| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Schön, Nadine A Hoffmann, Simon M Ochs, Steffen Burgold, Severin Filser, Sonja Steinbach, Mathias W Seeliger, Thomas Arzberger, Michel Goedert, Hans A Kretzschmar, Boris Schmidt, Jochen Herm. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300938. |
in contradiction to previous studies, our observations do not support the notion that aβ or tau in the retina are of diagnostic value in alzheimer's disease. |
2013-06-24 |
2023-08-12 |
mouse |
| Qian Huang, Hu Wang, Seth W Perry, Maria E Figueiredo-Pereir. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. The Journal of biological chemistry. vol 288. issue 17. 2013-06-24. PMID:23508964. |
in addition, calpain cleaved the microtubule-associated protein tau, a major component of neurofibrillary tangles in alzheimer disease and other tauopathies. |
2013-06-24 |
2023-08-12 |
rat |
| Biljana Georgievska, Johan Sandin, James Doherty, Anette Mörtberg, Jan Neelissen, Anita Andersson, Susanne Gruber, Yvonne Nilsson, Pär Schött, Per I Arvidsson, Sven Hellberg, Gunilla Osswald, Stefan Berg, Johanna Fälting, Ratan V Bha. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Journal of neurochemistry. vol 125. issue 3. 2013-06-20. PMID:23410232. |
abnormal tau phosphorylation resulting in detachment of tau from microtubules and aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary pathology seen in alzheimer's disease. |
2013-06-20 |
2023-08-12 |
mouse |
| Ines Moreno-Gonzalez, Lisbell D Estrada, Elisabeth Sanchez-Mejias, Claudio Sot. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease. Nature communications. vol 4. 2013-06-20. PMID:23422663. |
our results showed that smoking increases the severity of some abnormalities typical of alzheimer's disease, including amyloidogenesis, neuroinflammation and tau phosphorylation. |
2013-06-20 |
2023-08-12 |
mouse |
| Yu Luo, Yun-Juan Nie, Hai-Rong Shi, Zhong-Fei Ni, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochimica et biophysica acta. vol 1833. issue 5. 2013-06-20. PMID:23428800. |
protein phosphatase-2a (pp2a), an important phosphatase in dephosphorylating tau and preserving synapse, is significantly suppressed in alzheimer's disease (ad), but the mechanism is not well understood. |
2013-06-20 |
2023-08-12 |
mouse |
| Rodrigo A Quintanilla, Juan A Orellana, Rommy von Bernhard. Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress. Archives of medical research. vol 43. issue 8. 2013-06-18. PMID:23142264. |
alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by dementia and the presence of amyloid plaques and anomalous tau aggregates. |
2013-06-18 |
2023-08-12 |
Not clear |
| Ana M Cárdenas, Alvaro O Ardiles, Natalia Barraza, Ximena Baéz-Matus, Pablo Caviede. Role of tau protein in neuronal damage in Alzheimer's disease and Down syndrome. Archives of medical research. vol 43. issue 8. 2013-06-18. PMID:23142525. |
role of tau protein in neuronal damage in alzheimer's disease and down syndrome. |
2013-06-18 |
2023-08-12 |
human |
| Jürgen Götz, Di Xia, Gerhard Leinenga, Yee Lian Chew, Hannah Nichola. What Renders TAU Toxic. Frontiers in neurology. vol 4. 2013-06-18. PMID:23772223. |
tau is a microtubule-associated protein that under pathological conditions such as alzheimer's disease (ad) forms insoluble, filamentous aggregates. |
2013-06-18 |
2023-08-12 |
mouse |
| Umesh K Jinwal, Elias Akoury, Jose F Abisambra, John C O'Leary, Andrea D Thompson, Laura J Blair, Ying Jin, Justin Bacon, Bryce A Nordhues, Matthew Cockman, Juan Zhang, Pengfei Li, Bo Zhang, Sergiy Borysov, Vladimir N Uversky, Jacek Biernat, Eckhard Mandelkow, Jason E Gestwicki, Markus Zweckstetter, Chad A Dicke. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 4. 2013-06-17. PMID:23271055. |
despite its capacity to clear tau, hsp72 was not induced in the alzheimer's disease brain, suggesting a mechanism for age-associated onset of the disease. |
2013-06-17 |
2023-08-12 |
mouse |
| Margareta Hinterberger, Peter Fische. Folate and Alzheimer: when time matters. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22627695. |
it induces several alzheimer pathomechanisms like oxidative stress, ca(++) influx, accumulation of hyperphosphorylated tau and β-amyloid. |
2013-06-14 |
2023-08-12 |
human |
| Jasmin Bartl, Andrea Meyer, Svenja Brendler, Peter Riederer, Edna Grünblat. Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22782687. |
although alzheimer's dementia (ad) is not characterised any longer simply as the accumulation and deposition of amyloid beta (aβ) peptides and hyperphosphorylation of tau proteins within the brain, excessive aβ(42) deposition is still considered to play a major role in this illness. |
2013-06-14 |
2023-08-12 |
human |
| Alex Crowe, Michael J James, Virginia M-Y Lee, Amos B Smith, John Q Trojanowski, Carlo Ballatore, Kurt R Brunde. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of biological chemistry. vol 288. issue 16. 2013-06-13. PMID:23443659. |
alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein tau. |
2013-06-13 |
2023-08-12 |
Not clear |
| Alex Crowe, Michael J James, Virginia M-Y Lee, Amos B Smith, John Q Trojanowski, Carlo Ballatore, Kurt R Brunde. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of biological chemistry. vol 288. issue 16. 2013-06-13. PMID:23443659. |
interestingly, methylene blue, an inhibitor of tau fibrillization under evaluation in alzheimer disease clinical trials, caused a similar oxidation of cysteines in tau and other molecules. |
2013-06-13 |
2023-08-12 |
Not clear |
| Juanfang Liu, Xiaodong Yan, Ling Li, Yi Zhu, Kefeng Qin, Linfu Zhou, Dong Sun, Xiaohui Zhang, Ruidong Ye, Gang Zha. Ginsennoside rd attenuates cognitive dysfunction in a rat model of Alzheimer's disease. Neurochemical research. vol 37. issue 12. 2013-06-11. PMID:22903450. |
alzheimer's disease is a neurodegenerative disease characterized by the production of β-amyloid proteins and hyperphosphorylation of tau protein. |
2013-06-11 |
2023-08-12 |
rat |
| James K Chambers, Kazuyuki Uchida, Tomoyuki Harada, Masaya Tsuboi, Masumi Sato, Masahito Kubo, Hiroaki Kawaguchi, Noriaki Miyoshi, Hajime Tsujimoto, Hiroyuki Nakayam. Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. PloS one. vol 7. issue 10. 2013-06-11. PMID:23056312. |
the distributions of hyperphosphorylated tau-positive cells and the two major isoforms of aggregated tau proteins were quite similar to those seen in alzheimer's disease. |
2013-06-11 |
2023-08-12 |
human |
| Eunyoung Lee, Ji-Eun Eom, Hye-Lin Kim, Kyung Hye Baek, Kyu-Yeon Jun, Hwa-Jung Kim, Minyung Lee, Inhee Mook-Jung, Youngjoo Kwo. Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease. Biochimica et biophysica acta. vol 1831. issue 4. 2013-06-11. PMID:23246577. |
hyper-activated μ-calpain enhances the accumulation of β-amyloid peptide by increasing the expression level of β-secretase (bace1) and induces hyper-phosphorylation of tau along with the formation of neurofibrillary tangle by mediating p35 cleavage into p25, both of which are the major mechanisms of neurodegeneration in alzheimer's disease (ad). |
2013-06-11 |
2023-08-12 |
Not clear |
| Masafumi Hidaka, Tomoe Koga, Aina Gotoh, Mariko Sanada, Keiko Hirose, Takafumi Uchid. Alzheimer's disease-related protein hGas7b interferes with kinesin motility. Journal of biochemistry. vol 151. issue 6. 2013-06-10. PMID:22496485. |
we focused on the effect of hgas7b on microtubule dynamics in the absence of tau, on the assumption of healthy tau decrease in the brains of alzheimer's disease. |
2013-06-10 |
2023-08-12 |
Not clear |
| Rachel E Bennett, Thomas J Esparza, Hal A Lewis, Eddie Kim, Christine L Mac Donald, Patrick M Sullivan, David L Brod. Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. Journal of neuropathology and experimental neurology. vol 72. issue 5. 2013-06-10. PMID:23584199. |
by analogy to effects of apoe4 on the risk of alzheimer disease (ad), the apoe genotype may influence β-amyloid (aβ) and tau deposition after tbi. |
2013-06-10 |
2023-08-12 |
mouse |
| Dayong Wang, Qin Fu, Yuan Zhou, Bing Xu, Qian Shi, Benedict Igwe, Lucas Matt, Johannes W Hell, Elena V Wisely, Salvatore Oddo, Yang K Xian. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23430246. |
β2 adrenergic receptor, protein kinase a (pka) and c-jun n-terminal kinase (jnk) signaling pathways mediate tau pathology in alzheimer disease models. |
2013-06-07 |
2023-08-12 |
mouse |
| Dayong Wang, Qin Fu, Yuan Zhou, Bing Xu, Qian Shi, Benedict Igwe, Lucas Matt, Johannes W Hell, Elena V Wisely, Salvatore Oddo, Yang K Xian. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23430246. |
alzheimer disease (ad) is characterized by neurodegeneration marked by loss of synapses and spines associated with hyperphosphorylation of tau protein. |
2013-06-07 |
2023-08-12 |
mouse |