| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jerome Mertens, Kathrin Stüber, Daniel Poppe, Jonas Doerr, Julia Ladewig, Oliver Brüstle, Philipp Koc. Embryonic stem cell-based modeling of tau pathology in human neurons. The American journal of pathology. vol 182. issue 5. 2014-03-25. PMID:23499461. |
alterations in the microtubule (mt)-associated protein, tau, have emerged as a pivotal phenomenon in several neurodegenerative disorders, including frontotemporal dementia and alzheimer's disease. |
2014-03-25 |
2023-08-12 |
human |
| Adem Zengin, Ugur Tamer, Tuncer Caykar. A SERS-based sandwich assay for ultrasensitive and selective detection of Alzheimer's tau protein. Biomacromolecules. vol 14. issue 9. 2014-03-25. PMID:23885927. |
a sers-based sandwich assay for ultrasensitive and selective detection of alzheimer's tau protein. |
2014-03-25 |
2023-08-12 |
cattle |
| Noura B El Khoury, Maud Gratuze, Marie-Amélie Papon, Alexis Bretteville, Emmanuel Plane. Insulin dysfunction and Tau pathology. Frontiers in cellular neuroscience. vol 8. 2014-03-25. PMID:24574966. |
the neuropathological hallmarks of alzheimer's disease (ad) include senile plaques of β-amyloid (aβ) peptides (a cleavage product of the amyloid precursor protein, or app) and neurofibrillary tangles (nft) of hyperphosphorylated tau protein assembled in paired helical filaments (phf). |
2014-03-25 |
2023-08-12 |
mouse |
| Ane Korff, Changqin Liu, Carmen Ginghina, Min Shi, Jing Zhan. α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23603399. |
in addition to amyloid-β (aβ) and tau, α-synuclein, best known for its role in parkinson's disease (pd), has been suggested to be involved in cognition and pathogenesis of alzheimer's disease (ad). |
2014-03-24 |
2023-08-12 |
human |
| Usman A Khan, Li Liu, Frank A Provenzano, Diego E Berman, Caterina P Profaci, Richard Sloan, Richard Mayeux, Karen E Duff, Scott A Smal. Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease. Nature neuroscience. vol 17. issue 2. 2014-03-24. PMID:24362760. |
the entorhinal cortex has been implicated in the early stages of alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (app). |
2014-03-24 |
2023-08-12 |
mouse |
| Haikang Zhao, Rui Chang, Haijiang Che, Jianbang Wang, Lei Yang, Wei Fang, Yi Xia, Nan Li, Quanrui Ma, Xuelian Wan. Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse. Neuroscience letters. vol 551. 2014-03-21. PMID:23810804. |
hyperphosphorylation of tau protein by calpain regulation in retina of alzheimer's disease transgenic mouse. |
2014-03-21 |
2023-08-12 |
mouse |
| Haikang Zhao, Rui Chang, Haijiang Che, Jianbang Wang, Lei Yang, Wei Fang, Yi Xia, Nan Li, Quanrui Ma, Xuelian Wan. Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse. Neuroscience letters. vol 551. 2014-03-21. PMID:23810804. |
aim to investigate phosphorylated tau expression and its pathogenic mechanism in eye of alzheimer's disease (ad) transgenic mice. |
2014-03-21 |
2023-08-12 |
mouse |
| Caroline Lambrecht, Dorien Haesen, Ward Sents, Elitsa Ivanova, Veerle Janssen. Structure, regulation, and pharmacological modulation of PP2A phosphatases. Methods in molecular biology (Clifton, N.J.). vol 1053. 2014-03-21. PMID:23860660. |
moreover, in human disease, most notably in several cancers and alzheimer's disease, pp2a expression and/or activity have been found significantly decreased, underscoring its important functions as a major tumor suppressor and tau phosphatase. |
2014-03-21 |
2023-08-12 |
human |
| Eduardo Rigon Zimmer, Antoine Leuzy, Venkat Bhat, Serge Gauthier, Pedro Rosa-Net. In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Translational neurodegeneration. vol 3. issue 1. 2014-03-20. PMID:24628994. |
hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles (nfts) is a common feature in a wide range of neurodegenerative diseases known as tauopathies, which include alzheimer's disease (ad) and the frontotemporal dementias (ftds). |
2014-03-20 |
2023-08-12 |
Not clear |
| Ralph Michael, Cees Otto, Aufried Lenferink, Ellen Gelpi, Gustavo A Montenegro, Jurja Rosandić, Francisco Tresserra, Rafael I Barraquer, Gijs F J M Vrense. Absence of amyloid-beta in lenses of Alzheimer patients: a confocal Raman microspectroscopic study. Experimental eye research. vol 119. 2014-03-18. PMID:24333259. |
we focused on beta-sheet levels, a hallmarking property of amyloid-beta, the major protein of plaques and tau protein, the major protein of tangles in alzheimer brains. |
2014-03-18 |
2023-08-12 |
Not clear |
| Kishore V Kuchibhotla, Susanne Wegmann, Katherine J Kopeikina, Jonathan Hawkes, Nikita Rudinskiy, Mark L Andermann, Tara L Spires-Jones, Brian J Bacskai, Bradley T Hyma. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 1. 2014-03-12. PMID:24368848. |
alzheimer's disease (ad) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (nfts) (1, 2). |
2014-03-12 |
2023-08-12 |
mouse |
| Ramasamy Thangavel, Duraisamy Kempuraj, Deirdre Stolmeier, Poojya Anantharam, Mohammad Khan, Asgar Zahee. Glia maturation factor expression in entorhinal cortex of Alzheimer's disease brain. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23715664. |
alzheimer's disease (ad) is characterized by the presence of neuropathological lesions containing amyloid plaques (aps) and hyperphosphorylated tau containing neurofibrillary tangles (nfts) and is associated with neuroinflammation and neurodegeneration. |
2014-03-10 |
2023-08-12 |
Not clear |
| Zdena Kristofikova, Daniela Ripova, Katerina Hegnerová, Jana Sirova, Jiri Homol. Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ-amyloid β interactions. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23824558. |
it is suggested that intracellular tau protein (τ), when released extracellularly upon neuron degeneration, could evoke direct toxic effects on the cholinergic neurotransmitter system through muscarinic receptors and thus contribute to the pathogenesis of alzheimer's disease. |
2014-03-10 |
2023-08-12 |
rat |
| Anika Saul, Frederik Sprenger, Thomas A Bayer, Oliver Wirth. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23747045. |
accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of alzheimer's disease. |
2014-03-05 |
2023-08-12 |
mouse |
| Johannes Wolf, Carsten Jäger, Ingolf Lachmann, Peter Schönknecht, Markus Morawski, Thomas Arendt, Thomas Mothe. Tissue transglutaminase is not a biochemical marker for Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23747046. |
typical hallmarks of alzheimer's disease (ad) are pathologic deposits in cortical and subcortical regions consisting of self-aggregated proteins such as amyloid-beta (aβ) or tau. |
2014-03-05 |
2023-08-12 |
human |
| Andrea Pristerà, Daniele Saraulli, Stefano Farioli-Vecchioli, Georgios Strimpakos, Marco Costanzi, Maria Grazia di Certo, Sara Cannas, Maria Teresa Ciotti, Felice Tirone, Elisabetta Mattei, Vincenzo Cestari, Nadia Can. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769395. |
different pathological tau species are involved in memory loss in alzheimer's disease, the most common cause of dementia among older people. |
2014-03-05 |
2023-08-12 |
mouse |
| Mak Adam Daulatza. Death by a thousand cuts in Alzheimer's disease: hypoxia--the prodrome. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23400634. |
strong evidence underscores that cerebral amyloidogenesis and tau phosphorylation--two cardinal features of alzheimer's disease (ad), are triggered by hypoxia. |
2014-03-03 |
2023-08-12 |
mouse |
| Teikichi Ikura, Nobutoshi It. Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating. Protein engineering, design & selection : PEDS. vol 26. issue 9. 2014-03-03. PMID:23832849. |
the alzheimer's disease-related protein, tau, aggregates into neurofibrillary tangles when it is hyperphosphorylated. |
2014-03-03 |
2023-08-12 |
Not clear |
| Martin Schwalbe, Jacek Biernat, Stefan Bibow, Valéry Ozenne, Malene R Jensen, Harindranath Kadavath, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry. vol 52. issue 50. 2014-03-03. PMID:24251416. |
tau protein plays an important role in neuronal physiology and alzheimer's neurodegeneration. |
2014-03-03 |
2023-08-12 |
human |
| Hadas Erez, Or A Shemesh, Micha E Spir. Rescue of tau-induced synaptic transmission pathology by paclitaxel. Frontiers in cellular neuroscience. vol 8. 2014-02-27. PMID:24574970. |
behavioral and electrophysiological studies of alzheimer's disease (ad) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. |
2014-02-27 |
2023-08-12 |
aplysia |