All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jonathan M Schot. Using CSF biomarkers to replicate genetic associations in Alzheimer's disease. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21459483. independent of clinical diagnosis, alzheimer's disease neuroimaging initiative (adni) subjects with 2 csf biomarkers for ad (aβ1-42 < 192 pg/ml and tau phosphorylated at threonine 181 (p-tau) > 23 pg/ml, "csf-positive") were compared with those without csf evidence for ad (aβ1-42 > 192 pg/ml and 181-phosphorylated tau < 23 pg/ml, "csf-negative"). 2013-05-27 2023-08-12 human
Leonardo C de Souza, Marie Chupin, Foudil Lamari, Claude Jardel, Delphine Leclercq, Olivier Colliot, Stéphane Lehéricy, Bruno Dubois, Marie Sarazi. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21489655. csf tau markers are correlated with hippocampal volume in alzheimer's disease. 2013-05-27 2023-08-12 Not clear
Yan Xiong, Xiao-Peng Jing, Xin-Wen Zhou, Xiu-Lian Wang, Yang Yang, Xu-Ying Sun, Mei Qiu, Fu-Yuan Cao, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22892311. the activity of protein phosphatase (pp) 2a is downregulated and promotes the hyperphosphorylation of tau in the brains of alzheimer's disease (ad), but the mechanism for pp2a inactivation has not been elucidated. 2013-05-24 2023-08-12 mouse
Kunie Ando, Pierre Dourlen, Anne-Véronique Sambo, Alexis Bretteville, Karim Bélarbi, Valérie Vingtdeux, Sabiha Eddarkaoui, Hervé Drobecq, Antoine Ghestem, Séverine Bégard, Emmanuelle Demey-Thomas, Patricia Melnyk, Caroline Smet, Guy Lippens, Claude-Alain Maurage, Marie-Laure Caillet-Boudin, Yann Verdier, Joelle Vinh, Isabelle Landrieu, Marie-Christine Galas, David Blum, Malika Hamdane, Nicolas Sergeant, Luc Bué. Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22926167. through isomerization, pin1 regulates the function of a growing number of targets including the microtubule-associated tau protein and is supposed to be deregulated alzheimer's disease (ad). 2013-05-24 2023-08-12 mouse
Koushirou Sogawa, Ryouhei Okuda, Yasuko In, Toshimasa Ishida, Taizo Taniguchi, Katsuhiko Minoura, Koji Tomo. C-H ... π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four-repeat tau. Journal of biochemistry. vol 152. issue 3. 2013-05-23. PMID:22659094. information on the structural scaffold for tau aggregation is important in developing a method of preventing alzheimer's disease (ad). 2013-05-23 2023-08-12 human
Diana Seidel, Dana Krinke, Heinz-Georg Jahnke, Anika Hirche, Daniel Kloß, Till G A Mack, Frank Striggow, Andrea Robitzk. Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. PloS one. vol 7. issue 11. 2013-05-23. PMID:23145103. we were able to quantify a time- and concentration-dependent relative impedance decrease when alzheimer's disease-like tau pathology was induced in the neuronal 3d cell culture model. 2013-05-23 2023-08-12 human
R Killick, T R Hughes, B P Morgan, S Loveston. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience letters. vol 533. 2013-05-23. PMID:23153828. deletion of crry, the murine ortholog of the sporadic alzheimer's disease risk gene cr1, impacts tau phosphorylation and brain cfh. 2013-05-23 2023-08-12 mouse
R Killick, T R Hughes, B P Morgan, S Loveston. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience letters. vol 533. 2013-05-23. PMID:23153828. we measured complement factor h, a component of the complement system and biomarker for alzheimer's disease progression, and tau phosphorylation at the serine 235 site, hyperphosphorylated forms of tau being a defining neuropathological hallmark of the disease. 2013-05-23 2023-08-12 mouse
Ying Xiong, Kai Zhao, Jiaxi Wu, Zhiheng Xu, Shan Jin, Yong Q Zhan. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 12. 2013-05-23. PMID:23487739. neurons from the brains of alzheimer's disease (ad) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein. 2013-05-23 2023-08-12 mouse
Robyn A Honea, Eric D Vidoni, Russell H Swerdlow, Jeffrey M Burn. Maternal family history is associated with Alzheimer's disease biomarkers. Journal of Alzheimer's disease : JAD. vol 31. issue 3. 2013-05-21. PMID:22669011. we analyzed cross-sectional data from non-demented, mild cognitive impairment (mci), and load participants in the alzheimer's disease neuroimaging initiative (adni) with pet imaging using pittsburgh compound b (pib, n = 99) and cerebrospinal fluid (csf) analysis (n = 403) for amyloid-β peptide (aβ) and total tau. 2013-05-21 2023-08-12 human
Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. tau pathology and parietal white matter lesions have independent but synergistic effects on early development of alzheimer's disease. 2013-05-21 2023-08-12 Not clear
Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. this study investigates the relationship between wmls, hyperphosphorylated tau (p-tau) in cerebrospinal fluid (csf) and apolipoprotein e (apoe) ε4 genotype in prodromal alzheimer's disease (ad). 2013-05-21 2023-08-12 Not clear
Abhinav Nath, Maria Sammalkorpi, David C DeWitt, Adam J Trexler, Shana Elbaum-Garfinkle, Corey S O'Hern, Elizabeth Rhoade. The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations. Biophysical journal. vol 103. issue 9. 2013-05-20. PMID:23199922. here, we investigate the model idps α-synuclein (αs) and tau, that are involved in major neurodegenerative conditions including parkinson's and alzheimer's diseases, using excluded volume monte carlo simulations constrained by pairwise distance distributions from single-molecule fluorescence measurements. 2013-05-20 2023-08-12 human
Niklas Mattsson, Erik Portelius, Sindre Rolstad, Mikael Gustavsson, Ulf Andreasson, Mats Stridsberg, Anders Wallin, Kaj Blennow, Henrik Zetterber. Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22475796. cerebrospinal fluid (csf) measurements of amyloid-β42 (aβ42), total-tau (t-tau), and phosphorylated tau (p-tau) may be used to predict future alzheimer's disease (ad) dementia in patients with mild cognitive impairment (mci). 2013-05-15 2023-08-12 Not clear
Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. isomerase pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (cdk5)-dependent alzheimer phosphorylation sites. 2013-05-14 2023-08-12 Not clear
Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. alzheimer disease, the most common tauopathy, is characterized by neurofibrillary tangles that are mainly composed of abnormally phosphorylated tau. 2013-05-14 2023-08-12 Not clear
Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. pin1 deficiency is suggested to cause tau hyperphosphorylation in alzheimer disease. 2013-05-14 2023-08-12 Not clear
Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). 2013-05-14 2023-08-12 human
Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao, Shuo Shi, Liangnian J. Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid. Biochemistry. vol 52. issue 11. 2013-05-09. PMID:23442089. inhibition of anomalous aggregation of tau protein would be an attractive therapeutic target for alzheimer's disease (ad). 2013-05-09 2023-08-12 human
J Lasierra-Cirujeda, P Coronel, Mj Aza, M Gimen. Beta-amyloidolysis and glutathione in Alzheimer's disease. Journal of blood medicine. vol 4. 2013-05-08. PMID:23650462. the histopathological characteristic hallmark that gives personality to the diagnosis of alzheimer's disease is the accumulation of neurofibroid tangles located intracellularly in the brain, such as the protein tau and extracellular senile plaques made primarily of amyloidal substance. 2013-05-08 2023-08-12 Not clear