| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica S Damoiseaux, William W Seeley, Juan Zhou, William R Shirer, Giovanni Coppola, Anna Karydas, Howard J Rosen, Bruce L Miller, Joel H Kramer, Michael D Greiciu. Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699906. |
an additional analysis in an independent sample of healthy elderly using an independent marker of alzheimer's disease, i.e., spinal fluid levels of tau, provided corresponding evidence for this gender-by-apoe interaction. |
2012-09-24 |
2023-08-12 |
human |
| Tara Vanderweyde, Haung Yu, Megan Varnum, Liqun Liu-Yesucevitz, Allison Citro, Tsuneya Ikezu, Karen Duff, Benjamin Wolozi. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699908. |
we examined the relationship between sg proteins and neuropathology in brain tissue from p301l tau transgenic mice, as well as in cases of alzheimer's disease and ftdp-17. |
2012-09-24 |
2023-08-12 |
mouse |
| Mario Nizzari, Federica Barbieri, Maria Teresa Gentile, Daniela Passarella, Calentina Caorsi, Alberto Diaspro, Maurizio Taglialatela, Aldo Pagano, Luca Colucci-D'Amato, Tullio Florio, Claudio Russ. Amyloid-β protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau. Journal of Alzheimer's disease : JAD. vol 29. issue 1. 2012-09-21. PMID:22232001. |
with regards to alzheimer's disease (ad) pathogenesis, it is not yet established whether entangled tau represents a cause or a consequence of neurodegeneration. |
2012-09-21 |
2023-08-12 |
human |
| Leonardo P Navarrete, Leonardo Guzmán, Aurelio San Martín, Luis Astudillo-Saavedra, Ricardo B Maccion. Molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 1. 2012-09-21. PMID:22232002. |
molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for alzheimer's disease. |
2012-09-21 |
2023-08-12 |
human |
| Leonardo P Navarrete, Leonardo Guzmán, Aurelio San Martín, Luis Astudillo-Saavedra, Ricardo B Maccion. Molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 1. 2012-09-21. PMID:22232002. |
the neurofibrillary tangles (nfts) generated by self-aggregation of anomalous forms of tau represent a neuropathological hallmark of alzheimer's disease (ad). |
2012-09-21 |
2023-08-12 |
human |
| Leonardo P Navarrete, Leonardo Guzmán, Aurelio San Martín, Luis Astudillo-Saavedra, Ricardo B Maccion. Molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 1. 2012-09-21. PMID:22232002. |
we focused on the search for molecules that interact with aggregated tau of the alzheimer's type and that may block its aggregation before the formation of nfts. |
2012-09-21 |
2023-08-12 |
human |
| Maria Manczak, P Hemachandra Redd. Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Human molecular genetics. vol 21. issue 11. 2012-09-21. PMID:22367970. |
abnormal interaction between the mitochondrial fission protein drp1 and hyperphosphorylated tau in alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. |
2012-09-21 |
2023-08-12 |
mouse |
| Ismael Santa-Maria, Merina Varghese, Hanna Ksiezak-Reding, Anastasiya Dzhun, Jun Wang, Giulio M Pasinett. Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. The Journal of biological chemistry. vol 287. issue 24. 2012-09-21. PMID:22496370. |
paired helical filaments from alzheimer disease brain induce intracellular accumulation of tau protein in aggresomes. |
2012-09-21 |
2023-08-12 |
human |
| Ismael Santa-Maria, Merina Varghese, Hanna Ksiezak-Reding, Anastasiya Dzhun, Jun Wang, Giulio M Pasinett. Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. The Journal of biological chemistry. vol 287. issue 24. 2012-09-21. PMID:22496370. |
abnormal folding of tau protein leads to the generation of paired helical filaments (phfs) and neurofibrillary tangles, a key neuropathological feature in alzheimer disease and tauopathies. |
2012-09-21 |
2023-08-12 |
human |
| Ismael Santa-Maria, Merina Varghese, Hanna Ksiezak-Reding, Anastasiya Dzhun, Jun Wang, Giulio M Pasinett. Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. The Journal of biological chemistry. vol 287. issue 24. 2012-09-21. PMID:22496370. |
neuronal and non-neuronal cells overexpressing green fluorescent protein-tagged tau (gfp-tau) were treated with isolated fractions of human alzheimer disease-derived phfs for 24 h. we found that cells internalized phfs through an endocytic mechanism and developed intracellular gfp-tau aggregates with attributes of aggresomes. |
2012-09-21 |
2023-08-12 |
human |
| Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334661. |
hyperphosphorylated tau is the major component of neurofibrillary tangles in alzheimer disease (ad), and the tangle distribution largely overlaps with zinc-containing glutamatergic neurons, suggesting that zinc released in synaptic terminals may play a role in tau phosphorylation. |
2012-09-20 |
2023-08-12 |
Not clear |
| Teodoro Bottiglieri, Erland Arning, Brandi Wasek, Viyada Nunbhakdi-Craig, Jean-Marie Sontag, Estelle Sonta. Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 27. 2012-09-18. PMID:22764226. |
here we show in human sh-sy5y cells, in dopaminergic neurons, and in wild-type mice that l-dopa results in a reduced sam/sah ratio that is associated with hypomethylation of pp2a and increased phosphorylation of tau (p-tau) at the alzheimer's disease-like phf-1 phospho-epitope. |
2012-09-18 |
2023-08-12 |
mouse |
| Yuen-Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hui-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jianzhi Wang, Larry Baum, Kwok-Fai So, Raymond Chuen-Chung Chan. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 28. issue 4. 2012-09-17. PMID:22101233. |
endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in alzheimer's disease pathogenesis. |
2012-09-17 |
2023-08-12 |
mouse |
| Yuen-Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hui-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jianzhi Wang, Larry Baum, Kwok-Fai So, Raymond Chuen-Chung Chan. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 28. issue 4. 2012-09-17. PMID:22101233. |
recent data have shown that activation of upr can be found in postmortem brains of alzheimer's disease (ad) patients; and biological markers for activation of upr are abundant in neurons with diffuse phosphorylated tau. |
2012-09-17 |
2023-08-12 |
mouse |
| Nicole Schonrock, David T Humphreys, Thomas Preiss, Jürgen Göt. Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β. Journal of molecular neuroscience : MN. vol 46. issue 2. 2012-09-14. PMID:21720722. |
their profiles are significantly altered in neurodegenerative diseases such as alzheimer's disease (ad) that is characterized by amyloid-β (aβ) and tau deposition in brain. |
2012-09-14 |
2023-08-12 |
mouse |
| Yoon-Ha Kim, Eun-Kyung Lee, Seung-Ah Park, Nam-Hee Kim, Chan-Wha Ki. Proteomic analysis of plasma from a Tau transgenic mouse. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22406198. |
the neurofibrillary tangles (nfts) formed by the accumulation of abnormal tau filaments have been shown to be involved in alzheimer's disease (ad) brain degeneration. |
2012-09-13 |
2023-08-12 |
mouse |
| Yazi D Ke, Yazi Ke, Joe Dramiga, Ulrich Schütz, Jillian J Kril, Lars M Ittner, Hannsjörg Schröder, Jürgen Göt. Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PloS one. vol 7. issue 4. 2012-09-13. PMID:22558197. |
tau dysfunction characterizes neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld). |
2012-09-13 |
2023-08-12 |
mouse |
| H-Y Wang, L-I Juo, Y-T Lin, M Hsiao, J-T Lin, C-H Tsai, Y-H Tzeng, Y-C Chuang, N-S Chang, C-N Yang, P-J L. WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22193544. |
ww domain-containing oxidoreductase (wwox), a putative tumour suppressor, is suggested to be involved in the hyperphosphorylation of alzheimer's tau. |
2012-09-10 |
2023-08-12 |
Not clear |
| Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406441. |
effects of the superoxide dismutase/catalase mimetic euk-207 in a mouse model of alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. |
2012-09-10 |
2023-08-12 |
mouse |
| Jaya R P Prasanthi, Matthew Schrag, Bhanu Dasari, Gurdeep Marwarha, April Dickson, Wolff M Kirsch, Othman Ghrib. Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406440. |
accumulation of amyloid-β (aβ) peptide and the hyperphosphorylation of tau protein are major hallmarks of alzheimer's disease (ad). |
2012-09-10 |
2023-08-12 |
rabbit |