| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppina Amadoro, Veronica Corsetti, Giulia Maria Sancesario, Adele Lubrano, Gaia Melchiorri, Sergio Bernardini, Pietro Calissano, Giuseppe Sancesari. Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer's disease and other dementias. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24851856. |
truncation at n-terminal domain of tau protein is early associated with neurofibrillary pathology in several human tauopathies, including alzheimer's disease (ad). |
2015-05-11 |
2023-08-13 |
human |
| Maria V Fawaz, Allen F Brooks, Melissa E Rodnick, Garrett M Carpenter, Xia Shao, Timothy J Desmond, Phillip Sherman, Carole A Quesada, Brian G Hockley, Michael R Kilbourn, Roger L Albin, Kirk A Frey, Peter J H Scot. High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection. ACS chemical neuroscience. vol 5. issue 8. 2015-05-11. PMID:24896980. |
high affinity radiopharmaceuticals based upon lansoprazole for pet imaging of aggregated tau in alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection. |
2015-05-11 |
2023-08-13 |
human |
| Francesco Angelucci, Francesca Gelfo, Marco Fiore, Nicoletta Croce, Aleksander A Mathé, Sergio Bernardini, Carlo Caltagiron. The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease. Canadian journal of physiology and pharmacology. vol 92. issue 8. 2015-05-11. PMID:25026432. |
alzheimer's disease (ad) is a disorder characterized by the accumulation of abnormally folded protein fragments in neurons, i.e., β-amyloid (aβ) and tau protein, leading to cell death. |
2015-05-11 |
2023-08-13 |
Not clear |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
a link between tau phosphorylation and aggregation has been shown in different models for alzheimer disease, including yeast. |
2015-05-08 |
2023-08-13 |
mouse |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
in hippocampal homogenates from thy-tau22 mice and cortex homogenates obtained from alzheimer patients, adx215 consistently stained specific low order tau oligomers in diseased brain, which in size correspond to tau dimers. |
2015-05-08 |
2023-08-13 |
mouse |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
when used to assess tau levels in human cerebrospinal fluid, the antibodies permitted us to discriminate patients with alzheimer disease or other dementia like vascular dementia, indicative that these antibodies hold promising diagnostic potential. |
2015-05-08 |
2023-08-13 |
mouse |
| Zachary A Levine, Luca Larini, Nichole E LaPointe, Stuart C Feinstein, Joan-Emma She. Regulation and aggregation of intrinsically disordered peptides. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 9. 2015-05-08. PMID:25691742. |
however, dysfunctions in tau can lead to tau oligomerization, fibril formation, and neurodegenerative disease, including alzheimer's disease. |
2015-05-08 |
2023-08-13 |
Not clear |
| Balasubramaniam Annamalai, Je-Seong Won, Seungho Choi, Inderjit Singh, Avtar K Sing. Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25640839. |
hyperphosphorylation and polymerization of microtubule-associated protein tau into paired helical filaments (phfs) is one of the hallmarks of alzheimer's disease (ad). |
2015-05-06 |
2023-08-13 |
mouse |
| Sunhyo Kim, Daehoon Lee, Jae Chun Song, Sun-Jung Cho, Sang-Moon Yun, Young Ho Koh, Jihyun Song, Gail V W Johnson, Chulman J. NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model. Biochemical and biophysical research communications. vol 454. issue 1. 2015-05-01. PMID:25450380. |
ndp52 associates with phosphorylated tau in brains of an alzheimer disease mouse model. |
2015-05-01 |
2023-08-13 |
mouse |
| Brandon B Holmes, Jennifer L Furman, Thomas E Mahan, Tritia R Yamasaki, Hilda Mirbaha, William C Eades, Larisa Belaygorod, Nigel J Cairns, David M Holtzman, Marc I Diamon. Proteopathic tau seeding predicts tauopathy in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 41. 2015-04-30. PMID:25261551. |
in tauopathies such as alzheimer's disease, this model predicts that tau seeds propagate pathology through the brain via cell-cell transfer in neural networks. |
2015-04-30 |
2023-08-13 |
mouse |
| Xiong Wang, Lu Tan, Yanjun Lu, Jing Peng, Yaowu Zhu, Yadong Zhang, Ziyong Su. MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha. FEBS letters. vol 589. issue 6. 2015-04-29. PMID:25680531. |
alzheimer's disease (ad) is a progressive neurodegenerative dementia characterized by aβ deposition and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2015-04-29 |
2023-08-13 |
Not clear |
| Zhiyou Cai, Guanghui Chen, Wenbo He, Ming Xiao, Liang-Jun Ya. Activation of mTOR: a culprit of Alzheimer's disease? Neuropsychiatric disease and treatment. vol 11. 2015-04-28. PMID:25914534. |
alzheimer's disease (ad) is characterized by cognitive impairment in clinical presentation, and by β-amyloid (aβ) production and the hyper-phosphorylation of tau in basic research. |
2015-04-28 |
2023-08-13 |
Not clear |
| Christian Humpe. Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques. Frontiers in aging neuroscience. vol 7. 2015-04-27. PMID:25914642. |
alzheimer's disease is a severe neurodegenerative disorder of the brain, pathologically characterized by extracellular beta-amyloid plaques, intraneuronal tau inclusions, inflammation, reactive glial cells, vascular pathology and neuronal cell death. |
2015-04-27 |
2023-08-13 |
mouse |
| Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng, Jun Jiang, Keqiang Ye, Xiao-Chuan Wang, Jian-Zhi Wan. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25378699. |
intracellular accumulation of the abnormally modified tau is hallmark pathology of alzheimer's disease (ad), but the mechanism leading to tau aggregation is not fully characterized. |
2015-04-23 |
2023-08-13 |
rat |
| J Pretnar-Oblak, M Zaletel, T M Hajnsek, B Meglic, I Hocevar-Boltezar, M Popovi. Isolated bulbar paralysis in a patient with medullar tau pathology: a case report. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 8. 2015-04-22. PMID:20562453. |
whether the medullary tau pathology in this case was a rare aberrant progression of alzheimer's disease or a new presentation of tauopathy concomitant with subclinical alzheimer's disease should be elucidated by additional studies. |
2015-04-22 |
2023-08-12 |
Not clear |
| Ian Diner, Chadwick M Hales, Isaac Bishof, Lake Rabenold, Duc M Duong, Hong Yi, Oskar Laur, Marla Gearing, Juan Troncoso, Madhav Thambisetty, James J Lah, Allan I Levey, Nicholas T Seyfrie. Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25355317. |
recent evidence indicates that u1-70k and other u1 small nuclear ribonucleoproteins are sarkosyl-insoluble and associate with tau neurofibrillary tangles selectively in alzheimer disease (ad). |
2015-04-21 |
2023-08-13 |
Not clear |
| Laurence Booth, Jane L Roberts, Paul Den. HSPA5/Dna K may be a useful target for human disease therapies. DNA and cell biology. vol 34. issue 3. 2015-04-21. PMID:25689303. |
in alzheimer's disease, hspa5 has been shown to play a supportive role for the progression of tau phosphorylation and neurodegeneration. |
2015-04-21 |
2023-08-13 |
human |
| Flávio Roberto Pinsetta, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. Structure- and ligand-based drug design of novel p38-alpha MAPK inhibitors in the fight against the Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 32. issue 7. 2015-04-20. PMID:23805842. |
alzheimer's disease (ad) is characterized microscopically by the presence of amyloid plaques, which are accumulations of beta-amyloid protein inter-neurons, and neurofibrillary tangles formed predominantly by highly phosphorylated forms of the microtubule-associated protein, tau, which form tangled masses that consume neuronal cell body, possibly leading to neuronal dysfunction and ultimately death. |
2015-04-20 |
2023-08-12 |
Not clear |
| Leo F McCluskey, Felix Geser, Lauren B Elman, Vivianna M Van Deerlin, John L Robinson, Virginia M-Y Lee, John Q Trojanowsk. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic lateral sclerosis & frontotemporal degeneration. vol 15. issue 5-6. 2015-04-20. PMID:24809433. |
atypical alzheimer's disease in an elderly united states resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. |
2015-04-20 |
2023-08-13 |
Not clear |
| Jack A Wells, Holly E Holmes, James M O'Callaghan, Niall Colgan, Ozama Ismail, Elizabeth Mc Fisher, Bernard Siow, Tracey K Murray, Adam J Schwarz, Michael J O'Neill, Emily C Collins, Mark F Lythgo. Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 3. 2015-04-20. PMID:25515210. |
increased cerebral vascular reactivity in the tau expressing rtg4510 mouse: evidence against the role of tau pathology to impair vascular health in alzheimer's disease. |
2015-04-20 |
2023-08-13 |
mouse |