| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine M Roe, Anne M Fagan, Elizabeth A Grant, Jason Hassenstab, Krista L Moulder, Denise Maue Dreyfus, Courtney L Sutphen, Tammie L S Benzinger, Mark A Mintun, David M Holtzman, John C Morri. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology. vol 80. issue 19. 2013-07-02. PMID:23576620. |
we compared the ability of molecular biomarkers for alzheimer disease (ad), including amyloid imaging and csf biomarkers (aβ42, tau, ptau181, tau/aβ42, ptau181/aβ42), to predict time to incident cognitive impairment among cognitively normal adults aged 45 to 88 years and followed for up to 7.5 years. |
2013-07-02 |
2023-08-12 |
Not clear |
| Celia López-Menéndez, Andrea Gamir-Morralla, Jerónimo Jurado-Arjona, Alonso M Higuero, Miguel R Campanero, Isidro Ferrer, Félix Hernández, Jesús Ávila, Margarita Díaz-Guerra, Teresa Iglesia. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance. Human molecular genetics. vol 22. issue 3. 2013-07-01. PMID:23118350. |
kidins220 accumulates with tau in human alzheimer's disease and related models: modulation of its calpain-processing by gsk3β/pp1 imbalance. |
2013-07-01 |
2023-08-12 |
mouse |
| Linn Hege Nilsen, Caroline Rae, Lars M Ittner, Jürgen Götz, Ursula Sonnewal. Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 5. 2013-06-28. PMID:23340677. |
in neurodegenerative diseases including alzheimer's disease and frontotemporal dementia, the protein tau is hyperphosphorylated and eventually aggregates to develop neurofibrillary tangles. |
2013-06-28 |
2023-08-12 |
mouse |
| Philipp Görtz, Mario Siebler, Ralf Ihl, Uwe Henning, Christian Luckhaus, Tillmann Supprian, Christian Lange-Asschenfeld. Multielectrode array analysis of cerebrospinal fluid in Alzheimer's disease versus mild cognitive impairment: a potential diagnostic and treatment biomarker. Biochemical and biophysical research communications. vol 434. issue 2. 2013-06-28. PMID:23541573. |
pathological cerebrospinal fluid (csf) alterations like changes in amyloid-β1-42 and tau protein concentration are typical in alzheimer's disease (ad). |
2013-06-28 |
2023-08-12 |
human |
| Lei Wang, Anne M Fagan, Aarti R Shah, Mirza Faisal Beg, John G Csernansky, John C Morris, David M Holtzma. Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type. Alzheimer disease and associated disorders. vol 26. issue 4. 2013-06-26. PMID:22156755. |
the present study was conducted to assess the relationship between csf aβ and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the alzheimer type. |
2013-06-26 |
2023-08-12 |
Not clear |
| Giovanni Coppola, Subashchandrabose Chinnathambi, Jason JiYong Lee, Beth A Dombroski, Matt C Baker, Alexandra I Soto-Ortolaza, Suzee E Lee, Eric Klein, Alden Y Huang, Renee Sears, Jessica R Lane, Anna M Karydas, Robert O Kenet, Jacek Biernat, Li-San Wang, Carl W Cotman, Charles S Decarli, Allan I Levey, John M Ringman, Mario F Mendez, Helena C Chui, Isabelle Le Ber, Alexis Brice, Michelle K Lupton, Elisavet Preza, Simon Lovestone, John Powell, Neill Graff-Radford, Ronald C Petersen, Bradley F Boeve, Carol F Lippa, Eileen H Bigio, Ian Mackenzie, Elizabeth Finger, Andrew Kertesz, Richard J Caselli, Marla Gearing, Jorge L Juncos, Bernardino Ghetti, Salvatore Spina, Yvette M Bordelon, Wallace W Tourtellotte, Matthew P Frosch, Jean Paul G Vonsattel, Chris Zarow, Thomas G Beach, Roger L Albin, Andrew P Lieberman, Virginia M Lee, John Q Trojanowski, Vivianna M Van Deerlin, Thomas D Bird, Douglas R Galasko, Eliezer Masliah, Charles L White, Juan C Troncoso, Didier Hannequin, Adam L Boxer, Michael D Geschwind, Satish Kumar, Eva-Maria Mandelkow, Zbigniew K Wszolek, Ryan J Uitti, Dennis W Dickson, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Owen A Ross, Rosa Rademakers, Gerard D Schellenberg, Bruce L Miller, Eckhard Mandelkow, Daniel H Geschwin. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human molecular genetics. vol 21. issue 15. 2013-06-25. PMID:22556362. |
tau p.a152t significantly increases the risk for both ftd-s (n = 2139, or = 3.0, ci: 1.6-5.6, p = 0.0005) and alzheimer's disease (ad) (n = 3345, or = 2.3, ci: 1.3-4.2, p = 0.004) compared with 9047 controls. |
2013-06-25 |
2023-08-12 |
human |
| Ludovic Martin, Xenia Latypova, Cornelia M Wilson, Amandine Magnaudeix, Marie-Laure Perrin, Catherine Yardin, Faraj Terr. Tau protein kinases: involvement in Alzheimer's disease. Ageing research reviews. vol 12. issue 1. 2013-06-25. PMID:22742992. |
tau protein kinases: involvement in alzheimer's disease. |
2013-06-25 |
2023-08-12 |
Not clear |
| Ludovic Martin, Xenia Latypova, Cornelia M Wilson, Amandine Magnaudeix, Marie-Laure Perrin, Catherine Yardin, Faraj Terr. Tau protein kinases: involvement in Alzheimer's disease. Ageing research reviews. vol 12. issue 1. 2013-06-25. PMID:22742992. |
thus, understanding the regulation modes of tau phosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates in order to elaborate protection strategies to cope with these lesions in alzheimer's disease. |
2013-06-25 |
2023-08-12 |
Not clear |
| Ludovic Martin, Xenia Latypova, Cornelia M Wilson, Amandine Magnaudeix, Marie-Laure Perrin, Faraj Terr. Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A. Ageing research reviews. vol 12. issue 1. 2013-06-25. PMID:22771380. |
tau protein phosphatases in alzheimer's disease: the leading role of pp2a. |
2013-06-25 |
2023-08-12 |
Not clear |
| Dávid Lendvai, Markus Morawski, László Négyessy, Georgina Gáti, Carsten Jäger, Gábor Baksa, Tibor Glasz, Johannes Attems, Heikki Tanila, Thomas Arendt, Tibor Harkany, Alán Alpá. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. Acta neuropathologica. vol 125. issue 2. 2013-06-25. PMID:22961619. |
we demonstrate, by combining biochemical profiling and neuroanatomy in alzheimer's patients and transgenic (apde9) mice, the preserved turnover and distribution of axonal coats around functional synapses along dendrite segments containing hyperphosphorylated tau and in amyloid-β-laden hippocampal microdomains. |
2013-06-25 |
2023-08-12 |
mouse |
| Maria Luisa Rocco, Andrea Pristerà, Luana Pistillo, Luigi Aloe, Nadia Canu, Luigi Mann. Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. Journal of Alzheimer's disease : JAD. vol 33. issue 3. 2013-06-25. PMID:23001708. |
diabetes often correlates with tau phosphorylation and the development of alzheimer's disease. |
2013-06-25 |
2023-08-12 |
rat |
| Gucci Jijuan Gu, Di Wu, Harald Lund, Dan Sunnemark, Alexander J Kvist, Roy Milner, Sonia Eckersley, Lars N G Nilsson, Karin Agerman, Ulf Landegren, Masood Kamali-Moghadda. Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33. issue 3. 2013-06-25. PMID:23001711. |
elevated mark2-dependent phosphorylation of tau in alzheimer's disease. |
2013-06-25 |
2023-08-12 |
human |
| Gucci Jijuan Gu, Di Wu, Harald Lund, Dan Sunnemark, Alexander J Kvist, Roy Milner, Sonia Eckersley, Lars N G Nilsson, Karin Agerman, Ulf Landegren, Masood Kamali-Moghadda. Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33. issue 3. 2013-06-25. PMID:23001711. |
the appearance of neurofibrillary tangles (nft), one of the major hallmarks of alzheimer's disease (ad), is most likely caused by inappropriate phosphorylation and/or dephosphorylation of tau, eventually leading to the accumulation of nfts. |
2013-06-25 |
2023-08-12 |
human |
| Seong-Hun Chang, In-Soo Jung, Gi-Yeon Han, Nam-Hee Kim, Hyun-Jung Kim, Chan-Wha Ki. Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 430. issue 2. 2013-06-25. PMID:23211594. |
proteomic profiling of brain cortex tissues in a tau transgenic mouse model of alzheimer's disease. |
2013-06-25 |
2023-08-12 |
mouse |
| Yukako Sakagami, Takashi Kudo, Hitoshi Tanimukai, Daisuke Kanayama, Tsubasa Omi, Kikumi Horiguchi, Masayasu Okochi, Kazunori Imaizumi, Masatoshi Taked. Involvement of endoplasmic reticulum stress in tauopathy. Biochemical and biophysical research communications. vol 430. issue 2. 2013-06-25. PMID:23237806. |
tauopathy is a pathological condition with an abnormal intracellular accumulation of tau protein in neurons and glias, which is a feature of alzheimer's disease (ad) as well as frontotemporal lobar degenerations (ftld). |
2013-06-25 |
2023-08-12 |
Not clear |
| Martin H Schaefer, Tiago J S Lopes, Nancy Mah, Jason E Shoemaker, Yukiko Matsuoka, Jean-Fred Fontaine, Caroline Louis-Jeune, Amie J Eisfeld, Gabriele Neumann, Carol Perez-Iratxeta, Yoshihiro Kawaoka, Hiroaki Kitano, Miguel A Andrade-Navarr. Adding protein context to the human protein-protein interaction network to reveal meaningful interactions. PLoS computational biology. vol 9. issue 1. 2013-06-25. PMID:23300433. |
we use this approach to study the lung-specific pathways used by the influenza virus, pointing to irak1, bhlhe40 and tollip as potential regulators of influenza virus pathogenicity, and to study the signalling pathways that play a role in alzheimer's disease, identifying a pathway involving the altered phosphorylation of the tau protein. |
2013-06-25 |
2023-08-12 |
human |
| Carlos Cruchaga, John S K Kauwe, Oscar Harari, Sheng Chih Jin, Yefei Cai, Celeste M Karch, Bruno A Benitez, Amanda T Jeng, Tara Skorupa, David Carrell, Sarah Bertelsen, Matthew Bailey, David McKean, Joshua M Shulman, Philip L De Jager, Lori Chibnik, David A Bennett, Steve E Arnold, Denise Harold, Rebecca Sims, Amy Gerrish, Julie Williams, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Elaine R Peskind, Douglas Galasko, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. vol 78. issue 2. 2013-06-25. PMID:23562540. |
gwas of cerebrospinal fluid tau levels identifies risk variants for alzheimer's disease. |
2013-06-25 |
2023-08-12 |
Not clear |
| Carlos Cruchaga, John S K Kauwe, Oscar Harari, Sheng Chih Jin, Yefei Cai, Celeste M Karch, Bruno A Benitez, Amanda T Jeng, Tara Skorupa, David Carrell, Sarah Bertelsen, Matthew Bailey, David McKean, Joshua M Shulman, Philip L De Jager, Lori Chibnik, David A Bennett, Steve E Arnold, Denise Harold, Rebecca Sims, Amy Gerrish, Julie Williams, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Elaine R Peskind, Douglas Galasko, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. vol 78. issue 2. 2013-06-25. PMID:23562540. |
cerebrospinal fluid (csf) tau, tau phosphorylated at threonine 181 (ptau), and aβ₄₂ are established biomarkers for alzheimer's disease (ad) and have been used as quantitative traits for genetic analyses. |
2013-06-25 |
2023-08-12 |
Not clear |
| Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallai. Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. PloS one. vol 7. issue 11. 2013-06-24. PMID:23209707. |
soluble non-fibrillar assemblies of amyloid-beta (aβ) and aggregated tau protein are the proximate synaptotoxic species associated with alzheimer's disease (ad). |
2013-06-24 |
2023-08-12 |
human |
| Oliver B Villaflores, Ying-Ju Chen, Chih-Ping Chen, Jui-Ming Yeh, Tzong-Yuan W. Effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer's disease. Taiwanese journal of obstetrics & gynecology. vol 51. issue 4. 2013-06-24. PMID:23276558. |
effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for alzheimer's disease. |
2013-06-24 |
2023-08-12 |
Not clear |