All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. no antibody inhibited uptake of full-length recombinant fibrils into primary neurons, but hj9.3 blocked neuronal uptake of tau repeat domain fibrils and alzheimer disease-derived tau. 2015-11-20 2023-08-13 mouse
Pooja Joshi, Luisa Benussi, Roberto Furlan, Roberta Ghidoni, Claudia Verderi. Extracellular vesicles in Alzheimer's disease: friends or foes? Focus on aβ-vesicle interaction. International journal of molecular sciences. vol 16. issue 3. 2015-11-17. PMID:25741766. the intercellular transfer of amyloid-β (aβ) and tau proteins has received increasing attention in alzheimer's disease (ad). 2015-11-17 2023-08-13 Not clear
Felipe Dias Leal, Camilo Henrique da Silva Lima, Ricardo Bicca de Alencastro, Helena Carla Castro, Carlos Rangel Rodrigues, Magaly Girão Albuquerqu. Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme. International journal of molecular sciences. vol 16. issue 3. 2015-11-17. PMID:25756379. dual specificity tyrosine-phosphorylation-regulated kinase-1a (dyrk1a) is an enzyme directly involved in alzheimer's disease, since its increased expression leads to β-amyloidosis, tau protein aggregation, and subsequent formation of neurofibrillary tangles. 2015-11-17 2023-08-13 Not clear
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. progressive cognitive decline in combination with a cerebrospinal fluid biomarker pattern of low levels of amyloid-β1-42 and high levels of total tau and phosphorylated tau is typical of alzheimer's disease. 2015-11-16 2023-08-13 human
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. the highest levels of total tau and phosphorylated tau and the lowest levels of amyloid-β1-42 and amyloid-β1-42:phosphorylated tau ratios were found in alzheimer's disease. 2015-11-16 2023-08-13 human
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. low amyloid-β1-42, high total tau and high phosphorylated tau correlated with low mini-mental state examination scores in alzheimer's disease. 2015-11-16 2023-08-13 human
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. in addition, cerebrospinal fluid amyloid-β1-42, total tau, phosphorylated tau and the amyloid-β1-42:phosphorylated tau ratio all correlated with poor cognitive performance in alzheimer's disease, as did cerebrospinal fluid amyloid-β1-42 in parkinson's disease dementia and vascular dementia. 2015-11-16 2023-08-13 human
Jon B Toledo, Henrik Zetterberg, Argonde C van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T Hu, Jose A Monge Argilés, Ana Gorostidi, Charlotte E Teunissen, Peter P De Deyn, Bradley T Hyman, Jose L Molinuevo, Giovanni B Frisoni, Gurutz Linazasoro, Mony J de Leon, Wiesje M van der Flier, Philip Scheltens, Kaj Blennow, Leslie M Shaw, John Q Trojanowsk. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220940. in a large multicentre sample of cognitively normal subjects, as a function of age, gender and apoe genotype, we studied the frequency of abnormal cerebrospinal fluid levels of alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. 2015-11-16 2023-08-13 human
Jon B Toledo, Henrik Zetterberg, Argonde C van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T Hu, Jose A Monge Argilés, Ana Gorostidi, Charlotte E Teunissen, Peter P De Deyn, Bradley T Hyman, Jose L Molinuevo, Giovanni B Frisoni, Gurutz Linazasoro, Mony J de Leon, Wiesje M van der Flier, Philip Scheltens, Kaj Blennow, Leslie M Shaw, John Q Trojanowsk. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220940. amyloid-β amyloid status (negative or positive) and neurodegeneration status (negative or positive) was established based on the pathological cerebrospinal fluid alzheimer's disease cut-off values for cerebrospinal fluid amyloid-β1-42 and total tau, respectively. 2015-11-16 2023-08-13 human
Yasser Iturria-Medina, Roberto C Sotero, Paule J Toussaint, Alan C Evan. Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders. PLoS computational biology. vol 10. issue 11. 2015-11-13. PMID:25412207. for example, misfolded amyloid-ß (aß) and tau proteins are two neuropathogenic hallmarks of alzheimer's disease. 2015-11-13 2023-08-13 human
Yasser Iturria-Medina, Roberto C Sotero, Paule J Toussaint, Alan C Evan. Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders. PLoS computational biology. vol 10. issue 11. 2015-11-13. PMID:25412207. furthermore, this model strongly supports a) the leading role of aß clearance deficiency and early aß onset age during alzheimer's disease progression, b) that effective anatomical distance from aß outbreak region explains regional aß arrival time and aß deposition likelihood, c) the multi-factorial impact of apoe e4 genotype, gender and educational level on lifetime intra-brain aß propagation, and d) the modulatory impact of aß propagation history on tau proteins concentrations, supporting the hypothesis of an interrelated pathway between aß pathophysiology and tauopathy. 2015-11-13 2023-08-13 human
Arghya Barman, Donald Hamelber. Loss of intramolecular electrostatic interactions and limited conformational ensemble may promote self-association of cis-tau peptide. Proteins. vol 83. issue 3. 2015-11-13. PMID:25524218. in the brain of alzheimer's disease patients, the formation of intra-cellular neurofibrillary tangles deposition is a result of self-aggregation of hyper-phosphorylated tau protein. 2015-11-13 2023-08-13 Not clear
Yee Lian Chew, Xiaochen Fan, Jürgen Götz, Hannah R Nichola. Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific reports. vol 4. 2015-11-12. PMID:24898126. accumulation of tau is a pathological hallmark of neurodegenerative diseases such as alzheimer's disease. 2015-11-12 2023-08-13 caenorhabditis_elegans
Sivaraman Purushothuman, Jonathan Ston. The reaction of cerebral cortex to a nearby lesion: damage, survival, self-protection. Brain research. vol 1601. 2015-11-12. PMID:25591482. a needlestick injury to cerebral cortex causes immediate damage along the track of the needle (haemorrhage, cell death) and sequelae (the formation of amyloid-positive plaques, extracellular deposits of hyperphosphorylated tau protein, microglial proliferation, astrogliosis) that are long lasting, and mimic the neuropathology associated with alzheimer's disease. 2015-11-12 2023-08-13 rat
Huilai Tian, Eliot Davidowitz, Patricia Lopez, Ping He, Philip Schulz, James Moe, Michael R Sierk. Isolation and characterization of antibody fragments selective for toxic oligomeric tau. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25616912. oligomeric tau species are important in the onset and progression of alzheimer's disease (ad), as they are neurotoxic and can propagate tau-tangle pathology. 2015-11-12 2023-08-13 mouse
Alexandra J Mably, Daniel Kanmert, Jessica M Mc Donald, Wen Liu, Barbara J Caldarone, Cynthia A Lemere, Brian O'Nuallain, Kenneth S Kosik, Dominic M Wals. Tau immunization: a cautionary tale? Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25619661. the amyloid β (aβ)-protein and microtubule-associated protein, tau, are the major components of the amyloid plaques and neurofibrillary tangles that typify alzheimer's disease (ad) pathology. 2015-11-12 2023-08-13 mouse
D Porquet, P Andrés-Benito, C Griñán-Ferré, A Camins, I Ferrer, A M Canudas, J Del Valle, Mercè Pallà. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordrecht, Netherlands). vol 37. issue 1. 2015-11-12. PMID:25663420. amyloid and tau pathology of familial alzheimer's disease app/ps1 mouse model in a senescence phenotype background (samp8). 2015-11-12 2023-08-13 mouse
Naoyuki Sato, Ryuichi Morishit. The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Frontiers in aging neuroscience. vol 7. 2015-11-11. PMID:26557086. the roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of alzheimer disease. 2015-11-11 2023-08-13 Not clear
Yuan Zhou, Ikuo Hayashi, Jacky Wong, Katherine Tugusheva, John J Renger, Celina Zerbinatt. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PloS one. vol 9. issue 7. 2015-11-10. PMID:25051234. intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein tau in alzheimer's disease. 2015-11-10 2023-08-13 mouse
Izaskun Buendia, Javier Egea, Esther Parada, Elisa Navarro, Rafael León, María Isabel Rodríguez-Franco, Manuela G Lópe. The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction. ACS chemical neuroscience. vol 6. issue 2. 2015-11-10. PMID:25393881. we have investigated the protective effects of ith91/iqm157, a hybrid of melatonin and n,n-dibenzyl(n-methyl)amine, in an in vitro model of alzheimer's disease (ad)-like pathology that combines amyloid beta (aβ) and tau hyperphosphorylation induced by okadaic acid (oa), in the human neuroblastoma cell line sh-sy5y. 2015-11-10 2023-08-13 human