| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nguyen-Vi Mohamed, Thibaut Herrou, Vanessa Plouffe, Nicolas Piperno, Nicole Lecler. Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773063. |
spreading of tau pathology in alzheimer's disease by cell-to-cell transmission. |
2013-12-31 |
2023-08-12 |
mouse |
| Nguyen-Vi Mohamed, Thibaut Herrou, Vanessa Plouffe, Nicolas Piperno, Nicole Lecler. Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773063. |
it is well documented that neurofibrillary tangles composed of aggregated tau protein propagate in a predictable pattern in alzheimer's disease (ad). |
2013-12-31 |
2023-08-12 |
mouse |
| Kazuhiro Nakamura, Xiao Zhen Zhou, Kun Ping L. Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies. Prion. vol 7. issue 2. 2013-12-30. PMID:23154634. |
cis phosphorylated tau as the earliest detectable pathogenic conformation in alzheimer disease, offering novel diagnostic and therapeutic strategies. |
2013-12-30 |
2023-08-12 |
Not clear |
| Xia Jiang, Lin-Wei Jia, Xiao-Hong Li, Xiang-Shu Cheng, Jia-Zhao Xie, Zhi-Wei Ma, Wei-Jie Xu, Yue Liu, Yun Yao, Lai-Ling Du, Xin-Wen Zho. Capsaicin ameliorates stress-induced Alzheimer's disease-like pathological and cognitive impairments in rats. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23340038. |
hyperphosphorylated tau aggregated into neurofibrillary tangles is a hallmark lesion of alzheimer's disease (ad) and is linked to synaptic and cognitive impairments. |
2013-12-27 |
2023-08-12 |
rat |
| Jessica M Posimo, Amanda M Titler, Hailey J H Choi, Ajay S Unnithan, Rehana K Lea. Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo. PloS one. vol 8. issue 3. 2013-12-27. PMID:23536801. |
in parkinson's and alzheimer's diseases, the allocortex accumulates aggregated proteins such as synuclein and tau well before neocortex. |
2013-12-27 |
2023-08-12 |
rat |
| Min Jae Lee, Jung Hoon Lee, David C Rubinsztei. Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Progress in neurobiology. vol 105. 2013-12-26. PMID:23528736. |
the two hallmark lesions of alzheimer's disease (ad) are extracellular β-amyloid plaques and intracellular tau tangles. |
2013-12-26 |
2023-08-12 |
Not clear |
| Jhoana Mendoza, Michiko Sekiya, Taizo Taniguchi, Koichi M Iijima, Rong Wang, Kanae And. Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. Journal of proteome research. vol 12. issue 6. 2013-12-23. PMID:23550703. |
hyperphosphorylation of microtubule-associated protein tau is thought to contribute to alzheimer's disease (ad) pathogenesis. |
2013-12-23 |
2023-08-12 |
human |
| Irina Lonskaya, Michaeline L Hebron, Nicole M Desforges, Alexander Franjie, Charbel E-H Mouss. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO molecular medicine. vol 5. issue 8. 2013-12-23. PMID:23737459. |
alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated tau (tangles). |
2013-12-23 |
2023-08-12 |
mouse |
| Shuk Wai Ho, Yuk Tung Chanel Tsui, Ting Ting Wong, Stanley Kwok-Kuen Cheung, William B Goggins, Lau Ming Yi, Kwok Kin Cheng, Larry Bau. Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease. Translational neurodegeneration. vol 2. issue 1. 2013-12-20. PMID:24344631. |
alzheimer's disease (ad), the most common dementia, is characterized by potentially neurotoxic aggregation of aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (nfts). |
2013-12-20 |
2023-08-12 |
mouse |
| Richard L Veec. Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat. Annals of the New York Academy of Sciences. vol 1302. 2013-12-18. PMID:23909803. |
other effects of feeding ketone esters, in addition to their ability to induce brown fat, are discussed such as their ability to overcome certain aspects of insulin resistance and to ameliorate the accumulation of amyloid and phosphorylated tau protein in brain, and improve cognitive function, in a triple transgenic mouse model of alzheimer's disease. |
2013-12-18 |
2023-08-12 |
mouse |
| Artor Niccoli Asabella, Marilena Ruggeri, Domenico Rubini, Lorenzo Polimeno, Cristina Spinelli, Marella Polito, Michele Pennelli, Corinna Altini, Maria Sara De Caro, Giovanni Defazio, Giuseppe Rubin. [Correlation between cognitive impairment and plasma levels of clusterin/ApoJ in Parkinson disease patients not affected by dementia]. Recenti progressi in medicina. vol 104. issue 7-8. 2013-12-17. PMID:24042414. |
recently a contribution of alzheimer's disease for the cognitive dysfunction in pd has been proposed, whereas the presence of tau protein and amyloid was recognized. |
2013-12-17 |
2023-08-12 |
Not clear |
| Robert Siman, Yin-Guo Lin, Gauri Malthankar-Phatak, Yina Don. A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy. Journal of neuropathology and experimental neurology. vol 72. issue 11. 2013-12-17. PMID:24128676. |
the perforant pathway projection from the entorhinal cortex (ec) to the hippocampal dentate gyrus is critically important for long-term memory and develops tau and amyloid pathologies and progressive degeneration starting in the early stages of alzheimer disease (ad). |
2013-12-17 |
2023-08-12 |
mouse |
| Dong Liu, Michael Pitta, Haiyang Jiang, Jong-Hwan Lee, Guofeng Zhang, Xinzhi Chen, Elisa M Kawamoto, Mark P Mattso. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23273573. |
impaired brain energy metabolism and oxidative stress are implicated in cognitive decline and the pathologic accumulations of amyloid β-peptide (aβ) and hyperphosphorylated tau in alzheimer's disease (ad). |
2013-12-11 |
2023-08-12 |
mouse |
| Yoshihiro Kashiwaya, Christian Bergman, Jong-Hwan Lee, Ruiqian Wan, M Todd King, Mohamed R Mughal, Eitan Okun, Kieran Clarke, Mark P Mattson, Richard L Veec. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23276384. |
a ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of alzheimer's disease. |
2013-12-11 |
2023-08-12 |
mouse |
| Meaghan Morris, Patricia Hamto, Anthony Adame, Nino Devidze, Eliezer Masliah, Lennart Muck. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23332171. |
though tau ablation prevented synaptic, network, and cognitive dysfunctions in several models of alzheimer's disease and made mice more resistant to epileptic seizures, a recent study described a parkinsonian phenotype in aging tau knockout mice. |
2013-12-11 |
2023-08-12 |
mouse |
| b' Jin Chu, Domenico Pratic\\xc3\\xb. 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23332172.' |
our findings highlight the novel functional role that neuronal 5lo plays in modulating tau phosphorylation, and suggest that pharmacologic inhibition of 5lo could provide a novel therapeutic opportunity also for alzheimer's disease-related tau pathology. |
2013-12-11 |
2023-08-12 |
mouse |
| Masaki Ikeda, Kimie Yonemura, Satoko Kakuda, Yuichi Tashiro, Yukio Fujita, Eriko Takai, Yukiko Hashimoto, Kouki Makioka, Natsumi Furuta, Koichi Ishiguro, Risa Maruki, Jun'ichi Yoshida, Osamu Miyaguchi, Tamao Tsukie, Ryouzou Kuwano, Tsuneo Yamazaki, Haruyasu Yamaguchi, Masakuni Amari, Masamitsu Takatama, Yasuo Harigaya, Koichi Okamot. Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 20. issue 2. 2013-12-11. PMID:23638752. |
cerebrospinal fluid levels of phosphorylated tau and aβ1-38/aβ1-40/aβ1-42 in alzheimer's disease with ps1 mutations. |
2013-12-11 |
2023-08-12 |
human |
| Ester Aso, Salvador Juvés, Rafael Maldonado, Isidro Ferre. CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23515018. |
in conclusion, the present study lends support to the idea that stimulation of cb2 receptors ameliorates several altered parameters in alzheimer's disease such as impaired memory and learning, neuroinflammation, oxidative stress damage and oxidative stress responses, selected tau kinases, and tau hyperphosphorylation around plaques. |
2013-12-10 |
2023-08-12 |
mouse |
| Geoffrey A Kerchner, Jeffrey D Bernstein, Michelle C Fenesy, Gayle K Deutsch, Manojkumar Saranathan, Michael M Zeineh, Brian K Rut. Shared vulnerability of two synaptically-connected medial temporal lobe areas to age and cognitive decline: a seven tesla magnetic resonance imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 42. 2013-12-10. PMID:24133269. |
the medial temporal lobe (mtl) is the first brain area to succumb to neurofibrillary tau pathology in alzheimer's disease (ad). |
2013-12-10 |
2023-08-12 |
human |
| Roshni C George, John Lew, Donald J Grave. Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23531502. |
interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating alzheimer's disease pathogenesis. |
2013-12-09 |
2023-08-12 |
Not clear |