| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annika van Hummel, Goce Taleski, Jean-Marie Sontag, Astrid Feentje Feiten, Yazi D Ke, Lars M Ittner, Estelle Sonta. Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated PP2A levels, and mitigates learning and motor deficits in a mouse model of tauopathy. Neuropathology and applied neurobiology. 2023-08-11. PMID:37565253. |
disturbances in one-carbon metabolism are associated with the pathological accumulation of phosphorylated tau, a hallmark feature of prevalent dementia, including alzheimer's disease and subgroups of frontotemporal dementia. |
2023-08-11 |
2023-08-16 |
mouse |
| Rimil Guha Roy, Pravat K Mandal, Joseph C Maroo. Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer's Disease: Role of Glutathione and Metal Ions. ACS chemical neuroscience. 2023-08-10. PMID:37561556. |
oxidative stress occurs prior to amyloid aβ plaque formation and tau phosphorylation in alzheimer's disease: role of glutathione and metal ions. |
2023-08-10 |
2023-08-16 |
Not clear |
| Swati Rane Levendovszk. Cross-Sectional and Longitudinal Hippocampal Atrophy, Not Cortical Thinning, Occurs in Amyloid-Negative, p-Tau-Positive, Older Adults With Non-Amyloid Pathology and Mild Cognitive Impairment. Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555137. |
alzheimer's disease (ad) is a degenerative disease characterized by pathological accumulation of amyloid and phosphorylated tau. |
2023-08-09 |
2023-08-16 |
human |
| Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L Na, Hee Jin Kim, Sang Won Se. Emerging role of vascular burden in AT(N) classification in individuals with Alzheimer's and concomitant cerebrovascular burdens. Journal of neurology, neurosurgery, and psychiatry. 2023-08-09. PMID:37558399. |
alzheimer's disease (ad) is characterised by amyloid-beta accumulation (a), tau aggregation (t) and neurodegeneration (n). |
2023-08-09 |
2023-08-16 |
Not clear |
| Qianyun Chen, Jill Abrigo, Min Deng, Lin Shi, Yi-Xiang Wang, Winnie Cw Ch. Structural network topology reveals higher brain resilience in individuals with preclinical Alzheimer's disease. Brain connectivity. 2023-08-08. PMID:37551987. |
the diagnosis of alzheimer's disease (ad) requires the presence of amyloid and tau pathology, but it remains unclear how they affect structural network in the preclinical stage. |
2023-08-08 |
2023-08-14 |
Not clear |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
tau fibrils induce glial inflammation and neuropathology via tlr2 in alzheimer's disease-related mouse models. |
2023-08-08 |
2023-08-16 |
mouse |
| Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot, Zhanyun Fan, Rachel E Bennett, Bradley T Hyma. Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells. Molecular neurodegeneration. vol 18. issue 1. 2023-08-08. PMID:37553663. |
specific detection of tau seeding activity in alzheimer's disease using rationally designed biosensor cells. |
2023-08-08 |
2023-08-16 |
Not clear |
| Mengdi Wu, Ying Li, Yaodong Miao, Huanhuan Qiao, Yiwen Wan. Exploring the efficient natural products for Alzheimer's disease therapy via Journal of drug targeting. 2023-08-07. PMID:37545435. |
exploring the efficient natural products for alzheimer's disease therapy via alzheimer's disease (ad) is a grievous neurodegenerative disorder and a major form of senile dementia, which is partially caused by abnormal amyloid-beta peptide deposition and tau protein phosphorylation. |
2023-08-07 |
2023-08-14 |
Not clear |
| Nur Jury-Garfe, Yanwen You, Pablo Martínez, Javier Redding-Ochoa, Hande Karahan, Travis S Johnson, Jie Zhang, Jungsu Kim, Juan C Troncoso, Cristian A Lasagna-Reeve. Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546928. |
enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in alzheimer's disease. |
2023-08-07 |
2023-08-14 |
human |
| Jiayi Zhong, Xiaochen Zhang, Huanyu Xu, Xiaoran Zheng, Luyao Wang, Jiehui Jiang, Yunxia L. Unlocking the enigma: unraveling multiple cognitive dysfunction linked to glymphatic impairment in early Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-08-07. PMID:37547134. |
alzheimer's disease (ad) is one of the world's well-known neurodegenerative diseases, which is related to the balance mechanism of production and clearance of two proteins (amyloid-β and tau) regulated by the glymphatic system. |
2023-08-07 |
2023-08-14 |
Not clear |
| Silke M Wortha, Juliane Schulz, Jevri Hanna, Claudia Schwarz, Beate Stubbe, Stefan Frenzel, Robin Bülow, Nele Friedrich, Matthias Nauck, Henry Völzke, Ralf Ewert, Antje Vogelgesang, Hans J Grabe, Julia Ladenbauer, Agnes Flöe. Association of spermidine blood levels with microstructure of sleep-implications from a population-based study. GeroScience. 2023-08-07. PMID:37548882. |
deteriorations in slow wave sleep (sws) have been linked to brain aging and alzheimer's disease (ad), possibly due to its key role in clearance of amyloid-beta and tau (aß/tau), two pathogenic hallmarks of ad. |
2023-08-07 |
2023-08-14 |
human |
| Huixia Li, Hongyong Zha. Stability and bifurcation analysis of Alzheimer's disease model with diffusion and three delays. Chaos (Woodbury, N.Y.). vol 33. issue 8. 2023-08-07. PMID:37549120. |
a reaction-diffusion alzheimer's disease model with three delays, which describes the interaction of β-amyloid deposition, pathologic tau, and neurodegeneration biomarkers, is investigated. |
2023-08-07 |
2023-08-14 |
Not clear |
| Kenji Ishi. [Nuclear Medicine-based Early Diagnosis of Alzheimer's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 8. 2023-08-04. PMID:37537739. |
the advent of pathology-specific diagnostic methods such as amyloid positron emission tomography (pet) and tau pet has enabled early and pre-symptomatic diagnosis of alzheimer's disease. |
2023-08-04 |
2023-08-14 |
Not clear |
| Michael Ta, Cornelis Blauwendraat, Tarek Antar, Hampton L Leonard, Andrew B Singleton, Mike A Nalls, Hirotaka Iwak. Genome-Wide Meta-Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts. Movement disorders : official journal of the Movement Disorder Society. 2023-08-04. PMID:37539664. |
amyloid-β, phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for alzheimer's disease (ad). |
2023-08-04 |
2023-08-14 |
Not clear |
| Nirosen Vijiaratnam, Thomas Foltyni. How should we be using biomarkers in trials of disease modification in Parkinson's disease? Brain : a journal of neurology. 2023-08-03. PMID:37536279. |
for example; levels of cerebrospinal fluid proteins such as the lysosomal enzyme ß-glucocerebrosidase may assist in prognostication or allow enrichment of appropriate patients into disease modifying trials of agents with this enzyme as the target; the presence of coexisting alzheimer disease like pathology (detectable through cerebrospinal fluid levels of amyloid beta-42 and tau) can predict subsequent cognitive decline; imaging techniques such as free-water or neuromelanin mri may objectively track decline of parkinson's disease even in its later stages. |
2023-08-03 |
2023-08-14 |
Not clear |
| A fluid biomarker accurately detects tau aggregate pathology in Alzheimer's disease. Nature medicine. 2023-08-02. PMID:37532913. |
a fluid biomarker accurately detects tau aggregate pathology in alzheimer's disease. |
2023-08-02 |
2023-08-14 |
Not clear |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Ashini Singh, Niraj Kumar Sing. Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review. Current pharmaceutical biotechnology. 2023-08-01. PMID:37526460. |
alzheimer's disease (ad), one of the most common neurodegenerative disorders is hallmarked by cognitive impairment, amyloid-β (aβ) deposition, hyperphosphorylation of tau protein, cholinergic dysfunction, mitochondrial toxicity, and neurodegeneration. |
2023-08-01 |
2023-08-14 |
Not clear |
| Peng Chen, ZhiLei Guo, Benhong Zho. Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies. Journal of integrative neuroscience. vol 22. issue 4. 2023-07-31. PMID:37519162. |
considering the vulnerability of oligodendrocytes to alzheimer's disease, the myelin sheath breakdown and degeneration are easily induced, suggesting that dysfunction of the oligodendrocytes could be the first step in the progression at the early ad before the occurrence of amyloid and tau pathology. |
2023-07-31 |
2023-08-14 |
Not clear |
| André D G Leitão, Brian Spencer, Floyd Sarsoza, Jennifer Ngolab, Jessica Amalraj, Eliezer Masliah, Chengbiao Wu, Robert A Rissma. Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice. Journal of Alzheimer's disease : JAD. 2023-07-31. PMID:37522208. |
alzheimer's disease (ad) cases are often characterized by the pathological accumulation of α-synuclein (α-syn) in addition to amyloid-β (aβ) and tau hallmarks. |
2023-07-31 |
2023-08-14 |
mouse |