All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
N Satheesh Kumar, N Nish. Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease. Chinese journal of natural medicines. vol 12. issue 11. 2015-07-14. PMID:25480511. for the treatment of alzheimer's disease the drug discovery focus shifted from cholinesterase inhibitors, to other targets primarily based on two key neuropathological hallmarks, namely the hyperphosphorylation of the tau protein resulting in the formation of neurofibrillary tangles (nfts), and the increased formation and aggregation of amyloid-beta peptide (aβ) derived from amyloid precursor protein (app). 2015-07-14 2023-08-13 Not clear
Sylvie Slaets, Eugeen Vanmechelen, Nathalie Le Bastard, Hilde Decraemer, Manu Vandijck, Jean-Jacques Martin, Peter Paul De Deyn, Sebastiaan Engelborgh. Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5 Suppl. 2015-07-13. PMID:24439167. increased csf α-synuclein levels in alzheimer's disease: correlation with tau levels. 2015-07-13 2023-08-12 Not clear
Fehmida Bibi, Muhammad Yasir, Sayed S Sohrab, Esam I Azhar, Mohammed H Al-Qahtani, Adel M Abuzenadah, Mohammad A Kamal, Muhammad I Nasee. Link between chronic bacterial inflammation and Alzheimer disease. CNS & neurological disorders drug targets. vol 13. issue 7. 2015-07-13. PMID:25230225. alzheimer's disease (ad) is a degenerative disease of brain that is associated with dementia, brain atrophy, accumulation of hyperphosphorylated tau protein and amyloid-beta peptide in hippocampus and cortex region of the brain. 2015-07-13 2023-08-13 Not clear
Alfredo Ramirez, Wiesje M van der Flier, Christine Herold, David Ramonet, Stefanie Heilmann, Piotr Lewczuk, Julius Popp, André Lacour, Dmitriy Drichel, Eva Louwersheimer, Markus P Kummer, Carlos Cruchaga, Per Hoffmann, Charlotte Teunissen, Henne Holstege, Johannes Kornhuber, Oliver Peters, Adam C Naj, Vincent Chouraki, Céline Bellenguez, Amy Gerrish, Reiner Heun, Lutz Frölich, Michael Hüll, Lara Buscemi, Stefan Herms, Heike Kölsch, Philip Scheltens, Monique M Breteler, Eckart Rüther, Jens Wiltfang, Alison Goate, Frank Jessen, Wolfgang Maier, Michael T Heneka, Tim Becker, Markus M Nöthe. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human molecular genetics. vol 23. issue 24. 2015-07-09. PMID:25027320. cerebrospinal fluid amyloid-beta 1-42 (aβ1-42) and phosphorylated tau at position 181 (ptau181) are biomarkers of alzheimer's disease (ad). 2015-07-09 2023-08-13 Not clear
Chun-Jiang Yu, Wei Liu, Hong-Yuan Chen, Li Wang, Zhi-Ren Zhan. BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin-induced tau hyperphosphorylated rat model. Cell biochemistry and function. vol 32. issue 7. 2015-07-09. PMID:25230339. our results demonstrated that neurological defects and neurotoxic fragments, including aβ and β-ctf, were eliminated by bace1 rnai in the tau hyperphosphorylated model, implying the efficiency and safety of bace1rnai treatment against alzheimer's disease. 2015-07-09 2023-08-13 rat
Wei Tang, Qiong Huang, Yu-You Yao, Yan Wang, Yi-Le Wu, Zheng-Yu Wan. Does CSF p-tau181 help to discriminate Alzheimer's disease from other dementias and mild cognitive impairment? A meta-analysis of the literature. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24817210. to evaluate the clinical importance of cerebrospinal fluid (csf) phosphorylated tau 181 (p-tau181) in mild cognitive impairment (mci), alzheimer's disease (ad) and other dementias, more specifically: frontotemporal degeneration (ftd), dementia with lewy bodies (dlb), vascular dementia (vad) and parkinson's disease (pd) with dementia (pdd). 2015-07-07 2023-08-13 Not clear
Emanuela Maderna, Cristina Cattaneo, Francesca Cacciatore, Marcella Catania, Giuseppe Di Fede, Fabrizio Tagliavini, Giorgio Giaccon. Divergent cognitive status with the same Braak stage of neurofibrillary pathology: does the pattern of amyloid-β deposits make the difference? Journal of Alzheimer's disease : JAD. vol 43. issue 2. 2015-07-06. PMID:25096620. the neuropathological hallmark of alzheimer's disease (ad) is the co-occurrence of extracellular amyloid-β (aβ) deposition and intraneuronal neurofibrillary changes composed of abnormal tau. 2015-07-06 2023-08-13 Not clear
Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Karunya Ramani, Rashmi K Ambast. Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 2. 2015-07-06. PMID:25096626. tau phosphorylation, molecular chaperones, and ubiquitin e3 ligase: clinical relevance in alzheimer's disease. 2015-07-06 2023-08-13 Not clear
Hanne Struyfs, Ellis Niemantsverdriet, Joery Goossens, Erik Fransen, Jean-Jacques Martin, Peter P De Deyn, Sebastiaan Engelborgh. Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis. Frontiers in neurology. vol 6. 2015-07-03. PMID:26136723. the goal of this study is to investigate the value of tau phosphorylated at threonine 181 (p-tau181p) in the alzheimer's disease (ad) cerebrospinal fluid (csf) biomarker panel for differential dementia diagnosis in autopsy confirmed ad and non-ad patients. 2015-07-03 2023-08-13 Not clear
Nathalie Le Bastard, Peter Paul De Deyn, Sebastiaan Engelborgh. Importance and impact of preanalytical variables on Alzheimer disease biomarker concentrations in cerebrospinal fluid. Clinical chemistry. vol 61. issue 5. 2015-07-02. PMID:25869575. analyses of cerebrospinal fluid (csf) biomarkers (β-amyloid protein, total tau protein, and hyperphosphorylated tau protein) are part of the diagnostic criteria of alzheimer disease. 2015-07-02 2023-08-13 Not clear
John S K Kauwe, Matthew H Bailey, Perry G Ridge, Rachel Perry, Mark E Wadsworth, Kaitlyn L Hoyt, Lyndsay A Staley, Celeste M Karch, Oscar Harari, Carlos Cruchaga, Benjamin J Ainscough, Kelly Bales, Eve H Pickering, Sarah Bertelsen, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. PLoS genetics. vol 10. issue 10. 2015-06-30. PMID:25340798. cerebrospinal fluid (csf) 42 amino acid species of amyloid beta (aβ42) and tau levels are strongly correlated with the presence of alzheimer's disease (ad) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of ad. 2015-06-30 2023-08-13 human
Nathalie Sibille, Isabelle Huvent, Caroline Fauquant, Dries Verdegem, Laziza Amniai, Arnaud Leroy, Jean-Michel Wieruszeski, Guy Lippens, Isabelle Landrie. Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein. Proteins. vol 80. issue 2. 2015-06-29. PMID:22072628. phosphorylation of the neuronal tau protein is implicated in both the regulation of its physiological function of microtubule stabilization and its pathological propensity to aggregate into the fibers that characterize alzheimer's diseased neurons. 2015-06-29 2023-08-12 Not clear
Zdena Kristofikova, Jan Ricny, Michaela Kolarova, Martin Vyhnalek, Jakub Hort, Jan Laczo, Jana Sirova, Daniela Ripov. Interactions between amyloid-β and tau in cerebrospinal fluid of people with mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24670397. interactions between amyloid-β and tau in cerebrospinal fluid of people with mild cognitive impairment and alzheimer's disease. 2015-06-29 2023-08-12 Not clear
Zdena Kristofikova, Jan Ricny, Michaela Kolarova, Martin Vyhnalek, Jakub Hort, Jan Laczo, Jana Sirova, Daniela Ripov. Interactions between amyloid-β and tau in cerebrospinal fluid of people with mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24670397. despite the physiological sequestration of amyloid-β (aβ) peptides by various carriers, interactions between peptides and protein tau appear to be pathological and involved in the development of alzheimer's disease (ad). 2015-06-29 2023-08-12 Not clear
Micha M M Wilhelmus, Mieke de Jager, Erik N T P Bakker, Benjamin Drukarc. Tissue transglutaminase in Alzheimer's disease: involvement in pathogenesis and its potential as a therapeutic target. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24685636. protein misfolding and the formation of stable insoluble protein complexes by self-interacting proteins, in particular amyloid-β and tau protein, play a central role in the pathogenesis of alzheimer's disease (ad). 2015-06-29 2023-08-12 human
Stefanie Schreiber, Benjamin Drukarch, Cornelia Garz, Solveig Niklass, Luiza Stanaszek, Siegfried Kropf, Celine Bueche, Friederike Held, Stefan Vielhaber, Johannes Attems, Klaus G Reymann, Hans-Jochen Heinze, Roxana O Carare, Micha M M Wilhelmu. Interplay between age, cerebral small vessel disease, parenchymal amyloid-β, and tau pathology: longitudinal studies in hypertensive stroke-prone rats. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24825568. accumulation of amyloid-β (aβ) and hyperphosphorylated tau (ptau) accompany cerebral small vessel disease (csvd) in the aging brain and in alzheimer's disease. 2015-06-29 2023-08-13 rat
Dietmar Rudolf Thal, Johannes Attems, Michael Ewer. Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies. Journal of Alzheimer's disease : JAD. vol 42 Suppl 4. 2015-06-29. PMID:25227313. spreading of amyloid, tau, and microvascular pathology in alzheimer's disease: findings from neuropathological and neuroimaging studies. 2015-06-29 2023-08-13 human
Retraction. Winton et al., Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for Tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716869. winton et al., intraneuronal app, not free aβ peptides in 3xtg-ad mice: implications for tau versus aβ-mediated alzheimer neurodegeneration. 2015-06-29 2023-08-13 mouse
Seyyed Hani Moussavi Nik, Morgan Newman, Swamynathan Ganesan, Mengqi Chen, Ralph Martins, Giuseppe Verdile, Michael Lardell. Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. BMC research notes. vol 7. 2015-06-26. PMID:25359609. imbalance of the 3r-4r isoform ratio can affect microtubule binding and assembly and may promote tau hyperphosphorylation and neurofibrillary tangle formation as seen in neurodegenerative diseases such as frontotemporal dementia (ftd) and alzheimer's disease (ad). 2015-06-26 2023-08-13 human
Jared M Fine, Daniel B Renner, Anna C Forsberg, Rachel A Cameron, Benjamin T Galick, Clint Le, Patrick M Conway, Benjamin M Stroebel, William H Frey, Leah R Hanso. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neuroscience letters. vol 584. 2015-06-26. PMID:25445365. in addition to the hallmark accumulation of amyloid and hyper-phosphorylation of tau, brain changes in alzheimer's disease are multifactorial including inflammation, oxidative stress, and metal dysregulation. 2015-06-26 2023-08-13 mouse