| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masato Hasegaw. Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation. Biomolecules. vol 6. issue 2. 2016-12-19. PMID:27136595. |
neurofibrillary tau pathology (tangles and threads) and extracellular amyloid-β (aβ) pathology are defining features of alzheimer's disease. |
2016-12-19 |
2023-08-13 |
Not clear |
| Dario Tejera, Michael T Henek. Microglia in Alzheimer's disease: the good, the bad and the ugly. Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567746. |
alzheimer's disease, the leading cause of dementia, is characterized by amyloid beta deposition and tau hyperphosphorylation. |
2016-12-15 |
2023-08-13 |
Not clear |
| Marcel Levy Nogueira, Stéphane Epelbaum, Jean-Marc Steyaert, Bruno Dubois, Laurent Schwart. Mechanical stress models of Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 3. 2016-12-15. PMID:26718585. |
extracellular accumulation of amyloid-β protein and intracellular accumulation of tau in brain tissues have been described in animal models of alzheimer's disease (ad) and mechanical stress-based diseases of different mechanisms, such as traumatic brain injury (tbi), arterial hypertension (htn), and normal pressure hydrocephalus (nph). |
2016-12-15 |
2023-08-13 |
Not clear |
| Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kud. Preclinical Evaluation of [(18)F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer. Molecular imaging and biology. vol 18. issue 2. 2016-12-13. PMID:26194011. |
noninvasive imaging of tau and amyloid-β pathologies would facilitate diagnosis of alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Yonglan Zhang, Fei Yin, Jianhui Liu, Zixuan Li. Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin-deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26475430. |
geniposide attenuates the phosphorylation of tau protein in cellular and insulin-deficient app/ps1 transgenic mouse model of alzheimer's disease. |
2016-12-13 |
2023-08-13 |
mouse |
| Yonglan Zhang, Fei Yin, Jianhui Liu, Zixuan Li. Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin-deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26475430. |
taken together, our findings provide a mechanistic and perhaps a foundational link between diabetes and alzheimer's disease and are consistent with the notion that geniposide might play an essential role on the phosphorylation of tau protein via enhancing insulin signaling and may convey a therapeutic benefit in alzheimer's disease. |
2016-12-13 |
2023-08-13 |
mouse |
| Lidia Bakota, Roland Brand. Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. Drugs. vol 76. issue 3. 2016-12-13. PMID:26729186. |
tau biology and tau-directed therapies for alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Li Yan, Yaomin Chen, Wubo Li, Xiumei Huang, Hedieh Badie, Fan Jian, Timothy Huang, Yingjun Zhao, Stanley N Cohen, Limin Li, Yun-Wu Zhang, Huanmin Luo, Shichun Tu, Huaxi X. RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits. Scientific reports. vol 6. 2016-12-13. PMID:26733416. |
rps23rg1, a functional retroposed mouse gene, has been shown to reduce alzheimer's β-amyloid (aβ) production and tau phosphorylation. |
2016-12-13 |
2023-08-13 |
mouse |
| Thomas J Malia, Alexey Teplyakov, Robin Ernst, Sheng-Jiun Wu, Eilyn R Lacy, Xuesong Liu, Marc Vandermeeren, Marc Mercken, Jinquan Luo, Raymond W Sweet, Gary L Gillilan. Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8. Proteins. vol 84. issue 4. 2016-12-13. PMID:26800003. |
microtubule-associated protein tau becomes abnormally phosphorylated in alzheimer's disease and other tauopathies and forms aggregates of paired helical filaments (phf-tau). |
2016-12-13 |
2023-08-13 |
Not clear |
| Davide Seripa, Vincenzo Solfrizzi, Bruno P Imbimbo, Antonio Daniele, Andrea Santamato, Madia Lozupone, Giovanni Zuliani, Antonio Greco, Giancarlo Logroscino, Francesco Panz. Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium. Expert review of neurotherapeutics. vol 16. issue 3. 2016-12-13. PMID:26822031. |
small molecular weight compounds able to inhibit formation of tau oligomers and fibrils have already been tested for alzheimer's disease (ad) treatment. |
2016-12-13 |
2023-08-13 |
Not clear |
| Cui-cui Yang, Xue-xian Kuai, Wen-bin Gao, Jian-chun Yu, Qi Wang, Lin Li, Lan Zhan. Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836014. |
an accumulation of hyperphosphorylated tau in the brain is a hallmark of alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Moran Frenkel-Pinter, Sharon Tal, Roni Scherzer-Attali, Malak Abu-Hussien, Idan Alyagor, Tal Eisenbaum, Ehud Gazit, Daniel Sega. Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836184. |
tauopathies, such as alzheimer's disease (ad), are a group of disorders characterized neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed by misfolding of the microtubule-associated protein tau. |
2016-12-13 |
2023-08-13 |
human |
| Eun Ji Lee, Tae-Woo Kim, Dae Seung Lee, Hyunjoong Kim, Young Ho Park, Jungeun Kim, Joon Woo Lee, SangYun Ki. Increased CSF tau level is correlated with decreased lamina cribrosa thickness. Alzheimer's research & therapy. vol 8. 2016-12-13. PMID:26857246. |
this study was to investigate whether the previously proposed link between alzheimer's disease (ad) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal csf profiles and optic nerve head characteristics, focusing on the influence of csf tau protein on the lamina cribrosa (lc) thickness (lct). |
2016-12-13 |
2023-08-13 |
Not clear |
| Priyanka Joshi, Sean Chia, Johnny Habchi, Tuomas P J Knowles, Christopher M Dobson, Michele Vendruscol. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. ACS combinatorial science. vol 18. issue 3. 2016-12-13. PMID:26923286. |
we illustrate this approach by describing three distinct small-molecule libraries to target, aβ, tau, and α-synuclein, which are three idps implicated in alzheimer's and parkinson's diseases. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jonathan Gilley, Kunie Ando, Anjan Seereeram, Teresa Rodríguez-Martín, Amy M Pooler, Laura Sturdee, Brian H Anderton, Jean-Pierre Brion, Diane P Hanger, Michael P Colema. Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice. Neurobiology of aging. vol 39. 2016-12-13. PMID:26923397. |
hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of alzheimer's disease and other tauopathies. |
2016-12-13 |
2023-08-13 |
mouse |
| Tomohiro Miyasaka, Ce Xie, Satomi Yoshimura, Yuki Shinzaki, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani, Yasuo Ihar. Curcumin improves tau-induced neuronal dysfunction of nematodes. Neurobiology of aging. vol 39. 2016-12-13. PMID:26923403. |
because the extent of tau pathologies is closely linked to that of neuronal loss and the clinical symptoms in alzheimer's disease, anti-tau therapeutics, if any, could be beneficial to a broad spectrum of tauopathies. |
2016-12-13 |
2023-08-13 |
caenorhabditis_elegans |
| Lieven Declercq, Sofie Celen, Joan Lecina, Muneer Ahamed, Thomas Tousseyn, Diederik Moechars, Jesus Alcazar, Manuela Ariza, Katleen Fierens, Astrid Bottelbergs, Jonas Mariën, Rik Vandenberghe, Ignacio Jose Andres, Koen Van Laere, Alfons Verbruggen, Guy Borman. Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807. Molecular imaging. vol 15. 2016-12-13. PMID:27030397. |
in semiquantitative autoradiography studies on human alzheimer disease slices, we observed more than 50% tau selective blocking of [(18)f]t808 in the presence of 1 µmol/l of the novel ligands. |
2016-12-13 |
2023-08-13 |
mouse |
| Malin Degerman Gunnarsson, Martin Ingelsson, Kaj Blennow, Hans Basun, Lars Lannfelt, Lena Kilande. High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:27263933. |
high tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Malin Degerman Gunnarsson, Martin Ingelsson, Kaj Blennow, Hans Basun, Lars Lannfelt, Lena Kilande. High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:27263933. |
increased concentrations of cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated tau, as well as decreased amyloid-β 42 peptide, are biomarkers of alzheimer's disease (ad) pathology, but few studies have shown an association with ad progression rate. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yanuar Alan Sulistio, Klaus Hees. The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25561438. |
the accumulation of amyloid plaques (aps) composed of amyloid-beta peptide (aβ) aggregates and neurofibrillary tangles (nfts) composed of misfolded tau proteins are the defining pathological markers of alzheimer's disease (ad). |
2016-11-14 |
2023-08-13 |
Not clear |