| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Igor Yakushev, Matthias J Muller, Hans-Georg Buchholz, Ulrike Lang, Heidi Rossmann, Harald Hampel, Mathias Schreckenberger, Andreas Fellgiebe. Stage-dependent agreement between cerebrospinal fluid proteins and FDG-PET findings in Alzheimer's disease. Current Alzheimer research. vol 9. issue 2. 2012-07-20. PMID:22044023. |
cerebral hypometabolism and abnormal levels of amyloid beta (aβ), total (t-tau) and phosphorylated tau (ptau) proteins in cerebrospinal fluid (csf) are established biomarkers of alzheimer's disease (ad). |
2012-07-20 |
2023-08-12 |
human |
| Igor Yakushev, Matthias J Muller, Hans-Georg Buchholz, Ulrike Lang, Heidi Rossmann, Harald Hampel, Mathias Schreckenberger, Andreas Fellgiebe. Stage-dependent agreement between cerebrospinal fluid proteins and FDG-PET findings in Alzheimer's disease. Current Alzheimer research. vol 9. issue 2. 2012-07-20. PMID:22044023. |
csf tau proteins and fdg-pet might substitute each other as supportive diagnostic tools in patients with suspected moderate-to-severe alzheimer's dementia, while this is not the case in subjects at an earlier disease stage. |
2012-07-20 |
2023-08-12 |
human |
| L Torrent, I Ferre. PP2A and Alzheimer disease. Current Alzheimer research. vol 9. issue 2. 2012-07-20. PMID:22299660. |
activation of tau kinases plays a crucial role in tau- hyper-phosphorylation in alzheimer disease (ad) and related tauopathies. |
2012-07-20 |
2023-08-12 |
Not clear |
| P Fuentes, J Catala. A clinical perspective: anti tau's treatment in Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605037. |
a clinical perspective: anti tau's treatment in alzheimer's disease. |
2012-07-19 |
2023-08-12 |
Not clear |
| L P Navarrete, P Pérez, I Morales, R B Maccion. Novel drugs affecting tau behavior in the treatment of Alzheimer's disease and tauopathies. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605038. |
novel drugs affecting tau behavior in the treatment of alzheimer's disease and tauopathies. |
2012-07-19 |
2023-08-12 |
human |
| C A Lasagna-Reeves, D L Castillo-Carranza, G R Jackson, R Kaye. Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605039. |
tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies. |
2012-07-19 |
2023-08-12 |
Not clear |
| C A Lasagna-Reeves, D L Castillo-Carranza, G R Jackson, R Kaye. Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605039. |
the aggregation and accumulation of the microtubule-associated protein (tau) is a pathological hallmark of alzheimer disease (ad) and many neurodegenerative diseases. |
2012-07-19 |
2023-08-12 |
Not clear |
| L D Estrada, S M Zanlungo, A R Alvare. C-Abl tyrosine kinase signaling: a new player in AD tau pathology. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605041. |
hyperphosphorylated tau is a cardinal feature of alzheimer's disease (ad) pathology. |
2012-07-19 |
2023-08-12 |
Not clear |
| D J Bonda, R J Castellani, X Zhu, A Nunomura, H-g Lee, G Perry, M A Smit. A novel perspective on tau in Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605042. |
a novel perspective on tau in alzheimer's disease. |
2012-07-19 |
2023-08-12 |
Not clear |
| K Belarbi, S Burnouf, F-J Fernandez-Gomez, J Desmercières, L Troquier, J Brouillette, L Tsambou, M-E Grosjean, R Caillierez, D Demeyer, M Hamdane, K Schindowski, D Blum, L Bué. Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology? Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605043. |
alzheimer's disease (ad) is a neurodegenerative disorder histologically defined by the cerebral accumulation of amyloid deposits and neurofibrillary tangles composed of hyperphosphorylated tau proteins. |
2012-07-19 |
2023-08-12 |
mouse |
| E Lonati, M Masserini, A Bulbarell. Pin1: a new outlook in Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605045. |
neurodegenerative diseases termed tauopathies, including alzheimer disease, are characterized by the presence of intraneuronal neurofibrillary tangles (nfts), composed by hyperphosphorylated protein tau. |
2012-07-19 |
2023-08-12 |
Not clear |
| G Farías, A Cornejo, J Jiménez, L Guzmán, R B Maccion. Mechanisms of tau self-aggregation and neurotoxicity. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605046. |
pathological tau protein aggregates can be found in brain of patients with some of the neurodegenerative diseases collectively known as tauopathies, which include alzheimer's disease (ad). |
2012-07-19 |
2023-08-12 |
Not clear |
| A Boutajangout, E M Sigurdsson, P K Krishnamurth. Tau as a therapeutic target for Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21679154. |
tau as a therapeutic target for alzheimer's disease. |
2012-07-19 |
2023-08-12 |
Not clear |
| A Boutajangout, E M Sigurdsson, P K Krishnamurth. Tau as a therapeutic target for Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21679154. |
neurofibrillary tangles (nfts) are one of the pathological hallmarks of alzheimer's disease (ad) and are primarily composed of aggregates of hyperphosphorylated forms of the microtubule associated protein tau. |
2012-07-19 |
2023-08-12 |
Not clear |
| Mikio Shoj. [Biomarkers for Alzheimer's disease: after Alzheimer's disease neuroimaging initiative studies]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 5. 2012-07-17. PMID:22570063. |
csf aβ42, total tau, and phosphorylated tau181 are the most sensitive biomarkers for diagnosing alzheimer's disease (ad) and predicting the onset of ad in cases with mild cognitive impairment (mci) due to ad. |
2012-07-17 |
2023-08-12 |
Not clear |
| Gema Alvarez, Jesús Aldudo, María Alonso, Soraya Santana, Fernando Valdivies. Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells. Journal of neuroscience research. vol 90. issue 5. 2012-07-16. PMID:22252837. |
although tau is most widely known as a microtubule-associated protein found in a hyperphosphorylated state in the brains of patients with alzheimer's disease (ad), this protein has also been detected at other sites such as the nucleolus. |
2012-07-16 |
2023-08-12 |
human |
| Justin M Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G Glabe, Hans-Ulrich Demuth, George S Bloo. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature. vol 485. issue 7400. 2012-07-12. PMID:22660329. |
extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of alzheimer's disease. |
2012-07-12 |
2023-08-12 |
mouse |
| Eric Heuer, Rebecca F Rosen, Amarallys Cintron, Lary C Walke. Nonhuman primate models of Alzheimer-like cerebral proteopathy. Current pharmaceutical design. vol 18. issue 8. 2012-07-09. PMID:22288403. |
the aβ and tau proteins, two key players in the pathogenesis of alzheimer's disease (ad), are highly homologous among primates. |
2012-07-09 |
2023-08-12 |
human |
| Toshiki Uchihara, Makoto Hara, Ayako Nakamura, Katsuiku Hirokaw. Tangle evolution linked to differential 3- and 4-repeat tau isoform deposition: a double immunofluorolabeling study using two monoclonal antibodies. Histochemistry and cell biology. vol 137. issue 2. 2012-07-05. PMID:22116524. |
this novel method revealed that tau immunoreactivity (ir) in the hippocampal pyramidal neurons of alzheimer's disease (ad) brains is heterogeneous in that pretangle neurons exhibit 4r-selective (3r-/4r+) ir, ghost tangles exhibit 3r-selective (3r+/4r-) ir, and neurofibrillary tangles exhibit both 3r and 4r (3r+/4r+) ir. |
2012-07-05 |
2023-08-12 |
human |
| Rodrigo Medeiros, David Baglietto-Vargas, Frank M LaFerl. The role of tau in Alzheimer's disease and related disorders. CNS neuroscience & therapeutics. vol 17. issue 5. 2012-07-03. PMID:20553310. |
the role of tau in alzheimer's disease and related disorders. |
2012-07-03 |
2023-08-12 |
Not clear |