| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Tsen Tung, Bo-Jeng Wang, Wen-Ming Hsu, Ming-Kuan Hu, Guor Mour Her, Wei-Pang Huang, Yung-Feng Lia. Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23794287. |
mutations in presenilin-1 (ps1) are tightly associated with early-onset familial alzheimer's disease (fad), which is characterized by extracellular amyloid plaques and the accumulation of intracellular tau. |
2014-10-27 |
2023-08-12 |
Not clear |
| Caoyi Chen, Nana Jin, Wei Qian, Wen Liu, Xiangling Tan, Fei Ding, Xiaosong Gu, Khalid Iqbal, Cheng-Xin Gong, Ji Zuo, Fei Li. Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:24037441. |
in alzheimer's brain, down-regulation of the pka pathway could lead to dysregulation of tau exon 10, contributing to tau pathogenesis. |
2014-10-27 |
2023-08-12 |
human |
| Smita R Paranjape, Yi-Ming Chiang, James F Sanchez, Ruth Entwistle, Clay C C Wang, Berl R Oakley, T Chris Gambli. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta medica. vol 80. issue 1. 2014-10-27. PMID:24414310. |
the aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including alzheimer's disease. |
2014-10-27 |
2023-08-12 |
Not clear |
| Smita R Paranjape, Yi-Ming Chiang, James F Sanchez, Ruth Entwistle, Clay C C Wang, Berl R Oakley, T Chris Gambli. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta medica. vol 80. issue 1. 2014-10-27. PMID:24414310. |
together, our data demonstrates the potential of 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde as lead compounds for further development as therapeutics to inhibit tau aggregation in alzheimer's disease and neurodegenerative tauopathies. |
2014-10-27 |
2023-08-12 |
Not clear |
| Jiayi Zhou, Bingqian Li. Alzheimer's disease and prion protein. Intractable & rare diseases research. vol 2. issue 2. 2014-10-24. PMID:25343100. |
alzheimer's disease (ad) is a devastating neurodegenerative disease with progressive loss of memory and cognitive function, pathologically hallmarked by aggregates of the amyloid-beta (aβ) peptide and hyperphosphorylated tau in the brain. |
2014-10-24 |
2023-08-13 |
Not clear |
| Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogu. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551051. |
the misfolding of intrinsically disordered proteins such as α-synuclein, tau and the aβ peptide has been associated with many highly debilitating neurodegenerative syndromes including parkinson's and alzheimer's diseases. |
2014-10-21 |
2023-08-12 |
Not clear |
| B M Kim, M-H You, C-H Chen, S Lee, Y Hong, Y Hong, A Kimchi, X Z Zhou, T H Le. Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function. Cell death & disease. vol 5. 2014-10-21. PMID:24853415. |
the presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of alzheimer's disease (ad). |
2014-10-21 |
2023-08-13 |
mouse |
| Mariet Allen, Michaela Kachadoorian, Zachary Quicksall, Fanggeng Zou, High Seng Chai, Curtis Younkin, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Siddharth Krishnan, Thuy Nguyen, Li Ma, Kimberly Malphrus, Sarah Lincoln, Gina Bisceglio, Christopher P Kolbert, Jin Jen, Shubhabrata Mukherjee, John K Kauwe, Paul K Crane, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Joseph E Parisi, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Tane. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels. Alzheimer's research & therapy. vol 6. issue 4. 2014-10-17. PMID:25324900. |
mapt encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of alzheimer's disease (ad). |
2014-10-17 |
2023-08-13 |
Not clear |
| Xi Li, Ming Li, Yuan Li, Qiankun Quan, Juan Wan. Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317137. |
these results suggest that ginsenoside rg1 upregulates brain-derived neurotrophic factor expression and inhibits tau protein phosphorylation in brain slices from a rat model of alzheimer's disease. |
2014-10-15 |
2023-08-13 |
rat |
| John F Castro-Alvarez, S Alejandro Uribe-Arias, Kenneth S Kosik, Gloria P Cardona-Góme. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Frontiers in aging neuroscience. vol 6. 2014-10-13. PMID:25309427. |
long- and short-term cdk5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic alzheimer's mice. |
2014-10-13 |
2023-08-13 |
mouse |
| Michael Deuschle, Claudia Schilling, F Markus Leweke, Frank Enning, Thomas Pollmächer, Hermann Esselmann, Jens Wiltfang, Lutz Frölich, Isabella Heuse. Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau. Neuroscience letters. vol 561. 2014-10-07. PMID:24373987. |
we analyzed aβ40, aβ42, tau protein, phosphorylated tau (ptau) protein as well as hypocretin-1 concentrations in the csf of a detection sample of 10 patients with alzheimer's disease (ad) as well as 10 age- and gender-matched patients with major depression as a comparison group of different pathology. |
2014-10-07 |
2023-08-12 |
Not clear |
| Jamie Toombs, Ross W Paterson, Michael P Lunn, Jenifer M Nicholas, Nick C Fox, Miles D Chapman, Jonathan M Schott, Henrik Zetterber. Identification of an important potential confound in CSF AD studies: aliquot volume. Clinical chemistry and laboratory medicine. vol 51. issue 12. 2014-10-06. PMID:23940064. |
cerebrospinal fluid (csf) amyloid β1-42 (aβ1-42), total tau (t-tau) and phosphorylated tau181 (p-tau) are finding increasing utility as biomarkers of alzheimer's disease (ad). |
2014-10-06 |
2023-08-12 |
Not clear |
| Eloi Magnin, Claire Paquet, Maité Formaglio, Bernard Croisile, Ludivine Chamard, Carole Miguet-Alfonsi, Gregory Tio, Julien Dumurgier, Isabelle Roullet-Solignac, Mathilde Sauvée, Catherine Thomas-Antérion, Alain Vighetto, Jacques Hugon, Pierre Vande. Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 39. issue 3. 2014-10-06. PMID:24217280. |
increased cerebrospinal fluid tau levels in logopenic variant of alzheimer's disease. |
2014-10-06 |
2023-08-12 |
Not clear |
| Sergio Camero, María J Benítez, Alejandro Barrantes, José M Ayuso, Raquel Cuadros, Jesús Avila, Juan S Jiméne. Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex. Journal of Alzheimer's disease : JAD. vol 39. issue 3. 2014-10-06. PMID:24254705. |
tau protein has been proposed as a trigger of alzheimer's disease once it is hyperphosphorylated. |
2014-10-06 |
2023-08-12 |
Not clear |
| Min-Kyoo Shin, Hong-Gi Kim, Seung-Hyun Baek, Woo-Ram Jung, Dong-Ik Park, Jong-Sung Park, Dong-Gyu Jo, Kil-Lyong Ki. Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24268884. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by amyloid beta (aβ) deposits, hyperphosphorylated tau deposition, and cognitive dysfunction. |
2014-10-06 |
2023-08-12 |
mouse |
| Filipa I Baptista, Ana G Henriques, Artur M S Silva, Jens Wiltfang, Odete A B da Cruz e Silv. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 2. 2014-10-06. PMID:24328060. |
alzheimer's disease is characterized by pathological aggregation of protein tau and amyloid-β peptides, both of which are considered to be toxic to neurons. |
2014-10-06 |
2023-08-12 |
Not clear |
| Filipa I Baptista, Ana G Henriques, Artur M S Silva, Jens Wiltfang, Odete A B da Cruz e Silv. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 2. 2014-10-06. PMID:24328060. |
experimental evidence supports the hypothesis that certain flavonoids may protect against alzheimer's disease in part by interfering with the generation and assembly of amyloid-β peptides into neurotoxic oligomeric aggregates and also by reducing tau aggregation. |
2014-10-06 |
2023-08-12 |
Not clear |
| b' Yash B Joshi, Phillip F Giannopoulos, Jin Chu, Domenico Pratic\\xc3\\xb. Modulation of lipopolysaccharide-induced memory insult, \\xce\\xb3-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24332986.' |
besides amyloid and tau pathology, a constant feature of alzheimer's disease (ad) is an intense inflammatory response, which is considered an active player in its pathogenesis. |
2014-10-06 |
2023-08-12 |
mouse |
| Khalid Iqbal, Cheng-Xin Gong, Fei Li. Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease. Expert opinion on therapeutic targets. vol 18. issue 3. 2014-10-06. PMID:24387228. |
microtubule-associated protein tau as a therapeutic target in alzheimer's disease. |
2014-10-06 |
2023-08-12 |
Not clear |
| Ilie-Cosmin Stancu, Laurence Ris, Bruno Vasconcelos, Claudia Marinangeli, Léonie Goeminne, Vincent Laporte, Laetitia E Haylani, Julien Couturier, Olivier Schakman, Philippe Gailly, Nathalie Pierrot, Pascal Kienlen-Campard, Jean-Noël Octave, Ilse Dewachte. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 6. 2014-10-06. PMID:24604080. |
tau alterations are now considered an executor of neuronal demise and cognitive dysfunction in alzheimer's disease (ad). |
2014-10-06 |
2023-08-12 |
mouse |