All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. reduced mir-512 and the elevated expression of its targets cflip and mcl1 localize to neurons with hyperphosphorylated tau protein in alzheimer disease. 2016-07-18 2023-08-13 Not clear
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. the cause for the neurofibrillary tangles and plaques in alzheimer disease likely relates to an abnormal accumulation of their key components, which include β-amyloid and hyperphosphorylated tau protein. 2016-07-18 2023-08-13 Not clear
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. we segregated alzheimer brain sections from people with end-stage disease into those with abundant hyperphosphorylated tau protein and those without and compared each to normal brains for global microrna patterns. 2016-07-18 2023-08-13 Not clear
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. a significant reduced expression of several micrornas, including mir-512, was evident in the alzheimer brain sections with abundant hyperphosphorylated tau. 2016-07-18 2023-08-13 Not clear
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. mcm2 expression, a marker of neuroprogenitor cells, was significantly reduced in the alzheimer sections that contained the hyperphosphorylated tau. 2016-07-18 2023-08-13 Not clear
Louisa Mezache, Madison Mikhail, Michela Garofalo, Gerard J Nuov. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. Applied immunohistochemistry & molecular morphology : AIMM. vol 23. issue 9. 2016-07-18. PMID:26258756. this, in turn, could lead to the accumulation of key alzheimer proteins such as hyperphosphorylated tau that ultimately prevent normal neuronal function and lead to disease symptomatology. 2016-07-18 2023-08-13 Not clear
Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. the alterations of these two molecules were studied over the course of alzheimer's disease in relation to the expression of 4g8-stained amyloid-β, hyperphosphorylated tau stained by antibody at8, neuronal fibrillary tangles and neuropil threads stained by silver, and in relation to alterations in choline acetyltransferase. 2016-07-18 2023-08-13 Not clear
Elena Rodriguez-Vieitez, Laure Saint-Aubert, Stephen F Carter, Ove Almkvist, Karim Farid, Michael Schöll, Konstantinos Chiotis, Steinunn Thordardottir, Caroline Graff, Anders Wall, Bengt Långström, Agneta Nordber. Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26813969. alzheimer's disease is a multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation and neurodegeneration, where the interrelationships between the different pathophysiological events are not yet well characterized. 2016-07-18 2023-08-13 human
Eloi Magnin, Julius Pop. [Cerebrospinal fluid biomarkers of Alzheimer's disease in current clinical practice]. Revue medicale suisse. vol 12. issue 515. 2016-07-15. PMID:27276722. the cerebrospinal fluid levels of amyloid beta 1-42 (aβ1-42), total tau and tau phosphorylated at threonine 181 (ptau181) are well established biomarkers of cerebral amyloid pathology and tau related neurodegeneration, two hallmarks of alzheimer's disease. 2016-07-15 2023-08-13 Not clear
Shelby Meier, Michelle Bell, Danielle N Lyons, Alexandria Ingram, Jing Chen, John C Gensel, Haining Zhu, Peter T Nelson, Jose F Abisambr. Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 48. issue 3. 2016-07-14. PMID:26402096. identification of novel tau interactions with endoplasmic reticulum proteins in alzheimer's disease brain. 2016-07-14 2023-08-13 human
Shelby Meier, Michelle Bell, Danielle N Lyons, Alexandria Ingram, Jing Chen, John C Gensel, Haining Zhu, Peter T Nelson, Jose F Abisambr. Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 48. issue 3. 2016-07-14. PMID:26402096. alzheimer's disease (ad) is a progressive neurodegenerative disorder that is pathologically characterized by the formation of extracellular amyloid plaques and intraneuronal tau tangles. 2016-07-14 2023-08-13 human
Michael Schöll, Samuel N Lockhart, Daniel R Schonhaut, James P O'Neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L Baker, Jacob W Vogel, Jamie Faria, Henry D Schwimmer, Gil D Rabinovici, William J Jagus. PET Imaging of Tau Deposition in the Aging Human Brain. Neuron. vol 89. issue 5. 2016-07-13. PMID:26938442. tau pathology is a hallmark of alzheimer's disease (ad) but also occurs in normal cognitive aging. 2016-07-13 2023-08-13 human
Ben Ellis, Abdul Hye, Stuart G Snowde. Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis. Journal of Alzheimer's disease : JAD. vol 46. issue 2. 2016-07-11. PMID:25835424. alzheimer's disease (ad) is the most common neurodegenerative dementia, with the accumulation of extracellular amyloid-β and formation of neurofibrillary tau tangles as leading explanations of pathology. 2016-07-11 2023-08-13 human
Tim Stangner, Stefano Angioletti-Uberti, Daniel Knappe, David Singer, Carolin Wagner, Ralf Hoffmann, Friedrich Kreme. Epitope mapping of monoclonal antibody HPT-101: a study combining dynamic force spectroscopy, ELISA and molecular dynamics simulations. Physical biology. vol 12. issue 6. 2016-07-08. PMID:26689558. by combining enzyme-linked immunosorbent assay (elisa) and optical tweezers-assisted dynamic force spectroscopy (dfs), we identify for the first time the binding epitope of the phosphorylation-specific monoclonal antibody (mab) hpt-101 to the alzheimer's disease relevant peptide tau[pthr231/pser235] on the level of single amino acids. 2016-07-08 2023-08-13 Not clear
Carol J Huseby, Jeff Kure. Analyzing Tau Aggregation with Electron Microscopy. Methods in molecular biology (Clifton, N.J.). vol 1345. 2016-07-07. PMID:26453208. conversion of monomeric tau protein into filamentous aggregates is a defining event in the pathogenesis of alzheimer's disease. 2016-07-07 2023-08-13 Not clear
Virginia Meyer, Martin Margitta. Spin Labeling and Characterization of Tau Fibrils Using Electron Paramagnetic Resonance (EPR). Methods in molecular biology (Clifton, N.J.). vol 1345. 2016-07-07. PMID:26453213. template-assisted propagation of tau fibrils is essential for the spreading of tau pathology in alzheimer's disease. 2016-07-07 2023-08-13 Not clear
Andrew King, Istvan Bodi, Matthew Nolan, Claire Troakes, Safa Al-Sarra. Assessment of the degree of asymmetry of pathological features in neurodegenerative diseases. What is the significance for brain banks? Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:26021735. in 6 out 14 cases of ad (alzheimer's disease) (modified braak stage v-vi), there was some asymmetrical staining for tau. 2016-07-06 2023-08-13 Not clear
Ge Li, Kangping Xiong, Ane Korff, Catherine Pan, Joseph F Quinn, Douglas R Galasko, Chunfeng Liu, Thomas J Montine, Elaine R Peskind, Jing Zhan. Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF Aβ42 and Tau. Journal of Alzheimer's disease : JAD. vol 47. issue 4. 2016-07-06. PMID:26401768. increased csf e-selectin in clinical alzheimer's disease without altered csf aβ42 and tau. 2016-07-06 2023-08-13 Not clear
Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Qing-Ying Chen, Li-Jun Ge, Run-Sheng Li, Jian-Fei Wang, Mu Sun, Zhi-Cheng Xiao, Guo-Huang Fa. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 48. issue 1. 2016-07-06. PMID:26401931. cxcl1 triggers caspase-3 dependent tau cleavage in long-term neuronal cultures and in the hippocampus of aged mice: implications in alzheimer's disease. 2016-07-06 2023-08-13 mouse
Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Qing-Ying Chen, Li-Jun Ge, Run-Sheng Li, Jian-Fei Wang, Mu Sun, Zhi-Cheng Xiao, Guo-Huang Fa. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 48. issue 1. 2016-07-06. PMID:26401931. truncation of tau protein is considered an early event in alzheimer's disease (ad) and is believed to play a major pathogenic role in sporadic ad. 2016-07-06 2023-08-13 mouse