| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheryl A Hawkes, Roxana O Carare, Roy O Welle. Amyloid and tau in the brain in sporadic Alzheimer's disease: defining the chicken and the egg. Acta neuropathologica. vol 127. issue 4. 2014-11-04. PMID:24452628. |
amyloid and tau in the brain in sporadic alzheimer's disease: defining the chicken and the egg. |
2014-11-04 |
2023-08-12 |
chicken |
| Ludovic Collin, Bernd Bohrmann, Ulrich Göpfert, Krisztina Oroszlan-Szovik, Laurence Ozmen, Fiona Grüninge. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 137. issue Pt 10. 2014-11-04. PMID:25085375. |
neuronal uptake of tau/ps422 antibody and reduced progression of tau pathology in a mouse model of alzheimer's disease. |
2014-11-04 |
2023-08-13 |
mouse |
| Ludovic Collin, Bernd Bohrmann, Ulrich Göpfert, Krisztina Oroszlan-Szovik, Laurence Ozmen, Fiona Grüninge. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 137. issue Pt 10. 2014-11-04. PMID:25085375. |
the severity of tau pathology in alzheimer's disease brain correlates closely with disease progression. |
2014-11-04 |
2023-08-13 |
mouse |
| Ludovic Collin, Bernd Bohrmann, Ulrich Göpfert, Krisztina Oroszlan-Szovik, Laurence Ozmen, Fiona Grüninge. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 137. issue Pt 10. 2014-11-04. PMID:25085375. |
tau immunotherapy has therefore been proposed as a new therapeutic approach to alzheimer's disease and encouraging results have been obtained by active or passive immunization of tau transgenic mice. |
2014-11-04 |
2023-08-13 |
mouse |
| Ludovic Collin, Bernd Bohrmann, Ulrich Göpfert, Krisztina Oroszlan-Szovik, Laurence Ozmen, Fiona Grüninge. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 137. issue Pt 10. 2014-11-04. PMID:25085375. |
we demonstrate the development of alzheimer's disease-like tau pathology in a triple transgenic mouse model of alzheimer's disease and show that tau/ps422 is present in membrane microdomains on the neuronal cell surface. |
2014-11-04 |
2023-08-13 |
mouse |
| Virginia Meyer, Paul D Dinkel, Emily Rickman Hager, Martin Margitta. Amplification of Tau fibrils from minute quantities of seeds. Biochemistry. vol 53. issue 36. 2014-11-03. PMID:25153692. |
the propagation of tau pathology in alzheimer's disease (ad) is thought to proceed through templated conversion of tau protein into fibrils and cell-to-cell transfer of elongation-competent seeds. |
2014-11-03 |
2023-08-13 |
Not clear |
| Patrick S Murray, Caitlin M Kirkwood, Megan C Gray, Kenneth N Fish, Milos D Ikonomovic, Ronald L Hamilton, Julia K Kofler, William E Klunk, Oscar L Lopez, Robert A Swee. Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis. Journal of Alzheimer's disease : JAD. vol 39. issue 4. 2014-10-30. PMID:24270207. |
hyperphosphorylated tau is elevated in alzheimer's disease with psychosis. |
2014-10-30 |
2023-08-12 |
human |
| Pamela Salcedo-Tello, Karina Hernández-Ortega, Clorinda Aria. Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after Wnt signaling inhibition. Journal of Alzheimer's disease : JAD. vol 39. issue 4. 2014-10-30. PMID:24270208. |
the abnormal phosphorylation of the microtubule-associated protein tau is a prominent aspect of alzheimer's disease (ad). |
2014-10-30 |
2023-08-12 |
rat |
| Atsushi Iwata, Kenichi Nagata, Hiroyuki Hatsuta, Hiroshi Takuma, Miki Bundo, Kazuya Iwamoto, Akira Tamaoka, Shigeo Murayama, Takaomi Saido, Shoji Tsuj. Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation. Human molecular genetics. vol 23. issue 3. 2014-10-28. PMID:24101602. |
the hallmark of alzheimer's disease (ad) pathology is an accumulation of amyloid β (aβ) and phosphorylated tau, which are encoded by the amyloid precursor protein (app) and microtubule-associated protein tau (mapt) genes, respectively. |
2014-10-28 |
2023-08-12 |
Not clear |
| J Chapuis, F Hansmannel, M Gistelinck, A Mounier, C Van Cauwenberghe, K V Kolen, F Geller, Y Sottejeau, D Harold, P Dourlen, B Grenier-Boley, Y Kamatani, B Delepine, F Demiautte, D Zelenika, N Zommer, M Hamdane, C Bellenguez, J-F Dartigues, J-J Hauw, F Letronne, A-M Ayral, K Sleegers, A Schellens, L V Broeck, S Engelborghs, P P De Deyn, R Vandenberghe, M O'Donovan, M Owen, J Epelbaum, M Mercken, E Karran, M Bantscheff, G Drewes, G Joberty, D Campion, J-N Octave, C Berr, M Lathrop, P Callaerts, D Mann, J Williams, L Buée, I Dewachter, C Van Broeckhoven, P Amouyel, D Moechars, B Dermaut, J-C Lamber. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Molecular psychiatry. vol 18. issue 11. 2014-10-27. PMID:23399914. |
increased expression of bin1 mediates alzheimer genetic risk by modulating tau pathology. |
2014-10-27 |
2023-08-12 |
mouse |
| Ying-Tsen Tung, Bo-Jeng Wang, Wen-Ming Hsu, Ming-Kuan Hu, Guor Mour Her, Wei-Pang Huang, Yung-Feng Lia. Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23794287. |
mutations in presenilin-1 (ps1) are tightly associated with early-onset familial alzheimer's disease (fad), which is characterized by extracellular amyloid plaques and the accumulation of intracellular tau. |
2014-10-27 |
2023-08-12 |
Not clear |
| Caoyi Chen, Nana Jin, Wei Qian, Wen Liu, Xiangling Tan, Fei Ding, Xiaosong Gu, Khalid Iqbal, Cheng-Xin Gong, Ji Zuo, Fei Li. Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:24037441. |
in alzheimer's brain, down-regulation of the pka pathway could lead to dysregulation of tau exon 10, contributing to tau pathogenesis. |
2014-10-27 |
2023-08-12 |
human |
| Smita R Paranjape, Yi-Ming Chiang, James F Sanchez, Ruth Entwistle, Clay C C Wang, Berl R Oakley, T Chris Gambli. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta medica. vol 80. issue 1. 2014-10-27. PMID:24414310. |
the aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including alzheimer's disease. |
2014-10-27 |
2023-08-12 |
Not clear |
| Smita R Paranjape, Yi-Ming Chiang, James F Sanchez, Ruth Entwistle, Clay C C Wang, Berl R Oakley, T Chris Gambli. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta medica. vol 80. issue 1. 2014-10-27. PMID:24414310. |
together, our data demonstrates the potential of 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde as lead compounds for further development as therapeutics to inhibit tau aggregation in alzheimer's disease and neurodegenerative tauopathies. |
2014-10-27 |
2023-08-12 |
Not clear |
| Jiayi Zhou, Bingqian Li. Alzheimer's disease and prion protein. Intractable & rare diseases research. vol 2. issue 2. 2014-10-24. PMID:25343100. |
alzheimer's disease (ad) is a devastating neurodegenerative disease with progressive loss of memory and cognitive function, pathologically hallmarked by aggregates of the amyloid-beta (aβ) peptide and hyperphosphorylated tau in the brain. |
2014-10-24 |
2023-08-13 |
Not clear |
| Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogu. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551051. |
the misfolding of intrinsically disordered proteins such as α-synuclein, tau and the aβ peptide has been associated with many highly debilitating neurodegenerative syndromes including parkinson's and alzheimer's diseases. |
2014-10-21 |
2023-08-12 |
Not clear |
| B M Kim, M-H You, C-H Chen, S Lee, Y Hong, Y Hong, A Kimchi, X Z Zhou, T H Le. Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function. Cell death & disease. vol 5. 2014-10-21. PMID:24853415. |
the presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of alzheimer's disease (ad). |
2014-10-21 |
2023-08-13 |
mouse |
| Mariet Allen, Michaela Kachadoorian, Zachary Quicksall, Fanggeng Zou, High Seng Chai, Curtis Younkin, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Siddharth Krishnan, Thuy Nguyen, Li Ma, Kimberly Malphrus, Sarah Lincoln, Gina Bisceglio, Christopher P Kolbert, Jin Jen, Shubhabrata Mukherjee, John K Kauwe, Paul K Crane, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Joseph E Parisi, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Tane. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels. Alzheimer's research & therapy. vol 6. issue 4. 2014-10-17. PMID:25324900. |
mapt encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of alzheimer's disease (ad). |
2014-10-17 |
2023-08-13 |
Not clear |
| Xi Li, Ming Li, Yuan Li, Qiankun Quan, Juan Wan. Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317137. |
these results suggest that ginsenoside rg1 upregulates brain-derived neurotrophic factor expression and inhibits tau protein phosphorylation in brain slices from a rat model of alzheimer's disease. |
2014-10-15 |
2023-08-13 |
rat |
| John F Castro-Alvarez, S Alejandro Uribe-Arias, Kenneth S Kosik, Gloria P Cardona-Góme. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Frontiers in aging neuroscience. vol 6. 2014-10-13. PMID:25309427. |
long- and short-term cdk5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic alzheimer's mice. |
2014-10-13 |
2023-08-13 |
mouse |