All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jay Amin, Claire Paquet, Alex Baker, Ayodeji A Asuni, Seth Love, Clive Holmes, Jacques Hugon, James A R Nicoll, Delphine Boch. Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β. Neuropathology and applied neurobiology. vol 41. issue 4. 2016-02-01. PMID:25486988. active amyloid-β (aβ) immunotherapy in alzheimer's disease (ad) induces removal of aβ and phosphorylated tau (ptau). 2016-02-01 2023-08-13 Not clear
Hiroyuki Watanabe, Masahiro Ono, Hideo Saj. Novel PET/SPECT probes for imaging of tau in Alzheimer's disease. TheScientificWorldJournal. vol 2015. 2016-02-01. PMID:25879047. novel pet/spect probes for imaging of tau in alzheimer's disease. 2016-02-01 2023-08-13 Not clear
Marija Usenovic, Shahriar Niroomand, Robert E Drolet, Lihang Yao, Renee C Gaspar, Nathan G Hatcher, Joel Schachter, John J Renger, Sophie Parmentier-Batteu. Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 42. 2016-01-25. PMID:26490863. neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological hallmark of several neurodegenerative tauopathies, including alzheimer's disease (ad). 2016-01-25 2023-08-13 human
María José Delgado-Cortés, Ana M Espinosa-Oliva, Manuel Sarmiento, Sandro Argüelles, Antonio J Herrera, Raquel Mauriño, Ruth F Villarán, José L Venero, Alberto Machado, Rocío M de Pablo. Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus. Chemical research in toxicology. vol 28. issue 4. 2016-01-22. PMID:25658758. we found that chronic stress increases the levels of several proteins involved in alzheimer's disease pathogenesis, such as presenilin 1, presenilin 2, and s100β, besides inducing the aggregation of tau, ubiquitin, and β-amyloid proteins in the hippocampus. 2016-01-22 2023-08-13 mouse
Piotr Lewczuk, Barbara Mroczko, Anne Fagan, Johannes Kornhube. Biomarkers of Alzheimer's disease and mild cognitive impairment: a current perspective. Advances in medical sciences. vol 60. issue 1. 2016-01-21. PMID:25579841. biomarkers of alzheimer's disease (ad) were recently classified as these reflecting amyloid β pathology (decreased csf concentrations of aβ42 and/or positive aβ pet scan) and these reflecting neurodegeneration (increased csf tau concentrations, decreased uptake of fdg on fdg-pet, and cerebral atrophy on structural mri). 2016-01-21 2023-08-13 Not clear
Lauren G Friedman, Yasir H Qureshi, Wai Haung Y. Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 1. 2016-01-19. PMID:25421002. alzheimer's disease (ad) is associated with the buildup of β-amyloid peptides and tau, which aggregate into extracellular plaques and neurofibrillary tangles, respectively. 2016-01-19 2023-08-13 mouse
Catherine Pan, Ané Korff, Douglas Galasko, Carmen Ginghina, Elaine Peskind, Ge Li, Joseph Quinn, Thomas J Montine, Kevin Cain, Min Shi, Jing Zhan. Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ₄₂ using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25613100. meso scale discovery (msd) recently established electrochemiluminescence-based assays to measure cerebrospinal fluid (csf) levels of total tau (t-tau) and amyloid-β 1-42 peptide (aβ42) that can aid in the diagnosis of alzheimer's disease (ad). 2016-01-19 2023-08-13 Not clear
Fiorella Casamenti, Cristina Grossi, Stefania Rigacci, Daniela Pantano, Ilaria Luccarini, Massimo Stefan. Oleuropein Aglycone: A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25649656. the amyloid plaques and neurofibrillary tangles found in the alzheimer's disease (ad) brain arise as a result of self-assembly into fibrillar material of amyloid-β protein (aβ) and hyperphosphorylated tau, respectively, through a pathological process starting with the appearance of aggregation nuclei and neurotoxic oligomers. 2016-01-19 2023-08-13 Not clear
José Luis Millá. What Can We Learn About the Neural Functions of TNAP from Studies on Other Organs and Tissues? Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219711. finally, the potential involvement of tnap in dephosphorylating tau protein and its role in the pathogenesis of alzheimer's disease is intriguing. 2016-01-19 2023-08-13 mouse
Katherine A B Kellett, Nigel M Hoope. The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219720. tissue non-specific alkaline phosphatase (tnap) is present on neuronal membranes and induces neuronal toxicity via tau dephosphorylation; a mechanism which could play a role in the neuronal loss seen in alzheimer's disease (ad). 2016-01-19 2023-08-13 Not clear
Miguel Diaz-Hernandez, Felix Hernandez, Maria Teresa Miras-Portugal, Jesús Avil. TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219721. on the opposite stage, recent evidences indicate that tnap plays a key role in spreading the neurotoxicity effect induced by extracellular hyperphosphorylated tau protein, the main component of intracellular neurofibrillary tangles present in the brain of alzheimer disease patients. 2016-01-19 2023-08-13 Not clear
Miguel Diaz-Hernandez, Felix Hernandez, Maria Teresa Miras-Portugal, Jesús Avil. TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219721. besides, activation of muscarinic receptors by dephosphorylated tau increases the expression of tnap, which could explain the increase in tnap activity and protein levels detected in alzheimer disease. 2016-01-19 2023-08-13 Not clear
Gerhard Multhaup, Otmar Huber, Luc Buée, Marie-Christine Gala. Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles. The Journal of biological chemistry. vol 290. issue 39. 2016-01-19. PMID:26296890. amyloid precursor protein (app) metabolites (amyloid-β (aβ) peptides) and tau are the main components of senile plaques and neurofibrillary tangles, the two histopathological hallmarks of alzheimer disease. 2016-01-19 2023-08-13 Not clear
Sang-Won Min, Xu Chen, Tara E Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, Kotaro Shirakawa, S Sakura Minami, Erwin Defensor, Sue Ann Mok, Peter Dongmin Sohn, Birgit Schilling, Xin Cong, Lisa Ellerby, Bradford W Gibson, Jeffrey Johnson, Nevan Krogan, Mehrdad Shamloo, Jason Gestwicki, Eliezer Masliah, Eric Verdin, Li Ga. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature medicine. vol 21. issue 10. 2016-01-19. PMID:26390242. tauopathies, including frontotemporal dementia (ftd) and alzheimer's disease (ad), are neurodegenerative diseases in which tau fibrils accumulate. 2016-01-19 2023-08-13 mouse
Workalemahu M Berhanu, Artëm E Masuno. Atomistic mechanism of polyphenol amyloid aggregation inhibitors: molecular dynamics study of Curcumin, Exifone, and Myricetin interaction with the segment of tau peptide oligomer. Journal of biomolecular structure & dynamics. vol 33. issue 7. 2016-01-18. PMID:25093402. polyphenols such as curcumin, exifone, and myricetin exhibit modest inhibition toward fibril formation of tau peptide which is associated with alzheimer's disease. 2016-01-18 2023-08-13 Not clear
Diego Piedrahita, John Fredy Castro-Alvarez, Ryan L Boudreau, Andres Villegas-Lanau, Kenneth S Kosik, Juan Carlos Gallego-Gomez, Gloria Patricia Cardona-Góme. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Frontiers in cellular neuroscience. vol 9. 2016-01-18. PMID:26778963. β-site app cleaving enzyme 1 (bace1) initiates app cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in alzheimer's disease (ad). 2016-01-18 2023-08-13 mouse
Alex C Hradek, Hyun-Pil Lee, Sandra L Siedlak, Sandy L Torres, Wooyoung Jung, Ashley H Han, Hyoung-gon Le. Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25061053. distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xtg-ad mouse model and alzheimer's disease patients. 2016-01-15 2023-08-13 mouse
Xiu-Lian Wang, Ji Zeng, Yang Yang, Yan Xiong, Zhi-Hua Zhang, Mei Qiu, Xiong Yan, Xu-Ying Sun, Qing-Zhang Tuo, Rong Liu, Jian-Zhi Wan. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079798. abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including alzheimer's disease (ad). 2016-01-15 2023-08-13 mouse
Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. hippocampal laminar distribution of tau relates to alzheimer's disease and age of onset. 2016-01-15 2023-08-13 Not clear
Philip H Montenigro, Daniel T Corp, Thor D Stein, Robert C Cantu, Robert A Ster. Chronic traumatic encephalopathy: historical origins and current perspective. Annual review of clinical psychology. vol 11. 2016-01-15. PMID:25581233. the neuropathology of cte is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including alzheimer's disease. 2016-01-15 2023-08-13 Not clear