-18 |
2023-08-13 |
Not clear |
| Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Obioha Ukoumunne, Emma C Ladds, Steven Marti. CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). The Cochrane database of systematic reviews. vol 3. 2017-07-18. PMID:28328043. |
in this review, we aimed to assess the ability of csf tau biomarkers (t-tau and p-tau) and the csf tau (t-tau or p-tau)/abeta ratio to enable the detection of alzheimer's disease pathology in patients with mild cognitive impairment (mci). |
2017-07-18 |
2023-08-13 |
Not clear |
| Cristian A Lasagna-Reeves, Maria de Haro, Shuang Hao, Jeehye Park, Maxime W C Rousseaux, Ismael Al-Ramahi, Paymaan Jafar-Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio, Larissa Nitschke, Zhenyu Wu, Juan C Troncoso, Thomas F Westbrook, Jianrong Tang, Juan Botas, Huda Y Zoghb. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. vol 92. issue 2. 2017-07-17. PMID:27720485. |
as growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegeneration in animal models, we developed a strategy to screen for genes that decrease the levels of tau, whose accumulation contributes to the pathology of both alzheimer disease (ad) and progressive supranuclear palsy (psp). |
2017-07-17 |
2023-08-13 |
mouse |
| Brit Mollenhauer, Lucilla Parnetti, Irena Rektorova, Milica G Kramberger, Maria Pikkarainen, Walter J Schulz-Schaeffer, Dag Aarsland, Per Svenningsson, Lucia Farotti, Marcel M Verbeek, Michael G Schlossmache. Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:26452984. |
in alzheimer's disease, levels of increased csf tau protein and decreased levels of β-amyloid 1-42 (aβ42) have been shown to correlate with brain plaque formation and tangle pathology. |
2017-07-14 |
2023-08-13 |
human |
| Michael B Dinkins, John Enasko, Caterina Hernandez, Guanghu Wang, Jina Kong, Inas Helwa, Yutao Liu, Alvin V Terry, Erhard Bieberic. Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 33. 2017-07-14. PMID:27535912. |
recent evidence implicates exosomes in the aggregation of aβ and spreading of tau in alzheimer's disease. |
2017-07-14 |
2023-08-13 |
mouse |
| Soram Idiyasan Chanu, Surajit Sarka. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Molecular neurobiology. vol 54. issue 4. 2017-07-11. PMID:27000837. |
human tauopathies such as alzheimer's disease (ad), frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), pick's disease etc., are a group of neurodegenerative diseases which are characterized by abnormal hyperphosphorylation of tau that leads to formation of neurofibrillary tangles. |
2017-07-11 |
2023-08-13 |
human |
| Stefka Gyoneva, Sharon A Swanger, Jing Zhang, David Weinshenker, Stephen F Trayneli. Altered motility of plaque-associated microglia in a model of Alzheimer's disease. Neuroscience. vol 330. 2017-07-11. PMID:27288150. |
alzheimer's disease (ad), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (aβ) peptides and intracellular tau aggregates. |
2017-07-11 |
2023-08-13 |
mouse |
| Emese Kátai, József Pál, Viktor Soma Poór, Rupeena Purewal, Attila Miseta, Tamás Nag. Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells. Journal of cellular and molecular medicine. vol 20. issue 12. 2017-07-11. PMID:27456536. |
the chronic imbalance between phosphorylation and o-glcnac on tau protein is considered as one of the main hallmarks of alzheimer's disease. |
2017-07-11 |
2023-08-13 |
Not clear |
| Lei Tan, Xin Chen, Wei Wang, Jianfang Zhang, Shiyong Li, Yilin Zhao, Jintao Wang, Ailin Lu. Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats. Neuropharmacology. vol 114. 2017-07-11. PMID:27836791. |
additionally, it is demonstrated by others that pten inhibition could protect against cognitive impairment via reduction of tau phosphorylation in the alzheimer's disease model. |
2017-07-11 |
2023-08-13 |
rat |
| Brian Spencer, Paula A Desplats, Cassia R Overk, Elvira Valera-Martin, Robert A Rissman, Chengbiao Wu, Michael Mante, Anthony Adame, Jazmin Florio, Edward Rockenstein, Eliezer Maslia. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466341. |
alzheimer's disease (ad) is characterized by the progressive accumulation of amyloid β (aβ) and microtubule associate protein tau, leading to the selective degeneration of neurons in the neocortex, limbic system, and nucleus basalis, among others. |
2017-07-10 |
2023-08-13 |
mouse |
| Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P Imbimbo, Madia Lozupone, Andrea Santamato, Rosanna Tortelli, Ilaria Galizia, Camilla Prete, Antonio Daniele, Alberto Pilotto, Antonio Greco, Giancarlo Logroscin. Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy. Immunotherapy. vol 8. issue 9. 2017-07-10. PMID:27485083. |
pharmacological manipulation of tau protein in alzheimer's disease included microtubule-stabilizing agents, tau protein kinase inhibitors, tau aggregation inhibitors, active and passive immunotherapies and, more recently, inhibitors of tau acetylation. |
2017-07-10 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Alexandra Turner, Robert Stass, Leonie C Y Lee, Bethany Wilson, David A Nagel, Eric J Hill, Kevin G Moffa. Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag. Protein expression and purification. vol 130. 2017-07-10. PMID:27663563. |
recombinant tau protein is widely used to study the biochemical, cellular and pathological aspects of tauopathies, including alzheimer's disease and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftpd-17). |
2017-07-10 |
2023-08-13 |
Not clear |
| Sage C Arbor, Mike LaFontaine, Medhane Cumba. Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores. The Yale journal of biology and medicine. vol 89. issue 1. 2017-07-05. PMID:27505013. |
while alzheimer targets, such as the tau protein, amyloid precursor protein (app) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeutics may have failed and how to design the next round of compounds for clinical trials. |
2017-07-05 |
2023-08-13 |
Not clear |
| Jianlan Gu, Feng Chen, Khalid Iqbal, Cheng-Xin Gong, Xinglong Wang, Fei Li. Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies. The Journal of biological chemistry. vol 292. issue 25. 2017-07-05. PMID:28487370. |
cytoplasmic aggregation of tdp-43 has been observed in the brains of individuals with chronic traumatic encephalopathy or alzheimer's disease, diseases in which neurofibrillary tangles of hyperphosphorylated tau are hallmarks. |
2017-07-05 |
2023-08-13 |
mouse |
| Mackenzie D Martin, Jeremy D Baker, Amirthaa Suntharalingam, Bryce A Nordhues, Lindsey B Shelton, Dali Zheng, Jonathan J Sabbagh, Timothy A J Haystead, Jason E Gestwicki, Chad A Dicke. Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. ACS chemical biology. vol 11. issue 7. 2017-07-04. PMID:27177119. |
this is important because tau accumulation is linked to neurodegenerative diseases including alzheimer's disease (ad) and chronic traumatic encephalopathy (cte). |
2017-07-04 |
2023-08-13 |
Not clear |