All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Heiko Braak, Henrik Zetterberg, Kelly Del Tredici, Kaj Blenno. Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta neuropathologica. vol 126. issue 5. 2014-06-02. PMID:23756600. in comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of alzheimer's disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebrospinal fluid are detectable only with the onset and progression of clinical symptoms. 2014-06-02 2023-08-12 Not clear
Jon B Toledo, Ane Korff, Leslie M Shaw, John Q Trojanowski, Jing Zhan. CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease. Acta neuropathologica. vol 126. issue 5. 2014-06-02. PMID:23812319. csf α-synuclein improves diagnostic and prognostic performance of csf tau and aβ in alzheimer's disease. 2014-06-02 2023-08-12 human
Jon B Toledo, Ane Korff, Leslie M Shaw, John Q Trojanowski, Jing Zhan. CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease. Acta neuropathologica. vol 126. issue 5. 2014-06-02. PMID:23812319. in this investigation, we report the assessment of α-synuclein (α-syn) in cerebrospinal fluid (csf) and its association with csf total tau (t-tau), phosphorylated tau181 (p-tau181), and amyloid beta1-42 (aβ1-42) in subjects of the alzheimer's disease neuroimaging initiative (adni; n = 389), with longitudinal clinical assessments. 2014-06-02 2023-08-12 human
Jon B Toledo, Sharon X Xie, John Q Trojanowski, Leslie M Sha. Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI. Acta neuropathologica. vol 126. issue 5. 2014-06-02. PMID:23812320. the dynamics of cerebrospinal fluid (csf) tau and aβ biomarkers over time in alzheimer's disease (ad) patients from prodromal pre-symptomatic to severe stages of dementia have not been clearly defined and recent studies, most of which are cross-sectional, present conflicting findings. 2014-06-02 2023-08-12 human
Magali Dumont, Cliona Stack, Ceyhan Elipenahli, Shari Jainuddin, Nathalie Launay, Meri Gerges, Natalia Starkova, Anatoly A Starkov, Noel Y Calingasan, Davide Tampellini, Aurora Pujol, M Flint Bea. PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 4. 2014-06-02. PMID:24398293. pgc-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of alzheimer's disease. 2014-06-02 2023-08-12 mouse
Becky C Carlyle, Angus C Nairn, Min Wang, Yang Yang, Lu E Jin, Arthur A Simen, Brian P Ramos, Kelly A Bordner, George E Craft, Peter Davies, Mihovil Pletikos, Nenad Šestan, Amy F T Arnsten, Constantinos D Paspala. cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 13. 2014-06-02. PMID:24707050. the pattern of neurodegeneration in alzheimer's disease (ad) is very distinctive: neurofibrillary tangles (nfts) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. 2014-06-02 2023-08-13 mouse
Vanessa A Guzman, Owen T Carmichael, Christopher Schwarz, Giuseppe Tosto, Molly E Zimmerman, Adam M Brickma. White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 5 Suppl. 2014-05-28. PMID:23375566. current hypothetical models of alzheimer's disease (ad) pathogenesis emphasize the role of β-amyloid (aβ), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. 2014-05-28 2023-08-12 Not clear
Valeriy Duka, Jae-Hoon Lee, Joel Credle, Jonathan Wills, Adam Oaks, Ciaran Smolinsky, Ketul Shah, Deborah C Mash, Eliezer Masliah, Anita Sidh. Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. PloS one. vol 8. issue 9. 2014-05-27. PMID:24073234. identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and alzheimer's diseases. 2014-05-27 2023-08-12 Not clear
Valeriy Duka, Jae-Hoon Lee, Joel Credle, Jonathan Wills, Adam Oaks, Ciaran Smolinsky, Ketul Shah, Deborah C Mash, Eliezer Masliah, Anita Sidh. Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. PloS one. vol 8. issue 9. 2014-05-27. PMID:24073234. we examined for the first time epitopes at which tau is hyperphosphorylated in parkinson's disease, dementia with lewy bodies and alzheimer's disease, and also select tau kinases. 2014-05-27 2023-08-12 Not clear
Di Xia, Jürgen Göt. Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Frontiers in molecular neuroscience. vol 7. 2014-05-26. PMID:24860422. the kinase fyn, the microtubule-associated protein tau and the peptide amyloid-β (aβ) constitute a toxic triad in alzheimer's disease (ad). 2014-05-26 2023-08-13 mouse
Andréia M Pazini, Guilherme M Gomes, Jardel G Villarinho, Claudio da Cunha, Francielle Pinheiro, Ana P O Ferreira, Carlos F Mello, Juliano Ferreira, Maribel A Rubi. Selegiline reverses aβ₂₅₋₃₅-induced cognitive deficit in male mice. Neurochemical research. vol 38. issue 11. 2014-05-21. PMID:24005822. alzheimer's disease (ad) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related to the pathological hallmarks senile plaques and neurofibrillary tangles. 2014-05-21 2023-08-12 mouse
Henrik Zetterberg, David Wilson, Ulf Andreasson, Lennart Minthon, Kaj Blennow, Jeffrey Randall, Oskar Hansso. Plasma tau levels in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 2. 2014-05-20. PMID:23551972. plasma tau levels in alzheimer's disease. 2014-05-20 2023-08-12 Not clear
Michelle T Fodero-Tavoletti, Shozo Furumoto, Leanne Taylor, Catriona A McLean, Rachel S Mulligan, Ian Birchall, Ryuichi Harada, Colin L Masters, Kazuhiko Yanai, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura, Victor L Villemagn. Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies. Alzheimer's research & therapy. vol 6. issue 1. 2014-05-20. PMID:24572336. assessing thk523 selectivity for tau deposits in alzheimer's disease and non-alzheimer's disease tauopathies. 2014-05-20 2023-08-12 Not clear
Michelle T Fodero-Tavoletti, Shozo Furumoto, Leanne Taylor, Catriona A McLean, Rachel S Mulligan, Ian Birchall, Ryuichi Harada, Colin L Masters, Kazuhiko Yanai, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura, Victor L Villemagn. Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies. Alzheimer's research & therapy. vol 6. issue 1. 2014-05-20. PMID:24572336. the introduction of tau imaging agents such as (18)f-thk523 offers new hope for the in vivo assessment of tau deposition in tauopathies such as alzheimer's disease (ad), where preliminary (18)f-thk523-pet studies have demonstrated significantly higher cortical retention of (18)f-thk523 in ad compared to age-matched healthy individuals. 2014-05-20 2023-08-12 Not clear
Claude M Wischik, Charles R Harrington, John M D Store. Tau-aggregation inhibitor therapy for Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24361915. the alzheimer neurofibrillary tangle is composed of tau and the core of its constituent filaments are made of a truncated fragment from the repeat domain of tau. 2014-05-19 2023-08-12 Not clear
Miguel Medina, Jesús Avil. New perspectives on the role of tau in Alzheimer's disease. Implications for therapy. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24462919. new perspectives on the role of tau in alzheimer's disease. 2014-05-19 2023-08-12 Not clear
M J Hannula, T T Myöhänen, J Tenorio-Laranga, P T Männistö, J A Garcia-Horsma. Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases. Neuroscience. vol 242. 2014-05-16. PMID:23562579. prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with parkinson's and alzheimer's diseases. 2014-05-16 2023-08-12 human
M J Hannula, T T Myöhänen, J Tenorio-Laranga, P T Männistö, J A Garcia-Horsma. Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases. Neuroscience. vol 242. 2014-05-16. PMID:23562579. to clarify the possible interaction of prep with other markers of neurodegenerative diseases, we studied colocalizations of prep and (1) α-syn, (2) β-amyloid, (3) tau protein and (4) astroglial and microglial cells in human post-mortem brain samples from pd, alzheimer's disease (ad) patients and in healthy control brain samples. 2014-05-16 2023-08-12 human
Sachin P Patil, Nhung Tran, Hirosha Geekiyanage, Li Liu, Christina Cha. Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons. Neuroscience letters. vol 554. 2014-05-16. PMID:24035895. alzheimer's disease (ad) is a progressive, neurodegenerative disease characterized by extracellular deposits of amyloid beta (aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. 2014-05-16 2023-08-12 human
Bess Frost, Martin Hemberg, Jada Lewis, Mel B Fean. Tau promotes neurodegeneration through global chromatin relaxation. Nature neuroscience. vol 17. issue 3. 2014-05-16. PMID:24464041. the microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including alzheimer's disease. 2014-05-16 2023-08-12 mouse