All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ian Diner, Chadwick M Hales, Isaac Bishof, Lake Rabenold, Duc M Duong, Hong Yi, Oskar Laur, Marla Gearing, Juan Troncoso, Madhav Thambisetty, James J Lah, Allan I Levey, Nicholas T Seyfrie. Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25355317. recent evidence indicates that u1-70k and other u1 small nuclear ribonucleoproteins are sarkosyl-insoluble and associate with tau neurofibrillary tangles selectively in alzheimer disease (ad). 2015-04-21 2023-08-13 Not clear
Laurence Booth, Jane L Roberts, Paul Den. HSPA5/Dna K may be a useful target for human disease therapies. DNA and cell biology. vol 34. issue 3. 2015-04-21. PMID:25689303. in alzheimer's disease, hspa5 has been shown to play a supportive role for the progression of tau phosphorylation and neurodegeneration. 2015-04-21 2023-08-13 human
Flávio Roberto Pinsetta, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. Structure- and ligand-based drug design of novel p38-alpha MAPK inhibitors in the fight against the Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 32. issue 7. 2015-04-20. PMID:23805842. alzheimer's disease (ad) is characterized microscopically by the presence of amyloid plaques, which are accumulations of beta-amyloid protein inter-neurons, and neurofibrillary tangles formed predominantly by highly phosphorylated forms of the microtubule-associated protein, tau, which form tangled masses that consume neuronal cell body, possibly leading to neuronal dysfunction and ultimately death. 2015-04-20 2023-08-12 Not clear
Leo F McCluskey, Felix Geser, Lauren B Elman, Vivianna M Van Deerlin, John L Robinson, Virginia M-Y Lee, John Q Trojanowsk. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic lateral sclerosis & frontotemporal degeneration. vol 15. issue 5-6. 2015-04-20. PMID:24809433. atypical alzheimer's disease in an elderly united states resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. 2015-04-20 2023-08-13 Not clear
Jack A Wells, Holly E Holmes, James M O'Callaghan, Niall Colgan, Ozama Ismail, Elizabeth Mc Fisher, Bernard Siow, Tracey K Murray, Adam J Schwarz, Michael J O'Neill, Emily C Collins, Mark F Lythgo. Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 3. 2015-04-20. PMID:25515210. increased cerebral vascular reactivity in the tau expressing rtg4510 mouse: evidence against the role of tau pathology to impair vascular health in alzheimer's disease. 2015-04-20 2023-08-13 mouse
Sanjay W Pimplika. Neuroinflammation in Alzheimer's disease: from pathogenesis to a therapeutic target. Journal of clinical immunology. vol 34 Suppl 1. 2015-04-16. PMID:24711006. the top-down, reductionist approach of the past three decades has resulted in remarkable progress in identifying genes and proteins involved in alzheimer's disease (ad), including β-amyloid (aβ) peptides and tau protein. 2015-04-16 2023-08-13 Not clear
Lawrence Steinman, Jonathan B Rothbard, Michael P Kurnella. Janus faces of amyloid proteins in neuroinflammation. Journal of clinical immunology. vol 34 Suppl 1. 2015-04-16. PMID:24711007. in alzheimer's disease two amyloid molecules aβ a4 and tau vie for consideration as the main pathogenic culprit. 2015-04-16 2023-08-13 Not clear
Md Mamunul Haque, Dohee Kim, Young Hyun Yu, Sungsu Lim, Dong Jin Kim, Young-Tae Chang, Hyung-Ho Ha, Yun Kyung Ki. Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 21. issue 3. 2015-04-16. PMID:24919397. abnormal tau aggregates are presumed to be neurotoxic and are an important therapeutic target for multiple neurodegenerative disorders including alzheimer's disease. 2015-04-16 2023-08-13 Not clear
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Paha. A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease. PloS one. vol 9. issue 8. 2015-04-14. PMID:25089827. a physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of alzheimer's disease. 2015-04-14 2023-08-13 mouse
Paul Bishop, Philip Rubin, Andrew R Thomson, Dan Rocca, Jeremy M Henle. The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons. The Journal of biological chemistry. vol 289. issue 52. 2015-04-14. PMID:25326379. alzheimer brains show reduced levels of soluble uch-l1(c) correlating with the formation of uch-l1-immunoreactive tau tangles, whereas uch-l1(m) has been implicated in α-synuclein dysfunction. 2015-04-14 2023-08-13 Not clear
Hei-Man Chow, Dong Guo, Jie-Chao Zhou, Guan-Yun Zhang, Hui-Fang Li, Karl Herrup, Jie Zhan. CDK5 activator protein p25 preferentially binds and activates GSK3β. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 45. 2015-04-14. PMID:25331900. glycogen synthase kinase 3β (gsk3β) and cyclin-dependent kinase 5 (cdk5) are tau kinases and have been proposed to contribute to the pathogenesis of alzheimer's disease. 2015-04-14 2023-08-13 Not clear
Ismael Santa-Maria, Maria E Alaniz, Neil Renwick, Carolina Cela, Tudor A Fulga, David Van Vactor, Thomas Tuschl, Lorraine N Clark, Michael L Shelanski, Brian D McCabe, John F Crar. Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. The Journal of clinical investigation. vol 125. issue 2. 2015-04-10. PMID:25574843. tau is a highly abundant and multifunctional brain protein that accumulates in neurofibrillary tangles (nfts), most commonly in alzheimer's disease (ad) and primary age-related tauopathy. 2015-04-10 2023-08-13 human
Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. we studied the expression and distribution of the dynein subunit dynactin-p50, the β amyloid precursor protein (βapp), and hyperphosphorylated tau (p-tau) in tissues and tissue sections of brains from non-demented, neuropathology-free patients and from alzheimer patients, with either apoe ε3,3 or apoe ε4,4. 2015-04-10 2023-08-13 human
b' Jose O Esteves-Villanueva, Hanna Trzeciakiewicz, David A Loeffler, Sanela Marti\\xc4\\x8. Effects of tau domain-specific antibodies and intravenous immunoglobulin on tau aggregation and aggregate degradation. Biochemistry. vol 54. issue 2. 2015-04-08. PMID:25545358.' tau pathology, including neurofibrillary tangles, develops in alzheimer's disease (ad). 2015-04-08 2023-08-13 mouse
Laura J Blair, Jonathan J Sabbagh, Chad A Dicke. Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert opinion on therapeutic targets. vol 18. issue 10. 2015-04-07. PMID:25069659. alzheimer's disease, characterized by the accumulation of hyperphosphorylated tau and β amyloid (aβ), currently lacks effective treatment. 2015-04-07 2023-08-13 Not clear
Alison Spilsbury, Satomi Miwa, Johannes Attems, Gabriele Saretzk. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632141. here, we investigated the expression of tert at different stages of alzheimer's disease pathology (braak stages i-vi) in situ and the ability of tert to protect against oxidative damage in an in vitro model of tau pathology. 2015-04-07 2023-08-13 mouse
Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffe. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252661. tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (ftd) and alzheimer's disease (ad). 2015-03-31 2023-08-12 mouse
Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David M A Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama, Masato Hasegaw. Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252707. extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with rd4 antibody in alzheimer's disease brain. 2015-03-31 2023-08-12 Not clear
Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitoric. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252759. alzheimer's disease (ad) is characterized by the abnormal accumulation of extracellular beta-amyloid (abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. 2015-03-31 2023-08-12 mouse
Claire Boutet, Marie Chupin, Stéphane Lehéricy, Linda Marrakchi-Kacem, Stéphane Epelbaum, Cyril Poupon, Christopher Wiggins, Alexandre Vignaud, Dominique Hasboun, Bénédicte Defontaines, Olivier Hanon, Bruno Dubois, Marie Sarazin, Lucie Hertz-Pannier, Olivier Collio. Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: a feasibility study. NeuroImage. Clinical. vol 5. 2015-03-31. PMID:25161900. in alzheimer's disease (ad), the hippocampus is an early site of tau pathology and neurodegeneration. 2015-03-31 2023-08-13 human