| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Albert J Lyons, Neha S Gandhi, Ricardo L Mancer. Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment. Proteins. vol 82. issue 9. 2015-06-08. PMID:24577753. |
aggregation of the microtubule associated protein tau (mapt) within neurons of the brain is the leading cause of tauopathies such as alzheimer's disease. |
2015-06-08 |
2023-08-12 |
Not clear |
| Tarik Issad, Patrick Pages. [Protein O-GlcNAcylation and regulation of cell signalling: involvement in pathophysiology]. Biologie aujourd'hui. vol 208. issue 2. 2015-06-08. PMID:25190571. |
a reciprocal relationship between tau protein phosphorylation and o-glcnacylation has been observed, and decreased o-glcnacylation in the brain of patients with alzheimer diseases may favour tau aggregation, destabilisation of microtubules and neuronal alterations. |
2015-06-08 |
2023-08-13 |
human |
| Emma C Phillips, Cara L Croft, Ksenia Kurbatskaya, Michael J O'Neill, Michael L Hutton, Diane P Hanger, Claire J Garwood, Wendy Nobl. Astrocytes and neuroinflammation in Alzheimer's disease. Biochemical Society transactions. vol 42. issue 5. 2015-06-05. PMID:25233410. |
increased production of amyloid β-peptide (aβ) and altered processing of tau in alzheimer's disease (ad) are associated with synaptic dysfunction, neuronal death and cognitive and behavioural deficits. |
2015-06-05 |
2023-08-13 |
Not clear |
| Gertjan van Dijk, Steffen van Heijningen, Aaffien C Reijne, Csaba Nyakas, Eddy A van der Zee, Ulrich L M Eise. Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration. Frontiers in neuroscience. vol 9. 2015-06-04. PMID:26041981. |
alzheimer's disease (ad) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (app) to amyloid β peptide, tau protein hyperphosphorylation, relocalization, and deposition. |
2015-06-04 |
2023-08-13 |
Not clear |
| Javier G Villamil-Ortiz, Gloria P Cardona-Gome. Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer's disease animal models. Frontiers in aging neuroscience. vol 7. 2015-06-04. PMID:26042033. |
alzheimer's disease (ad) and cerebral ischemia (ci) are neuropathologies that are characterized by aggregates of tau protein, a hallmark of cognitive disorder and dementia. |
2015-06-04 |
2023-08-13 |
mouse |
| Fadia El Bitar, Johann Meunier, Vanessa Villard, Marion Alméras, Kathiresan Krishnan, Douglas F Covey, Tangui Maurice, Yvette Akw. Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice. Psychopharmacology. vol 231. issue 17. 2015-06-02. PMID:24481566. |
in alzheimer's disease (ad) patient's brains, their low concentrations are correlated with high levels of aβ and tau proteins. |
2015-06-02 |
2023-08-12 |
mouse |
| Christoph Köhler, Maja Dinekov, Jürgen Göt. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis. Neurobiology of disease. vol 71. 2015-06-02. PMID:25073087. |
histopathological studies on the brains of tauopathy cases including cases with alzheimer's disease (ad) demonstrate that neurons with hyperphosphorylated protein tau display granulovacuolar degeneration (gvd), as evidenced by vacuolar lesions harboring a central granule, together with markers of the activated unfolded protein response (upr). |
2015-06-02 |
2023-08-13 |
mouse |
| Shinichiro Fuse, Keisuke Matsumura, Yuki Fujita, Hachiro Sugimoto, Takashi Takahash. Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein. European journal of medicinal chemistry. vol 85. 2015-06-02. PMID:25086914. |
aggregations of both amyloid-β (aβ) and hyper-phosphorylated tau proteins are recognized as key pathological manifestations of alzheimer's disease (ad). |
2015-06-02 |
2023-08-13 |
Not clear |
| Rodrigo A Quintanilla, Rommy von Bernhardi, Juan A Godoy, Nibaldo C Inestrosa, Gail V W Johnso. Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons. Neurobiology of disease. vol 71. 2015-06-02. PMID:25134729. |
tau phosphorylated at the phf-1 epitope (s396/s404) is likely involved in the pathogenesis of alzheimer's disease (ad). |
2015-06-02 |
2023-08-13 |
Not clear |
| Julien Dumurgier, Susanna Schraen, Audrey Gabelle, Olivier Vercruysse, Stéphanie Bombois, Jean-Louis Laplanche, Katell Peoc'h, Bernard Sablonnière, Ksenia V Kastanenka, Constance Delaby, Florence Pasquier, Jacques Touchon, Jacques Hugon, Claire Paquet, Sylvain Lehman. Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimer's research & therapy. vol 7. issue 1. 2015-06-02. PMID:26034513. |
the cerebrospinal fluid (csf) biomarkers amyloid-β (aβ), tau and phosphorylated tau (p-tau181) are now used for the diagnosis of alzheimer's disease (ad). |
2015-06-02 |
2023-08-13 |
Not clear |
| Fan Zhang, Bo Su, Chunyu Wang, Sandra L Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-Gon Lee, Xinglong Wang, George Perry, Xiongwei Zh. Posttranslational modifications of α-tubulin in alzheimer disease. Translational neurodegeneration. vol 4. 2015-06-01. PMID:26029362. |
in alzheimer disease (ad), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. |
2015-06-01 |
2023-08-13 |
human |
| Qian Chen, Zhou Zhou, Lei Zhang, Shangcheng Xu, Chunhai Chen, Zhengping Y. The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro. PloS one. vol 9. issue 3. 2015-05-29. PMID:24618580. |
the brain-enriched microtubule-associated protein tau, a critical regulator of cytoskeletal dynamics, forms insoluble aggregates in a number of neurodegenerative diseases termed tauopathies, including alzheimer's disease (ad). |
2015-05-29 |
2023-08-12 |
Not clear |
| Henrieta Scholtzova, Peter Chianchiano, Jason Pan, Yanjie Sun, Fernando Goñi, Pankaj D Mehta, Thomas Wisniewsk. Amyloid β and Tau Alzheimer's disease related pathology is reduced by Toll-like receptor 9 stimulation. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25178404. |
amyloid β and tau alzheimer's disease related pathology is reduced by toll-like receptor 9 stimulation. |
2015-05-29 |
2023-08-13 |
mouse |
| Shinsui Tatsumi, Toshiki Uchihara, Ikuko Aiba, Yasushi Iwasaki, Maya Mimuro, Ryosuke Takahashi, Mari Yoshid. Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25497147. |
pretangles are defined under the light microscope as diffuse and granular tau immunoreactivity in neurons in tissue from patients with alzheimer disease (ad) or corticobasal degeneration (cbd) and are considered to be a premature stage before neurofibrillary tangle formation. |
2015-05-29 |
2023-08-13 |
Not clear |
| Lokraj Subedee, R N Suresh, Jayanthi Mk, Kalabharathi Hl, Satish Am, Pushpa V. Preventive role of Indian black pepper in animal models of Alzheimer's disease. Journal of clinical and diagnostic research : JCDR. vol 9. issue 4. 2015-05-29. PMID:26023568. |
brain cholinesterase levels and behavioural changes are the markers for alzheimer's disease and aluminium chloride is one causative agent for polymerization of tau protein and amyloid plaque formation in alzheimer's disease. |
2015-05-29 |
2023-08-13 |
Not clear |
| Laura J Blair, Jeremy D Baker, Jonathan J Sabbagh, Chad A Dicke. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25628064. |
the emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and alzheimer's disease. |
2015-05-27 |
2023-08-13 |
Not clear |
| Laura J Blair, Jeremy D Baker, Jonathan J Sabbagh, Chad A Dicke. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25628064. |
tau has been shown to become hyperphosphorylated and accumulate as one of the two main pathological hallmarks in alzheimer's disease, the other being amyloid beta (ab). |
2015-05-27 |
2023-08-13 |
Not clear |
| Ben A Bah. A single pathway targets several health challenges of the elderly. Rejuvenation research. vol 17. issue 4. 2015-05-26. PMID:24953230. |
previous studies have also linked the autophagy-lysosomal pathway to the protective clearing of the aβ peptides of alzheimer's disease and tau species of tauopathies. |
2015-05-26 |
2023-08-13 |
Not clear |
| Kai-Yuan Tzen, Shieh-Yueh Yang, Ta-Fu Chen, Ting-Wen Cheng, Herng-Er Horng, Hsiang-Ping Wen, Ya-Yao Huang, Chyng-Yann Shiue, Ming-Jang Chi. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25054847. |
plasma aβ but not tau is related to brain pib retention in early alzheimer's disease. |
2015-05-26 |
2023-08-13 |
human |
| Kai-Yuan Tzen, Shieh-Yueh Yang, Ta-Fu Chen, Ting-Wen Cheng, Herng-Er Horng, Hsiang-Ping Wen, Ya-Yao Huang, Chyng-Yann Shiue, Ming-Jang Chi. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25054847. |
currently, decreased levels of aβ-42 and increased levels of tau proteins in cerebral spinal fluid are considered reliable biomarkers of alzheimer's disease (ad); however, little evidence exists for the use of amyloid and tau protein levels in the plasma as useful biomarkers. |
2015-05-26 |
2023-08-13 |
human |