| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in alzheimer's disease, though how this occurs is not well understood. |
2023-07-11 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
the rate of longitudinal amyloid-beta and tau accumulation (both measured via pet) within this group did not differ from normal aging, supporting the distinction of primary age-related tauopathy from alzheimer's disease. |
2023-07-11 |
2023-08-14 |
Not clear |
| Danko Jeremic, Juan D Navarro-López, Lydia Jiménez-Día. Efficacy and Safety of Anti-Amyloid-β Monoclonal Antibodies in Current Alzheimer's Disease Phase III Clinical Trials: A Systematic Review and Interactive Web App-based Meta-Analysis. Ageing research reviews. 2023-07-09. PMID:37423541. |
secondary and tertiary outcomes included biomarkers of aβ and tau pathology, adverse events, and performance on alzheimer's disease cooperative study - activities of daily living scale. |
2023-07-09 |
2023-08-14 |
Not clear |
| Karthivashan Govindarajan, Satyabrata Ka. Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of alzheimer's disease. Journal of nanobiotechnology. vol 21. issue 1. 2023-07-09. PMID:37424018. |
evidence suggests that increased level/aggregation of β-amyloid (aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of alzheimer's disease (ad), the leading cause of dementia in the elderly. |
2023-07-09 |
2023-08-14 |
mouse |
| Shudan Gao, Yun Wang, Tao Ma, Junying Zhan. The Late Stage of Abnormal Aging: Dementia. Advances in experimental medicine and biology. vol 1419. 2023-07-07. PMID:37418213. |
currently, many related mechanisms of the pathogenesis of alzheimer's disease have been proposed, such as beta-amyloid (a) theory, tau protein theory, and nerve and blood vessel theory. |
2023-07-07 |
2023-08-14 |
Not clear |
| Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
tau protein hyperphosphorylation and formation of intracellular neurofibrillary tangles (nfts) are one of the histopathological hallmarks of alzheimer's disease (ad) and positively correlated with the severity of ad symptoms. |
2023-07-07 |
2023-08-14 |
human |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
her amnestic symptoms that were suggestive of alzheimer's type dementia are best explained by diffuse agd and medial temporal tdp-43 proteinopathy, and her motor symptoms were likely explained by neuronal loss and gliosis due to tau pathology in the substantia nigra. |
2023-07-06 |
2023-08-14 |
Not clear |
| Francesco Panza, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Nicoletta Cirillo, Christian Damiani, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Madia Lozupon. Clinical Development of Passive Tau-Based Immunotherapeutics for Treating Primary and Secondary Tauopathies. Expert opinion on investigational drugs. 2023-07-05. PMID:37405389. |
alzheimer's disease (ad), tau deposition can be observed, but tau coexists with another protein (amyloid-β). |
2023-07-05 |
2023-08-14 |
Not clear |
| Mark A Dubbelman, Kayden J Mimmack, Emily H Sprague, Rebecca E Amariglio, Patrizia Vannini, Gad A Marshal. Regional cerebral tau predicts decline in everyday functioning across the Alzheimer's disease spectrum. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-05. PMID:37408004. |
regional cerebral tau predicts decline in everyday functioning across the alzheimer's disease spectrum. |
2023-07-05 |
2023-08-14 |
Not clear |
| Angelina Holcom, Matias Fuentealba, Renuka Sivapatham, Christina D King, Hadley Osman, Anna Foulger, Dipa Bhaumik, Birgit Schilling, David Furman, Julie K Andersen, Gordon J Lithgo. Simultaneous neuronal expression of human amyloid-β and Tau genes drives global phenotypic and multi-omic changes in bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398058. |
simultaneous neuronal expression of human amyloid-β and tau genes drives global phenotypic and multi-omic changes in alzheimer's disease and alzheimer's related diseases (adrd) are a class of prevalent age-related neurodegenerative disorders characterized by the accumulation of amyloid- β (aβ) plaques and tau neurofibrillary tangles. |
2023-07-03 |
2023-08-14 |
human |
| Michael Ta, Cornelis Blauwendraat, Tarek Antar, Hampton L Leonard, Andrew B Singleton, Mike A Nalls, Hirotaka Iwak. Genome-wide meta-analysis of CSF biomarkers in Alzheimer's disease and Parkinson's disease cohorts. medRxiv : the preprint server for health sciences. 2023-07-03. PMID:37398091. |
amyloid beta (aβ), phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for alzheimer's disease (ad). |
2023-07-03 |
2023-08-14 |
Not clear |
| Avi J Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Darrin Goodness, Ruilin Tian, Parker Grosjean, Romany Abskharon, David Eisenberg, Nicholas M Kanaan, Li Gan, Carlo Condello, Danielle L Swaney, Martin Kampman. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398204. |
aggregation of the protein tau defines tauopathies, which include alzheimer's disease and frontotemporal dementia. |
2023-07-03 |
2023-08-14 |
human |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2023-07-03 |
2023-08-14 |
mouse |
| Jinlei Wang, Ying Lin, Xiaoyu Xu, Yonghui Wang, Qiong Xi. Identification of Tau-Tubulin Kinase 1 Inhibitors by Microfluidics-based Mobility Shift Assay from a Kinase Inhibitor Library. SLAS discovery : advancing life sciences R & D. 2023-07-03. PMID:37399991. |
hyperphosphorylated tau is the main cause of tauopathy, such as alzheimer's disease (ad). |
2023-07-03 |
2023-08-14 |
human |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
effects of the apoeɛ4 allele on the relationship between tau and amyloid-β in early- and late-onset alzheimer's disease. |
2023-07-02 |
2023-08-14 |
Not clear |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
little is known regarding the differential effects of the apolipoprotein e (apoe) ɛ4 on the regional topography of amyloid and tau in patients with both early-onset (eoad) and late-onset alzheimer's disease (load). |
2023-07-02 |
2023-08-14 |
Not clear |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
| Collyn M Kellogg, Kevin Pham, Adeline H Machalinski, Hunter L Porter, Harris E Blankenship, Kyla B Tooley, Michael B Stout, Heather C Rice, Amanda L Sharpe, Michael J Beckstead, Ana J Chucair-Elliott, Sarah R Ocañas, Willard M Freema. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. GeroScience. 2023-07-01. PMID:37393197. |
neuronal mhc-i is proposed to regulate developmental synapse elimination and tau pathology in alzheimer's disease (ad). |
2023-07-01 |
2023-08-14 |
mouse |
| Taeko Kimura, Haruaki Sato, Maria Kano, Lisa Tatsumi, Taisuke Tomit. Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers. FEBS open bio. 2023-06-30. PMID:37391389. |
the deposition of highly phosphorylated and aggregated tau is characteristic of tauopathies, including alzheimer disease. |
2023-06-30 |
2023-08-14 |
Not clear |
| Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsud. Relationship between the tau protein and choroid plexus volume in Alzheimer's disease. Neuroreport. vol 34. issue 11. 2023-06-29. PMID:37384934. |
relationship between the tau protein and choroid plexus volume in alzheimer's disease. |
2023-06-29 |
2023-08-14 |
human |