| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing L Guo, Arjan Buist, Alberto Soares, Kathleen Callaerts, Sara Calafate, Frederik Stevenaert, Joshua P Daniels, Bryan E Zoll, Alex Crowe, Kurt R Brunden, Diederik Moechars, Virginia M Y Le. The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES. The Journal of biological chemistry. vol 291. issue 25. 2016-11-14. PMID:27129267. |
filamentous tau aggregates, the hallmark lesions of alzheimer disease (ad), play key roles in neurodegeneration. |
2016-11-14 |
2023-08-13 |
Not clear |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
evidence for an imbalance between tau o-glcnacylation and phosphorylation in the hippocampus of a mouse model of alzheimer's disease. |
2016-11-11 |
2023-08-13 |
mouse |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
intracellular accumulation of hyperphosphorylated tau protein is linked to neuronal degeneration in alzheimer's disease (ad). |
2016-11-11 |
2023-08-13 |
mouse |
| Juan Carlos Polanco, Benjamin James Scicluna, Andrew Francis Hill, Jürgen Göt. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. The Journal of biological chemistry. vol 291. issue 24. 2016-11-11. PMID:27030011. |
the microtubule-associated protein tau has a critical role in alzheimer disease and related tauopathies. |
2016-11-11 |
2023-08-13 |
mouse |
| Juan Carlos Polanco, Benjamin James Scicluna, Andrew Francis Hill, Jürgen Göt. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. The Journal of biological chemistry. vol 291. issue 24. 2016-11-11. PMID:27030011. |
the characteristics of tau in extracellular vesicles and the seeding threshold we identified may explain why tau pathology develops very slowly in neurodegenerative diseases such as alzheimer disease. |
2016-11-11 |
2023-08-13 |
mouse |
| Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26538351. |
immunotherapy directed against tau is a promising treatment strategy for alzheimer's disease (ad) and tauopathies. |
2016-11-09 |
2023-08-13 |
mouse |
| Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26538351. |
the general absence of extracellular tau deposits may avoid the opsonization and phagocytosis mechanisms activated by antibodies against amyloid, and make anti tau approaches a safer method of immunotherapy for alzheimer's disease. |
2016-11-09 |
2023-08-13 |
mouse |
| Erica Barini, Odetta Antico, Yingjun Zhao, Francesco Asta, Valter Tucci, Tiziano Catelani, Roberto Marotta, Huaxi Xu, Laura Gasparin. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26858121. |
alzheimer disease (ad) and other tauopathies develop cerebral intracellular inclusions of hyperphosphorylated tau. |
2016-11-08 |
2023-08-13 |
mouse |
| Robert Weissmann, Melanie Hüttenrauch, Tim Kacprowski, Yvonne Bouter, Laurent Pradier, Thomas A Bayer, Andreas W Kuss, Oliver Wirth. Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 50. issue 2. 2016-11-04. PMID:26639971. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder characterized by early intraneuronal amyloid-β (aβ) accumulation, extracellular deposition of aβ peptides, and intracellular hyperphosphorylated tau aggregates. |
2016-11-04 |
2023-08-13 |
mouse |
| Bess Frost, Farah H Bardai, Mel B Fean. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Current biology : CB. vol 26. issue 1. 2016-11-04. PMID:26725200. |
similarly, we have recently reported the widespread relaxation of heterochromatin in tauopathies [1]: age-related progressive neurodegenerative disorders, including alzheimer's disease, that are pathologically characterized by aggregates of phosphorylated tau protein in the brain [2, 3]. |
2016-11-04 |
2023-08-13 |
human |
| Giacomo Koch, Francesco Di Lorenzo, Miguel Fernandez Del Olmo, Sonia Bonní, Viviana Ponzo, Carlo Caltagirone, Marco Bozzali, Alessandro Martoran. Reversal of LTP-Like Cortical Plasticity in Alzheimer's Disease Patients with Tau-Related Faster Clinical Progression. Journal of Alzheimer's disease : JAD. vol 50. issue 2. 2016-11-04. PMID:26757193. |
cerebrospinal fluid (csf) concentrations of amyloid-β (aβ), total tau (t-tau), and phosphorylated tau proteins are associated with different clinical progression in alzheimer's disease (ad). |
2016-11-04 |
2023-08-13 |
Not clear |
| Sandro Alves, Romain Fol, Nathalie Cartie. Gene Therapy Strategies for Alzheimer's Disease: An Overview. Human gene therapy. vol 27. issue 2. 2016-11-04. PMID:26838997. |
key neuropathological hallmarks of alzheimer's disease (ad) are extracellular amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. |
2016-11-04 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Nobuyuki Okamur. Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26397020. |
tau imaging in the study of ageing, alzheimer's disease, and other neurodegenerative conditions. |
2016-11-01 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Nobuyuki Okamur. Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26397020. |
in vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. |
2016-11-01 |
2023-08-13 |
Not clear |
| Lars Krüger, Eva Maria Mandelko. Tau neurotoxicity and rescue in animal models of human Tauopathies. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26431808. |
pathological tau is a hallmark of various neuronal disorders and spreads in the brain of alzheimer patients in a well-defined manner. |
2016-11-01 |
2023-08-13 |
human |
| Pia Jul, Christiane Volbracht, Inge E M de Jong, Lone Helboe, Anders Brandt Elvang, Jan Torleif Pederse. Hyperactivity with Agitative-Like Behavior in a Mouse Tauopathy Model. Journal of Alzheimer's disease : JAD. vol 49. issue 3. 2016-11-01. PMID:26519432. |
tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia (ftd), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. |
2016-11-01 |
2023-08-13 |
mouse |
| Jaap Goudsmi. The incubation period of Alzheimer's disease and the timing of tau versus amyloid misfolding and spreading within the brain. European journal of epidemiology. vol 31. issue 2. 2016-10-31. PMID:27017509. |
the incubation period of alzheimer's disease and the timing of tau versus amyloid misfolding and spreading within the brain. |
2016-10-31 |
2023-08-13 |
Not clear |
| Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Estifanos Ghebremedhin, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 49. issue 4. 2016-10-28. PMID:26519431. |
in spite of considerable progress in neuropathological research on alzheimer's disease (ad), knowledge regarding the exact pathoanatomical distribution of the tau cytoskeletal pathology in the thalamus of ad patients in the advanced braak and braak ad stages v or vi of the cortical cytoskeletal pathology is still fragmentary. |
2016-10-28 |
2023-08-13 |
human |
| Eleonora Gargantini, Laura Lazzari, Fabio Settanni, Marina Taliano, Letizia Trovato, Iacopo Gesmundo, Ezio Ghigo, Riccarda Granat. Obestatin promotes proliferation and survival of adult hippocampal progenitors and reduces amyloid-β-induced toxicity. Molecular and cellular endocrinology. vol 422. 2016-10-24. PMID:26586206. |
obestatin also counteracted aβ1-42-induced detrimental effects through inhibition of gsk-3β activity and tau hyperphosphorylation, main hallmarks of neuronal death in alzheimer's disease. |
2016-10-24 |
2023-08-13 |
rat |
| Onno N Groeneveld, L Jaap Kappelle, Geert Jan Biessel. Potentials of incretin-based therapies in dementia and stroke in type 2 diabetes mellitus. Journal of diabetes investigation. vol 7. issue 1. 2016-10-24. PMID:26816596. |
experimental studies on alzheimer's disease have found beneficial effects of incretin-based therapies on cognition, synaptic plasticity and metabolism of amyloid-β and microtubule-associated protein tau. |
2016-10-24 |
2023-08-13 |
Not clear |