All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Masafumi Hidaka, Tomoe Koga, Aina Gotoh, Mariko Sanada, Keiko Hirose, Takafumi Uchid. Alzheimer's disease-related protein hGas7b interferes with kinesin motility. Journal of biochemistry. vol 151. issue 6. 2013-06-10. PMID:22496485. we focused on the effect of hgas7b on microtubule dynamics in the absence of tau, on the assumption of healthy tau decrease in the brains of alzheimer's disease. 2013-06-10 2023-08-12 Not clear
Rachel E Bennett, Thomas J Esparza, Hal A Lewis, Eddie Kim, Christine L Mac Donald, Patrick M Sullivan, David L Brod. Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. Journal of neuropathology and experimental neurology. vol 72. issue 5. 2013-06-10. PMID:23584199. by analogy to effects of apoe4 on the risk of alzheimer disease (ad), the apoe genotype may influence β-amyloid (aβ) and tau deposition after tbi. 2013-06-10 2023-08-12 mouse
Dayong Wang, Qin Fu, Yuan Zhou, Bing Xu, Qian Shi, Benedict Igwe, Lucas Matt, Johannes W Hell, Elena V Wisely, Salvatore Oddo, Yang K Xian. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23430246. β2 adrenergic receptor, protein kinase a (pka) and c-jun n-terminal kinase (jnk) signaling pathways mediate tau pathology in alzheimer disease models. 2013-06-07 2023-08-12 mouse
Dayong Wang, Qin Fu, Yuan Zhou, Bing Xu, Qian Shi, Benedict Igwe, Lucas Matt, Johannes W Hell, Elena V Wisely, Salvatore Oddo, Yang K Xian. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23430246. alzheimer disease (ad) is characterized by neurodegeneration marked by loss of synapses and spines associated with hyperphosphorylation of tau protein. 2013-06-07 2023-08-12 mouse
Heiko Braak, Kelly Del Tredic. Evolutional aspects of Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22699850. tau lesions (pretangles, neuropil threads, neurofibrillary tangles) that develop in a few types of nerve cells in the brain are essential to the pathogenesis of alzheimer's disease (ad). 2013-06-06 2023-08-12 human
Felix Hernandez, Jose J Lucas, Jesus Avil. GSK3 and tau: two convergence points in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22710914. gsk3 and tau: two convergence points in alzheimer's disease. 2013-06-06 2023-08-12 mouse
Jian-Zhi Wang, Yi-Yuan Xia, Inge Grundke-Iqbal, Khalid Iqba. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22710920. in alzheimer's disease brain, tau is abnormally hyperphosphorylated to a stoichiometry of at least three-fold greater than normal tau, and in this altered state it is aggregated into paired helical filaments forming neurofibrillary tangles, a histopathological hallmark of the disease. 2013-06-06 2023-08-12 Not clear
Robert M Cohen, Kavon Rezai-Zadeh, Tara M Weitz, Altan Rentsendorj, David Gate, Inna Spivak, Yasmin Bholat, Vitaly Vasilevko, Charles G Glabe, Joshua J Breunig, Pasko Rakic, Hayk Davtyan, Michael G Agadjanyan, Vladimir Kepe, Jorge R Barrio, Serguei Bannykh, Christine A Szekely, Robert N Pechnick, Terrence Tow. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 15. 2013-06-05. PMID:23575824. a transgenic alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. 2013-06-05 2023-08-12 mouse
Li-San Wang, Yuk Yee Leung, Shu-Kai Chang, Susan Leight, Malgorzata Knapik-Czajka, Young Baek, Leslie M Shaw, Virginia M-Y Lee, John Q Trojanowski, Christopher M Clar. Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22571982. the best-studied biomarkers of alzheimer's disease (ad) are the pathologically-linked cerebrospinal fluid (csf) proteins amyloid-β 42 (aβ(1-42)), total tau (t-tau), and tau phosphorylated on amino acid 181 (p-tau(181)). 2013-06-04 2023-08-12 human
Aranda R Duan, Holly V Goodso. Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro. Molecular biology of the cell. vol 23. issue 24. 2013-06-03. PMID:23087208. tau is a neuronal protein that stabilizes the microtubule (mt) network, but it also forms filaments associated with alzheimer's disease. 2013-06-03 2023-08-12 Not clear
Aranda R Duan, Holly V Goodso. Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro. Molecular biology of the cell. vol 23. issue 24. 2013-06-03. PMID:23087208. these observations suggest that the mt-induced tau filaments provide a new model for alzheimer's studies and that mts might play a role in the formation of alzheimer's-associated neurofibrillary tangles. 2013-06-03 2023-08-12 Not clear
M R Carratù, C Marasco, A Signorile, C Scuderi, L Steard. Are retinoids a promise for Alzheimer's disease management? Current medicinal chemistry. vol 19. issue 36. 2013-06-03. PMID:23092137. the ability of retinoids to exert antioxidant effects, inhibit amyloid-β (aβ) deposits and likely aβ-induced mitochondrial dysfunction, tau hyperphosphorylation, aβ-induced il6 production and neuroinflammation, increase survival in hippocampal neurons, and reverse cognitive deficits in animal models of alzheimer's disease (ad) is discussed. 2013-06-03 2023-08-12 Not clear
Emma Richet, Amy M Pooler, Teresa Rodriguez, Sergey S Novoselov, Gunter Schmidtke, Marcus Groettrup, Diane P Hanger, Michael E Cheetham, Jacqueline van der Spu. NUB1 modulation of GSK3β reduces tau aggregation. Human molecular genetics. vol 21. issue 24. 2013-05-31. PMID:22965877. abnormal phosphorylation of the microtubule-associated protein tau in neurodegenerative disorders, including alzheimer's disease (ad) and frontotemporal lobar degeneration, is associated with disrupted axonal transport and synaptic dysfunction ultimately manifesting as histopathological lesions of protein aggregates. 2013-05-31 2023-08-12 Not clear
Adrian C Lo, Zsuzsanna Callaerts-Vegh, Ana F Nunes, Cecília M P Rodrigues, Rudi D'Hoog. Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. Neurobiology of disease. vol 50. 2013-05-31. PMID:22974733. alzheimer's disease (ad) is a neurodegenerative disease hallmarked by extracellular aβ(1-42) containing plaques, and intracellular neurofibrillary tangles (nft) containing hyperphosphorylated tau protein. 2013-05-31 2023-08-12 mouse
Yan Yang, Delin Ma, Yuping Wang, Teng Jiang, Shuhong Hu, Muxun Zhang, Xuefeng Yu, Cheng-Xin Gon. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22936005. we have found dysregulation of brain insulin signaling in both alzheimer's disease (ad) and type 2 diabetes (t2d), which correlates to hyperphosphorylation of tau, a key abnormal tau modification leading to neurofibrillary tangles. 2013-05-28 2023-08-12 rat
Alena Opattova, Peter Filipcik, Martin Cente, Michal Nova. Intracellular degradation of misfolded tau protein induced by geldanamycin is associated with activation of proteasome. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22936006. misfolded, n- and c-terminally truncated tau protein is the primary constituent of neurofibrillary tangles in brains of patients afflicted with alzheimer's disease (ad). 2013-05-28 2023-08-12 Not clear
Stefanie K Forest, Christopher M Acker, Cristina d'Abramo, Peter Davie. Methods for measuring tau pathology in transgenic mouse models. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22976073. in alzheimer's disease (ad) and tauopathies, tau becomes hyperphosphorylated, undergoes a conformational change, and becomes aggregated and insoluble. 2013-05-28 2023-08-12 mouse
Simona Capsoni, Anne-Sophie Carlo, Domenico Vignone, Gianluca Amato, Chiara Criscuolo, Thomas E Willnow, Antonino Cattane. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22986780. sorla deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of alzheimer's disease. 2013-05-28 2023-08-12 mouse
Peter Filipcik, Norbert Zilka, Ondrej Bugos, Juraj Kucerak, Peter Koson, Petr Novak, Michal Nova. First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21196063. neurofibrillary degeneration induced by misfolded protein tau is considered to be one of the key pathological hallmarks of alzheimer's disease (ad). 2013-05-27 2023-08-12 human
Hanna Ksiezak-Reding, Lap Ho, Ismael Santa-Maria, Carmen Diaz-Ruiz, Jun Wang, Giulio Maria Pasinett. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21196065. abnormal folding of the microtubule-associated protein tau leads to aggregation of tau into paired helical filaments (phfs) and neurofibrillary tangles, the major hallmark of alzheimer's disease (ad). 2013-05-27 2023-08-12 mouse