Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Sébastien S Hébert, Nicolas Sergeant, Luc Bué. MicroRNAs and the Regulation of Tau Metabolism. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720189. |
abnormal regulation of tau phosphorylation and/or alternative splicing is associated with the development of a large (>20) group of neurodegenerative disorders collectively known as tauopathies, the most common being alzheimer's disease. |
2012-08-23 |
2023-08-12 |
mouse |
Yazi D Ke, Alexandra K Suchowerska, Julia van der Hoven, Dineeka M De Silva, Christopher W Wu, Janet van Eersel, Arne Ittner, Lars M Ittne. Lessons from tau-deficient mice. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720190. |
both alzheimer's disease (ad) and frontotemporal dementia (ftd) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-08-23 |
2023-08-12 |
mouse |
Nadia Canu, Ilaria Filesi, Andrea Pristerà, Maria Teresa Ciotti, Silvia Biocc. Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841253. |
the microtubule associated protein tau plays a crucial role in alzheimer's disease and in many neurodegenerative disorders collectively known as tauopathies. |
2012-08-20 |
2023-08-12 |
Not clear |
Nikolai N Sluchanko, Nikolai B Guse. Probable participation of 14-3-3 in tau protein oligomerization and aggregation. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21876254. |
aggregation of tau proteins followed by formation of paired helical filaments and neurofibrillary tangles is considered as a hallmark of certain neurodegenerative disorders such as different tauopathies and alzheimer's disease (ad). |
2012-08-20 |
2023-08-12 |
human |
Najla Kfoury, Brandon B Holmes, Hong Jiang, David M Holtzman, Marc I Diamon. Trans-cellular propagation of Tau aggregation by fibrillar species. The Journal of biological chemistry. vol 287. issue 23. 2012-08-20. PMID:22461630. |
aggregation of the microtubule associated protein tau is associated with several neurodegenerative disorders, including alzheimer disease and frontotemporal dementia. |
2012-08-20 |
2023-08-12 |
Not clear |
Najla Kfoury, Brandon B Holmes, Hong Jiang, David M Holtzman, Marc I Diamon. Trans-cellular propagation of Tau aggregation by fibrillar species. The Journal of biological chemistry. vol 287. issue 23. 2012-08-20. PMID:22461630. |
in alzheimer disease, tau pathology spreads progressively throughout the brain, possibly along existing neural networks. |
2012-08-20 |
2023-08-12 |
Not clear |
José L Molinuevo, Juan D Gispert, Jesús Pujol, Santiago Rojas, Albert Lladó, Mircea Balasa, Anna Antonell, Raquel Sánchez-Valle, Lorena Ram. [A new approach to the Alzheimer's disease diagnosis with biomarkers: description of the AD-CSF-Index]. Revista de neurologia. vol 54. issue 9. 2012-08-20. PMID:22532214. |
studies with cerebrospinal fluid (csf) biomarkers in patients with confirmed alzheimer's disease (ad) pathology have shown that decreased levels of abeta(1-42) and increased levels of tau and p-tau, are a specific feature of the ad type pathology. |
2012-08-20 |
2023-08-12 |
Not clear |
Julia Miralbell, Gabriela Spulber, Babak Hooshmand, Ariadna Besga, Maria Mataró, Angel Cedazo-Minguez, Miia Kivipelto, Lars-Olof Wahlun. Grey matter and cognitive patterns in cognitive impaired subjects using CSF biomarker cut-offs. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22330819. |
patients with abnormal levels of csf tau (but not aβ1-42) showed an alzheimer's disease-like pattern for both gm distribution and cognitive profile, compared to those with normal levels. |
2012-08-17 |
2023-08-12 |
human |
María Llorens-Martin, Cátia M Teixeira, Almudena Fuster-Matanzo, Jerónimo Jurado-Arjona, Víctor Borrell, Eduardo Soriano, Jesús Avila, Félix Hernánde. Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22337826. |
tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for alzheimer's disease. |
2012-08-17 |
2023-08-12 |
mouse |
Nancy Beyer, David T R Coulson, Shirley Heggarty, Rivka Ravid, Jan Hellemans, G Brent Irvine, Janet A Johnsto. Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22349685. |
zn2+ can accelerate assembly of the amyloid-β peptides (aβ) and tau protein central to the neuropathological changes found in alzheimer's disease (ad). |
2012-08-17 |
2023-08-12 |
human |
Zan-Chao Liu, Zheng-Qi Fu, Jie Song, Jia-Yu Zhang, Yu-Ping Wei, Jiang Chu, Li Han, Na Qu, Jian-Zhi Wang, Qing Tia. Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22460328. |
hyperphosphorylated tau is the major component of intracellular neurofibrillary tangles, which is positively correlated with the cognitive decline in alzheimer's disease (ad). |
2012-08-17 |
2023-08-12 |
rat |
José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ana Pozueta, Miguel Calero, José Luis Dobato, Ana Frank-García, Fernando Valdivieso, José Berciano, Maria J Bullido, Onofre Combarro. Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21811019. |
genetic variation in the tau kinases pathway may modify the risk and age at onset of alzheimer's disease. |
2012-08-16 |
2023-08-12 |
Not clear |
José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ana Pozueta, Miguel Calero, José Luis Dobato, Ana Frank-García, Fernando Valdivieso, José Berciano, Maria J Bullido, Onofre Combarro. Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21811019. |
tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in the alzheimer's disease (ad) brain is the result of upregulation of tau kinases. |
2012-08-16 |
2023-08-12 |
Not clear |
Min Shi, Yu-Ting Sui, Elaine R Peskind, Ge Li, HyeJin Hwang, Ivana Devic, Carmen Ginghina, John Scott Edgar, Catherine Pan, David R Goodlett, Amy R Furay, Luis F Gonzalez-Cuyar, Jing Zhan. Salivary tau species are potential biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21841250. |
salivary tau species are potential biomarkers of alzheimer's disease. |
2012-08-16 |
2023-08-12 |
human |
Min Shi, Yu-Ting Sui, Elaine R Peskind, Ge Li, HyeJin Hwang, Ivana Devic, Carmen Ginghina, John Scott Edgar, Catherine Pan, David R Goodlett, Amy R Furay, Luis F Gonzalez-Cuyar, Jing Zhan. Salivary tau species are potential biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21841250. |
phosphorylation of tau protein is a critical event in the pathogenesis of alzheimer's disease (ad). |
2012-08-16 |
2023-08-12 |
human |
Marjolein B Aerts, Rianne A J Esselink, Jugen A H R Claassen, Wilson Farid Abdo, Bastiaan R Bloem, Marcel M Verbee. CSF tau, Aβ42, and MHPG differentiate dementia with Lewy bodies from Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21841257. |
csf tau, aβ42, and mhpg differentiate dementia with lewy bodies from alzheimer's disease. |
2012-08-16 |
2023-08-12 |
Not clear |
Anaïs Wanet, Aurélie Tacheny, Thierry Arnould, Patricia Renar. miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic acids research. vol 40. issue 11. 2012-08-16. PMID:22362752. |
mir-132 and mir-212 are tandem mirnas whose expression is necessary for the proper development, maturation and function of neurons and whose deregulation is associated with several neurological disorders, such as alzheimer's disease and tauopathies (neurodegenerative diseases resulting from the pathological aggregation of tau protein in the human brain). |
2012-08-16 |
2023-08-12 |
human |
Norbert Zilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladar Madari, Dominika Obetkova, Ondrej Bugos, Michal Nova. Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. Journal of neuroinflammation. vol 9. 2012-08-14. PMID:22397366. |
neurodegeneration, induced by misfolded tau protein, and neuroinflammation, driven by glial cells, represent the salient features of alzheimer's disease (ad) and related human tauopathies. |
2012-08-14 |
2023-08-12 |
human |
Norbert Zilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladar Madari, Dominika Obetkova, Ondrej Bugos, Michal Nova. Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. Journal of neuroinflammation. vol 9. 2012-08-14. PMID:22397366. |
on the other hand, our recent data show that misfolded tau could represent a trigger for microglial activation, suggesting the dual role of misfolded tau in the alzheimer's disease inflammatory cascade. |
2012-08-14 |
2023-08-12 |
human |
Norbert Zilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladar Madari, Dominika Obetkova, Ondrej Bugos, Michal Nova. Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. Journal of neuroinflammation. vol 9. 2012-08-14. PMID:22397366. |
thus disease-modified tau represents an important target for potential therapeutic strategies for patients with alzheimer's disease. |
2012-08-14 |
2023-08-12 |
human |