All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Yipeng Wang, Eckhard Mandelko. Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817709. tau aggregates are present in several neurodegenerative diseases and correlate with the severity of memory deficit in ad (alzheimer's disease). 2012-12-07 2023-08-12 Not clear
Jesus Avila, Elena Gomez de Barreda, Almudena Fuster-Matanzo, Diana Simón, María Llorens-Martín, Tobias Engel, Jose J Lucas, Miguel Díaz-Hernández, Félix Hernánde. Looking for novel functions of tau. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817710. furthermore, tau can be found in the extracellular space because of the neuronal cell death occurring in neurodegenerative disorders such as alzheimer's disease. 2012-12-07 2023-08-12 mouse
Jeanna M Wheeler, Chris R Guthrie, Brian C Kraeme. Potential neuroprotective strategies against tauopathy. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817711. tauopathies are neurodegenerative diseases, including ad (alzheimer's disease) and ftld-t (tau-positive frontotemporal lobar degeneration), with shared pathology presenting as accumulation of detergent-insoluble hyperphosphorylated tau deposits in the central nervous system. 2012-12-07 2023-08-12 caenorhabditis_elegans
Kurt R Brunden, Carlo Ballatore, Virginia M-Y Lee, Amos B Smith, John Q Trojanowsk. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817712. neurons within the brains of those with ad (alzheimer's disease) and related neurodegenerative disorders, collectively termed 'tauopathies', contain fibrillar inclusions composed of hyperphosphorylated tau protein. 2012-12-07 2023-08-12 mouse
Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Lester I Binde. Tau oligomers and tau toxicity in neurodegenerative disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817713. ad (alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. 2012-12-07 2023-08-12 squid
Michael Niblock, Jean-Marc Gall. Tau alternative splicing in familial and sporadic tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817715. thus an accurate regulation of tau alternative splicing is critical for the maintenance of neuronal viability, and its alteration might be a contributing factor to alzheimer's disease. 2012-12-07 2023-08-12 human
Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. the relationship between subcortical tau pathology and alzheimer's disease. 2012-12-07 2023-08-12 Not clear
Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. the stepwise progression of tau pathology [nfts (neurofibrillary tangles) and nts (neuropil threads)] in ad (alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). 2012-12-07 2023-08-12 Not clear
Cora O'Neill, Aoife P Kiely, Meghan F Coakley, Sean Manning, Caitriona M Long-Smit. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817723. thus, in ad (alzheimer's disease), soluble oligomers, protofibrils and fibrils of the aβ (amyloid β-peptide) and tau protein accumulate in specific brain regions. 2012-12-07 2023-08-12 Not clear
Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. roles of the tau gene short tandem repeats in late-onset alzheimer's disease. 2012-12-06 2023-08-12 human
Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. this study assessed the roles of tau gene short tandem repeats (strs) nested within intron 1 (rs5820604 and rs10675722) and apolipoprotein e (apoe) gene polymorphisms in 70 late-onset alzheimer's disease (ad) subjects, 70 vascular dementia (vd) subjects, and 70 normal controls (ncs) in guizhou han population. 2012-12-06 2023-08-12 human
Yang Hong-Qi, Sun Zhi-Kun, Chen Sheng-D. Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23210837. current advances in the treatment of alzheimer's disease: focused on considerations targeting aβ and tau. 2012-12-06 2023-08-12 Not clear
Sean J Colloby, Shane McParland, John T O'Brien, Johannes Attem. Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22961551. we aimed to investigate the influence of nigral neuronal loss as well as nigral (α-synuclein, tau) and striatal (α-synuclein, tau, amyloid β) pathology on striatal uptake in a cohort of autopsy-confirmed alzheimer's disease (n = 4), dementia with lewy bodies (n = 7) and parkinson's disease dementia (n = 12) cases. 2012-12-05 2023-08-12 human
Siddhartha Mondragón-Rodríguez, Emilie Trillaud-Doppia, Anthony Dudilot, Catherine Bourgeois, Michel Lauzon, Nicole Leclerc, Jannic Boeh. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. The Journal of biological chemistry. vol 287. issue 38. 2012-12-04. PMID:22833681. amyloid-β and tau protein are the two most prominent factors in the pathology of alzheimer disease. 2012-12-04 2023-08-12 Not clear
Gonzalo Farías, Patricio Pérez, Andrea Slachevsky, Ricardo B Maccion. Platelet tau pattern correlates with cognitive status in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495344. platelet tau pattern correlates with cognitive status in alzheimer's disease. 2012-12-03 2023-08-12 human
Armand Perret-Liaudet, Mathieu Pelpel, Yannick Tholance, Benoit Dumont, Hugo Vanderstichele, Willy Zorzi, Benaissa Elmoualij, Susanna Schraen, Olivier Moreaud, Audrey Gabelle, Eric Thouvenot, Catherine Thomas-Anterion, Jacques Touchon, Pierre Krolak-Salmon, Gabor G Kovacs, Arnaud Coudreuse, Isabelle Quadrio, Sylvain Lehman. Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495345. tau proteins and amyloid-β (aβ) peptides are the current recognized cerebrospinal fluid (csf) biomarkers used as an aid in the diagnosis of alzheimer's disease (ad). 2012-12-03 2023-08-12 Not clear
b' Yash B Joshi, Jin Chu, Domenico Pratic\\xc3\\xb. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer\'s disease. Journal of Alzheimer\'s disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22531419.' stress hormone leads to memory deficits and altered tau phosphorylation in a model of alzheimer's disease. 2012-12-03 2023-08-12 mouse
Rodrigo Medeiros, Masashi Kitazawa, Meredith A Chabrier, David Cheng, David Baglietto-Vargas, Andreas Kling, Achim Moeller, Kim N Green, Frank M LaFerl. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. The American journal of pathology. vol 181. issue 2. 2012-11-26. PMID:22688056. exacerbated activation of calpain has been implicated as a major component in the signaling cascade that leads to β-amyloid (aβ) production and tau hyperphosphorylation in alzheimer's disease (ad). 2012-11-26 2023-08-12 mouse
Sebastiaan Engelborghs, Nathalie Le Bastar. The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease. Molecular diagnosis & therapy. vol 16. issue 3. 2012-11-19. PMID:22646065. the cerebrospinal fluid (csf) biomarkers β-amyloid(1-42) (aβ(1-42)), total tau protein (t-tau), and tau phosphorylated at threonine 181 (p-tau(181p)) are gradually finding their way into routine clinical practice as an affirmative diagnostic tool for alzheimer's disease (ad). 2012-11-19 2023-08-12 Not clear
Qi-Rui Ong, Mei-Li Lim, Ching-Ching Chua, Nam Sang Cheung, Boon-Seng Won. Impaired insulin signaling in an animal model of Niemann-Pick Type C disease. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22776200. studies have shown similarities between the histopathological characteristics of npc and alzheimer's disease (ad) including amyloid and tau pathologies. 2012-11-19 2023-08-12 mouse