All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Laura J Blair, Jeremy D Baker, Jonathan J Sabbagh, Chad A Dicke. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25628064. tau has been shown to become hyperphosphorylated and accumulate as one of the two main pathological hallmarks in alzheimer's disease, the other being amyloid beta (ab). 2015-05-27 2023-08-13 Not clear
Ben A Bah. A single pathway targets several health challenges of the elderly. Rejuvenation research. vol 17. issue 4. 2015-05-26. PMID:24953230. previous studies have also linked the autophagy-lysosomal pathway to the protective clearing of the aβ peptides of alzheimer's disease and tau species of tauopathies. 2015-05-26 2023-08-13 Not clear
Kai-Yuan Tzen, Shieh-Yueh Yang, Ta-Fu Chen, Ting-Wen Cheng, Herng-Er Horng, Hsiang-Ping Wen, Ya-Yao Huang, Chyng-Yann Shiue, Ming-Jang Chi. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25054847. plasma aβ but not tau is related to brain pib retention in early alzheimer's disease. 2015-05-26 2023-08-13 human
Kai-Yuan Tzen, Shieh-Yueh Yang, Ta-Fu Chen, Ting-Wen Cheng, Herng-Er Horng, Hsiang-Ping Wen, Ya-Yao Huang, Chyng-Yann Shiue, Ming-Jang Chi. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25054847. currently, decreased levels of aβ-42 and increased levels of tau proteins in cerebral spinal fluid are considered reliable biomarkers of alzheimer's disease (ad); however, little evidence exists for the use of amyloid and tau protein levels in the plasma as useful biomarkers. 2015-05-26 2023-08-13 human
Takeshi Kanno, Ayako Tsuchiya, Tomoyuki Nishizak. Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice. Behavioural brain research. vol 274. 2015-05-26. PMID:25172181. the present study investigated the relation of age-dependent spatial learning/memory impairment and tau phosphorylation in 5xfad mice, a model of alzheimer's disease. 2015-05-26 2023-08-13 mouse
Young Ju Lee, Ji Eun Kim, Moon Hwa Kwak, Jun Go, Seung Yun Yang, Hyeog Soong Kwon, Byoung Chul Kim, Joo Man Kim, Dae Youn Hwan. Selenium treatment significantly inhibits tumor necrosis factor-α-induced cell death and tau hyperphosphorylation in neuroblastoma cells. Molecular medicine reports. vol 10. issue 4. 2015-05-22. PMID:25109896. the hyperphosphorylation of the protein tau disrupts its normal function on regulating axonal transport and leads to the accumulation of neurofibrillary tangles (nft), which are involved in the pathogenesis of alzheimer's disease (ad). 2015-05-22 2023-08-13 Not clear
Liang Wang, Tammie L Benzinger, Jason Hassenstab, Tyler Blazey, Christopher Owen, Jingxia Liu, Anne M Fagan, John C Morris, Beau M Ance. Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease. Neurology. vol 84. issue 12. 2015-05-22. PMID:25716355. spatially distinct atrophy is linked to β-amyloid and tau in preclinical alzheimer disease. 2015-05-22 2023-08-13 Not clear
Rozalyn A Simon, Hamid Shirani, K O Andreas Aslund, Marcus Bäck, Vahram Haroutunian, Sam Gandy, K Peter R Nilsso. Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (Weinheim an der Bergstrasse, Germany). vol 20. issue 39. 2015-05-20. PMID:25111601. in this regard, luminescent conjugated oligothiophenes (lcos) have proven useful for spectral discrimination of amyloid-beta (aβ) and tau neurofibrillary tangles (nfts), two of the pathological hallmarks associated with alzheimer's disease. 2015-05-20 2023-08-13 Not clear
Thanh D Do, Nicholas J Economou, Ali Chamas, Steven K Buratto, Joan-Emma Shea, Michael T Bower. Interactions between amyloid-β and Tau fragments promote aberrant aggregates: implications for amyloid toxicity. The journal of physical chemistry. B. vol 118. issue 38. 2015-05-20. PMID:25153942. we have investigated at the oligomeric level interactions between aβ(25-35) and tau(273-284), two important fragments of the amyloid-β and tau proteins, implicated in alzheimer's disease. 2015-05-20 2023-08-13 Not clear
Huan Lu, Xi-Chen Zhu, Teng Jiang, Jin-Tai Yu, Lan Ta. Body fluid biomarkers in Alzheimer's disease. Annals of translational medicine. vol 3. issue 5. 2015-05-20. PMID:25992369. a heterogeneous and slowly progressive disease with extracellular amyloid-β (aβ) deposits and intracellular hyperphosphorylated tau protein aggregates, alzheimer's disease (ad) is already a hard nut to crack, featured with cognitive decline and memory lapse. 2015-05-20 2023-08-13 Not clear
M Del Campo, C R Oliveira, W Scheper, R Zwart, C Korth, A Müller-Schiffmann, G Kostallas, H Biverstal, J Presto, J Johansson, J J Hoozemans, C F Pereira, C E Teunisse. BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells. Cellular and molecular life sciences : CMLS. vol 72. issue 8. 2015-05-18. PMID:25336154. alzheimer's disease (ad) is pathologically characterized by the presence of misfolded proteins such as amyloid beta (aβ) in senile plaques, and hyperphosphorylated tau and truncated tau in neurofibrillary tangles (nft). 2015-05-18 2023-08-13 human
Qun Wang, Jia-Yu Zhang, Shi-Jie Liu, Hong-Lian L. Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 4. 2015-05-16. PMID:18690390. one of the pathological feathers of alzheimer's disease (ad) is neurofibrillary tangles (nfts), which consist of paired helical filaments (phfs) formed by hyperphosphorylated microtubule-associated protein tau. 2015-05-16 2023-08-12 mouse
I A Kuznetsov, A V Kuznetso. What tau distribution maximizes fast axonal transport toward the axonal synapse? Mathematical biosciences. vol 253. 2015-05-15. PMID:24747683. this theoretical research is aimed at investigating the question of why tau protein concentration exhibits a proximal-distal increase in healthy axons and a proximal-distal decrease in degenerating axons in alzheimer's disease. 2015-05-15 2023-08-13 Not clear
Chun-Wei Chang, Wen-Chuin Hsu, Alan Pittman, Yih-Ru Wu, John Hardy, Hon-Chung Fun. Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan. Biomedical journal. vol 37. issue 3. 2015-05-15. PMID:24923570. structural study of the microtubule-associated protein tau locus of alzheimer's disease in taiwan. 2015-05-15 2023-08-13 Not clear
Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolna. Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25218483. neurodegenerative diseases, including alzheimer's disease and parkinson's disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. 2015-05-14 2023-08-13 Not clear
Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Tau PET imaging in Alzheimer's disease. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25239654. tau pet imaging in alzheimer's disease. 2015-05-14 2023-08-13 Not clear
Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Tau PET imaging in Alzheimer's disease. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25239654. for use of tau pet as a biomarker of tau pathology in alzheimer's disease, pet tracers should have high affinity to phf-tau and high selectivity for tau over amyloid-β and other protein deposits. 2015-05-14 2023-08-13 Not clear
Zsófia Majláth, József Toldi, László Vécse. The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 8. 2015-05-12. PMID:24346138. the pathomechanism of alzheimer's disease (ad) is associated with characteristic neuropathological features such as extracellular amyloid-β and intracellular tau deposition. 2015-05-12 2023-08-12 Not clear
Debomoy K Lahiri, Balmiki Ra. Intravenous immunoglobulin treatment preserves and protects primary rat hippocampal neurons and primary human brain cultures against oxidative insults. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115544. alzheimer's disease (ad) is characterized by deleterious accumulation of amyloid-β (aβ) peptide into senile plaque, neurofibrillary tangles formed from hyperphosphorylated tau protein, and loss of cholinergic synapses in the cerebral cortex. 2015-05-12 2023-08-13 human
Lakshman Puli, Heikki Tanila, Norman Relki. Intravenous immunoglobulins for Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115546. alzheimer's disease (ad) is a chronic neurodegenerative disease associated with intracerebral accumulation of aggregated amyloid-beta (aβ) and tau proteins, as well as neuroinflammation. 2015-05-12 2023-08-13 mouse