Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jose Vicente Sanchez-Mut, Ester Aso, Holger Heyn, Tadashi Matsuda, Christoph Bock, Isidre Ferrer, Manel Estelle. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436131. |
promoter hypermethylation of the phosphatase dusp22 mediates pka-dependent tau phosphorylation and creb activation in alzheimer's disease. |
2014-12-03 |
2023-08-12 |
human |
Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mor. Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531886. |
senile plaques comprised of aβ aggregates and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau filaments are the hallmarks of alzheimer's disease (ad). |
2014-12-03 |
2023-08-12 |
mouse |
Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. |
intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of alzheimer's disease, progressive supranuclear palsy, pick's disease and other sporadic neurodegenerative tauopathies. |
2014-12-03 |
2023-08-12 |
mouse |
Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. |
this process is referred to as 'tau propagation' and may explain the stereotypic progression of tau pathology in the brains of alzheimer's disease patients. |
2014-12-03 |
2023-08-12 |
mouse |
Wei Qian, Fei Li. Regulation of alternative splicing of tau exon 10. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627328. |
the neuronal microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in the brains of individuals with alzheimer's disease and related neurodegenerative disorders. |
2014-12-03 |
2023-08-12 |
human |
Jian-Zhi Wang, Zhi-Hao Wang, Qing Tia. Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627329. |
tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in alzheimer's disease. |
2014-12-03 |
2023-08-12 |
Not clear |
Jian-Zhi Wang, Zhi-Hao Wang, Qing Tia. Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627329. |
it is recognized that tau hyperphosphorylation is the root cause of neurodegeneration in alzheimer's disease (ad); however, it is not clear how it causes neurodegeneration. |
2014-12-03 |
2023-08-12 |
Not clear |
Chong Gao, Yueze Liu, Yuanhong Jiang, Jianming Ding, Lin L. Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model. Brain pathology (Zurich, Switzerland). vol 24. issue 3. 2014-11-28. PMID:24329968. |
geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via gsk3β pathway in streptozotocin-induced alzheimer rat model. |
2014-11-28 |
2023-08-12 |
rat |
Monique Richter, Ralf Hoffmann, David Singe. T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice. Journal of peptide science : an official publication of the European Peptide Society. vol 19. issue 7. 2014-11-25. PMID:23728915. |
alzheimer's disease is characterized by two pathological hallmarks, the intracellular deposition of hyperphosphorylated tau protein and the extracellular deposition of aβ1-40/42 , both being targets for immunotherapy. |
2014-11-25 |
2023-08-12 |
mouse |
Kristyn Bates, Robert Vink, Ralph Martins, Alan Harve. Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24360504. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized histopathologically by the abnormal deposition of the proteins amyloid-beta (aβ) and tau. |
2014-11-25 |
2023-08-12 |
human |
Qian Jiang, Lu Wang, Yang Guan, Hui Xu, Yi Niu, Li Han, Yu-Ping Wei, Li Lin, Jiang Chu, Qun Wang, Ying Yang, Lei Pei, Jian-Zhi Wang, Qing Tia. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24368089. |
tau hyperphosphorylation is a critical event in alzheimer's disease, in which the neuronal golgi fragmentation occurs earlier than tau hyperphosphorylation. |
2014-11-25 |
2023-08-12 |
mouse |
Naruhiko Sahara, Pablo D Perez, Wen-Lang Lin, Dennis W Dickson, Yan Ren, Huadong Zeng, Jada Lewis, Marcelo Feb. Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24411290. |
elevated expression of human hyperphosphorylated tau is associated with neuronal loss and white matter (wm) pathology in alzheimer's disease (ad) and related neurodegenerative disorders. |
2014-11-25 |
2023-08-12 |
mouse |
Joe Atherton, Ksenia Kurbatskaya, Marie Bondulich, Cara L Croft, Claire J Garwood, Resham Chhabra, Selina Wray, Andreas Jeromin, Diane P Hanger, Wendy Nobl. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging cell. vol 13. issue 1. 2014-11-21. PMID:23919677. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (aβ) in senile plaques, intracellular neurofibrillary tangles (nfts) comprising hyperphosphorylated aggregated tau, synaptic dysfunction and neuronal death. |
2014-11-21 |
2023-08-12 |
Not clear |
Li Li, Wenzhang Wang, Scott Welford, Teng Zhang, Xinglong Wang, Xiongwei Zh. Ionizing radiation causes increased tau phosphorylation in primary neurons. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24861936. |
in this study, we investigated whether ionizing radiation causes changes in tau phosphorylation in cultured primary neurons similar to that in alzheimer's disease. |
2014-11-21 |
2023-08-13 |
Not clear |
Li Li, Wenzhang Wang, Scott Welford, Teng Zhang, Xinglong Wang, Xiongwei Zh. Ionizing radiation causes increased tau phosphorylation in primary neurons. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24861936. |
overall, our studies suggest that ionizing radiation may cause increased risk for development of alzheimer's disease by promoting abnormal tau phosphorylation. |
2014-11-21 |
2023-08-13 |
Not clear |
Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
patients with diabetes in the aging population are at high risk of alzheimer's disease (ad), and reduction of sirtuin 1 (sirt1) activity occurs simultaneously with the accumulation of hyperphosphorylated tau in the ad-affected brain. |
2014-11-18 |
2023-08-12 |
rat |
Susan E Kiefer, Chiehying J Chang, S Roy Kimura, Mian Gao, Dianlin Xie, Yaqun Zhang, Guifen Zhang, Martin B Gill, Harold Mastalerz, Lorin A Thompson, Angela M Cacace, Steven Sherif. The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta crystallographica. Section F, Structural biology communications. vol 70. issue Pt 2. 2014-11-14. PMID:24637750. |
hyperphosphorylation of tau is implicated in the pathogenesis of alzheimer's disease. |
2014-11-14 |
2023-08-12 |
human |
Brianda Barrios-Lopez, Mari Raki, Kim Bergströ. Radiolabeled peptides for Alzheimer's diagnostic imaging: mini review. Current radiopharmaceuticals. vol 6. issue 4. 2014-11-12. PMID:24283961. |
the pathology of alzheimer's disease (ad) is characterized by the extracellular and intracellular accumulation of amyloid-β (aβ) fibrillar plaques formed by the aβ1-42 peptide, neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau, extensive neuritic and synaptic degradation, and neuron loss. |
2014-11-12 |
2023-08-12 |
human |
Meredith A Chabrier, David Cheng, Nicholas A Castello, Kim N Green, Frank M LaFerl. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiology of disease. vol 64. 2014-11-12. PMID:24440055. |
synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of alzheimer's disease. |
2014-11-12 |
2023-08-12 |
mouse |
Meredith A Chabrier, David Cheng, Nicholas A Castello, Kim N Green, Frank M LaFerl. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiology of disease. vol 64. 2014-11-12. PMID:24440055. |
synapse number is the best indicator of cognitive impairment in alzheimer's disease (ad), yet the respective contributions of aβ and tau, particularly human wild-type tau, to synapse loss remain undefined. |
2014-11-12 |
2023-08-12 |
mouse |