| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathrin M Kniewallner, Daniela Ehrlich, Andreas Kiefer, Josef Marksteiner, Christian Humpe. Platelets in the Alzheimer's disease brain: do they play a role in cerebral amyloid angiopathy? Current neurovascular research. vol 12. issue 1. 2015-12-28. PMID:25557380. |
alzheimer's disease (ad) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. |
2015-12-28 |
2023-08-13 |
mouse |
| Heiko Braak, Kelly Del Tredic. The preclinical phase of the pathological process underlying sporadic Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26283673. |
abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads, neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic alzheimer's disease. |
2015-12-28 |
2023-08-13 |
human |
| Heiko Braak, Kelly Del Tredic. The preclinical phase of the pathological process underlying sporadic Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26283673. |
ongoing formation of these tau lesions persists into end-stage alzheimer's disease and is not subject to remission. |
2015-12-28 |
2023-08-13 |
human |
| Heiko Braak, Kelly Del Tredic. The preclinical phase of the pathological process underlying sporadic Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26283673. |
the early pretangle disease phase is a focus of increasing interest because only abnormal forms of the microtubule-associated protein tau are involved at that point and, in contrast to late-stage disease when amyloid-β deposition is present, this phase is temporally closer to the prevailing conditions that induce the pathological process underlying alzheimer's disease. |
2015-12-28 |
2023-08-13 |
human |
| Heiko Braak, Kelly Del Tredic. The preclinical phase of the pathological process underlying sporadic Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26283673. |
one potential trigger for tau protein hyperphosphorylation and conformational change in alzheimer's disease may be the presence of a non-endogenous pathogen. |
2015-12-28 |
2023-08-13 |
human |
| Jue Jiang, Zhifeng Chen, Bing Liang, Jia Yan, Ying Zhang, Hong Jian. Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction. SpringerPlus. vol 4. 2015-12-24. PMID:26702376. |
experimental studies have suggested that the igf-1 system is beneficial in cognition, especially in alzheimer's disease (ad), by opposing aβ amyloid processing and hyperphosphorylated tau toxicity. |
2015-12-24 |
2023-08-13 |
Not clear |
| Marcos J Guerrero-Muñoz, Julia Gerson, Diana L Castillo-Carranz. Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 9. 2015-12-23. PMID:26696824. |
tau oligomers: the toxic player at synapses in alzheimer's disease. |
2015-12-23 |
2023-08-13 |
Not clear |
| Alejandro Antón-Fernández, Gonzalo León-Espinosa, Javier DeFelipe, Alberto Muño. Changes in the Golgi Apparatus of Neocortical and Hippocampal Neurons in the Hibernating Hamster. Frontiers in neuroanatomy. vol 9. 2015-12-23. PMID:26696838. |
these models are also of interest in the study of alzheimer's disease because the microtubule-associated protein tau is hyperphosphorylated during the hibernation state known as torpor, similar to the pretangle stage of alzheimer's disease. |
2015-12-23 |
2023-08-13 |
Not clear |
| Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Lynn B DeCarr, Amy Truong, Aiqing He, Nestor X Barrezueta, Craig Polson, Clotilde Bourin, Marianne E Flynn, Stefanie Keenan, Regina Lidge, Jere Meredith, Joanne Natale, Sethu Sankaranarayanan, Greg W Cadelina, Charlie F Albright, Angela M Cacac. Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease. PloS one. vol 9. issue 8. 2015-12-18. PMID:25153994. |
tau overexpression impacts a neuroinflammation gene expression network perturbed in alzheimer's disease. |
2015-12-18 |
2023-08-13 |
mouse |
| Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Lynn B DeCarr, Amy Truong, Aiqing He, Nestor X Barrezueta, Craig Polson, Clotilde Bourin, Marianne E Flynn, Stefanie Keenan, Regina Lidge, Jere Meredith, Joanne Natale, Sethu Sankaranarayanan, Greg W Cadelina, Charlie F Albright, Angela M Cacac. Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease. PloS one. vol 9. issue 8. 2015-12-18. PMID:25153994. |
filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including alzheimer's disease (ad). |
2015-12-18 |
2023-08-13 |
mouse |
| Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Lynn B DeCarr, Amy Truong, Aiqing He, Nestor X Barrezueta, Craig Polson, Clotilde Bourin, Marianne E Flynn, Stefanie Keenan, Regina Lidge, Jere Meredith, Joanne Natale, Sethu Sankaranarayanan, Greg W Cadelina, Charlie F Albright, Angela M Cacac. Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease. PloS one. vol 9. issue 8. 2015-12-18. PMID:25153994. |
our results suggest that the alterations in microglial phenotypes that appear to contribute to the pathogenesis of alzheimer's disease may be driven by tau dysfunction, in addition to the direct effects of beta-amyloid. |
2015-12-18 |
2023-08-13 |
mouse |
| Aamena Valiji Bharmal, Brianne A Kent, Timothy J Bussey, Lisa M Saksid. Performance of transgenic TgTau-P301L mice in a 5-choice serial reaction time task (5-CSRTT) as a model of Alzheimer's disease. Psychiatria Danubina. vol 27 Suppl 1. 2015-12-17. PMID:26540742. |
tgtaup301l mice have a single tau mutation in the p301l gene and develop the tau pathology that represents the observed tauopathy in patients with alzheimer's disease. |
2015-12-17 |
2023-08-13 |
mouse |
| Chun-ling Dai, Xia Chen, Syed Faraz Kazim, Fei Liu, Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqba. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25233799. |
passive immunization targeting the n-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of alzheimer disease and tauopathies. |
2015-12-16 |
2023-08-13 |
mouse |
| Chun-ling Dai, Xia Chen, Syed Faraz Kazim, Fei Liu, Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqba. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25233799. |
intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. |
2015-12-16 |
2023-08-13 |
mouse |
| Chun-ling Dai, Xia Chen, Syed Faraz Kazim, Fei Liu, Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqba. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25233799. |
thus, targeting selective epitopes of n-terminal domain of tau may present a novel effective therapeutic opportunity for alzheimer disease and other tauopathies. |
2015-12-16 |
2023-08-13 |
mouse |
| Heather Woo. Alzheimer disease: Alzheimer disease risk factor CALM modulates tau turnover. Nature reviews. Neurology. vol 10. issue 11. 2015-12-16. PMID:25311586. |
alzheimer disease: alzheimer disease risk factor calm modulates tau turnover. |
2015-12-16 |
2023-08-13 |
Not clear |
| Thomas Arendt, Jens Stieler, Max Holze. Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25480630. |
brain hypometabolism triggers phf-like phosphorylation of tau, a major hallmark of alzheimer's disease pathology. |
2015-12-16 |
2023-08-13 |
Not clear |
| Thomas Arendt, Jens Stieler, Max Holze. Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25480630. |
sporadic alzheimer's disease (ad) is a chronic progressive neurodegenerative disorder of unknown cause characterized by fibrillar accumulation of the aß-peptide and aggregates of the microtubule-associated protein tau in a hyperphosphorylated form. |
2015-12-16 |
2023-08-13 |
Not clear |
| Kenji Fukunaga, Daiki Sakai, Kazutoshi Watanabe, Kazuki Nakayama, Toshiyuki Kohara, Hiroshi Tanaka, Shinji Sunada, Mika Nabeno, Masako Okamoto, Ken-Ichi Saito, Jun-ichi Eguchi, Akiko Mori, Shinji Tanaka, Keiko Inazawa, Takashi Horikaw. Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 25. issue 5. 2015-12-15. PMID:25655721. |
we herein describe the results of further evolution of gsk-3β inhibitors for alzheimer's disease from our promising compounds with in vivo tau phosphorylation inhibitory activity by oral administration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Peipei Wang, Kan Din. Proteoglycans and glycosaminoglycans in misfolded proteins formation in Alzheimer's disease. Protein and peptide letters. vol 21. issue 10. 2015-12-14. PMID:24975673. |
misfolded protein amyloid-beta protein (aβ) and tau protein are two high hallmarks of alzheimer's disease (ad), representing significant targets in treating ad. |
2015-12-14 |
2023-08-13 |
Not clear |