| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B K Binukumar, Varsha Shukla, Niranjana D Amin, Preethi Reddy, Suzanne Skuntz, Philip Grant, Harish C Pan. Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration. Histochemistry and cell biology. vol 140. issue 1. 2014-01-22. PMID:23793952. |
aggregated forms of hyperphosphorylated tau and phosphorylated nfs are found in pathological cell body accumulations in the central nervous system of patients suffering from alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2014-01-22 |
2023-08-12 |
Not clear |
| Johanna L Crimins, Amy Pooler, Manuela Polydoro, Jennifer I Luebke, Tara L Spires-Jone. The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing research reviews. vol 12. issue 3. 2014-01-21. PMID:23528367. |
the intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in alzheimer's disease. |
2014-01-21 |
2023-08-12 |
Not clear |
| Hans Zempel, Julia Luedtke, Yatender Kumar, Jacek Biernat, Hana Dawson, Eckhard Mandelkow, Eva-Maria Mandelko. Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. The EMBO journal. vol 32. issue 22. 2014-01-21. PMID:24065130. |
mislocalization and aggregation of aβ and tau combined with loss of synapses and microtubules (mts) are hallmarks of alzheimer disease. |
2014-01-21 |
2023-08-12 |
mouse |
| Kelsey N Schafer, Katryna Cisek, Carol J Huseby, Edward Chang, Jeff Kure. Structural determinants of Tau aggregation inhibitor potency. The Journal of biological chemistry. vol 288. issue 45. 2014-01-20. PMID:24072703. |
small-molecule tau aggregation inhibitors are under investigation as potential therapeutic agents against alzheimer disease. |
2014-01-20 |
2023-08-12 |
Not clear |
| Rocio Perez-Gonzalez, Consuelo Pascual, Desiree Antequera, Marta Bolos, Miriam Redondo, Daniel I Perez, Virginia Pérez-Grijalba, Agnieszka Krzyzanowska, Manuel Sarasa, Carmen Gil, Isidro Ferrer, Ana Martinez, Eva Carr. Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 9. 2014-01-17. PMID:23582662. |
elevated levels of amyloid beta (aβ) peptide, hyperphosphorylation of tau protein, and inflammation are pathological hallmarks in alzheimer's disease (ad). |
2014-01-17 |
2023-08-12 |
mouse |
| Teresa Rodríguez-Martín, Inmaculada Cuchillo-Ibáñez, Wendy Noble, Fanon Nyenya, Brian H Anderton, Diane P Hange. Tau phosphorylation affects its axonal transport and degradation. Neurobiology of aging. vol 34. issue 9. 2014-01-17. PMID:23601672. |
phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in alzheimer's disease. |
2014-01-17 |
2023-08-12 |
mouse |
| Diana A T Nijholt, Anna Nölle, Elise S van Haastert, Hessel Edelijn, Ruud F Toonen, Jeroen J M Hoozemans, Wiep Schepe. Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation. Neurobiology of aging. vol 34. issue 7. 2014-01-16. PMID:23415837. |
in alzheimer's disease, as well as in other tauopathies, the upr is activated in neurons that contain early tau pathology. |
2014-01-16 |
2023-08-12 |
Not clear |
| Giulia Povellato, Richard I Tuxworth, Diane P Hanger, Guy Tea. Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β. Biology open. vol 3. issue 1. 2014-01-16. PMID:24429107. |
hyperphosphorylation of the microtubule associated protein, tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes alzheimer's disease. |
2014-01-16 |
2023-08-12 |
human |
| James Potticar. Acquisition of diagnostic tracers to enhance understanding of tau protein in Alzheimer's disease. Bioanalysis. vol 5. issue 12. 2014-01-13. PMID:23795923. |
acquisition of diagnostic tracers to enhance understanding of tau protein in alzheimer's disease. |
2014-01-13 |
2023-08-12 |
Not clear |
| Jose J Jarero-Basulto, Jose Luna-Muñoz, Raul Mena, Zdena Kristofikova, Daniela Ripova, George Perry, Lester I Binder, Francisco Garcia-Sierr. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 12. 2014-01-13. PMID:24226268. |
proteolytic cleavage of polymeric tau protein by caspase-3: implications for alzheimer disease. |
2014-01-13 |
2023-08-12 |
Not clear |
| Jose J Jarero-Basulto, Jose Luna-Muñoz, Raul Mena, Zdena Kristofikova, Daniela Ripova, George Perry, Lester I Binder, Francisco Garcia-Sierr. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 12. 2014-01-13. PMID:24226268. |
truncated tau protein at asp(421) is associated with neurofibrillary pathology in alzheimer disease (ad); however, little is known about its presence in the form of nonfibrillary aggregates. |
2014-01-13 |
2023-08-12 |
Not clear |
| Takashi Kurashige, Tetsuya Takahashi, Yuu Yamazaki, Masanori Hiji, Yuishin Izumi, Takemori Yamawaki, Masayasu Matsumot. Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 33. issue 3. 2014-01-10. PMID:22989140. |
we examined the brainstems of 17 patients with parkinson's disease (pd), incidental lewy body disease (ilbd), multiple system atrophy (msa), and alzheimer's disease (ad) immunohistochemically using antibodies against phosphorylated αs (pαs), phosphorylated tau and chmp2b. |
2014-01-10 |
2023-08-12 |
Not clear |
| Kiran Yanamandra, Najla Kfoury, Hong Jiang, Thomas E Mahan, Shengmei Ma, Susan E Maloney, David F Wozniak, Marc I Diamond, David M Holtzma. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. vol 80. issue 2. 2014-01-09. PMID:24075978. |
tau aggregation occurs in neurodegenerative diseases including alzheimer's disease and many other disorders collectively termed tauopathies. |
2014-01-09 |
2023-08-12 |
mouse |
| Hans Brunnström, Oskar Hansson, Henrik Zetterberg, Elisabet Londos, Elisabet Englun. Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies. International journal of geriatric psychiatry. vol 28. issue 7. 2014-01-08. PMID:22911491. |
correlations of csf tau and amyloid levels with alzheimer pathology in neuropathologically verified dementia with lewy bodies. |
2014-01-08 |
2023-08-12 |
Not clear |
| María Elena Avale, Teresa Rodríguez-Martín, Jean-Marc Gall. Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing. Human molecular genetics. vol 22. issue 13. 2014-01-07. PMID:23459933. |
abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including alzheimer's disease. |
2014-01-07 |
2023-08-12 |
mouse |
| Andrew Cameron, Brandy Giacomozzi, John Joyce, Audrey Gray, Danielle Graham, Solenne Ousson, Maud Neny, Dirk Beher, George Carlson, Jill O'Moore, Mark Shearman, Heike Herin. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS letters. vol 587. issue 22. 2014-01-07. PMID:24113653. |
aggregation of tau into paired helical filaments is a pathological process leading to neurotoxicity in alzheimer's disease and other tauopathies. |
2014-01-07 |
2023-08-12 |
rabbit |
| Miguel Medina, Jesús Avila, Nieves Villanuev. Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration. Marine drugs. vol 11. issue 5. 2014-01-06. PMID:23697949. |
finally, its effect on tau hyperhosphorylation and its relevance in neurodegenerative pathologies such as alzheimer's disease and related dementia will be discussed. |
2014-01-06 |
2023-08-12 |
Not clear |
| Manuela Mellone, Dimitra Kestoras, Melissa R Andrews, Elisa Dassie, R Anthony Crowther, Gorazd B Stokin, Jon Tinsley, Graeme Horne, Michel Goedert, Aviva M Tolkovsky, Maria Grazia Spillantin. Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227726. |
intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative diseases, including alzheimer's disease, progressive supranuclear palsy, and cases of frontotemporal dementia, but the link between these aggregates and neurodegeneration remains unclear. |
2014-01-06 |
2023-08-12 |
mouse |
| Kim Henriksen, Yaguo Wang, Mette G Sørensen, Natasha Barascuk, Joyce Suhy, Jan T Pedersen, Kevin L Duffin, Robert A Dean, Monika Pajak, Claus Christiansen, Qinlong Zheng, Morten A Karsda. An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function. PloS one. vol 8. issue 5. 2014-01-02. PMID:23717682. |
alzheimer's disease (ad) is a devastating neurological disease characterized by pathological proteolytic cleavage of tau protein, which appears to initiate death of the neurons. |
2014-01-02 |
2023-08-12 |
Not clear |
| Jannic Boeh. A 'danse macabre': tau and Fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773061. |
alzheimer's disease, with its two most prominent pathological factors amyloid beta and tau protein, can be described as a disease of the synapse. |
2013-12-31 |
2023-08-12 |
Not clear |