| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bess Frost, Farah H Bardai, Mel B Fean. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Current biology : CB. vol 26. issue 1. 2016-11-04. PMID:26725200. |
similarly, we have recently reported the widespread relaxation of heterochromatin in tauopathies [1]: age-related progressive neurodegenerative disorders, including alzheimer's disease, that are pathologically characterized by aggregates of phosphorylated tau protein in the brain [2, 3]. |
2016-11-04 |
2023-08-13 |
human |
| Giacomo Koch, Francesco Di Lorenzo, Miguel Fernandez Del Olmo, Sonia Bonní, Viviana Ponzo, Carlo Caltagirone, Marco Bozzali, Alessandro Martoran. Reversal of LTP-Like Cortical Plasticity in Alzheimer's Disease Patients with Tau-Related Faster Clinical Progression. Journal of Alzheimer's disease : JAD. vol 50. issue 2. 2016-11-04. PMID:26757193. |
cerebrospinal fluid (csf) concentrations of amyloid-β (aβ), total tau (t-tau), and phosphorylated tau proteins are associated with different clinical progression in alzheimer's disease (ad). |
2016-11-04 |
2023-08-13 |
Not clear |
| Sandro Alves, Romain Fol, Nathalie Cartie. Gene Therapy Strategies for Alzheimer's Disease: An Overview. Human gene therapy. vol 27. issue 2. 2016-11-04. PMID:26838997. |
key neuropathological hallmarks of alzheimer's disease (ad) are extracellular amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. |
2016-11-04 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Nobuyuki Okamur. Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26397020. |
tau imaging in the study of ageing, alzheimer's disease, and other neurodegenerative conditions. |
2016-11-01 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Nobuyuki Okamur. Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26397020. |
in vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. |
2016-11-01 |
2023-08-13 |
Not clear |
| Lars Krüger, Eva Maria Mandelko. Tau neurotoxicity and rescue in animal models of human Tauopathies. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26431808. |
pathological tau is a hallmark of various neuronal disorders and spreads in the brain of alzheimer patients in a well-defined manner. |
2016-11-01 |
2023-08-13 |
human |
| Pia Jul, Christiane Volbracht, Inge E M de Jong, Lone Helboe, Anders Brandt Elvang, Jan Torleif Pederse. Hyperactivity with Agitative-Like Behavior in a Mouse Tauopathy Model. Journal of Alzheimer's disease : JAD. vol 49. issue 3. 2016-11-01. PMID:26519432. |
tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia (ftd), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. |
2016-11-01 |
2023-08-13 |
mouse |
| Jaap Goudsmi. The incubation period of Alzheimer's disease and the timing of tau versus amyloid misfolding and spreading within the brain. European journal of epidemiology. vol 31. issue 2. 2016-10-31. PMID:27017509. |
the incubation period of alzheimer's disease and the timing of tau versus amyloid misfolding and spreading within the brain. |
2016-10-31 |
2023-08-13 |
Not clear |
| Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Estifanos Ghebremedhin, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 49. issue 4. 2016-10-28. PMID:26519431. |
in spite of considerable progress in neuropathological research on alzheimer's disease (ad), knowledge regarding the exact pathoanatomical distribution of the tau cytoskeletal pathology in the thalamus of ad patients in the advanced braak and braak ad stages v or vi of the cortical cytoskeletal pathology is still fragmentary. |
2016-10-28 |
2023-08-13 |
human |
| Eleonora Gargantini, Laura Lazzari, Fabio Settanni, Marina Taliano, Letizia Trovato, Iacopo Gesmundo, Ezio Ghigo, Riccarda Granat. Obestatin promotes proliferation and survival of adult hippocampal progenitors and reduces amyloid-β-induced toxicity. Molecular and cellular endocrinology. vol 422. 2016-10-24. PMID:26586206. |
obestatin also counteracted aβ1-42-induced detrimental effects through inhibition of gsk-3β activity and tau hyperphosphorylation, main hallmarks of neuronal death in alzheimer's disease. |
2016-10-24 |
2023-08-13 |
rat |
| Onno N Groeneveld, L Jaap Kappelle, Geert Jan Biessel. Potentials of incretin-based therapies in dementia and stroke in type 2 diabetes mellitus. Journal of diabetes investigation. vol 7. issue 1. 2016-10-24. PMID:26816596. |
experimental studies on alzheimer's disease have found beneficial effects of incretin-based therapies on cognition, synaptic plasticity and metabolism of amyloid-β and microtubule-associated protein tau. |
2016-10-24 |
2023-08-13 |
Not clear |
| Adrianne S Chesser, Veena Ganeshan, Jonathan Yang, Gail V W Johnso. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutritional neuroscience. vol 19. issue 1. 2016-10-19. PMID:26207957. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by intracellular accumulations of phosphorylated forms of the microtubule binding protein tau. |
2016-10-19 |
2023-08-13 |
Not clear |
| Timothy M Hughes, Kaycee M Sin. Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. American journal of hypertension. vol 29. issue 2. 2016-10-19. PMID:26563965. |
in addition, recent studies of hypertension and alzheimer's biomarkers show that elevated blood pressure and pulse pressure are associated with the extent of brain beta amyloid (aβ) deposition and altered cerebral spinal fluid profiles of aβ and tau indicative of alzheimer's pathology. |
2016-10-19 |
2023-08-13 |
Not clear |
| Mohammad Haddadi, Upendra Nongthomba, S R Rames. Biochemical and Behavioral Evaluation of Human MAPT Mutations in Transgenic Drosophila melanogaster. Biochemical genetics. vol 54. issue 1. 2016-10-19. PMID:26581847. |
these mutations lead to hyperphosphorylation and aggregation of tau protein which is a known genetic factor underlying development of alzheimer's disease (ad). |
2016-10-19 |
2023-08-13 |
human |
| Yijing Chen, Shuangxue Han, Xiuxian Huang, Jiazuan Ni, Xiaoyang H. The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26828481. |
icariin, a pharmacologically active component isolated from the chinese herb epimedium, has been shown to improve spatial learning and memory abilities in alzheimer's disease (ad) rats through inhibition of aβ production and tau protein hyperphosphorylation. |
2016-10-19 |
2023-08-13 |
mouse |
| Feng Bai, Wei Liao, Chunxian Yue, Mengjia Pu, Yongmei Shi, Hui Yu, Yonggui Yuan, Leiyu Geng, Zhijun Zhan. Genetics pathway-based imaging approaches in Chinese Han population with Alzheimer's disease risk. Brain structure & function. vol 221. issue 1. 2016-10-17. PMID:25344117. |
the tau hypothesis has been raised with regard to the pathophysiology of alzheimer's disease (ad). |
2016-10-17 |
2023-08-13 |
Not clear |
| Sayuri Taniguchi-Watanabe, Tetsuaki Arai, Fuyuki Kametani, Takashi Nonaka, Masami Masuda-Suzukake, Airi Tarutani, Shigeo Murayama, Yuko Saito, Kunimasa Arima, Mari Yoshida, Haruhiko Akiyama, Andrew Robinson, David M A Mann, Takeshi Iwatsubo, Masato Hasegaw. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta neuropathologica. vol 131. issue 2. 2016-10-17. PMID:26538150. |
we have analyzed pathological tau in alzheimer's disease, and in frontotemporal lobar degeneration associated with tauopathy to include cases with pick bodies, corticobasal degeneration, progressive supranuclear palsy, and ones due to intronic mutations in mapt. |
2016-10-17 |
2023-08-13 |
Not clear |
| Shu-Sheng Jiao, Xian-Le Bu, Yu-Hui Liu, Chi Zhu, Qing-Hua Wang, Lin-Lin Shen, Cheng-Hui Liu, Ye-Ran Wang, Xiu-Qing Yao, Yan-Jiang Wan. Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26707129. |
alzheimer's disease (ad) is the most common form of dementia among the elderly, characterized by parenchymal and vascular beta-amyloid (aβ) burden, tau pathology, neuroinflammation, and loss of neurons and synapses. |
2016-10-14 |
2023-08-13 |
mouse |
| Bo-Kai Wu, Rey-Yue Yuan, Huang-Wei Lien, Chin-Chun Hung, Pung-Pung Hwang, Rita Pei-Yeh Chen, Chun-Che Chang, Yung-Feng Liao, Chang-Jen Huan. Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. Journal of biomedical science. vol 23. 2016-10-14. PMID:26852117. |
paired helical filaments of tau and extracellular plaques containing beta-amyloid are found in the brain of alzheimer's disease (ad) patients. |
2016-10-14 |
2023-08-13 |
human |
| Stephen B Wharton, Thais Minett, David Drew, Gillian Forster, Fiona Matthews, Carol Brayne, Paul G Inc. Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:26857919. |
deposition of abnormally phosphorylated tau (phospho-tau) occurs in alzheimer's disease but also with brain ageing. |
2016-10-14 |
2023-08-13 |
Not clear |