| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuko Kitagishi, Atsuko Nakanishi, Yasunori Ogura, Satoru Matsud. Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease. Alzheimer's research & therapy. vol 6. issue 3. 2014-07-17. PMID:25031641. |
alzheimer's disease (ad) is characterized by the formation of senile plaques and neurofibrillary tangles composed of phosphorylated tau. |
2014-07-17 |
2023-08-13 |
Not clear |
| Lucie Stegurová, Eduarda Dráberová, Ales Bartos, Pavel Dráber, Daniela Rípová, Petr Drábe. Gold nanoparticle-based immuno-PCR for detection of tau protein in cerebrospinal fluid. Journal of immunological methods. vol 406. 2014-07-15. PMID:24642424. |
tau protein in cerebrospinal fluid (csf) is an important biomarker of alzheimer's disease and some other brain diseases. |
2014-07-15 |
2023-08-12 |
human |
| Ezio Giacobini, Gabriel Gol. Alzheimer disease therapy--moving from amyloid-β to tau. Nature reviews. Neurology. vol 9. issue 12. 2014-07-14. PMID:24217510. |
alzheimer disease therapy--moving from amyloid-β to tau. |
2014-07-14 |
2023-08-12 |
Not clear |
| Tara L Spires-Jones, Bradley T Hyma. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron. vol 82. issue 4. 2014-07-14. PMID:24853936. |
the intersection of amyloid beta and tau at synapses in alzheimer's disease. |
2014-07-14 |
2023-08-13 |
Not clear |
| Dong-Xiao Duan, Gao-Shang Chai, Zhong-Fei Ni, Yu Hu, Yu Luo, Xiang-Shu Cheng, Ning-Ning Chen, Jian-Zhi Wang, Gong-Ping Li. Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis. Journal of Alzheimer's disease : JAD. vol 37. issue 4. 2014-07-13. PMID:23948915. |
the intracellular accumulation of hyperphosphorylated tau plays a crucial role in neurodegeneration of alzheimer's disease (ad), but the mechanism is not fully understood. |
2014-07-13 |
2023-08-12 |
mouse |
| Yan-Si Xiong, Dan-Li Wang, Lu Tan, Xiong Wang, Li-Ming Chen, Cheng-Xin Gong, Jian-Zhi Wang, Ling-Qiang Zh. Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 down-regulation. CNS & neurological disorders drug targets. vol 12. issue 3. 2014-07-11. PMID:23469846. |
one of the neuropathological hallmarks of alzheimer's disease (ad) is the occurrence of neurofibrillary tangles (nfts) that are composed of abnormally hyperphosphorylated microtubule-associated protein tau. |
2014-07-11 |
2023-08-12 |
Not clear |
| Qiu-Lan Ma, Xiaohong Zuo, Fusheng Yang, Oliver J Ubeda, Dana J Gant, Mher Alaverdyan, Nicolae C Kiosea, Sean Nazari, Ping Ping Chen, Fatiha Nothias, Piu Chan, Edmond Teng, Sally A Frautschy, Greg M Col. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849348. |
hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood. |
2014-07-11 |
2023-08-13 |
mouse |
| Suzee E Lee, Maria C Tartaglia, Görsev Yener, Sermin Genç, William W Seeley, Pascual Sanchez-Juan, Fermin Moreno, Mario F Mendez, Eric Klein, Rosa Rademakers, Adolfo López de Munain, Onofre Combarros, Joel H Kramer, Robert O Kenet, Adam L Boxer, Michael D Geschwind, Maria-Luisa Gorno-Tempini, Anna M Karydas, Gil D Rabinovici, Giovanni Coppola, Daniel H Geschwind, Bruce L Mille. Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. Alzheimer disease and associated disorders. vol 27. issue 4. 2014-07-08. PMID:23518664. |
recently, coppola and colleagues demonstrated that a rare microtubule-associated protein tau (mapt) sequence variant, c.454g>a (p.a152t) significantly increases the risk of frontotemporal dementia (ftd) spectrum disorders and alzheimer disease (ad) in a screen of 15,369 subjects. |
2014-07-08 |
2023-08-12 |
human |
| Abhay P Sagare, Robert D Bell, Zhen Zhao, Qingyi Ma, Ethan A Winkler, Anita Ramanathan, Berislav V Zlokovi. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nature communications. vol 4. 2014-07-08. PMID:24336108. |
pericytes are cells in the blood-brain barrier that degenerate in alzheimer's disease (ad), a neurological disorder associated with neurovascular dysfunction, abnormal elevation of amyloid β-peptide (aβ), tau pathology and neuronal loss. |
2014-07-08 |
2023-08-12 |
mouse |
| Hiroki Inoue, Yuuki Hiradate, Yoshiki Shirakata, Kenta Kanai, Keita Kosaka, Aina Gotoh, Yasuhiro Fukuda, Yutaka Nakai, Takafumi Uchida, Eimei Sato, Kentaro Tanemur. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS letters. vol 588. issue 11. 2014-07-07. PMID:24768523. |
tau is one of the microtubule-associated proteins and a major component of paired helical filaments, a hallmark of alzheimer's disease. |
2014-07-07 |
2023-08-13 |
mouse |
| Amina Kamah, Isabelle Huvent, François-Xavier Cantrelle, Haoling Qi, Guy Lippens, Isabelle Landrieu, Caroline Smet-Nocc. Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein. Biochemistry. vol 53. issue 18. 2014-07-06. PMID:24708343. |
lysine acetylation of the neuronal tau protein was described as a novel mechanism of posttranslational regulation of tau functions with important outcomes in microtubule binding and aggregation processes related to alzheimer's disease. |
2014-07-06 |
2023-08-13 |
Not clear |
| E Orta-Salazar, A Feria-Velasco, G I Medina-Aguirre, S Díaz-Cintr. [Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease]. Neurologia (Barcelona, Spain). vol 28. issue 8. 2014-07-02. PMID:23972735. |
different animal models for alzheimer disease (ad) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with aβ and tau deposition in these models is similar to that in the human brain. |
2014-07-02 |
2023-08-12 |
mouse |
| Mauricio O Nava-Mesa, Lydia Jiménez-Díaz, Javier Yajeya, Juan D Navarro-Lope. GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease. Frontiers in cellular neuroscience. vol 8. 2014-07-02. PMID:24987334. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two pathological lesions: extracellular amyloid plaques, composed largely of amyloid-beta peptide (aβ), and neurofibrillary tangles formed by intracellular aggregates of hyperphosphorylated tau protein. |
2014-07-02 |
2023-08-13 |
Not clear |
| Yao Zhang, Rong-Hong Ma, Xia-Chun Li, Jia-Yu Zhang, Hai-Rong Shi, Wei Wei, Dan-Ju Luo, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Frontiers in aging neuroscience. vol 6. 2014-07-02. PMID:24987368. |
increase of inhibitor-2 of protein phosphatase-2a [formula: see text] is associated with protein phosphatase-2a (pp2a) inhibition and tau hyperphosphorylation in alzheimer's disease (ad). |
2014-07-02 |
2023-08-13 |
mouse |
| Marta Dobarro, Gorka Gerenu, María J Ramíre. Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23768694. |
propranolol reduces cognitive deficits, amyloid and tau pathology in alzheimer's transgenic mice. |
2014-07-01 |
2023-08-12 |
mouse |
| Chang Liu, Jürgen Göt. How it all started: tau and protein phosphatase 2A. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948891. |
this review is dedicated to inge grundke-iqbal who laid the foundations of the tau field, by isolating tau from the alzheimer's disease (ad) brain, discovering that tau is hyperphosphorylated, and proving a critical role of protein phosphatase 2a (pp2a) and its endogenous inhibitor i2pp2a in this process. |
2014-06-27 |
2023-08-12 |
Not clear |
| Félix Hernández, Esther García-García, Jesús Avil. Microtubule depolymerization and tau phosphorylation. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948896. |
inge grundke-iqbal and khalid iqbal found a connection between microtubule associated tau and alzheimer's disease. |
2014-06-27 |
2023-08-12 |
human |
| Félix Hernández, Esther García-García, Jesús Avil. Microtubule depolymerization and tau phosphorylation. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948896. |
these findings suggest that microtubule depolymerization can be a primary event in neurodegenerative disorders like alzheimer's disease and that tau phosphorylation takes place afterwards. |
2014-06-27 |
2023-08-12 |
human |
| Aidong Yuan, Asok Kumar, Takahiro Sasaki, Karen Duff, Ralph A Nixo. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948900. |
microtubule-based axonal transport is believed to become globally disrupted in alzheimer's disease in part due to alterations of tau expression or phosphorylation. |
2014-06-27 |
2023-08-12 |
mouse |
| Cindy Beharry, Maria Eugenia Alaniz, Alejandra Del Carmen Alons. Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948901. |
a key characteristic of alzheimer's disease and other tauopathies is the progressive accumulation of neurofibrillary tangles mainly composed of hyperphosphorylated tau protein. |
2014-06-27 |
2023-08-12 |
human |