All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Aidong Yuan, Asok Kumar, Takahiro Sasaki, Karen Duff, Ralph A Nixo. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948900. microtubule-based axonal transport is believed to become globally disrupted in alzheimer's disease in part due to alterations of tau expression or phosphorylation. 2014-06-27 2023-08-12 mouse
Cindy Beharry, Maria Eugenia Alaniz, Alejandra Del Carmen Alons. Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948901. a key characteristic of alzheimer's disease and other tauopathies is the progressive accumulation of neurofibrillary tangles mainly composed of hyperphosphorylated tau protein. 2014-06-27 2023-08-12 human
Wei Qian, Nana Jin, Jianhua Shi, Xiaomin Yin, Xiaoxia Jin, Shibao Wang, Maohong Cao, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948904. microtubule-associated protein tau is found to be accumulated and aggregated in the brains of individuals with alzheimer's disease and related tauopathies. 2014-06-27 2023-08-12 mouse
Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Yifan Fu, Kristina R Patterson, Lester I Binde. TOC1: characterization of a selective oligomeric tau antibody. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23979027. the work presented herein addresses a specific portion of the tau pathology, pre-fibrillar oligomers, now thought to be important pathological components in alzheimer's disease and other neurodegenerative tauopathies. 2014-06-27 2023-08-12 Not clear
Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Yifan Fu, Kristina R Patterson, Lester I Binde. TOC1: characterization of a selective oligomeric tau antibody. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23979027. toc1 recognizes tau oligomers and its immunoreactivity is elevated in alzheimer's disease brains. 2014-06-27 2023-08-12 Not clear
Cheng-Xin Gong, Alejandra del Carmen Alons. Tau and beyond for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:24064504. tau and beyond for alzheimer's disease. 2014-06-27 2023-08-12 Not clear
Yang Lu, Hai-Jin He, Jun Zhou, Jun-Ye Miao, Jing Lu, Ying-Ge He, Rong Pan, Yan Wei, Ying Liu, Rong-Qiao H. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:24064506. hyperphosphorylation of tau occurs in preclinical and clinical stages of alzheimer's disease (ad), and hyperphosphorylated tau is the main constituent of the paired helical filaments in the brains of mild cognitive impairment and ad patients. 2014-06-27 2023-08-12 Not clear
Micaela Glat, Hadas Skaat, Noa Menkes-Caspi, Shlomo Margel, Edward A Ster. Age-dependent effects of microglial inhibition in vivo on Alzheimer's disease neuropathology using bioactive-conjugated iron oxide nanoparticles. Journal of nanobiotechnology. vol 11. 2014-06-26. PMID:24059692. tau dysfunction is believed to be the primary cause of neurodegenerative disorders referred to as tauopathies, including alzheimer's disease, pick's disease, frontotemporal dementia and parkinsonism. 2014-06-26 2023-08-12 mouse
Fernando Goñi, Krystal Herline, Daniel Peyser, Kinlung Wong, Yong Ji, Yanjie Sun, Pankaj Mehta, Thomas Wisniewsk. Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24330773. immunomodulation targeting of both aβ and tau pathological conformers ameliorates alzheimer's disease pathology in tgswdi and 3xtg mouse models. 2014-06-25 2023-08-12 mouse
Adrianne S Chesser, Susanne M Pritchard, Gail V W Johnso. Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24027553. tau clearance mechanisms and their possible role in the pathogenesis of alzheimer disease. 2014-06-24 2023-08-12 Not clear
Adrianne S Chesser, Susanne M Pritchard, Gail V W Johnso. Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24027553. one of the defining pathological features of alzheimer disease (ad) is the intraneuronal accumulation of tau. 2014-06-24 2023-08-12 Not clear
Leonardo Guzmán-Martinez, Gonzalo A Farías, Ricardo Benjamin Maccion. Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs. Frontiers in neurology. vol 4. 2014-06-24. PMID:24191153. tau oligomers as potential targets for alzheimer's diagnosis and novel drugs. 2014-06-24 2023-08-12 Not clear
Thor D Stein, Victor E Alvarez, Ann C McKe. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimer's research & therapy. vol 6. issue 1. 2014-06-24. PMID:24423082. the pathology of cte is characterized by the accumulation of phosphorylated tau protein in neurons and astrocytes in a pattern that is unique from other tauopathies, including alzheimer's disease. 2014-06-24 2023-08-12 Not clear
Ester Aso, Isidre Ferre. Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24634659. several findings indicate that the activation of both cb1 and cb2 receptors by natural or synthetic agonists, at non-psychoactive doses, have beneficial effects in alzheimer experimental models by reducing the harmful β-amyloid peptide action and tau phosphorylation, as well as by promoting the brain's intrinsic repair mechanisms. 2014-06-24 2023-08-12 Not clear
Shana Elbaum-Garfinkle, Garrett Cobb, Jocelyn T Compton, Xiao-Han Li, Elizabeth Rhoade. Tau mutants bind tubulin heterodimers with enhanced affinity. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 17. 2014-06-24. PMID:24733915. tau is a microtubule binding protein that forms pathological aggregates in the brain in alzheimer's disease and other tauopathies. 2014-06-24 2023-08-13 Not clear
Miguel Medina, Jesús Avil. The role of extracellular Tau in the spreading of neurofibrillary pathology. Frontiers in cellular neuroscience. vol 8. 2014-06-24. PMID:24795568. the microtubule-associated protein (map) tau plays a critical role in the pathogenesis of alzheimer's disease (ad) and several related disorders collectively known as tauopathies. 2014-06-24 2023-08-13 Not clear
Michael S Wolf. Targeting mRNA for Alzheimer's and related dementias. Scientifica. vol 2014. 2014-06-24. PMID:24876993. brain deposition of the amyloid beta-protein (a β ) and tau are characteristic features in alzheimer's disease (ad). 2014-06-24 2023-08-13 Not clear
Yangang Wang, Weiping Liu, Xiaosheng He, Fei Zho. Parkinson's disease-associated DJ-1 mutations increase abnormal phosphorylation of tau protein through Akt/GSK-3β pathways. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23979838. hyperphosphorylated tau protein is the main component of neurofibrillary tangles found in alzheimer's disease and parkinson's disease (pd). 2014-06-23 2023-08-12 Not clear
Chun-Fang Xia, Janna Arteaga, Gang Chen, Umesh Gangadharmath, Luis F Gomez, Dhanalakshmi Kasi, Chung Lam, Qianwa Liang, Changhui Liu, Vani P Mocharla, Fanrong Mu, Anjana Sinha, Helen Su, A Katrin Szardenings, Joseph C Walsh, Eric Wang, Chul Yu, Wei Zhang, Tieming Zhao, Hartmuth C Kol. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 6. 2014-06-20. PMID:23411393. [(18)f]t807, a novel tau positron emission tomography imaging agent for alzheimer's disease. 2014-06-20 2023-08-12 human
Ryszard Pluta, Mirosław Jabłoński, Marzena Ułamek-Kozioł, Janusz Kocki, Judyta Brzozowska, Sławomir Januszewski, Wanda Furmaga-Jabłońska, Anna Bogucka-Kocka, Ryszard Maciejewski, Stanisław J Czuczwa. Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23519520. recent evidence suggests that the pathophysiology and neuropathology of alzheimer's disease comprises more than amyloid accumulation, tau protein pathology and finally brain atrophy with dementia. 2014-06-18 2023-08-12 Not clear