| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Attems, A Thomas, K Jellinge. Correlations between cortical and subcortical tau pathology. Neuropathology and applied neurobiology. vol 38. issue 6. 2013-02-22. PMID:22115520. |
recent studies indicate that tau pathology in alzheimer's disease (ad) does not initially manifest in the cerebral cortex but in selected subcortical nuclei, in particular the locus ceruleus (lc). |
2013-02-22 |
2023-08-12 |
Not clear |
| Yi Hong, Chi Bun Chan, Il-Sun Kwon, Xuekun Li, Mingke Song, Hyun-Pil Lee, Xia Liu, Pradoldej Sompol, Peng Jin, Hyoung-gon Lee, Shan Ping Yu, Keqiang Y. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197718. |
srpk2 phosphorylates tau and mediates the cognitive defects in alzheimer's disease. |
2013-02-19 |
2023-08-12 |
mouse |
| Meredith A Chabrier, Mathew Blurton-Jones, Andranik A Agazaryan, Joy L Nerhus, Hilda Martinez-Coria, Frank M LaFerl. Soluble aβ promotes wild-type tau pathology in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197725. |
growing evidence suggests that soluble aβ species can drive alzheimer disease (ad) pathogenesis by inducing a cascade of events including tau hyperphosphorylation, proteasome impairment, and synaptic dysfunction. |
2013-02-19 |
2023-08-12 |
mouse |
| Masahiro Nakamori, Tetsuya Takahashi, Yuu Yamazaki, Takashi Kurashige, Takemori Yamawaki, Masayasu Matsumot. Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration. Neuroreport. vol 23. issue 15. 2013-02-12. PMID:22968343. |
moreover, cdk5-positive granulovacuolar degeneration and phosphorylated tau colocalized in pyramidal neurons in alzheimer's disease and myd cases. |
2013-02-12 |
2023-08-12 |
Not clear |
| Yue Huagn, Yu-ming Xu, Jie-wen Zhang, Xiu-hua Ren, Ai-qin Su. [Effects of estrogen on P-Tau, ChAT and nerve growth factor protein expressions in the brain tissue of rats with Alzheimer's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 10. 2013-02-11. PMID:20965859. |
to examine the effect of estrogen on the expressions of phosphorylated tau (p-tau), chat and nerve growth factor (ngf) protein in the brain tissue of rat models of alzheimer disease (ad). |
2013-02-11 |
2023-08-12 |
rat |
| Kaj Blennow, John Hardy, Henrik Zetterber. The neuropathology and neurobiology of traumatic brain injury. Neuron. vol 76. issue 5. 2013-02-11. PMID:23217738. |
we also consider how the neuropathology and neurobiology of cte in many ways resembles other neurodegenerative illnesses such as alzheimer's disease, particularly with respect to mismetabolism and aggregation of tau, β-amyloid, and tdp-43. |
2013-02-11 |
2023-08-12 |
Not clear |
| Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, Bradley T Hyma. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22867711. |
the synaptic accumulation of hyperphosphorylated tau oligomers in alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. |
2013-02-06 |
2023-08-12 |
human |
| Gurdeep Marwarha, Othman Ghrib. Leptin signaling and Alzheimer's disease. American journal of neurodegenerative disease. vol 1. issue 3. 2013-02-06. PMID:23383396. |
in laboratory studies, several in vivo and in vitro studies have shown that leptin supplementation decreases amyloid-β (aβ) production and tau phosphorylation, two major biochemical events that play a key role in the pathogenesis of alzheimer's disease. |
2013-02-06 |
2023-08-12 |
Not clear |
| Zhou Chen, Bin Chen, Wen-Fang Xu, Rong-Fang Liu, Jian Yang, Chang-Xi Y. Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22906543. |
one of pathological hallmarks of alzheimer's disease (ad) is neurofibrillary tangles (nfts) consisting of abnormally hyperphosphorylated tau. |
2013-02-05 |
2023-08-12 |
Not clear |
| D Larry Sparks, Richard J Kryscio, Marwan N Sabbagh, Chuck Ziolkowski, Yushun Lin, Lisa M Sparks, Carolyn Liebsack, Sherry Johnson-Trave. Tau is reduced in AD plasma and validation of employed ELISA methods. American journal of neurodegenerative disease. vol 1. issue 1. 2013-02-05. PMID:23383382. |
measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (mci) and/or alzheimer's disease (ad). |
2013-02-05 |
2023-08-12 |
Not clear |
| b' Megan Larson, Mathew A Sherman, Fatou Amar, Mario Nuvolone, Julie A Schneider, David A Bennett, Adriano Aguzzi, Sylvain E Lesn\\xc3\\xa. The complex PrP(c)-Fyn couples human oligomeric A\\xce\\xb2 with pathological tau changes in Alzheimer\'s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175838.' |
the complex prp(c)-fyn couples human oligomeric aβ with pathological tau changes in alzheimer's disease. |
2013-02-01 |
2023-08-12 |
mouse |
| b' Megan Larson, Mathew A Sherman, Fatou Amar, Mario Nuvolone, Julie A Schneider, David A Bennett, Adriano Aguzzi, Sylvain E Lesn\\xc3\\xa. The complex PrP(c)-Fyn couples human oligomeric A\\xce\\xb2 with pathological tau changes in Alzheimer\'s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175838.' |
together, our findings identify a complete signaling cascade linking one specific endogenous aβ oligomer, fyn alteration, and tau hyperphosphorylation in cellular and animal models modeling aspects of the molecular pathogenesis of alzheimer's disease. |
2013-02-01 |
2023-08-12 |
mouse |
| Thomas Arend. Cell cycle activation and aneuploid neurons in Alzheimer's disease. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22528601. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder, characterized by synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the microtubule-associated protein tau. |
2013-01-31 |
2023-08-12 |
Not clear |
| Haruyuki Hongo, Takeshi Kihara, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Hachiro Sugimoto, Akinori Akaik. Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. Biochemical and biophysical research communications. vol 426. issue 1. 2013-01-31. PMID:22922102. |
tau, a microtubule-associated protein and substrate for gsk3β, has been implicated in the pathogenesis of tauopathies such as alzheimer's disease. |
2013-01-31 |
2023-08-12 |
Not clear |
| Takayuki Nemoto, Toshihiko Yanagita, Shinya Satoh, Toyoaki Maruta, Tasuku Kanai, Manabu Murakami, Akihiko Wad. Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway. Neurochemistry international. vol 59. issue 6. 2013-01-29. PMID:21854819. |
both insulin and tau, promoting neuronal differentiation (neurite outgrowth, neuronal polarity, and myelination) and cell survival, are associated with neurodegenerative disease (e.g., alzheimer's disease). |
2013-01-29 |
2023-08-12 |
cattle |
| Wing-Lau Ho, Yen Leung, Andrea Wing-Ting Tsang, Kwok-Fai So, Kin Chiu, Raymond Chuen-Chung Chan. Review: tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain? Molecular vision. vol 18. 2013-01-29. PMID:23170062. |
similar pathological changes of tau protein can be found in alzheimer's disease, frontotemporal lobe dementia, and glaucoma. |
2013-01-29 |
2023-08-12 |
human |
| Gabriele Ciasca, Gaetano Campi, Anna Battisti, Giuseppina Rea, Marina Rodio, Massimiliano Papi, Petra Pernot, Alexander Tenenbaum, Antonio Biancon. Continuous thermal collapse of the intrinsically disordered protein tau is driven by its entropic flexible domain. Langmuir : the ACS journal of surfaces and colloids. vol 28. issue 37. 2013-01-24. PMID:22891813. |
tau is also involved in the genesis and in the development of the alzheimer disease when it detaches from mt surfaces and aggregates in paired helical filaments. |
2013-01-24 |
2023-08-12 |
Not clear |
| Hanna Rosenman. CSF biomarkers for amyloid and tau pathology in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 47. issue 1. 2013-01-23. PMID:22058061. |
csf biomarkers for amyloid and tau pathology in alzheimer's disease. |
2013-01-23 |
2023-08-12 |
human |
| Markos Poulopoulos, Etty Cortes, Jean-Paul G Vonsattel, Stanley Fahn, Cheryl Waters, Lucien J Cote, Carol Moskowitz, Lawrence S Honig, Lorraine N Clark, Karen S Marder, Roy N Alcala. Clinical and pathological characteristics of LRRK2 G2019S patients with PD. Journal of molecular neuroscience : MN. vol 47. issue 1. 2013-01-23. PMID:22194196. |
cortical involvement varied significantly: one had diffuse lewy body (lb) pathology, tau inclusions, and amyloid pathology consistent with advanced alzheimer's disease; one had diffuse cortical lb; and one had only brainstem predominant lb pathology. |
2013-01-23 |
2023-08-12 |
human |
| Ulrike Krüger, Yipeng Wang, Satish Kumar, Eva-Maria Mandelko. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22169203. |
modulating the tau level may represent a therapeutic target for alzheimer's disease (ad), as accumulating evidence shows that abeta-induced neurodegeneration is mediated by tau. |
2013-01-21 |
2023-08-12 |
Not clear |