Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Catherine Pan, Ané Korff, Douglas Galasko, Carmen Ginghina, Elaine Peskind, Ge Li, Joseph Quinn, Thomas J Montine, Kevin Cain, Min Shi, Jing Zhan. Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ₄₂ using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25613100. |
meso scale discovery (msd) recently established electrochemiluminescence-based assays to measure cerebrospinal fluid (csf) levels of total tau (t-tau) and amyloid-β 1-42 peptide (aβ42) that can aid in the diagnosis of alzheimer's disease (ad). |
2016-01-19 |
2023-08-13 |
Not clear |
Fiorella Casamenti, Cristina Grossi, Stefania Rigacci, Daniela Pantano, Ilaria Luccarini, Massimo Stefan. Oleuropein Aglycone: A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25649656. |
the amyloid plaques and neurofibrillary tangles found in the alzheimer's disease (ad) brain arise as a result of self-assembly into fibrillar material of amyloid-β protein (aβ) and hyperphosphorylated tau, respectively, through a pathological process starting with the appearance of aggregation nuclei and neurotoxic oligomers. |
2016-01-19 |
2023-08-13 |
Not clear |
José Luis Millá. What Can We Learn About the Neural Functions of TNAP from Studies on Other Organs and Tissues? Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219711. |
finally, the potential involvement of tnap in dephosphorylating tau protein and its role in the pathogenesis of alzheimer's disease is intriguing. |
2016-01-19 |
2023-08-13 |
mouse |
Katherine A B Kellett, Nigel M Hoope. The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219720. |
tissue non-specific alkaline phosphatase (tnap) is present on neuronal membranes and induces neuronal toxicity via tau dephosphorylation; a mechanism which could play a role in the neuronal loss seen in alzheimer's disease (ad). |
2016-01-19 |
2023-08-13 |
Not clear |
Miguel Diaz-Hernandez, Felix Hernandez, Maria Teresa Miras-Portugal, Jesús Avil. TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219721. |
on the opposite stage, recent evidences indicate that tnap plays a key role in spreading the neurotoxicity effect induced by extracellular hyperphosphorylated tau protein, the main component of intracellular neurofibrillary tangles present in the brain of alzheimer disease patients. |
2016-01-19 |
2023-08-13 |
Not clear |
Miguel Diaz-Hernandez, Felix Hernandez, Maria Teresa Miras-Portugal, Jesús Avil. TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders. Sub-cellular biochemistry. vol 76. 2016-01-19. PMID:26219721. |
besides, activation of muscarinic receptors by dephosphorylated tau increases the expression of tnap, which could explain the increase in tnap activity and protein levels detected in alzheimer disease. |
2016-01-19 |
2023-08-13 |
Not clear |
Gerhard Multhaup, Otmar Huber, Luc Buée, Marie-Christine Gala. Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles. The Journal of biological chemistry. vol 290. issue 39. 2016-01-19. PMID:26296890. |
amyloid precursor protein (app) metabolites (amyloid-β (aβ) peptides) and tau are the main components of senile plaques and neurofibrillary tangles, the two histopathological hallmarks of alzheimer disease. |
2016-01-19 |
2023-08-13 |
Not clear |
Sang-Won Min, Xu Chen, Tara E Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, Kotaro Shirakawa, S Sakura Minami, Erwin Defensor, Sue Ann Mok, Peter Dongmin Sohn, Birgit Schilling, Xin Cong, Lisa Ellerby, Bradford W Gibson, Jeffrey Johnson, Nevan Krogan, Mehrdad Shamloo, Jason Gestwicki, Eliezer Masliah, Eric Verdin, Li Ga. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature medicine. vol 21. issue 10. 2016-01-19. PMID:26390242. |
tauopathies, including frontotemporal dementia (ftd) and alzheimer's disease (ad), are neurodegenerative diseases in which tau fibrils accumulate. |
2016-01-19 |
2023-08-13 |
mouse |
Workalemahu M Berhanu, Artëm E Masuno. Atomistic mechanism of polyphenol amyloid aggregation inhibitors: molecular dynamics study of Curcumin, Exifone, and Myricetin interaction with the segment of tau peptide oligomer. Journal of biomolecular structure & dynamics. vol 33. issue 7. 2016-01-18. PMID:25093402. |
polyphenols such as curcumin, exifone, and myricetin exhibit modest inhibition toward fibril formation of tau peptide which is associated with alzheimer's disease. |
2016-01-18 |
2023-08-13 |
Not clear |
Diego Piedrahita, John Fredy Castro-Alvarez, Ryan L Boudreau, Andres Villegas-Lanau, Kenneth S Kosik, Juan Carlos Gallego-Gomez, Gloria Patricia Cardona-Góme. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Frontiers in cellular neuroscience. vol 9. 2016-01-18. PMID:26778963. |
β-site app cleaving enzyme 1 (bace1) initiates app cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in alzheimer's disease (ad). |
2016-01-18 |
2023-08-13 |
mouse |
Alex C Hradek, Hyun-Pil Lee, Sandra L Siedlak, Sandy L Torres, Wooyoung Jung, Ashley H Han, Hyoung-gon Le. Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25061053. |
distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xtg-ad mouse model and alzheimer's disease patients. |
2016-01-15 |
2023-08-13 |
mouse |
Xiu-Lian Wang, Ji Zeng, Yang Yang, Yan Xiong, Zhi-Hua Zhang, Mei Qiu, Xiong Yan, Xu-Ying Sun, Qing-Zhang Tuo, Rong Liu, Jian-Zhi Wan. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079798. |
abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including alzheimer's disease (ad). |
2016-01-15 |
2023-08-13 |
mouse |
Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. |
hippocampal laminar distribution of tau relates to alzheimer's disease and age of onset. |
2016-01-15 |
2023-08-13 |
Not clear |
Philip H Montenigro, Daniel T Corp, Thor D Stein, Robert C Cantu, Robert A Ster. Chronic traumatic encephalopathy: historical origins and current perspective. Annual review of clinical psychology. vol 11. 2016-01-15. PMID:25581233. |
the neuropathology of cte is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
Nina Rostgaard, Gunhild Waldemar, Jørgen Erik Nielsen, Anja Hviid Simonse. Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia. Dementia and geriatric cognitive disorders. vol 40. issue 1-2. 2016-01-15. PMID:25998699. |
today, the core protein biomarkers amyloid-β42, total tau and phosphorylated tau in the cerebrospinal fluid (csf) are used to diagnose alzheimer's disease (ad), because these biomarkers have shown to reflect the underlying amyloid and tau pathology. |
2016-01-15 |
2023-08-13 |
Not clear |
A Miyashita, H Hatsuta, M Kikuchi, A Nakaya, Y Saito, T Tsukie, N Hara, S Ogishima, N Kitamura, K Akazawa, A Kakita, H Takahashi, S Murayama, Y Ihara, T Ikeuchi, R Kuwan. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Translational psychiatry. vol 4. 2016-01-15. PMID:26126179. |
the spreading of neurofibrillary tangles (nfts), intraneuronal aggregates of highly phosphorylated microtubule-associated protein tau, across the human brain is correlated with the cognitive severity of alzheimer's disease (ad). |
2016-01-15 |
2023-08-13 |
human |
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. |
a systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. |
amyloid 1-42 (aβ42) and tau in cerebrospinal fluid are currently used as markers for diagnosis of alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. |
a meta-analysis was performed to statistically validate the use of plasma aβ42 and tau as biomarkers for alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
Roger Pamphlett, Stephen Kum Je. Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 2. 2016-01-14. PMID:25547633. |
different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated tau: implications for amyloid-β and tau pathology in alzheimer's disease. |
2016-01-14 |
2023-08-13 |
human |