All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Nicholas M Kanaan, Kristine Cox, Victor E Alvarez, Thor D Stein, Sharra Poncil, Ann C McKe. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. vol 75. issue 1. 2016-06-22. PMID:26671985. additionally, phosphorylation at serine 422 in tau occurs early and correlates with cognitive decline in patients with alzheimer disease (ad). 2016-06-22 2023-08-13 Not clear
Jun Jiang, Zhi-Hao Wang, Min Qu, Di Gao, Xiu-Ping Liu, Ling-Qiang Zhu, Jian-Zhi Wan. Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β. Scientific reports. vol 5. 2016-06-21. PMID:26119563. abnormal tau hyperphosphorylation is an early pathological marker of alzheimer's disease (ad), however, the upstream factors that regulate tau phosphorylation are not illustrated and there is no efficient strategy to arrest tau hyperphosphorylation. 2016-06-21 2023-08-13 mouse
Vedad Delic, Milene Brownlow, Aurelie Joly-Amado, Sandra Zivkovic, Kenyaria Noble, Tam-Anh Phan, Yen Ta, Yumeng Zhang, Stephen D Bell, Crupa Kurien, Christian Reynes, Dave Morgan, Patrick C Bradsha. Calorie restriction does not restore brain mitochondrial function in P301L tau mice, but it does decrease mitochondrial F0F1-ATPase activity. Molecular and cellular neurosciences. vol 67. 2016-06-17. PMID:26048366. in mouse models of alzheimer's disease (ad), cr has been shown to decrease amyloid-beta and hyperphosphorylated tau levels and preserve cognitive function. 2016-06-17 2023-08-13 mouse
Min Wang, Mingzhang Gao, Zhidong Xu, Qi-Huang Zhen. Synthesis of a PET tau tracer [(11)C]PBB3 for imaging of Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 25. issue 20. 2016-06-17. PMID:26323870. synthesis of a pet tau tracer [(11)c]pbb3 for imaging of alzheimer's disease. 2016-06-17 2023-08-13 Not clear
Keith A Johnson, Aaron Schultz, Rebecca A Betensky, J Alex Becker, Jorge Sepulcre, Dorene Rentz, Elizabeth Mormino, Jasmeer Chhatwal, Rebecca Amariglio, Kate Papp, Gad Marshall, Mark Albers, Samantha Mauro, Lesley Pepin, Jonathan Alverio, Kelly Judge, Marlie Philiossaint, Timothy Shoup, Daniel Yokell, Bradford Dickerson, Teresa Gomez-Isla, Bradley Hyman, Neil Vasdev, Reisa Sperlin. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Annals of neurology. vol 79. issue 1. 2016-06-17. PMID:26505746. tau positron emission tomographic imaging in aging and early alzheimer disease. 2016-06-17 2023-08-13 Not clear
Keith A Johnson, Aaron Schultz, Rebecca A Betensky, J Alex Becker, Jorge Sepulcre, Dorene Rentz, Elizabeth Mormino, Jasmeer Chhatwal, Rebecca Amariglio, Kate Papp, Gad Marshall, Mark Albers, Samantha Mauro, Lesley Pepin, Jonathan Alverio, Kelly Judge, Marlie Philiossaint, Timothy Shoup, Daniel Yokell, Bradford Dickerson, Teresa Gomez-Isla, Bradley Hyman, Neil Vasdev, Reisa Sperlin. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Annals of neurology. vol 79. issue 1. 2016-06-17. PMID:26505746. detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of alzheimer disease (ad), staging and monitoring of disease progression, and development of disease-modifying therapies. 2016-06-17 2023-08-13 Not clear
Tina Löffler, Stefanie Flunkert, Magdalena Temmel, Birgit Hutter-Paie. Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction. Frontiers in neuroscience. vol 10. 2016-06-17. PMID:27313503. besides the continued focus on aβ and tau in alzheimer's disease (ad), it is increasingly evident that other pathologic characteristics, such as vascular alterations or inflammation, are associated with ad. 2016-06-17 2023-08-13 mouse
Eva C Schulte, Akio Fukumori, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelman. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European journal of human genetics : EJHG. vol 23. issue 10. 2016-06-15. PMID:25604855. we investigated the contribution of rare variants in seven genes of known relevance to dementias (β-amyloid precursor protein (app), psen1/2, mapt (microtubule-associated protein tau), fused in sarcoma (fus), granulin (grn) and tar dna-binding protein 43 (tdp-43)) to pd and pd plus dementia (pd+d) in a discovery sample of 376 individuals with pd and followed by the genotyping of 25 out of the 27 identified variants with a minor allele frequency <5% in 975 individuals with pd, 93 cases with lewy body disease on neuropathological examination, 613 individuals with alzheimer's disease (ad), 182 cases with frontotemporal dementia and 1014 general population controls. 2016-06-15 2023-08-13 Not clear
Taeko Kimura, Hiroyuki Hatsuta, Masami Masuda-Suzukake, Masato Hosokawa, Koichi Ishiguro, Haruhiko Akiyama, Shigeo Murayama, Masato Hasegawa, Shin-ichi Hisanag. The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687814. a slightly higher phosphorylation of tau, which may represent the early step of hyperphosphorylation, was increased in alzheimer disease patients at braak stage v. tau with this phosphorylation state was pelleted by centrifugation, and sarkosyl-soluble tau in either alzheimer disease or corticobasal degeneration brains showed phosphorylation profiles similar to tau in normal human brain, suggesting that hyperphosphorylation occurs in aggregated tau. 2016-06-14 2023-08-13 mouse
J M. Efficacy of the Phosphorylated Tau P181 for the Alzheimer's Disease Dementia - a Systematic Review and Meta Analysis. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. vol 17. issue 7. 2016-06-10. PMID:27201252. efficacy of the phosphorylated tau p181 for the alzheimer's disease dementia - a systematic review and meta analysis. 2016-06-10 2023-08-13 Not clear
Yang Hu, Wen-ting Ding, Xiao-nan Zhu, Xue-lan Wan. A mini review: Tau transgenic mouse models and olfactory dysfunction in Alzheimer's Disease. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 31. issue 6. 2016-06-10. PMID:27215014. a mini review: tau transgenic mouse models and olfactory dysfunction in alzheimer's disease. 2016-06-10 2023-08-13 mouse
Aiko Ishiki, Nobuyuki Okamura, Katsutoshi Furukawa, Shozo Furumoto, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Yoichi Ishikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Ara. Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography. PloS one. vol 10. issue 10. 2016-06-06. PMID:26461913. longitudinal assessment of tau pathology in patients with alzheimer's disease using [18f]thk-5117 positron emission tomography. 2016-06-06 2023-08-13 human
Kwang-Su Park, Yujin Seo, Mi Kyoung Kim, Kyungdo Kim, Yun Kyung Kim, Hyunah Choo, Youhoon Chon. A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease. Organic & biomolecular chemistry. vol 13. issue 46. 2016-06-06. PMID:26488450. a curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in alzheimer's disease. 2016-06-06 2023-08-13 Not clear
Kwang-Su Park, Yujin Seo, Mi Kyoung Kim, Kyungdo Kim, Yun Kyung Kim, Hyunah Choo, Youhoon Chon. A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease. Organic & biomolecular chemistry. vol 13. issue 46. 2016-06-06. PMID:26488450. in recent years, there has been growing interest in the near-infrared (nir) fluorescence imaging of tau fibrils for the early diagnosis of alzheimer's disease (ad). 2016-06-06 2023-08-13 Not clear
Étienne-Émile Baulie. From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches. Comptes rendus biologies. vol 338. issue 8-9. 2016-06-01. PMID:26251072. protein fkbp52 is involved in the dysfunction of the tau protein in alzheimer's disease and senile dementias. 2016-06-01 2023-08-13 Not clear
Koushirou Sogawa, Katsuhiko Minoura, Yasuko In, Toshimasa Ishida, Taizo Taniguchi, Koji Tomo. CH-π interaction in VQIVYK sequence elucidated by NMR spectroscopy is essential for PHF formation of tau. Biopolymers. vol 102. issue 3. 2016-05-30. PMID:24687309. one of the histopathological features of alzheimer's disease (ad) is higher order neurofibrillary tangles formed by abnormally aggregated tau protein. 2016-05-30 2023-08-12 Not clear
Yunpeng Huang, Zhihao Wu, Bing Zho. Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity. Cellular and molecular life sciences : CMLS. vol 73. issue 1. 2016-05-27. PMID:26403791. under disease conditions such as pick's disease, progressive supranuclear palsy, frontotemporal dementia, parkinsonism linked to chromosome 17 and alzheimer's disease, tau proteins can self-assemble to paired helical filaments progressing to neurofibrillary tangles. 2016-05-27 2023-08-13 Not clear
Kirsty E McAleese, Michael Firbank, Madhurima Dey, Sean J Colloby, Lauren Walker, Mary Johnson, Joshua R Beverley, John Paul Taylor, Alan J Thomas, John T O'Brien, Johannes Attem. Cortical tau load is associated with white matter hyperintensities. Acta neuropathologica communications. vol 3. 2016-05-27. PMID:26419828. however, it has been suggested that wm damage may also be the result of degenerative axonal loss that is secondary to cortical alzheimer's disease (ad) pathologies i.e., hyperphosphorylated tau (hpτ) and amyloid-beta (aβ). 2016-05-27 2023-08-13 Not clear
Samuel J Jackson, Caroline Kerridge, Jane Cooper, Annalisa Cavallini, Benjamin Falcon, Claire V Cella, Alessia Landi, Philip G Szekeres, Tracey K Murray, Zeshan Ahmed, Michel Goedert, Michael Hutton, Michael J O'Neill, Suchira Bos. Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 3. 2016-05-27. PMID:26791207. significance statement: the spread of tau pathology from neuron to neuron is postulated to account for, or at least to contribute to, the overall propagation of tau pathology during the development of human tauopathies including alzheimer's disease. 2016-05-27 2023-08-13 mouse
Jing-Zhang Wang, Yong Zhan. Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease. Journal of the neurological sciences. vol 348. issue 1-2. 2016-05-26. PMID:25467137. configuration-specific immunotherapy targeting cis pthr231-pro232 tau for alzheimer disease. 2016-05-26 2023-08-13 Not clear