| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Jiang, Jin-Tai Yu, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Hui-Fu Wang, Meng-Shan Tan, Qing Gao, Hao Qin, Ying-Dong Zhang, Lan Ta. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. vol 85. 2015-03-30. PMID:24880087. |
in a variety of neurodegenerative tauopathies including alzheimer's disease, frontotemporal dementia and some types of parkinson's disease, tau protein is abnormally hyperphosphorylated by several kinases and eventually aggregates to form neurofibrillary tangles, a neurotoxic pathological characteristic that closely correlates with cognitive impairments. |
2015-03-30 |
2023-08-13 |
mouse |
| Victor L Villemagne, Nobuyuki Okamur. In vivo tau imaging: obstacles and progress. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3 Suppl. 2015-03-30. PMID:24924676. |
the considerable evidence pointing at the accumulation of tau aggregates and its recognition as a risk factor in neurodegenerative conditions such as alzheimer's disease have led to a major effort to develop selective tau ligands that would allow research into the physiopathologic underpinnings of traumatic brain injury and chronic traumatic encephalopathy in military personnel and the civilian population. |
2015-03-30 |
2023-08-13 |
human |
| Victor L Villemagne, Nobuyuki Okamur. In vivo tau imaging: obstacles and progress. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3 Suppl. 2015-03-30. PMID:24924676. |
these tracers will allow new insights into tau pathology in the human brain, facilitating research into causes, diagnosis, and treatment of traumatic encephalopathy and major neurodegenerative dementias, such as alzheimer's disease and some variants of frontotemporal lobar degeneration, in which tau plays a role. |
2015-03-30 |
2023-08-13 |
human |
| Maj-Linda B Selenica, Hayk Davtyan, Steven B Housley, Laura J Blair, Anne Gillies, Bryce A Nordhues, Bo Zhang, Joseph Liu, Jason E Gestwicki, Daniel C Lee, Marcia N Gordon, Dave Morgan, Chad A Dicke. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of neuroinflammation. vol 11. 2015-03-30. PMID:25183004. |
abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in alzheimer's disease and similar tauopathies. |
2015-03-30 |
2023-08-13 |
mouse |
| Irina Lonskaya, Michaeline Hebron, Wenqiang Chen, Joel Schachter, Charbel Mouss. Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models. Molecular neurodegeneration. vol 9. 2015-03-30. PMID:25384392. |
hyper-phosphorylation of tau reduces its binding to microtubules and it is associated with β-amyloid deposition in alzheimer's disease. |
2015-03-30 |
2023-08-13 |
Not clear |
| Yi Li, Wai Tsui, Henry Rusinek, Tracy Butler, Lisa Mosconi, Elizabeth Pirraglia, David Mozley, Shankar Vallabhajosula, Ryuichi Harada, Shozo Furumoto, Katsutoshi Furukawa, Hiroyuki Arai, Yukitsuka Kudo, Nobuyuki Okamura, Mony J de Leo. Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 2. 2015-03-30. PMID:25572087. |
cortical laminar binding of pet amyloid and tau tracers in alzheimer disease. |
2015-03-30 |
2023-08-13 |
Not clear |
| Yi Li, Wai Tsui, Henry Rusinek, Tracy Butler, Lisa Mosconi, Elizabeth Pirraglia, David Mozley, Shankar Vallabhajosula, Ryuichi Harada, Shozo Furumoto, Katsutoshi Furukawa, Hiroyuki Arai, Yukitsuka Kudo, Nobuyuki Okamura, Mony J de Leo. Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 2. 2015-03-30. PMID:25572087. |
neurofibrillary tau pathology and amyloid β (aβ) plaques, characteristic lesions of alzheimer disease (ad), show different neocortical laminar distributions. |
2015-03-30 |
2023-08-13 |
Not clear |
| Carolyn C Rudy, Holly C Hunsberger, Daniel S Weitzner, Miranda N Ree. The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease. Aging and disease. vol 6. issue 2. 2015-03-30. PMID:25821641. |
alzheimer's disease (ad) is the most common form of dementia in individuals over 65 years of age and is characterized by accumulation of beta-amyloid (aβ) and tau. |
2015-03-30 |
2023-08-13 |
Not clear |
| Tomohiro Umeda, Hiroshi Eguchi, Yuichi Kunori, Yoichi Matsumoto, Taizo Taniguchi, Hiroshi Mori, Takami Tomiyam. Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice. Annals of clinical and translational neurology. vol 2. issue 3. 2015-03-27. PMID:25815351. |
cellular inclusions of hyperphosphorylated tau are a hallmark of tauopathies, which are neurodegenerative disorders that include alzheimer's disease (ad). |
2015-03-27 |
2023-08-13 |
mouse |
| Olga G James, P Murali Doraiswamy, Salvador Borges-Net. PET Imaging of Tau Pathology in Alzheimer's Disease and Tauopathies. Frontiers in neurology. vol 6. 2015-03-25. PMID:25806018. |
pet imaging of tau pathology in alzheimer's disease and tauopathies. |
2015-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Nynke I Kramer, Bas J Blaauboer, Willem Seinen, Ruud Brand. An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer's disease and neurodegeneration. Chemico-biological interactions. vol 226. 2015-03-24. PMID:25500268. |
it is also associated specifically with the characteristic amyloid-β and tau pathologies of alzheimer's disease. |
2015-03-24 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Daniel R Schonhaut, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Pia M Ghosh, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy. Annals of neurology. vol 77. issue 2. 2015-03-20. PMID:25448043. |
we report a patient with posterior cortical atrophy (visual variant of alzheimer disease) who was studied using the novel tau tracer [(18) f]av-1451 in conjunction with [(11) c]pittsburgh compound b (pib; amyloid) and [(18) f]fluorodeoxyglucose (fdg) positron emission tomography. |
2015-03-20 |
2023-08-13 |
Not clear |
| Masato Hosokawa, Tetsuaki Arai, Masami Masuda-Suzukake, Hiromi Kondo, Takashi Matsuwaki, Masugi Nishihara, Masato Hasegawa, Haruhiko Akiyam. Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice. Journal of neuropathology and experimental neurology. vol 74. issue 2. 2015-03-17. PMID:25575133. |
moreover, recent findings indicate that grn mutations are associated with other neurodegenerative disorders with tau pathology, including alzheimer disease and corticobasal degeneration. |
2015-03-17 |
2023-08-13 |
mouse |
| Tong Chen, Wei-Ping Gai, Catherine A Abbot. Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. BioMed research international. vol 2014. 2015-03-12. PMID:25025038. |
the neuropathological features associated with alzheimer's disease (ad) include the presence of extracellular amyloid-β peptide-containing plaques and intracellular tau positive neurofibrillary tangles and the loss of synapses and neurons in defined regions of the brain. |
2015-03-12 |
2023-08-13 |
human |
| Victor L Villemagne, Michelle T Fodero-Tavoletti, Colin L Masters, Christopher C Row. Tau imaging: early progress and future directions. The Lancet. Neurology. vol 14. issue 1. 2015-03-10. PMID:25496902. |
use of selective in-vivo tau imaging will enable improved understanding of tau aggregation in the brain, facilitating research into causes, diagnosis, and treatment of major tauopathies such as alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. |
2015-03-10 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Michelle T Fodero-Tavoletti, Colin L Masters, Christopher C Row. Tau imaging: early progress and future directions. The Lancet. Neurology. vol 14. issue 1. 2015-03-10. PMID:25496902. |
neuropathological studies of alzheimer's disease show a strong association between tau deposits, decreased cognitive function, and neurodegenerative changes. |
2015-03-10 |
2023-08-13 |
Not clear |
| Viswanath Das, Dalice A Sim, John H Mille. Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture. Journal of neuroscience research. vol 92. issue 9. 2015-03-09. PMID:24788108. |
these results support a neuroprotective effect of microtubule stabilization in maintaining axonal transport in neurons overexpressing tau protein and may be beneficial in reducing the severity of neurodegenerative diseases such as alzheimer's disease. |
2015-03-09 |
2023-08-13 |
rat |
| Dexin Sui, Mengyu Liu, Min-Hao Ku. In vitro aggregation assays using hyperphosphorylated tau protein. Journal of visualized experiments : JoVE. issue 95. 2015-03-06. PMID:25590418. |
alzheimer's disease is one of a large group of neurodegenerative disorders known as tauopathies that are manifested by the neuronal deposits of hyperphosphorylated tau protein in the form of neurofibrillary tangles (nfts). |
2015-03-06 |
2023-08-13 |
human |
| Dexin Sui, Mengyu Liu, Min-Hao Ku. In vitro aggregation assays using hyperphosphorylated tau protein. Journal of visualized experiments : JoVE. issue 95. 2015-03-06. PMID:25590418. |
novel therapeutics for alzheimer's disease and other tauopathies can potentially be discovered using hyperphosphorylated tau isoforms. |
2015-03-06 |
2023-08-13 |
human |
| Daniel Paris, Ghania Ait-Ghezala, Corbin Bachmeier, Gary Laco, David Beaulieu-Abdelahad, Yong Lin, Chao Jin, Fiona Crawford, Michael Mulla. The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25331948. |
the spleen tyrosine kinase (syk) regulates alzheimer amyloid-β production and tau hyperphosphorylation. |
2015-03-03 |
2023-08-13 |
mouse |