All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D'Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B Klee, Can Zhang, Brian J Wainger, Michael Peitz, Dora M Kovacs, Clifford J Woolf, Steven L Wagner, Rudolph E Tanzi, Doo Yeon Ki. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. vol 515. issue 7526. 2014-12-15. PMID:25307057. human neurons derived from alzheimer's disease patients have shown elevated levels of toxic amyloid-β species and phosphorylated tau but did not demonstrate amyloid-β plaques or neurofibrillary tangles. 2014-12-15 2023-08-13 mouse
David Peterson, Caitlin Munger, Jared Crowley, Chris Corcoran, Carlos Cruchaga, Alison M Goate, Maria C Norton, Robert C Green, Ronald G Munger, John C S Breitner, Kathleen A Welsh-Bohmer, Constantine Lyketsos, Joann Tschanz, John S K Kauw. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23727081. single-nucleotide polymorphisms (snps) located in the gene encoding the regulatory subunit of the protein phosphatase 2b (ppp3r1, rs1868402) and the microtubule-associated protein tau (mapt, rs3785883) gene were recently associated with higher cerebrospinal fluid (csf) tau levels in samples from the knight alzheimer's disease research center at washington university (wu) and alzheimer's disease neuroimaging initiative (adni). 2014-12-10 2023-08-12 Not clear
Qinxi Guo, Hongmei Li, Allysa L Cole, Ji-Yeun Hur, Yueming Li, Hui Zhen. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278307. modeling alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of aβ and tau. 2014-12-10 2023-08-12 mouse
Qinxi Guo, Hongmei Li, Allysa L Cole, Ji-Yeun Hur, Yueming Li, Hui Zhen. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278307. alzheimer's disease (ad), the most common cause of dementia in the elderly, has two pathological hallmarks: aβ plaques and aggregation of hyperphosphorylated tau (p-tau). 2014-12-10 2023-08-12 mouse
Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jone. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278327. neurofibrillary tangles (nfts) of tau are one of the defining hallmarks of alzheimer's disease (ad), and are closely associated with neuronal degeneration. 2014-12-10 2023-08-12 mouse
Ania L Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J Craft, Kaitlyn Ho, Weikun Guo, Mariel M Finucane, Pascal E Sanchez, Lennart Muck. Tau reduction prevents disease in a mouse model of Dravet syndrome. Annals of neurology. vol 76. issue 3. 2014-12-10. PMID:25042160. reducing levels of the microtubule-associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as alzheimer disease. 2014-12-10 2023-08-13 mouse
Gyungah Jun, Hirohide Asai, Ella Zeldich, Elodie Drapeau, CiDi Chen, Jaeyoon Chung, Jong-Ho Park, Sehwa Kim, Vahram Haroutunian, Tatiana Foroud, Ryozo Kuwano, Jonathan L Haines, Margaret A Pericak-Vance, Gerard D Schellenberg, Kathryn L Lunetta, Jong-Won Kim, Joseph D Buxbaum, Richard Mayeux, Tsuneya Ikezu, Carmela R Abraham, Lindsay A Farre. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of neurology. vol 76. issue 3. 2014-12-10. PMID:25043464. plxna4 is associated with alzheimer disease and modulates tau phosphorylation. 2014-12-10 2023-08-13 Not clear
Koji Kasanuki, Eizo Iseki, Daizo Kondo, Hiroshige Fujishiro, Michiko Minegishi, Kiyoshi Sato, Omi Katsuse, Hiroaki Hino, Kenji Kosaka, Heii Ara. Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies. Neuroscience letters. vol 569. 2014-12-09. PMID:24704327. in the present study, we quantitatively examined hcrt immunoreactivity and α-synuclein and tau pathologies in the lht and locus coeruleus (lc) in dementia with lewy bodies (dlb) (n=15), alzheimer's disease (ad) (n=14), and controls (n=7). 2014-12-09 2023-08-13 Not clear
Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, Gabriel von Eule. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24533944. mark4 and mark3 associate with early tau phosphorylation in alzheimer's disease granulovacuolar degeneration bodies. 2014-12-08 2023-08-12 Not clear
Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, Gabriel von Eule. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24533944. the progression of alzheimer's disease (ad) is associated with an increase of phosphorylated tau in the brain. 2014-12-08 2023-08-12 Not clear
b' Antonio Di Meco, Yash B Joshi, Domenico Pratic\\xc3\\xb. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer\'s disease with plaques and tangles. Neurobiology of aging. vol 35. issue 8. 2014-12-08. PMID:24629673.' sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of alzheimer's disease with plaques and tangles. 2014-12-08 2023-08-12 mouse
Elysse M Knight, Isaura V A Martins, Sarah Gümüsgöz, Stuart M Allan, Catherine B Lawrenc. High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology. Neurobiology of aging. vol 35. issue 8. 2014-12-08. PMID:24630364. high-fat diet-induced memory impairment in triple-transgenic alzheimer's disease (3xtgad) mice is independent of changes in amyloid and tau pathology. 2014-12-08 2023-08-12 mouse
M Florencia Iulita, Simon Allard, Luise Richter, Lisa-Marie Munter, Adriana Ducatenzeiler, Christoph Weise, Sonia Do Carmo, William L Klein, Gerhard Multhaup, A Claudio Cuell. Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24903713. numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (aβ) as an important contributor to alzheimer's disease (ad) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. 2014-12-08 2023-08-13 human
Jon B Toledo, Ané Korff, Leslie M Shaw, John Q Trojanowski, Jing Zhan. Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment. Alzheimer's research & therapy. vol 6. issue 3. 2014-12-05. PMID:25478014. alzheimer's disease (ad) is characterized by the deposition of tau and amyloid in the brain. 2014-12-05 2023-08-13 Not clear
Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak, Michal Nova. First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478017. first-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an alzheimer's disease model. 2014-12-05 2023-08-13 Not clear
Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak, Michal Nova. First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478017. we have identified structural determinants on tau protein that are essential for pathological tau-tau interaction in alzheimer's disease (ad). 2014-12-05 2023-08-13 Not clear
Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Michal Nova. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478018. identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in alzheimer's disease. 2014-12-05 2023-08-13 Not clear
Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Michal Nova. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478018. pathologically modified tau protein is the main feature of alzheimer's disease (ad) and related tauopathies. 2014-12-05 2023-08-13 Not clear
Tomohiro Onishi, Yoshio Matsumoto, Masahiko Hattori, Yuka Obayashi, Kimie Nakamura, Takashi Yano, Takashi Horiguchi, Hiroki Iwashit. Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neuroscience research. vol 80. 2014-12-04. PMID:24406748. alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld) are neurodegenerative "tauopathies" characterized by hyperphosphorylated tau accumulation and neurofibrillary tangles. 2014-12-04 2023-08-12 mouse
Danielle L Graham, Audrey J Gray, John A Joyce, Dongzi Yu, Jill O'Moore, George A Carlson, Mark S Shearman, Tammy L Dellovade, Heike Herin. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. vol 79. 2014-12-03. PMID:24326295. neurofibrillary tangles (nft), mainly consisting of fibrillar aggregates of hyperphosphorylated tau, are a defining pathological feature of alzheimer's disease and other tauopathies. 2014-12-03 2023-08-12 mouse