| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. |
this study investigates the relationship between wmls, hyperphosphorylated tau (p-tau) in cerebrospinal fluid (csf) and apolipoprotein e (apoe) ε4 genotype in prodromal alzheimer's disease (ad). |
2013-05-21 |
2023-08-12 |
Not clear |
| Abhinav Nath, Maria Sammalkorpi, David C DeWitt, Adam J Trexler, Shana Elbaum-Garfinkle, Corey S O'Hern, Elizabeth Rhoade. The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations. Biophysical journal. vol 103. issue 9. 2013-05-20. PMID:23199922. |
here, we investigate the model idps α-synuclein (αs) and tau, that are involved in major neurodegenerative conditions including parkinson's and alzheimer's diseases, using excluded volume monte carlo simulations constrained by pairwise distance distributions from single-molecule fluorescence measurements. |
2013-05-20 |
2023-08-12 |
human |
| Niklas Mattsson, Erik Portelius, Sindre Rolstad, Mikael Gustavsson, Ulf Andreasson, Mats Stridsberg, Anders Wallin, Kaj Blennow, Henrik Zetterber. Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22475796. |
cerebrospinal fluid (csf) measurements of amyloid-β42 (aβ42), total-tau (t-tau), and phosphorylated tau (p-tau) may be used to predict future alzheimer's disease (ad) dementia in patients with mild cognitive impairment (mci). |
2013-05-15 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
isomerase pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (cdk5)-dependent alzheimer phosphorylation sites. |
2013-05-14 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
alzheimer disease, the most common tauopathy, is characterized by neurofibrillary tangles that are mainly composed of abnormally phosphorylated tau. |
2013-05-14 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
pin1 deficiency is suggested to cause tau hyperphosphorylation in alzheimer disease. |
2013-05-14 |
2023-08-12 |
Not clear |
| Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. |
to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). |
2013-05-14 |
2023-08-12 |
human |
| Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao, Shuo Shi, Liangnian J. Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid. Biochemistry. vol 52. issue 11. 2013-05-09. PMID:23442089. |
inhibition of anomalous aggregation of tau protein would be an attractive therapeutic target for alzheimer's disease (ad). |
2013-05-09 |
2023-08-12 |
human |
| J Lasierra-Cirujeda, P Coronel, Mj Aza, M Gimen. Beta-amyloidolysis and glutathione in Alzheimer's disease. Journal of blood medicine. vol 4. 2013-05-08. PMID:23650462. |
the histopathological characteristic hallmark that gives personality to the diagnosis of alzheimer's disease is the accumulation of neurofibroid tangles located intracellularly in the brain, such as the protein tau and extracellular senile plaques made primarily of amyloidal substance. |
2013-05-08 |
2023-08-12 |
Not clear |
| Xiao-Hong Li, Jia-Zhao Xie, Xia Jiang, Bing-Ling Lv, Xiang-Shu Cheng, Lai-Ling Du, Jia-Yu Zhang, Jian-Zhi Wang, Xin-Wen Zho. Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation. Neuromolecular medicine. vol 14. issue 4. 2013-05-07. PMID:22798221. |
the hyperphosphorylated tau is a major protein component of neurofibrillary tangle, which is one of hallmarks of alzheimer's disease (ad). |
2013-05-07 |
2023-08-12 |
Not clear |
| Hayk Davtyan, Anahit Ghochikyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Anna Poghosyan, Annette M Marleau, Nina Movsesyan, Anatoly Kiyatkin, Suhail Rasool, Anna Kirstine Larsen, Peter Juul Madsen, Karen Malene Wegener, Dorte Kornerup Ditlevsen, David H Cribbs, Lars Ostergaard Pedersen, Michael G Agadjanya. Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486963. |
the alzheimer's disease (ad) process is understood to involve the accumulation of amyloid plaques and tau tangles in the brain. |
2013-05-06 |
2023-08-12 |
mouse |
| Simantini Ghosh, Michael D Wu, Solomon S Shaftel, Stephanos Kyrkanides, Frank M LaFerla, John A Olschowka, M Kerry O'Banio. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486975. |
sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer's mouse model. |
2013-05-06 |
2023-08-12 |
mouse |
| Donata Paternicò, Samantha Galluzzi, Valeria Drago, Luisella Bocchio-Chiavetto, Roberta Zanardini, Laura Pedrini, Manuela Baronio, Giovanni Amicucci, Giovanni B Frison. Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 6. 2013-05-03. PMID:22677492. |
low amyloid β42 (aβ42) and high total tau and phosphorylated tau (p-tau) concentrations in the cerebrospinal fluid (csf) are biomarkers of alzheimer's disease (ad), reflecting brain deposition of amyloid plaques and tangles. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. |
origins of alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. |
this review aims to address the temporal sequencing of involvement of amyloid-beta (aβ) and tau in the pathogenesis of alzheimer's disease and reconcile apparently conflicting neuropathologic and biomarker data. |
2013-05-03 |
2023-08-12 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Where, when, and in what form does sporadic Alzheimer's disease begin? Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23160422. |
intraneuronal lesions consisting of abnormal tau protein are seen to develop from the beginning until the end-phase of the pathological process underlying alzheimer's disease. |
2013-05-03 |
2023-08-12 |
Not clear |
| Anna Urbania. [p75NTR receptor--role in cell growth and apoptosis]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-05-02. PMID:22706116. |
p75ntr can interact with the aggregated form of aβ peptides and by influencing protein tau hyperphosphorylation plays an important role in etiopathogenesis of alzheimer's disease. |
2013-05-02 |
2023-08-12 |
Not clear |
| Karelle Leroy, Kunie Ando, Vincent Laporte, Robert Dedecker, Valérie Suain, Michèle Authelet, Céline Héraud, Nathalie Pierrot, Zehra Yilmaz, Jean-Noël Octave, Jean-Pierre Brio. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. The American journal of pathology. vol 181. issue 6. 2013-05-01. PMID:23026200. |
lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (app) identified in familial alzheimer disease. |
2013-05-01 |
2023-08-12 |
mouse |
| Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. |
the microtubule-associated protein tau plays a critical role in the pathogenesis of alzheimer's disease and several related disorders. |
2013-04-30 |
2023-08-12 |
human |
| Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. |
if previously postulated pathogenic extracellular tau intermediates are released by this route, low level constitutive tau secretion could play a role in the spread of tau pathology in alzheimer's disease and other human tauopathies. |
2013-04-30 |
2023-08-12 |
human |