| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nirosen Vijiaratnam, Thomas Foltyni. How should we be using biomarkers in trials of disease modification in Parkinson's disease? Brain : a journal of neurology. 2023-08-03. PMID:37536279. |
for example; levels of cerebrospinal fluid proteins such as the lysosomal enzyme ß-glucocerebrosidase may assist in prognostication or allow enrichment of appropriate patients into disease modifying trials of agents with this enzyme as the target; the presence of coexisting alzheimer disease like pathology (detectable through cerebrospinal fluid levels of amyloid beta-42 and tau) can predict subsequent cognitive decline; imaging techniques such as free-water or neuromelanin mri may objectively track decline of parkinson's disease even in its later stages. |
2023-08-03 |
2023-08-14 |
Not clear |
| A fluid biomarker accurately detects tau aggregate pathology in Alzheimer's disease. Nature medicine. 2023-08-02. PMID:37532913. |
a fluid biomarker accurately detects tau aggregate pathology in alzheimer's disease. |
2023-08-02 |
2023-08-14 |
Not clear |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Ashini Singh, Niraj Kumar Sing. Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review. Current pharmaceutical biotechnology. 2023-08-01. PMID:37526460. |
alzheimer's disease (ad), one of the most common neurodegenerative disorders is hallmarked by cognitive impairment, amyloid-β (aβ) deposition, hyperphosphorylation of tau protein, cholinergic dysfunction, mitochondrial toxicity, and neurodegeneration. |
2023-08-01 |
2023-08-14 |
Not clear |
| Peng Chen, ZhiLei Guo, Benhong Zho. Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies. Journal of integrative neuroscience. vol 22. issue 4. 2023-07-31. PMID:37519162. |
considering the vulnerability of oligodendrocytes to alzheimer's disease, the myelin sheath breakdown and degeneration are easily induced, suggesting that dysfunction of the oligodendrocytes could be the first step in the progression at the early ad before the occurrence of amyloid and tau pathology. |
2023-07-31 |
2023-08-14 |
Not clear |
| André D G Leitão, Brian Spencer, Floyd Sarsoza, Jennifer Ngolab, Jessica Amalraj, Eliezer Masliah, Chengbiao Wu, Robert A Rissma. Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice. Journal of Alzheimer's disease : JAD. 2023-07-31. PMID:37522208. |
alzheimer's disease (ad) cases are often characterized by the pathological accumulation of α-synuclein (α-syn) in addition to amyloid-β (aβ) and tau hallmarks. |
2023-07-31 |
2023-08-14 |
mouse |
| Enze Xu, Jingwen Zhang, Jiadi Li, Qianqian Song, Defu Yang, Guorong Wu, Minghan Che. Pathology steered stratification network for subtype identification in Alzheimer's disease. Medical physics. 2023-07-31. PMID:37522278. |
alzheimer's disease (ad) is a heterogeneous, multifactorial neurodegenerative disorder characterized by three neurobiological factors beta-amyloid, pathologic tau, and neurodegeneration. |
2023-07-31 |
2023-08-14 |
Not clear |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
current hypothesis of alzheimer's disease (ad) postulates that amyloid β (aβ) deposition in the brain causes tau inclusion in neurons and leads to cognitive decline. |
2023-07-31 |
2023-08-14 |
mouse |
| Víctor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega García-Escuder. Alzheimer's Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37507998. |
alzheimer's disease (ad) is the most common cause of dementia, characterised by a marked decline of both memory and cognition, along with pathophysiological hallmarks including amyloid beta peptide (aβ) accumulation, tau protein hyperphosphorylation, neuronal loss and inflammation in the brain. |
2023-07-29 |
2023-08-14 |
Not clear |
| George E Barret. Repurposing of Tibolone in Alzheimer's Disease. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509151. |
alzheimer's disease (ad) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sarah E Torraville, Cassandra M Flynn, Tori L Kendall, Qi Yua. Life Experience Matters: Enrichment and Stress Can Influence the Likelihood of Developing Alzheimer's Disease via Gut Microbiome. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509523. |
alzheimer's disease (ad) is a chronic neurodegenerative disease, characterized by the presence of β-amyloid (aβ) plaques and neurofibrillary tangles (nfts) formed from abnormally phosphorylated tau proteins (ptau). |
2023-07-29 |
2023-08-14 |
Not clear |
| Shojiro Ichimata, Ivan Martinez-Valbuena, Seojin Lee, Jun Li, Ali M Karakani, Gabor G Kovac. Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511361. |
distinct molecular signatures of amyloid-beta and tau in alzheimer's disease associated with down syndrome. |
2023-07-29 |
2023-08-14 |
Not clear |
| Shojiro Ichimata, Ivan Martinez-Valbuena, Seojin Lee, Jun Li, Ali M Karakani, Gabor G Kovac. Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511361. |
limited comparative data exist on the molecular spectrum of amyloid-beta (aβ) and tau deposition in individuals with down syndrome (ds) and sporadic alzheimer's disease (sad). |
2023-07-29 |
2023-08-14 |
Not clear |
| Nicholas J Ashton, Wagner S Brum, Guglielmo Di Molfetta, Andrea L Benedet, Burak Arslan, Erin Jonatis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterber. Diagnostic accuracy of the plasma ALZpath pTau217 immunoassay to identify Alzheimer's disease pathology. medRxiv : the preprint server for health sciences. 2023-07-28. PMID:37502842. |
phosphorylated tau (ptau) is a specific blood biomarker for alzheimer's disease (ad) pathology, with ptau217 considered to have the most utility. |
2023-07-28 |
2023-08-14 |
Not clear |
| Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medin. Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity decoder. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502947. |
revealing the combined roles of aβ and tau in alzheimer's disease via a pathophysiological activity decoder. |
2023-07-28 |
2023-08-14 |
human |
| Zhikai Zeng, Vishnu Vijayan, Karen Tsay, Matthew P Frost, Athena Quddus, Alexa Albert, Michael Vigers, Amanda L Woerman, Songi Ha. CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502998. |
the recent discovery by cryo-electron microscopy that the neuropatho-logical hallmarks of different tauopathies, including alzheimer's disease, corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), are caused by unique misfolded conformations of the protein tau is among the most profound developments in neurodegenerative disease research. |
2023-07-28 |
2023-08-14 |
Not clear |
| Gemma Salvadó, Kanta Horie, Nicolas R Barthélemy, Jacob W Vogel, Alexa Pichet Binette, Charles D Chen, Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Rik Ossenkoppele, Suzanne E Schindler, Randall J Bateman, Oskar Hansso. Novel CSF tau biomarkers can be used for disease staging of sporadic Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-07-28. PMID:37503281. |
novel csf tau biomarkers can be used for disease staging of sporadic alzheimer's disease. |
2023-07-28 |
2023-08-14 |
human |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
alzheimer's disease (ad) is characterized with senile plaques formed by aβ deposition, and neurofibrillary tangles composed of hyperphosphorylated tau protein, which ultimately lead to cognitive impairment. |
2023-07-28 |
2023-08-14 |
mouse |
| Ana María M Murillo, María Fe Laguna, Luis G Valle, Luca Tramarin, Yolanda Ramirez, Álvaro Lavín, Beatriz Santamaría, Miguel Holgad. A New Optical Interferometric Biosensing System Enhanced with Nanoparticles for Alzheimer's Disease in Serum. Biosensors. vol 13. issue 7. 2023-07-28. PMID:37504106. |
in this scientific work, we demonstrate, for the first time, a new biosensing system and procedure to measure specifically the total tau (t-tau) protein in serum, one of the most relevant biomarkers of alzheimer's disease (ad). |
2023-07-28 |
2023-08-14 |
Not clear |