| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer M Deger, Julia E Gerson, Rakez Kaye. The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration. Aging cell. vol 14. issue 5. 2016-09-19. PMID:26053162. |
many proteins involved in neurodegeneration have been found to be sumoylated, notably tau protein in brains afflicted with alzheimer's. |
2016-09-19 |
2023-08-13 |
Not clear |
| Yan Wei, Chanshuai Han, Yujing Wang, Beibei Wu, Tao Su, Ying Liu, Rongqiao H. Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII. Aging cell. vol 14. issue 5. 2016-09-19. PMID:26095350. |
ribosylation triggering alzheimer's disease-like tau hyperphosphorylation via activation of camkii. |
2016-09-19 |
2023-08-13 |
mouse |
| Yan Wei, Chanshuai Han, Yujing Wang, Beibei Wu, Tao Su, Ying Liu, Rongqiao H. Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII. Aging cell. vol 14. issue 5. 2016-09-19. PMID:26095350. |
targeting ribosylation by inhibiting age formation may be a promising therapeutic strategy to prevent alzheimer's disease-like tau hyperphosphorylation and diabetic encephalopathies. |
2016-09-19 |
2023-08-13 |
mouse |
| Jonathan Spiegel, Elizabeth Pirraglia, Ricardo S Osorio, Lidia Glodzik, Yi Li, Wai Tsui, Leslie A Saint Louis, Catherine Randall, Tracy Butler, Jinfeng Xu, Raymond P Zinkowski, Henrik Zetterberg, Juan Fortea, Silvia Fossati, Thomas Wisniewski, Peter Davies, Kaj Blennow, Mony J de Leo. Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 49. issue 1. 2016-09-19. PMID:26444757. |
cerebrospinal fluid (csf) measures of phosphorylated-tau (p-tau) 231 and p-tau181 are two biomarkers for the identification of tau pathology as related to alzheimer's disease (ad). |
2016-09-19 |
2023-08-13 |
human |
| Laura B Eisenmenger, Eugene J Huo, John M Hoffman, Satoshi Minoshima, Manuela C Matesan, David H Lewis, Brian J Lopresti, Chester A Mathis, David O Okonkwo, James M Mount. Advances in PET Imaging of Degenerative, Cerebrovascular, and Traumatic Causes of Dementia. Seminars in nuclear medicine. vol 46. issue 1. 2016-09-19. PMID:26687858. |
in addition, the recognition of the importance of neocortical neurofibrillary tangles as related to alzheimer disease progression has led to the development of promising tau imaging agents such as [(18)f]t807. |
2016-09-19 |
2023-08-13 |
Not clear |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
consumption of caffeine, a non-selective adenosine a2a receptor (a2ar) antagonist, reduces the risk of developing alzheimer's disease (ad) in humans and mitigates both amyloid and tau burden in transgenic mouse models. |
2016-09-16 |
2023-08-13 |
mouse |
| G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung, A C Naj, B W Kunkle, L-S Wang, J C Bis, C Bellenguez, D Harold, K L Lunetta, A L Destefano, B Grenier-Boley, R Sims, G W Beecham, A V Smith, V Chouraki, K L Hamilton-Nelson, M A Ikram, N Fievet, N Denning, E R Martin, H Schmidt, Y Kamatani, M L Dunstan, O Valladares, A R Laza, D Zelenika, A Ramirez, T M Foroud, S-H Choi, A Boland, T Becker, W A Kukull, S J van der Lee, F Pasquier, C Cruchaga, D Beekly, A L Fitzpatrick, O Hanon, M Gill, R Barber, V Gudnason, D Campion, S Love, D A Bennett, N Amin, C Berr, Magda Tsolaki, J D Buxbaum, O L Lopez, V Deramecourt, N C Fox, L B Cantwell, L Tárraga, C Dufouil, J Hardy, P K Crane, G Eiriksdottir, D Hannequin, R Clarke, D Evans, T H Mosley, L Letenneur, C Brayne, W Maier, P De Jager, V Emilsson, J-F Dartigues, H Hampel, M I Kamboh, R F A G de Bruijn, C Tzourio, P Pastor, E B Larson, J I Rotter, M C O'Donovan, T J Montine, M A Nalls, S Mead, E M Reiman, P V Jonsson, C Holmes, P H St George-Hyslop, M Boada, P Passmore, J R Wendland, R Schmidt, K Morgan, A R Winslow, J F Powell, M Carasquillo, S G Younkin, J Jakobsdóttir, J S K Kauwe, K C Wilhelmsen, D Rujescu, M M Nöthen, A Hofman, L Jones, J L Haines, B M Psaty, C Van Broeckhoven, P Holmans, L J Launer, R Mayeux, M Lathrop, A M Goate, V Escott-Price, S Seshadri, M A Pericak-Vance, P Amouyel, J Williams, C M van Duijn, G D Schellenberg, L A Farre. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25778476. |
a novel alzheimer disease locus located near the gene encoding tau protein. |
2016-09-16 |
2023-08-13 |
human |
| Richard M Zweig, Elizabeth A Disbrow, Vijayakumar Javalka. Cognitive and Psychiatric Disturbances in Parkinsonian Syndromes. Neurologic clinics. vol 34. issue 1. 2016-09-15. PMID:26614001. |
older age, presence of apoe-4 gene, and/or other factors result in amyloid plaque deposition that, in turn, accelerates cortical lewy body plus tau pathology, linking dementia with lewy bodies and parkinson's disease with early dementia with alzheimer's disease. |
2016-09-15 |
2023-08-13 |
Not clear |
| Melanie Dani, Paul Edison, David J Brook. Imaging biomarkers in tauopathies. Parkinsonism & related disorders. vol 22 Suppl 1. 2016-09-12. PMID:26299160. |
abnormally aggregated tau protein is central to the pathophysiology of alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. |
2016-09-12 |
2023-08-13 |
Not clear |
| Min Xie, Yun Han, Quntao Yu, Xia Wang, Shaohui Wang, Xiaomei Lia. UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein. Journal of Alzheimer's disease : JAD. vol 49. issue 2. 2016-09-12. PMID:26444754. |
in alzheimer's disease brains, uch-l1 is negatively related to neurofibrillary tangles whose major component is hyperphosphorylated tau protein, but the direct action of uch-l1 on tau has not been reported. |
2016-09-12 |
2023-08-13 |
mouse |
| Dandan Chu, Jianxin Tan, Shutao Xie, Nana Jin, Xiaomin Yin, Cheng-Xin Gong, Khalid Iqbal, Fei Li. GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner. Journal of Alzheimer's disease : JAD. vol 49. issue 2. 2016-09-12. PMID:26484916. |
hyperphosphorylation of tau is pivotally involved in the pathogenesis of alzheimer's disease (ad) and related tauopathies. |
2016-09-12 |
2023-08-13 |
mouse |
| Christoffer Rosén, Bahman Farahmand, Tobias Skillbäck, Katarina Nägga, Niklas Mattsson, Lena Kilander, Dorota Religa, Anders Wimo, Kaj Blennow, Bengt Winblad, Henrik Zetterberg, Maria Eriksdotte. Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 12. 2016-09-08. PMID:26079415. |
new research guidelines for the diagnosis of alzheimer's disease (ad) include biomarker evidence of amyloid-β (aβ) and tau pathology. |
2016-09-08 |
2023-08-13 |
Not clear |
| Edward Rockenstein, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Eliezer Maslia. Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. BMC neuroscience. vol 16. 2016-08-29. PMID:26611895. |
while 3r tau is found in pick's disease and alzheimer's disease (ad), 4r tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and ad. |
2016-08-29 |
2023-08-13 |
mouse |
| Michael Ewers, Niklas Mattsson, Lennart Minthon, José L Molinuevo, Anna Antonell, Julius Popp, Frank Jessen, Sanna-Kaisa Herukka, Hilka Soininen, Walter Maetzler, Thomas Leyhe, Katharina Bürger, Miyako Taniguchi, Katsuya Urakami, Simone Lista, Bruno Dubois, Kaj Blennow, Harald Hampe. CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 11. 2016-08-26. PMID:25804998. |
the aim of this study was to test the diagnostic value of cerebrospinal fluid (csf) beta-amyloid (aβ1-42), phosphorylated tau, and total tau (tau) to discriminate alzheimer's disease (ad) dementia from other forms of dementia. |
2016-08-26 |
2023-08-13 |
Not clear |
| Pascal Y Smith, Julia Hernandez-Rapp, Francis Jolivette, Cynthia Lecours, Kanchan Bisht, Claudia Goupil, Veronique Dorval, Sepideh Parsi, Françoise Morin, Emmanuel Planel, David A Bennett, Francisco-Jose Fernandez-Gomez, Nicolas Sergeant, Luc Buée, Marie-Ève Tremblay, Frédéric Calon, Sébastien S Héber. miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Human molecular genetics. vol 24. issue 23. 2016-08-26. PMID:26362250. |
alzheimer's disease (ad) and related tauopathies comprise a large group of neurodegenerative diseases associated with the pathological aggregation of tau protein. |
2016-08-26 |
2023-08-13 |
mouse |
| Prateep Pakavathkumar, Gyanesh Sharma, Vikas Kaushal, Bénédicte Foveau, Andrea C LeBlan. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Scientific reports. vol 5. 2016-08-26. PMID:26400108. |
methylene blue, currently in phase 3 clinical trials against alzheimer disease, disaggregates the tau protein of neurofibrillary tangles by oxidizing specific cysteine residues. |
2016-08-26 |
2023-08-13 |
mouse |
| Kaoru Yamada, Tirth K Patel, Katja Hochgräfe, Thomas E Mahan, Hong Jiang, Floy R Stewart, Eva-Maria Mandelkow, David M Holtzma. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26502977. |
intracellular accumulation of tau as neurofibrillary tangles (nfts) is the hallmark of alzheimer's disease (ad) as well as in other tauopathies. |
2016-08-24 |
2023-08-13 |
mouse |
| Hans Zempel, Eva-Maria Mandelko. Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26691836. |
tau missorting and spastin-induced microtubule disruption in neurodegeneration: alzheimer disease and hereditary spastic paraplegia. |
2016-08-24 |
2023-08-13 |
human |
| Hans Zempel, Eva-Maria Mandelko. Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26691836. |
in alzheimer disease (ad), the mechanistic connection of the two major pathological hallmarks, namely deposition of amyloid-beta (aβ) in the form of extracellular plaques, and the pathological changes of the intracellular protein tau (such as phosphorylation, missorting, aggregation), is not well understood. |
2016-08-24 |
2023-08-13 |
human |
| J-Y Chang, N-S Chan. WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis. Cell death discovery. vol 1. 2016-08-23. PMID:27551439. |
aggregated vesicle-trafficking protein isoform trappc6aΔ (tpc6aΔ) has a critical role in causing caspase activation, tau aggregation and aβ generation in the brains of nondemented middle-aged humans, patients with alzheimer's disease (ad) and 3-week-old wwox gene knockout mice. |
2016-08-23 |
2023-08-13 |
mouse |