| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario M Dorostkar, Chengyu Zou, Lidia Blazquez-Llorca, Jochen Herm. Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities. Acta neuropathologica. vol 130. issue 1. 2016-03-22. PMID:26063233. |
furthermore, tau hyperphosphorylation and microglia activation, which are thought to be consequences of amyloidosis in alzheimer's disease, may also contribute to spine loss. |
2016-03-22 |
2023-08-13 |
mouse |
| Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Feng Qian, Guo-Huang Fan, Richard Bucala, Richard D Y. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26382037. |
deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of alzheimer's disease. |
2016-03-22 |
2023-08-13 |
mouse |
| Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Feng Qian, Guo-Huang Fan, Richard Bucala, Richard D Y. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26382037. |
pathological features of alzheimer's disease (ad) include aggregation of amyloid beta (aβ) and tau protein. |
2016-03-22 |
2023-08-13 |
mouse |
| Lilian Calderón-Garcidueñas, Ana Calderón-Garcidueñas, Ricardo Torres-Jardón, José Avila-Ramírez, Randy J Kulesza, Amedeo D Angiull. Air pollution and your brain: what do you need to know right now. Primary health care research & development. vol 16. issue 4. 2016-03-21. PMID:25256239. |
in adults, ambient pollution is associated to stroke and depression, whereas the emerging picture in children show significant systemic inflammation, immunodysregulation at systemic, intratechal and brain levels, neuroinflammation and brain oxidative stress, along with the main hallmarks of alzheimer and parkinson's diseases: hyperphosphorilated tau, amyloid plaques and misfolded α-synuclein. |
2016-03-21 |
2023-08-13 |
Not clear |
| Feng Zheng, Biao Zhang, Yanan Sun, Mingfeng Qiu, Jing S. Evaluation of WO2011045166A1, Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction. Expert opinion on therapeutic patents. vol 25. issue 7. 2016-03-21. PMID:25945965. |
the invention establishes that the fkbp52-tau interaction provides a new target that may be used advantageously for novel therapeutic approaches for neurological disorders involving tau dysfunction, and especially for alzheimer's disease. |
2016-03-21 |
2023-08-13 |
human |
| Jenna M Tarasoff-Conway, Roxana O Carare, Ricardo S Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V Zlokovic, Blas Frangione, Kaj Blennow, Joël Ménard, Henrik Zetterberg, Thomas Wisniewski, Mony J de Leo. Clearance systems in the brain-implications for Alzheimer disease. Nature reviews. Neurology. vol 11. issue 8. 2016-03-21. PMID:26195256. |
accumulation of toxic protein aggregates-amyloid-β (aβ) plaques and hyperphosphorylated tau tangles-is the pathological hallmark of alzheimer disease (ad). |
2016-03-21 |
2023-08-13 |
Not clear |
| Melissa C Wren, Jing Zhao, Chia-Chen Liu, Melissa E Murray, Yuka Atagi, Mary D Davis, Yuan Fu, Hirotaka J Okano, Kotaro Ogaki, Audrey J Strongosky, Pawel Tacik, Rosa Rademakers, Owen A Ross, Dennis W Dickson, Zbigniew K Wszolek, Takahisa Kanekiyo, Guojun B. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Molecular neurodegeneration. vol 10. 2016-03-21. PMID:26373282. |
although mutations in the mapt gene have been linked to multiple tauopathies including alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, knowledge regarding how tau n279k mutation causes ppnd/ftdp-17 is limited. |
2016-03-21 |
2023-08-13 |
Not clear |
| Pierre-olivier Lang, Sylvain Nguyen, Nabila Ferahta, Kristof Major, Christophe Büla, Gabriel Gol. [Geriatry]. Revue medicale suisse. vol 12. issue 500. 2016-03-21. PMID:26946701. |
the value of imaging technologies using tau protein radiotracers is confirmed for monitoring the evolution of alzheimer's disease and the latest studies about anti-amyloid vaccines finally demonstrate encouraging results. |
2016-03-21 |
2023-08-13 |
Not clear |
| Daniel Ortuno, Holly J Carlisle, Silke Mille. Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? F1000Research. vol 5. 2016-03-21. PMID:26998235. |
a common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in parkinson's disease, tdp-43 in als, and tau in alzheimer's disease. |
2016-03-21 |
2023-08-13 |
Not clear |
| Daniel Saiz-Sanchez, Carlos De la Rosa-Prieto, Isabel Ubeda-Banon, Alino Martinez-Marco. Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer's disease. Brain structure & function. vol 220. issue 4. 2016-03-18. PMID:24748561. |
interneurons, tau and amyloid-β in the piriform cortex in alzheimer's disease. |
2016-03-18 |
2023-08-13 |
human |
| Peter J Chung, Myung Chul Choi, Herbert P Miller, H Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C Feinstein, Cyrus R Safiny. Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 47. 2016-03-15. PMID:26542680. |
aberrant tau behavior is associated with neurodegenerative dementias, including alzheimer's. |
2016-03-15 |
2023-08-13 |
Not clear |
| Lenka Hromadkova, Michala Kolarova, Barbora Jankovicova, Ales Bartos, Jan Ricny, Zuzana Bilkova, Daniela Ripov. Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product. Journal of neuroimmunology. vol 289. 2016-03-14. PMID:26616881. |
we have focused on characterization of antibodies isolated against tau protein, a biomarker of alzheimer's disease, from flebogamma ivig product. |
2016-03-14 |
2023-08-13 |
Not clear |
| Yasuyuki Kimura, Hironobu Endo, Masanori Ichise, Hitoshi Shimada, Chie Seki, Yoko Ikoma, Hitoshi Shinotoh, Makiko Yamada, Makoto Higuchi, Ming-Rong Zhang, Tetsuya Suhar. A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter. EJNMMI research. vol 6. issue 1. 2016-03-12. PMID:26969002. |
the cerebellar cortex has been used as a reference region in analyses of tau positron emission tomography (pet) data in alzheimer's disease (ad). |
2016-03-12 |
2023-08-13 |
Not clear |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
role of prp(c) expression in tau protein levels and phosphorylation in alzheimer's disease evolution. |
2016-03-10 |
2023-08-13 |
mouse |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
alzheimer's disease (ad) is characterized by the presence of amyloid plaques mainly consisting of hydrophobic β-amyloid peptide (aβ) aggregates and neurofibrillary tangles (nfts) composed principally of hyperphosphorylated tau. |
2016-03-10 |
2023-08-13 |
mouse |
| Antoine Leuzy, Stephen F Carter, Konstantinos Chiotis, Ove Almkvist, Anders Wall, Agneta Nordber. Concordance and Diagnostic Accuracy of [11C]PIB PET and Cerebrospinal Fluid Biomarkers in a Sample of Patients with Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25649653. |
alzheimer's disease (ad) pathology can be quantified in vivo using cerebrospinal fluid (csf) levels of amyloid-β1-42 (aβ1-42), total-tau (t-tau), and phosphorylated tau (p-tau181p), as well as with positron emission tomography (pet) using [(11)c]pittsburgh compound-b ([(11)c]pib). |
2016-03-08 |
2023-08-13 |
Not clear |
| Sylvina Bouleau, Hervé Tricoir. Drosophila models of Alzheimer's disease: advances, limits, and perspectives. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25697708. |
amyloid-β protein precursor (aβpp) and the microtubule-associated protein tau (mapt) are the two key players involved in alzheimer's disease (ad) and are associated with amyloid plaques and neurofibrillary tangles respectively, two key hallmarks of the disease. |
2016-03-08 |
2023-08-13 |
human |
| Mingzhang Gao, Min Wang, Qi-Huang Zhen. Fully automated synthesis of [(18)F]T807, a PET tau tracer for Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 25. issue 15. 2016-03-08. PMID:26048805. |
fully automated synthesis of [(18)f]t807, a pet tau tracer for alzheimer's disease. |
2016-03-08 |
2023-08-13 |
Not clear |
| Manuela Tondelli, Roberta Bedin, Annalisa Chiari, Maria Angela Molinari, Guendalina Bonifacio, Nicoletta Lelli, Tommaso Trenti, Paolo Nichell. Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study. Clinical chemistry and laboratory medicine. vol 53. issue 3. 2016-03-07. PMID:25274948. |
cerebrospinal fluid (csf) levels assessment of aβ1-42 and tau proteins may be accurate diagnostic biomarkers for the differentiation of preclinical alzheimer's disease (ad) from age-associated memory impairment, depression and other forms of dementia in patients with mild cognitive impairment (mci). |
2016-03-07 |
2023-08-13 |
Not clear |
| Smita R Paranjape, Andrew P Riley, Amber D Somoza, C Elizabeth Oakley, Clay C C Wang, Thomas E Prisinzano, Berl R Oakley, T Chris Gambli. Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25822288. |
the aggregation of the microtubule-associated protein tau is a seminal event in many neurodegenerative diseases, including alzheimer's disease. |
2016-03-07 |
2023-08-13 |
Not clear |