| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Overk, E Rockenstein, J Florio, Q Cheng, E Maslia. Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. Neuroscience. vol 310. 2016-08-15. PMID:26341908. |
abnormal accumulation of amyloid β (aβ), α-synuclein (α-syn), and microtubule-associated protein tau (tau) have been implicated in neurodegenerative diseases including alzheimer's disease (ad), parkinson's disease (pd), and pick's disease (pid). |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
tau pathology is a pathological hallmark for several neurodegenerative diseases including alzheimer's disease and frontotemporal dementia. |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
recently, a correlation between trem2 expression and hyperphosphorylated tau has been revealed in the brain of alzheimer's disease patients, suggesting a potential association between trem2 and tau pathology. |
2016-08-15 |
2023-08-13 |
mouse |
| Bernadeta Michalski, Maria M Corrada, Claudia H Kawas, Margaret Fahnestoc. Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26410307. |
decreased brain-derived neurotrophic factor (bdnf) contributes to memory loss in alzheimer's disease (ad), and soluble assemblies of amyloid-beta (aβ) and tau contribute to neurodegeneration. |
2016-08-15 |
2023-08-13 |
human |
| Shabab B Hannan, Nina M Dräger, Tobias M Rasse, Aaron Voigt, Thomas R Jah. Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models. Journal of neurochemistry. vol 137. issue 1. 2016-08-15. PMID:26756400. |
abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by alzheimer's disease (ad) long before the identification of mutations in the microtubule-associated protein tau (mapt) gene, encoding the tau protein, in a different neurodegenerative disease called frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2016-08-15 |
2023-08-13 |
human |
| Haoling Qi, Sudhakaran Prabakaran, François-Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, Guy Lippens, Isabelle Landrie. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. The Journal of biological chemistry. vol 291. issue 14. 2016-08-15. PMID:26858248. |
tau neuronal protein has a central role in neurodegeneration and is implicated in alzheimer disease development. |
2016-08-15 |
2023-08-13 |
rat |
| Haoling Qi, Sudhakaran Prabakaran, François-Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, Guy Lippens, Isabelle Landrie. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. The Journal of biological chemistry. vol 291. issue 14. 2016-08-15. PMID:26858248. |
phosphorylation with rat brain extract is known to transform tau into an alzheimer disease-like state. |
2016-08-15 |
2023-08-13 |
rat |
| Haoling Qi, Sudhakaran Prabakaran, François-Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, Guy Lippens, Isabelle Landrie. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. The Journal of biological chemistry. vol 291. issue 14. 2016-08-15. PMID:26858248. |
our results suggest that erk2 dysregulation in alzheimer disease could lead to abnormal phosphorylation of tau resulting in the pathology of the disease. |
2016-08-15 |
2023-08-13 |
rat |
| A Kamah, F X Cantrelle, I Huvent, J Giustiniani, K Guillemeau, C Byrne, Y Jacquot, I Landrieu, E E Baulieu, C Smet, B Chambraud, G Lippen. Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes. Journal of molecular biology. vol 428. issue 6. 2016-08-15. PMID:26903089. |
the aggregation of the neuronal tau protein is one molecular hallmark of alzheimer's disease and other related tauopathies, but the precise molecular mechanisms of the aggregation process remain unclear. |
2016-08-15 |
2023-08-13 |
human |
| C Geeth Gunawardana, Mohadeseh Mehrabian, Xinzhu Wang, Iris Mueller, Isabela B Lubambo, James E N Jonkman, Hansen Wang, Gerold Schmitt-Ulm. The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome. Molecular & cellular proteomics : MCP. vol 14. issue 11. 2016-08-11. PMID:26269332. |
the tau protein is central to the etiology of several neurodegenerative diseases, including alzheimer's disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a systematic discovery approach. |
2016-08-11 |
2023-08-13 |
human |
| Jens Wagner, Sybille Krauss, Song Shi, Sergey Ryazanov, Julia Steffen, Carolin Miklitz, Andrei Leonov, Alexander Kleinknecht, Bettina Göricke, Jochen H Weishaupt, Daniel Weckbecker, Anne M Reiner, Wolfgang Zinth, Johannes Levin, Dan Ehninger, Stefan Remy, Hans A Kretzschmar, Christian Griesinger, Armin Giese, Martin Fuhrman. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta neuropathologica. vol 130. issue 5. 2016-08-11. PMID:26439832. |
pathological tau aggregation leads to filamentous tau inclusions and characterizes neurodegenerative tauopathies such as alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. |
2016-08-11 |
2023-08-13 |
mouse |
| Amir Nazem, Roman Sankowski, Michael Bacher, Yousef Al-Abe. Rodent models of neuroinflammation for Alzheimer's disease. Journal of neuroinflammation. vol 12. 2016-08-10. PMID:25890375. |
the etiology of late-onset alzheimer's disease is not based on mutations related to amyloid-β (aβ) or tau production which are currently the basis of in vivo models of alzheimer's disease. |
2016-08-10 |
2023-08-13 |
Not clear |
| Amir Nazem, Roman Sankowski, Michael Bacher, Yousef Al-Abe. Rodent models of neuroinflammation for Alzheimer's disease. Journal of neuroinflammation. vol 12. 2016-08-10. PMID:25890375. |
it has recently been suggested that mechanisms like chronic neuroinflammation may occur prior to amyloid-β and tau pathologies in late-onset alzheimer's disease. |
2016-08-10 |
2023-08-13 |
Not clear |
| Amir Nazem, Roman Sankowski, Michael Bacher, Yousef Al-Abe. Rodent models of neuroinflammation for Alzheimer's disease. Journal of neuroinflammation. vol 12. 2016-08-10. PMID:25890375. |
therefore, a model based on the inflammation hypothesis of late-onset alzheimer's disease should include the following features: (i) primary chronic neuroinflammation, (ii) manifestations of memory and cognitive impairment, and (iii) late development of tau and aβ pathologies. |
2016-08-10 |
2023-08-13 |
Not clear |
| Stephanie M Williams, Lalitha Venkataraman, Huilai Tian, Galam Khan, Brent T Harris, Michael R Sierk. Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis. Journal of visualized experiments : JoVE. issue 96. 2016-08-09. PMID:25742170. |
because protein variants play critical roles in many diseases including tdp-43 in amyotrophic lateral sclerosis (als), alpha-synuclein in parkinson's disease and beta-amyloid and tau in alzheimer's disease, it is critically important to develop morphology specific reagents that can selectively target these disease-specific protein variants to study the role of these variants in disease pathology and for potential diagnostic and therapeutic applications. |
2016-08-09 |
2023-08-13 |
human |
| Charisse N Winston, Anastasia Noël, Aidan Neustadtl, Maia Parsadanian, David J Barton, Deepa Chellappa, Tiffany E Wilkins, Andrew D Alikhani, David N Zapple, Sonia Villapol, Emmanuel Planel, Mark P Burn. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. The American journal of pathology. vol 186. issue 3. 2016-08-09. PMID:26857506. |
however, rmtbis did not increase β-amyloid levels or tau phosphorylation in the 3xtg-ad mouse model of alzheimer disease. |
2016-08-09 |
2023-08-13 |
mouse |
| Kanae Ando, Akiko Maruko-Otake, Yosuke Ohtake, Motoki Hayashishita, Michiko Sekiya, Koichi M Iijim. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS genetics. vol 12. issue 3. 2016-08-08. PMID:27023670. |
abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including alzheimer's disease (ad). |
2016-08-08 |
2023-08-13 |
human |
| Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshim. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26400044. |
colocalization of phosphorylated forms of wave1, crmp2, and tau in alzheimer's disease model mice: involvement of cdk5 phosphorylation and the effect of atra treatment. |
2016-08-05 |
2023-08-13 |
mouse |
| Chingli Lee, Clara Y B Low, Paul T Francis, Johannes Attems, Peter T-H Wong, Mitchell K P Lai, Michelle G K Ta. An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26561212. |
fyn kinase is known to interact with β-amyloid and tau, and contributes to alzheimer's disease pathogenesis. |
2016-08-05 |
2023-08-13 |
rat |
| Zhiva Skachokova, Frederik Sprenger, Karin Breu, Dorothee Abramowski, Florence Clavaguera, Jürgen Hench, Matthias Staufenbiel, Markus Tolnay, David T Winkle. Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties. Current Alzheimer research. vol 12. issue 9. 2016-08-04. PMID:26159190. |
early diagnosis of alzheimer`s disease (ad) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement of amyloid-β (aβ) and tau levels in cerebrospinal fluid (csf). |
2016-08-04 |
2023-08-13 |
mouse |