Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yipeng Wang, Eckhard Mandelko. Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817709. |
tau aggregates are present in several neurodegenerative diseases and correlate with the severity of memory deficit in ad (alzheimer's disease). |
2012-12-07 |
2023-08-12 |
Not clear |
Jesus Avila, Elena Gomez de Barreda, Almudena Fuster-Matanzo, Diana Simón, María Llorens-Martín, Tobias Engel, Jose J Lucas, Miguel Díaz-Hernández, Félix Hernánde. Looking for novel functions of tau. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817710. |
furthermore, tau can be found in the extracellular space because of the neuronal cell death occurring in neurodegenerative disorders such as alzheimer's disease. |
2012-12-07 |
2023-08-12 |
mouse |
Jeanna M Wheeler, Chris R Guthrie, Brian C Kraeme. Potential neuroprotective strategies against tauopathy. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817711. |
tauopathies are neurodegenerative diseases, including ad (alzheimer's disease) and ftld-t (tau-positive frontotemporal lobar degeneration), with shared pathology presenting as accumulation of detergent-insoluble hyperphosphorylated tau deposits in the central nervous system. |
2012-12-07 |
2023-08-12 |
caenorhabditis_elegans |
Kurt R Brunden, Carlo Ballatore, Virginia M-Y Lee, Amos B Smith, John Q Trojanowsk. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817712. |
neurons within the brains of those with ad (alzheimer's disease) and related neurodegenerative disorders, collectively termed 'tauopathies', contain fibrillar inclusions composed of hyperphosphorylated tau protein. |
2012-12-07 |
2023-08-12 |
mouse |
Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Lester I Binde. Tau oligomers and tau toxicity in neurodegenerative disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817713. |
ad (alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. |
2012-12-07 |
2023-08-12 |
squid |
Michael Niblock, Jean-Marc Gall. Tau alternative splicing in familial and sporadic tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817715. |
thus an accurate regulation of tau alternative splicing is critical for the maintenance of neuronal viability, and its alteration might be a contributing factor to alzheimer's disease. |
2012-12-07 |
2023-08-12 |
human |
Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the relationship between subcortical tau pathology and alzheimer's disease. |
2012-12-07 |
2023-08-12 |
Not clear |
Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the stepwise progression of tau pathology [nfts (neurofibrillary tangles) and nts (neuropil threads)] in ad (alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). |
2012-12-07 |
2023-08-12 |
Not clear |
Cora O'Neill, Aoife P Kiely, Meghan F Coakley, Sean Manning, Caitriona M Long-Smit. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817723. |
thus, in ad (alzheimer's disease), soluble oligomers, protofibrils and fibrils of the aβ (amyloid β-peptide) and tau protein accumulate in specific brain regions. |
2012-12-07 |
2023-08-12 |
Not clear |
Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
roles of the tau gene short tandem repeats in late-onset alzheimer's disease. |
2012-12-06 |
2023-08-12 |
human |
Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
this study assessed the roles of tau gene short tandem repeats (strs) nested within intron 1 (rs5820604 and rs10675722) and apolipoprotein e (apoe) gene polymorphisms in 70 late-onset alzheimer's disease (ad) subjects, 70 vascular dementia (vd) subjects, and 70 normal controls (ncs) in guizhou han population. |
2012-12-06 |
2023-08-12 |
human |
Yang Hong-Qi, Sun Zhi-Kun, Chen Sheng-D. Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23210837. |
current advances in the treatment of alzheimer's disease: focused on considerations targeting aβ and tau. |
2012-12-06 |
2023-08-12 |
Not clear |
Sean J Colloby, Shane McParland, John T O'Brien, Johannes Attem. Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22961551. |
we aimed to investigate the influence of nigral neuronal loss as well as nigral (α-synuclein, tau) and striatal (α-synuclein, tau, amyloid β) pathology on striatal uptake in a cohort of autopsy-confirmed alzheimer's disease (n = 4), dementia with lewy bodies (n = 7) and parkinson's disease dementia (n = 12) cases. |
2012-12-05 |
2023-08-12 |
human |
Siddhartha Mondragón-Rodríguez, Emilie Trillaud-Doppia, Anthony Dudilot, Catherine Bourgeois, Michel Lauzon, Nicole Leclerc, Jannic Boeh. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. The Journal of biological chemistry. vol 287. issue 38. 2012-12-04. PMID:22833681. |
amyloid-β and tau protein are the two most prominent factors in the pathology of alzheimer disease. |
2012-12-04 |
2023-08-12 |
Not clear |
Gonzalo Farías, Patricio Pérez, Andrea Slachevsky, Ricardo B Maccion. Platelet tau pattern correlates with cognitive status in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495344. |
platelet tau pattern correlates with cognitive status in alzheimer's disease. |
2012-12-03 |
2023-08-12 |
human |
Armand Perret-Liaudet, Mathieu Pelpel, Yannick Tholance, Benoit Dumont, Hugo Vanderstichele, Willy Zorzi, Benaissa Elmoualij, Susanna Schraen, Olivier Moreaud, Audrey Gabelle, Eric Thouvenot, Catherine Thomas-Anterion, Jacques Touchon, Pierre Krolak-Salmon, Gabor G Kovacs, Arnaud Coudreuse, Isabelle Quadrio, Sylvain Lehman. Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495345. |
tau proteins and amyloid-β (aβ) peptides are the current recognized cerebrospinal fluid (csf) biomarkers used as an aid in the diagnosis of alzheimer's disease (ad). |
2012-12-03 |
2023-08-12 |
Not clear |
b' Yash B Joshi, Jin Chu, Domenico Pratic\\xc3\\xb. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer\'s disease. Journal of Alzheimer\'s disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22531419.' |
stress hormone leads to memory deficits and altered tau phosphorylation in a model of alzheimer's disease. |
2012-12-03 |
2023-08-12 |
mouse |
Rodrigo Medeiros, Masashi Kitazawa, Meredith A Chabrier, David Cheng, David Baglietto-Vargas, Andreas Kling, Achim Moeller, Kim N Green, Frank M LaFerl. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. The American journal of pathology. vol 181. issue 2. 2012-11-26. PMID:22688056. |
exacerbated activation of calpain has been implicated as a major component in the signaling cascade that leads to β-amyloid (aβ) production and tau hyperphosphorylation in alzheimer's disease (ad). |
2012-11-26 |
2023-08-12 |
mouse |
Sebastiaan Engelborghs, Nathalie Le Bastar. The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease. Molecular diagnosis & therapy. vol 16. issue 3. 2012-11-19. PMID:22646065. |
the cerebrospinal fluid (csf) biomarkers β-amyloid(1-42) (aβ(1-42)), total tau protein (t-tau), and tau phosphorylated at threonine 181 (p-tau(181p)) are gradually finding their way into routine clinical practice as an affirmative diagnostic tool for alzheimer's disease (ad). |
2012-11-19 |
2023-08-12 |
Not clear |
Qi-Rui Ong, Mei-Li Lim, Ching-Ching Chua, Nam Sang Cheung, Boon-Seng Won. Impaired insulin signaling in an animal model of Niemann-Pick Type C disease. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22776200. |
studies have shown similarities between the histopathological characteristics of npc and alzheimer's disease (ad) including amyloid and tau pathologies. |
2012-11-19 |
2023-08-12 |
mouse |