| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Seidel, Dana Krinke, Heinz-Georg Jahnke, Anika Hirche, Daniel Kloß, Till G A Mack, Frank Striggow, Andrea Robitzk. Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. PloS one. vol 7. issue 11. 2013-05-23. PMID:23145103. |
we were able to quantify a time- and concentration-dependent relative impedance decrease when alzheimer's disease-like tau pathology was induced in the neuronal 3d cell culture model. |
2013-05-23 |
2023-08-12 |
human |
| R Killick, T R Hughes, B P Morgan, S Loveston. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience letters. vol 533. 2013-05-23. PMID:23153828. |
deletion of crry, the murine ortholog of the sporadic alzheimer's disease risk gene cr1, impacts tau phosphorylation and brain cfh. |
2013-05-23 |
2023-08-12 |
mouse |
| R Killick, T R Hughes, B P Morgan, S Loveston. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience letters. vol 533. 2013-05-23. PMID:23153828. |
we measured complement factor h, a component of the complement system and biomarker for alzheimer's disease progression, and tau phosphorylation at the serine 235 site, hyperphosphorylated forms of tau being a defining neuropathological hallmark of the disease. |
2013-05-23 |
2023-08-12 |
mouse |
| Ying Xiong, Kai Zhao, Jiaxi Wu, Zhiheng Xu, Shan Jin, Yong Q Zhan. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 12. 2013-05-23. PMID:23487739. |
neurons from the brains of alzheimer's disease (ad) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2013-05-23 |
2023-08-12 |
mouse |
| Robyn A Honea, Eric D Vidoni, Russell H Swerdlow, Jeffrey M Burn. Maternal family history is associated with Alzheimer's disease biomarkers. Journal of Alzheimer's disease : JAD. vol 31. issue 3. 2013-05-21. PMID:22669011. |
we analyzed cross-sectional data from non-demented, mild cognitive impairment (mci), and load participants in the alzheimer's disease neuroimaging initiative (adni) with pet imaging using pittsburgh compound b (pib, n = 99) and cerebrospinal fluid (csf) analysis (n = 403) for amyloid-β peptide (aβ) and total tau. |
2013-05-21 |
2023-08-12 |
human |
| Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. |
tau pathology and parietal white matter lesions have independent but synergistic effects on early development of alzheimer's disease. |
2013-05-21 |
2023-08-12 |
Not clear |
| Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. |
this study investigates the relationship between wmls, hyperphosphorylated tau (p-tau) in cerebrospinal fluid (csf) and apolipoprotein e (apoe) ε4 genotype in prodromal alzheimer's disease (ad). |
2013-05-21 |
2023-08-12 |
Not clear |
| Abhinav Nath, Maria Sammalkorpi, David C DeWitt, Adam J Trexler, Shana Elbaum-Garfinkle, Corey S O'Hern, Elizabeth Rhoade. The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations. Biophysical journal. vol 103. issue 9. 2013-05-20. PMID:23199922. |
here, we investigate the model idps α-synuclein (αs) and tau, that are involved in major neurodegenerative conditions including parkinson's and alzheimer's diseases, using excluded volume monte carlo simulations constrained by pairwise distance distributions from single-molecule fluorescence measurements. |
2013-05-20 |
2023-08-12 |
human |
| Niklas Mattsson, Erik Portelius, Sindre Rolstad, Mikael Gustavsson, Ulf Andreasson, Mats Stridsberg, Anders Wallin, Kaj Blennow, Henrik Zetterber. Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22475796. |
cerebrospinal fluid (csf) measurements of amyloid-β42 (aβ42), total-tau (t-tau), and phosphorylated tau (p-tau) may be used to predict future alzheimer's disease (ad) dementia in patients with mild cognitive impairment (mci). |
2013-05-15 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
isomerase pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (cdk5)-dependent alzheimer phosphorylation sites. |
2013-05-14 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
alzheimer disease, the most common tauopathy, is characterized by neurofibrillary tangles that are mainly composed of abnormally phosphorylated tau. |
2013-05-14 |
2023-08-12 |
Not clear |
| Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, Shin-Ichi Hisanag. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23362255. |
pin1 deficiency is suggested to cause tau hyperphosphorylation in alzheimer disease. |
2013-05-14 |
2023-08-12 |
Not clear |
| Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. |
to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). |
2013-05-14 |
2023-08-12 |
human |
| Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao, Shuo Shi, Liangnian J. Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid. Biochemistry. vol 52. issue 11. 2013-05-09. PMID:23442089. |
inhibition of anomalous aggregation of tau protein would be an attractive therapeutic target for alzheimer's disease (ad). |
2013-05-09 |
2023-08-12 |
human |
| J Lasierra-Cirujeda, P Coronel, Mj Aza, M Gimen. Beta-amyloidolysis and glutathione in Alzheimer's disease. Journal of blood medicine. vol 4. 2013-05-08. PMID:23650462. |
the histopathological characteristic hallmark that gives personality to the diagnosis of alzheimer's disease is the accumulation of neurofibroid tangles located intracellularly in the brain, such as the protein tau and extracellular senile plaques made primarily of amyloidal substance. |
2013-05-08 |
2023-08-12 |
Not clear |
| Xiao-Hong Li, Jia-Zhao Xie, Xia Jiang, Bing-Ling Lv, Xiang-Shu Cheng, Lai-Ling Du, Jia-Yu Zhang, Jian-Zhi Wang, Xin-Wen Zho. Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation. Neuromolecular medicine. vol 14. issue 4. 2013-05-07. PMID:22798221. |
the hyperphosphorylated tau is a major protein component of neurofibrillary tangle, which is one of hallmarks of alzheimer's disease (ad). |
2013-05-07 |
2023-08-12 |
Not clear |
| Hayk Davtyan, Anahit Ghochikyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Anna Poghosyan, Annette M Marleau, Nina Movsesyan, Anatoly Kiyatkin, Suhail Rasool, Anna Kirstine Larsen, Peter Juul Madsen, Karen Malene Wegener, Dorte Kornerup Ditlevsen, David H Cribbs, Lars Ostergaard Pedersen, Michael G Agadjanya. Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486963. |
the alzheimer's disease (ad) process is understood to involve the accumulation of amyloid plaques and tau tangles in the brain. |
2013-05-06 |
2023-08-12 |
mouse |
| Simantini Ghosh, Michael D Wu, Solomon S Shaftel, Stephanos Kyrkanides, Frank M LaFerla, John A Olschowka, M Kerry O'Banio. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486975. |
sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer's mouse model. |
2013-05-06 |
2023-08-12 |
mouse |
| Donata Paternicò, Samantha Galluzzi, Valeria Drago, Luisella Bocchio-Chiavetto, Roberta Zanardini, Laura Pedrini, Manuela Baronio, Giovanni Amicucci, Giovanni B Frison. Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 6. 2013-05-03. PMID:22677492. |
low amyloid β42 (aβ42) and high total tau and phosphorylated tau (p-tau) concentrations in the cerebrospinal fluid (csf) are biomarkers of alzheimer's disease (ad), reflecting brain deposition of amyloid plaques and tangles. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. |
origins of alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. |
2013-05-03 |
2023-08-12 |
Not clear |