| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amina Kamah, Isabelle Huvent, François-Xavier Cantrelle, Haoling Qi, Guy Lippens, Isabelle Landrieu, Caroline Smet-Nocc. Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein. Biochemistry. vol 53. issue 18. 2014-07-06. PMID:24708343. |
lysine acetylation of the neuronal tau protein was described as a novel mechanism of posttranslational regulation of tau functions with important outcomes in microtubule binding and aggregation processes related to alzheimer's disease. |
2014-07-06 |
2023-08-13 |
Not clear |
| E Orta-Salazar, A Feria-Velasco, G I Medina-Aguirre, S Díaz-Cintr. [Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease]. Neurologia (Barcelona, Spain). vol 28. issue 8. 2014-07-02. PMID:23972735. |
different animal models for alzheimer disease (ad) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with aβ and tau deposition in these models is similar to that in the human brain. |
2014-07-02 |
2023-08-12 |
mouse |
| Mauricio O Nava-Mesa, Lydia Jiménez-Díaz, Javier Yajeya, Juan D Navarro-Lope. GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease. Frontiers in cellular neuroscience. vol 8. 2014-07-02. PMID:24987334. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two pathological lesions: extracellular amyloid plaques, composed largely of amyloid-beta peptide (aβ), and neurofibrillary tangles formed by intracellular aggregates of hyperphosphorylated tau protein. |
2014-07-02 |
2023-08-13 |
Not clear |
| Yao Zhang, Rong-Hong Ma, Xia-Chun Li, Jia-Yu Zhang, Hai-Rong Shi, Wei Wei, Dan-Ju Luo, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Frontiers in aging neuroscience. vol 6. 2014-07-02. PMID:24987368. |
increase of inhibitor-2 of protein phosphatase-2a [formula: see text] is associated with protein phosphatase-2a (pp2a) inhibition and tau hyperphosphorylation in alzheimer's disease (ad). |
2014-07-02 |
2023-08-13 |
mouse |
| Marta Dobarro, Gorka Gerenu, María J Ramíre. Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23768694. |
propranolol reduces cognitive deficits, amyloid and tau pathology in alzheimer's transgenic mice. |
2014-07-01 |
2023-08-12 |
mouse |
| Chang Liu, Jürgen Göt. How it all started: tau and protein phosphatase 2A. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948891. |
this review is dedicated to inge grundke-iqbal who laid the foundations of the tau field, by isolating tau from the alzheimer's disease (ad) brain, discovering that tau is hyperphosphorylated, and proving a critical role of protein phosphatase 2a (pp2a) and its endogenous inhibitor i2pp2a in this process. |
2014-06-27 |
2023-08-12 |
Not clear |
| Félix Hernández, Esther García-García, Jesús Avil. Microtubule depolymerization and tau phosphorylation. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948896. |
inge grundke-iqbal and khalid iqbal found a connection between microtubule associated tau and alzheimer's disease. |
2014-06-27 |
2023-08-12 |
human |
| Félix Hernández, Esther García-García, Jesús Avil. Microtubule depolymerization and tau phosphorylation. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948896. |
these findings suggest that microtubule depolymerization can be a primary event in neurodegenerative disorders like alzheimer's disease and that tau phosphorylation takes place afterwards. |
2014-06-27 |
2023-08-12 |
human |
| Aidong Yuan, Asok Kumar, Takahiro Sasaki, Karen Duff, Ralph A Nixo. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948900. |
microtubule-based axonal transport is believed to become globally disrupted in alzheimer's disease in part due to alterations of tau expression or phosphorylation. |
2014-06-27 |
2023-08-12 |
mouse |
| Cindy Beharry, Maria Eugenia Alaniz, Alejandra Del Carmen Alons. Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948901. |
a key characteristic of alzheimer's disease and other tauopathies is the progressive accumulation of neurofibrillary tangles mainly composed of hyperphosphorylated tau protein. |
2014-06-27 |
2023-08-12 |
human |
| Wei Qian, Nana Jin, Jianhua Shi, Xiaomin Yin, Xiaoxia Jin, Shibao Wang, Maohong Cao, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948904. |
microtubule-associated protein tau is found to be accumulated and aggregated in the brains of individuals with alzheimer's disease and related tauopathies. |
2014-06-27 |
2023-08-12 |
mouse |
| Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Yifan Fu, Kristina R Patterson, Lester I Binde. TOC1: characterization of a selective oligomeric tau antibody. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23979027. |
the work presented herein addresses a specific portion of the tau pathology, pre-fibrillar oligomers, now thought to be important pathological components in alzheimer's disease and other neurodegenerative tauopathies. |
2014-06-27 |
2023-08-12 |
Not clear |
| Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Yifan Fu, Kristina R Patterson, Lester I Binde. TOC1: characterization of a selective oligomeric tau antibody. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23979027. |
toc1 recognizes tau oligomers and its immunoreactivity is elevated in alzheimer's disease brains. |
2014-06-27 |
2023-08-12 |
Not clear |
| Cheng-Xin Gong, Alejandra del Carmen Alons. Tau and beyond for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:24064504. |
tau and beyond for alzheimer's disease. |
2014-06-27 |
2023-08-12 |
Not clear |
| Yang Lu, Hai-Jin He, Jun Zhou, Jun-Ye Miao, Jing Lu, Ying-Ge He, Rong Pan, Yan Wei, Ying Liu, Rong-Qiao H. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:24064506. |
hyperphosphorylation of tau occurs in preclinical and clinical stages of alzheimer's disease (ad), and hyperphosphorylated tau is the main constituent of the paired helical filaments in the brains of mild cognitive impairment and ad patients. |
2014-06-27 |
2023-08-12 |
Not clear |
| Micaela Glat, Hadas Skaat, Noa Menkes-Caspi, Shlomo Margel, Edward A Ster. Age-dependent effects of microglial inhibition in vivo on Alzheimer's disease neuropathology using bioactive-conjugated iron oxide nanoparticles. Journal of nanobiotechnology. vol 11. 2014-06-26. PMID:24059692. |
tau dysfunction is believed to be the primary cause of neurodegenerative disorders referred to as tauopathies, including alzheimer's disease, pick's disease, frontotemporal dementia and parkinsonism. |
2014-06-26 |
2023-08-12 |
mouse |
| Fernando Goñi, Krystal Herline, Daniel Peyser, Kinlung Wong, Yong Ji, Yanjie Sun, Pankaj Mehta, Thomas Wisniewsk. Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24330773. |
immunomodulation targeting of both aβ and tau pathological conformers ameliorates alzheimer's disease pathology in tgswdi and 3xtg mouse models. |
2014-06-25 |
2023-08-12 |
mouse |
| Adrianne S Chesser, Susanne M Pritchard, Gail V W Johnso. Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24027553. |
tau clearance mechanisms and their possible role in the pathogenesis of alzheimer disease. |
2014-06-24 |
2023-08-12 |
Not clear |
| Adrianne S Chesser, Susanne M Pritchard, Gail V W Johnso. Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24027553. |
one of the defining pathological features of alzheimer disease (ad) is the intraneuronal accumulation of tau. |
2014-06-24 |
2023-08-12 |
Not clear |
| Leonardo Guzmán-Martinez, Gonzalo A Farías, Ricardo Benjamin Maccion. Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs. Frontiers in neurology. vol 4. 2014-06-24. PMID:24191153. |
tau oligomers as potential targets for alzheimer's diagnosis and novel drugs. |
2014-06-24 |
2023-08-12 |
Not clear |