All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jose Vicente Sanchez-Mut, Ester Aso, Holger Heyn, Tadashi Matsuda, Christoph Bock, Isidre Ferrer, Manel Estelle. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436131. promoter hypermethylation of the phosphatase dusp22 mediates pka-dependent tau phosphorylation and creb activation in alzheimer's disease. 2014-12-03 2023-08-12 human
Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mor. Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531886. senile plaques comprised of aβ aggregates and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau filaments are the hallmarks of alzheimer's disease (ad). 2014-12-03 2023-08-12 mouse
Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of alzheimer's disease, progressive supranuclear palsy, pick's disease and other sporadic neurodegenerative tauopathies. 2014-12-03 2023-08-12 mouse
Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. this process is referred to as 'tau propagation' and may explain the stereotypic progression of tau pathology in the brains of alzheimer's disease patients. 2014-12-03 2023-08-12 mouse
Wei Qian, Fei Li. Regulation of alternative splicing of tau exon 10. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627328. the neuronal microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in the brains of individuals with alzheimer's disease and related neurodegenerative disorders. 2014-12-03 2023-08-12 human
Jian-Zhi Wang, Zhi-Hao Wang, Qing Tia. Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627329. tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in alzheimer's disease. 2014-12-03 2023-08-12 Not clear
Jian-Zhi Wang, Zhi-Hao Wang, Qing Tia. Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627329. it is recognized that tau hyperphosphorylation is the root cause of neurodegeneration in alzheimer's disease (ad); however, it is not clear how it causes neurodegeneration. 2014-12-03 2023-08-12 Not clear
Chong Gao, Yueze Liu, Yuanhong Jiang, Jianming Ding, Lin L. Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model. Brain pathology (Zurich, Switzerland). vol 24. issue 3. 2014-11-28. PMID:24329968. geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via gsk3β pathway in streptozotocin-induced alzheimer rat model. 2014-11-28 2023-08-12 rat
Monique Richter, Ralf Hoffmann, David Singe. T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice. Journal of peptide science : an official publication of the European Peptide Society. vol 19. issue 7. 2014-11-25. PMID:23728915. alzheimer's disease is characterized by two pathological hallmarks, the intracellular deposition of hyperphosphorylated tau protein and the extracellular deposition of aβ1-40/42 , both being targets for immunotherapy. 2014-11-25 2023-08-12 mouse
Kristyn Bates, Robert Vink, Ralph Martins, Alan Harve. Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24360504. alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized histopathologically by the abnormal deposition of the proteins amyloid-beta (aβ) and tau. 2014-11-25 2023-08-12 human
Qian Jiang, Lu Wang, Yang Guan, Hui Xu, Yi Niu, Li Han, Yu-Ping Wei, Li Lin, Jiang Chu, Qun Wang, Ying Yang, Lei Pei, Jian-Zhi Wang, Qing Tia. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24368089. tau hyperphosphorylation is a critical event in alzheimer's disease, in which the neuronal golgi fragmentation occurs earlier than tau hyperphosphorylation. 2014-11-25 2023-08-12 mouse
Naruhiko Sahara, Pablo D Perez, Wen-Lang Lin, Dennis W Dickson, Yan Ren, Huadong Zeng, Jada Lewis, Marcelo Feb. Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24411290. elevated expression of human hyperphosphorylated tau is associated with neuronal loss and white matter (wm) pathology in alzheimer's disease (ad) and related neurodegenerative disorders. 2014-11-25 2023-08-12 mouse
Joe Atherton, Ksenia Kurbatskaya, Marie Bondulich, Cara L Croft, Claire J Garwood, Resham Chhabra, Selina Wray, Andreas Jeromin, Diane P Hanger, Wendy Nobl. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging cell. vol 13. issue 1. 2014-11-21. PMID:23919677. alzheimer's disease (ad) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (aβ) in senile plaques, intracellular neurofibrillary tangles (nfts) comprising hyperphosphorylated aggregated tau, synaptic dysfunction and neuronal death. 2014-11-21 2023-08-12 Not clear
Li Li, Wenzhang Wang, Scott Welford, Teng Zhang, Xinglong Wang, Xiongwei Zh. Ionizing radiation causes increased tau phosphorylation in primary neurons. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24861936. in this study, we investigated whether ionizing radiation causes changes in tau phosphorylation in cultured primary neurons similar to that in alzheimer's disease. 2014-11-21 2023-08-13 Not clear
Li Li, Wenzhang Wang, Scott Welford, Teng Zhang, Xinglong Wang, Xiongwei Zh. Ionizing radiation causes increased tau phosphorylation in primary neurons. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24861936. overall, our studies suggest that ionizing radiation may cause increased risk for development of alzheimer's disease by promoting abnormal tau phosphorylation. 2014-11-21 2023-08-13 Not clear
Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. patients with diabetes in the aging population are at high risk of alzheimer's disease (ad), and reduction of sirtuin 1 (sirt1) activity occurs simultaneously with the accumulation of hyperphosphorylated tau in the ad-affected brain. 2014-11-18 2023-08-12 rat
Susan E Kiefer, Chiehying J Chang, S Roy Kimura, Mian Gao, Dianlin Xie, Yaqun Zhang, Guifen Zhang, Martin B Gill, Harold Mastalerz, Lorin A Thompson, Angela M Cacace, Steven Sherif. The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta crystallographica. Section F, Structural biology communications. vol 70. issue Pt 2. 2014-11-14. PMID:24637750. hyperphosphorylation of tau is implicated in the pathogenesis of alzheimer's disease. 2014-11-14 2023-08-12 human
Brianda Barrios-Lopez, Mari Raki, Kim Bergströ. Radiolabeled peptides for Alzheimer's diagnostic imaging: mini review. Current radiopharmaceuticals. vol 6. issue 4. 2014-11-12. PMID:24283961. the pathology of alzheimer's disease (ad) is characterized by the extracellular and intracellular accumulation of amyloid-β (aβ) fibrillar plaques formed by the aβ1-42 peptide, neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau, extensive neuritic and synaptic degradation, and neuron loss. 2014-11-12 2023-08-12 human
Meredith A Chabrier, David Cheng, Nicholas A Castello, Kim N Green, Frank M LaFerl. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiology of disease. vol 64. 2014-11-12. PMID:24440055. synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of alzheimer's disease. 2014-11-12 2023-08-12 mouse
Meredith A Chabrier, David Cheng, Nicholas A Castello, Kim N Green, Frank M LaFerl. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiology of disease. vol 64. 2014-11-12. PMID:24440055. synapse number is the best indicator of cognitive impairment in alzheimer's disease (ad), yet the respective contributions of aβ and tau, particularly human wild-type tau, to synapse loss remain undefined. 2014-11-12 2023-08-12 mouse