All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Peipei Wang, Kan Din. Proteoglycans and glycosaminoglycans in misfolded proteins formation in Alzheimer's disease. Protein and peptide letters. vol 21. issue 10. 2015-12-14. PMID:24975673. misfolded protein amyloid-beta protein (aβ) and tau protein are two high hallmarks of alzheimer's disease (ad), representing significant targets in treating ad. 2015-12-14 2023-08-13 Not clear
Wenbin Zeng, Yue-Lei Che. Editorial: advances in therapeutic glycopeptides. Protein and peptide letters. vol 21. issue 10. 2015-12-14. PMID:25214033. proteoglycans (pgs), a core protein and glycosaminoglycans (gags) chain, play important roles in amyloid-beta protein as well as tau processing, and have potential significance in alzheimer's disease (ad) therapy. 2015-12-14 2023-08-13 Not clear
Louise M Wait. Treatment for Alzheimer's disease: has anything changed? Australian prescriber. vol 38. issue 2. 2015-12-09. PMID:26648618. clinical trials of drugs targeting amyloid and tau in established alzheimer's disease have been unsuccessful as it is thought that treating established disease may be too late. 2015-12-09 2023-08-13 Not clear
Irene Sola, Ester Aso, Daniela Frattini, Irene López-González, Alba Espargaró, Raimon Sabaté, Ornella Di Pietro, F Javier Luque, M Victòria Clos, Isidro Ferrer, Diego Muñoz-Torrer. Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies. Journal of medicinal chemistry. vol 58. issue 15. 2015-12-08. PMID:26181606. we have synthesized a series of heptamethylene-linked levetiracetam-huprine and levetiracetam-(6-chloro)tacrine hybrids to hit amyloid, tau, and cholinergic pathologies as well as β-amyloid (aβ)-induced epileptiform activity, some of the mechanisms that eventually lead to cognitive deficits in alzheimer's disease patients. 2015-12-08 2023-08-13 mouse
Aline Dorey, Armand Perret-Liaudet, Yannick Tholance, Anthony Fourier, Isabelle Quadri. Cerebrospinal Fluid Aβ40 Improves the Interpretation of Aβ42 Concentration for Diagnosing Alzheimer's Disease. Frontiers in neurology. vol 6. 2015-12-07. PMID:26640457. the combination of decreased amyloid β42 (aβ42) and increased total tau proteins (t-tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (csf) has recently been considered as a biological diagnostic criterion of alzheimer's disease (ad). 2015-12-07 2023-08-13 Not clear
X Luo, H Shi, L Hou, X Zhong, X Chen, Y Zhang, D Zheng, Y Tan, G Hu, N Mu, J Chen, Y Fang, H He, Y Nin. Different cerebrospinal fluid levels of Alzheimer-type biomarker Aβ42 between general paresis and asymptomatic neurosyphilis. European journal of neurology. vol 22. issue 5. 2015-12-03. PMID:25707998. to explore the amyloid and tau metabolism in neurosyphilis patients in different stages, the levels of alzheimer-type biomarkers in general paresis (gp) and asymptomatic neurosyphilis (ans) patients in comparison to patients with alzheimer's disease (ad) and normal controls (ncs) were investigated. 2015-12-03 2023-08-13 Not clear
A C Ludolph, J Brettschneide. TDP-43 in amyotrophic lateral sclerosis - is it a prion disease? European journal of neurology. vol 22. issue 5. 2015-12-03. PMID:25846565. importantly, many of these proteins such as tau and amyloid-β in alzheimer's disease and α-synuclein in parkinson's show a stereotypical sequential distribution pattern with progressing disease. 2015-12-03 2023-08-13 Not clear
Nana Jin, Xiaomin Yin, Dian Yu, Maohong Cao, Cheng-Xin Gong, Khalid Iqbal, Fei Ding, Xiaosong Gu, Fei Li. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific reports. vol 5. 2015-12-01. PMID:25641096. truncation and activation of gsk-3β by calpain i: a molecular mechanism links to tau hyperphosphorylation in alzheimer's disease. 2015-12-01 2023-08-13 mouse
Nana Jin, Xiaomin Yin, Dian Yu, Maohong Cao, Cheng-Xin Gong, Khalid Iqbal, Fei Ding, Xiaosong Gu, Fei Li. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific reports. vol 5. 2015-12-01. PMID:25641096. abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of alzheimer's disease (ad) and related tauopathies. 2015-12-01 2023-08-13 mouse
Zhi-Yuan Zhang, Chaoyun Li, Caroline Zug, Hermann J Schluesene. Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis. PloS one. vol 9. issue 8. 2015-11-30. PMID:25101849. therefore, icariin might be applied in treatment of neurodegenerative disorders, including alzheimer's disease (ad), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. 2015-11-30 2023-08-13 mouse
Matthew Wozniak, Tracey Bell, Ádám Dénes, Ruth Falshaw, Ruth Itzhak. Anti-HSV1 activity of brown algal polysaccharides and possible relevance to the treatment of Alzheimer's disease. International journal of biological macromolecules. vol 74. 2015-11-30. PMID:25583021. herpes simplex virus type 1 (hsv1) induces the formation of the characteristic abnormal molecules of alzheimer's disease (ad) brains, beta-amyloid, and abnormally phosphorylated, ad-like tau (p-tau). 2015-11-30 2023-08-13 Not clear
Judith M van der Harg, Leslie Eggels, Silvie R Ruigrok, Jeroen J M Hoozemans, Susanne E la Fleur, Wiep Schepe. Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation. Frontiers in neuroscience. vol 9. 2015-11-30. PMID:26617484. abnormal phosphorylation and aggregation of tau is a key hallmark of alzheimer's disease (ad). 2015-11-30 2023-08-13 rat
Francine Hehn de Oliveira, Edson Rodrigues Neto, Mariana Kumaira Fonseca, André Silvestre Reitz da Costa, Marcio Aloisio Bezerra Cavalcanti Rockenbach, Renata dos Santos Padilha, Liana Lisboa Fernandez, Arlete Hilbi. Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study. Arquivos de neuro-psiquiatria. vol 73. issue 7. 2015-11-25. PMID:26200050. of the 7 individuals who had a final diagnosis of alzheimer's disease (ad), 6 presented tau deposits in some region of the brainstem. 2015-11-25 2023-08-13 Not clear
Miranda E Orr, Valentina R Garbarino, Angelica Salinas, Rochelle Buffenstei. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25576082. tau phosphorylation, aggregation, and subcellular mislocalization coincide with neurodegeneration in numerous diseases, including alzheimer's disease (ad). 2015-11-24 2023-08-13 mouse
Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuch. PET Quantification of Tau Pathology in Human Brain with 11C-PBB3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 9. 2015-11-24. PMID:26182966. tau accumulation in the brain is a pathologic hallmark of alzheimer disease and other tauopathies. 2015-11-24 2023-08-13 human
Yingjun Zhao, I-Chu Tseng, Charles J Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C Mobley, Yun-Wu Zhang, Peter St George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi X. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. vol 87. issue 5. 2015-11-23. PMID:26335643. increased appoptosin and caspase-3-cleaved tau were also observed in brain samples of patients with alzheimer's disease and frontotemporal dementia with tau inclusions. 2015-11-23 2023-08-13 mouse
Rebecca B Weinberg, Elliott J Mufson, Scott E Count. Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. Frontiers in neuroscience. vol 9. 2015-11-23. PMID:26594146. micrornas (mirnas) that regulate mrna stability have been linked to amyloid production, tau phosphorylation, and inflammation in alzheimer's disease (ad). 2015-11-23 2023-08-13 human
Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. tauopathies are neurodegenerative diseases characterized by accumulation of tau amyloids, and include alzheimer disease and certain frontotemporal dementias. 2015-11-20 2023-08-13 mouse
Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. surprisingly, hj9.3 promoted uptake of fibrils composed of the tau repeat domain or alzheimer disease-derived tau aggregates, but failed to influence full-length recombinant tau fibrils. 2015-11-20 2023-08-13 mouse
Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. no antibody inhibited uptake of full-length recombinant fibrils into primary neurons, but hj9.3 blocked neuronal uptake of tau repeat domain fibrils and alzheimer disease-derived tau. 2015-11-20 2023-08-13 mouse