All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Eva Alonso, Carmen Vale, Mercedes R Vieytes, Luis M Botan. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology. ACS chemical neuroscience. vol 4. issue 7. 2013-11-25. PMID:23527608. the data presented here shows that 1 nm yessotoxin activates protein kinase c with beneficial effects over the main alzheimer's disease hallmarks, tau and aβ, in a cellular model obtained from 3xtg-ad fetuses. 2013-11-25 2023-08-12 mouse
Izaak den Daas, Johan Wemer, Khalid Abou Farha, Wim Tamminga, Theo de Boer, Rob Spanjersberg, Michel M R F Struys, Anthony R Absalo. Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile. European journal of clinical pharmacology. vol 69. issue 5. 2013-11-19. PMID:23143156. csf sampling in studies on drug candidates for alzheimer's disease have been conducted in evaluations of the biomarkers acetylcholine (ach), tau proteins, amyloid precursor protein and beta-amyloid fragments. 2013-11-19 2023-08-12 human
Jun-Ichi Satoh, Natsuki Kawana, Yoji Yamamot. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. Gene regulation and systems biology. vol 7. 2013-11-19. PMID:24250222. we identified a panel of neurodegenerative disease-related genes, such as park2 (parkin), park6 (pink1), park7 (dj-1), and paelr (gpr37) for parkinson's disease, as well as psenen (pen2) and mapt (tau) for alzheimer's disease, as previously unrecognized nrf1 targets. 2013-11-19 2023-08-12 human
Jeremy Koppel, Suzanne Sunday, Justin Buthorn, Terry Goldberg, Peter Davies, Blaine Greenwal. Elevated CSF Tau is associated with psychosis in Alzheimer's disease. The American journal of psychiatry. vol 170. issue 10. 2013-11-18. PMID:24084821. elevated csf tau is associated with psychosis in alzheimer's disease. 2013-11-18 2023-08-12 Not clear
S Flunkert, M Hierzer, T Löffler, R Rabl, J Neddens, S Duller, E L Schofield, M A Ward, M Posch, H Jungwirth, M Windisch, B Hutter-Paie. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neuro-degenerative diseases. vol 11. issue 4. 2013-11-13. PMID:22797329. tauopathies, characterized by hyperphosphorylation and aggregation of tau protein, include frontotemporal dementias and alzheimer's disease. 2013-11-13 2023-08-12 mouse
Chester A Mathis, William E Klun. Imaging tau deposits in vivo: progress in viewing more of the proteopathy picture. Neuron. vol 79. issue 6. 2013-11-13. PMID:24050394. (2013) demonstrate the binding of a new class of selective tau ligands, termed pbbs, to tau deposits in transgenic mice and in human subjects with normal cognition, alzheimer's disease, or a corticobasal syndrome. 2013-11-13 2023-08-12 mouse
Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q Trojanowski, Virginia M-Y Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuch. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. vol 79. issue 6. 2013-11-13. PMID:24050400. imaging of tau pathology in a tauopathy mouse model and in alzheimer patients compared to normal controls. 2013-11-13 2023-08-12 mouse
Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q Trojanowski, Virginia M-Y Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuch. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. vol 79. issue 6. 2013-11-13. PMID:24050400. accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in alzheimer's disease (ad) and related tauopathies. 2013-11-13 2023-08-12 mouse
Jagadeesh Kumar Dasappa, H G Nagendr. Preferential selectivity of inhibitors with human tau protein kinase gsk3β elucidates their potential roles for off-target Alzheimer's therapy. International journal of Alzheimer's disease. vol 2013. 2013-11-13. PMID:24222885. preferential selectivity of inhibitors with human tau protein kinase gsk3β elucidates their potential roles for off-target alzheimer's therapy. 2013-11-13 2023-08-12 human
Hamid Y Qureshi, Tong Li, Ryen MacDonald, Chul Min Cho, Nicole Leclerc, Hemant K Paude. Interaction of 14-3-3ζ with microtubule-associated protein tau within Alzheimer's disease neurofibrillary tangles. Biochemistry. vol 52. issue 37. 2013-11-12. PMID:23962087. interaction of 14-3-3ζ with microtubule-associated protein tau within alzheimer's disease neurofibrillary tangles. 2013-11-12 2023-08-12 Not clear
Zhimin Long, Min Zheng, Lei Zhao, Peng Xie, Cong Song, Yalan Chu, Weihong Song, Guiqiong H. Valproic acid attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer's disease mice model. Current Alzheimer research. vol 10. issue 3. 2013-11-11. PMID:23036022. alzheimer's disease (ad) is characterized by senile plaques (sp) of extracellular amyloid β peptides(aβ), neurofibrillary tangles (nft) of intracellular hyper-phosphorylated tau and widespread loss of neurons. 2013-11-11 2023-08-12 mouse
Hanna Rosenman. Immunotherapy for targeting tau pathology in Alzheimer's disease and tauopathies. Current Alzheimer research. vol 10. issue 3. 2013-11-11. PMID:23534533. immunotherapy for targeting tau pathology in alzheimer's disease and tauopathies. 2013-11-11 2023-08-12 mouse
H Braak, S Feldengut, K Del Tredic. [Pathogenesis and prevention of Alzheimer's disease: when and in what way does the pathological process begin?]. Der Nervenarzt. vol 84. issue 4. 2013-11-07. PMID:23508204. abnormal tau lesions (e.g., pretangles, neuropil threads, and neurofibrillary tangles) that develop in a few types of nerve cells in the central nervous system are essential to the pathogenesis of alzheimer's disease. 2013-11-07 2023-08-12 human
David Blum, Luc Bué. Alzheimer's disease risk, obesity and tau: is insulin resistance guilty? Expert review of neurotherapeutics. vol 13. issue 5. 2013-11-07. PMID:23621301. alzheimer's disease risk, obesity and tau: is insulin resistance guilty? 2013-11-07 2023-08-12 Not clear
Jon B Toledo, Steven E Arnold, Kevin Raible, Johannes Brettschneider, Sharon X Xie, Murray Grossman, Sarah E Monsell, Walter A Kukull, John Q Trojanowsk. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain : a journal of neurology. vol 136. issue Pt 9. 2013-11-07. PMID:23842566. presence of cerebrovascular disease, vascular pathology and vascular risk factors was studied in 5715 cases of the national alzheimer's coordinating centre database with a single neurodegenerative disease diagnosis (alzheimer's disease, frontotemporal lobar degeneration due to tau, and tar dna-binding protein 43 immunoreactive deposits, α-synucleinopathies, hippocampal sclerosis and prion disease) based on a neuropathological examination with or without cerebrovascular disease, defined neuropathologically. 2013-11-07 2023-08-12 human
Jon B Toledo, Steven E Arnold, Kevin Raible, Johannes Brettschneider, Sharon X Xie, Murray Grossman, Sarah E Monsell, Walter A Kukull, John Q Trojanowsk. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain : a journal of neurology. vol 136. issue Pt 9. 2013-11-07. PMID:23842566. after controlling for age and gender as fixed effects and centre as a random effect, we observed that α-synucleinopathies, frontotemporal lobar degeneration due to tau and tar dna-binding protein 43, and prion disease showed a lower prevalence of coincident cerebrovascular disease than patients with alzheimer's disease, and this was more significant in younger subjects. 2013-11-07 2023-08-12 human
Elina Zotova, Viraj Bharambe, Matthew Cheaveau, William Morgan, Clive Holmes, Scott Harris, James W Neal, Seth Love, James A R Nicoll, Delphine Boch. Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization. Brain : a journal of neurology. vol 136. issue Pt 9. 2013-11-07. PMID:23943781. our findings indicate that different microglial populations co-exist in the alzheimer's disease brain, and that the local inflammatory status within the grey matter is importantly linked with tau pathology. 2013-11-07 2023-08-12 human
Stéphanie Bombois, Alain Duhamel, Julia Salleron, Vincent Deramecourt, Marie-Anne Mackowiak, Valérie Deken, Nicholas Sergeant, Florence Pasquier, Luc Buée, Bernard Sablonniére, Susanna Schraen-Maschk. A new decision tree combining Abeta 1-42 and p-Tau levels in Alzheimer's diagnosis. Current Alzheimer research. vol 10. issue 4. 2013-11-05. PMID:23061918. the objective of this work was to improve the clinical diagnosis of alzheimer's disease (ad) by proposing a simple decision tree based on three major biomarkers of ad found in the cerebrospinal fluid (csf): amyloid peptide aβ1- 42, total tau (t-tau) and tau phosphorylated at thr181 (p-tau). 2013-11-05 2023-08-12 Not clear
Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. mtor and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and alzheimer's disease. 2013-11-04 2023-08-12 rat
Hirosha Geekiyanage, Aditi Upadhye, Christina Cha. Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiology of aging. vol 34. issue 8. 2013-11-04. PMID:23528227. inhibition of serine palmitoyltransferase reduces aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for alzheimer's disease. 2013-11-04 2023-08-12 mouse